目的观察原发性肝癌(primary hepatocellular carcinoma,PHC)与血清25(OH)维生素D水平的相关性。方法抽取2018年8月—2020年8月莆田市第一医院PHC患者50例作为观察组,抽取同时期健康体检者50例作为对照组。检测两组血清25(OH)D3水平以...目的观察原发性肝癌(primary hepatocellular carcinoma,PHC)与血清25(OH)维生素D水平的相关性。方法抽取2018年8月—2020年8月莆田市第一医院PHC患者50例作为观察组,抽取同时期健康体检者50例作为对照组。检测两组血清25(OH)D3水平以及甲胎蛋白(alpha fetoprotein,AFP)水平。结果观察组血清25(OH)D3水平低于对照组,差异有统计学意义(P<0.05)。观察组AFP水平高于对照组,差异有统计学意义(P<0.05)。PHC血清患者25(OH)D3水平与中国肝癌分期(China live cancer staging,CNLC)、淋巴结转移有关,差异有统计学意义(P<0.05)。结论针对PHC患者,其血清25(OH)D3水平主要相关因素为CNLC分期、淋巴结转移,根据血清25(OH)D3水平可为疾病治疗及其预后评估提供依据。展开更多
Objective To study the effect of oral vitamin D （VD） supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men. Methods Twenty-one obese men with their body mass index （BMI）〉28 k...Objective To study the effect of oral vitamin D （VD） supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men. Methods Twenty-one obese men with their body mass index （BMI）〉28 kg/m2 served as an obese group and 22 healthy normal-weight men with their BMI〈24 kg/m2 served as a control group in this study. After they were given 50 000 IU of oral VD, once a week for 8 weeks, the serum 25-hydroxyvitamin D [25（OH）D] concentration was measured with an enzyme-immunoassay kit. Results After oral VD supplementation, the serum 25（OH）D concentration significantly increased from 46.1＋9.1 nmol/L to 116.7_＋20.3 nmol/L in the obese subjects （P〈O.01） and from 52.8_＋17.8 nmol/L to 181.3_＋30.2 nmol/L in the control ones （P=0.13）. The serum high-density lipoprotein cholesterol （HDL-C） level was reduced within the normal reference range in the obese group. However, no significant change was observed in the level of other serum lipids （triglycerides, total cholesterol, and low-density lipoprotein cholesterol） in either of the two groups. Conclusion The effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group. High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.展开更多
目的探讨非酒精性脂肪肝(NAFLD)患者血浆25-OH维生素D(25-OH Vit D)水平变化。方法随机入组NAFLD患者50例,年龄匹配的健康对照者50例,留取血清及血浆标本测定血糖及血脂。使用液相色谱-质谱法测定血清25-OH Vit D水平。用t检验比较两组...目的探讨非酒精性脂肪肝(NAFLD)患者血浆25-OH维生素D(25-OH Vit D)水平变化。方法随机入组NAFLD患者50例,年龄匹配的健康对照者50例,留取血清及血浆标本测定血糖及血脂。使用液相色谱-质谱法测定血清25-OH Vit D水平。用t检验比较两组间各指标间的差异,用Spearman相关分析检测血清25-OH Vit D水平与NAFLD之间的相关性。结果 NAFLD组血清25-OH Vit D水平较健康对照组显著下降(P=0.03);25-OH Vit D水平与NAFLD明显相关(r=-0.128,P=0.002)。结论NAFLD患者存在25-OH Vit D缺乏,且低25-OH Vit D水平与NAFLD显著相关。展开更多
文摘目的观察原发性肝癌(primary hepatocellular carcinoma,PHC)与血清25(OH)维生素D水平的相关性。方法抽取2018年8月—2020年8月莆田市第一医院PHC患者50例作为观察组,抽取同时期健康体检者50例作为对照组。检测两组血清25(OH)D3水平以及甲胎蛋白(alpha fetoprotein,AFP)水平。结果观察组血清25(OH)D3水平低于对照组,差异有统计学意义(P<0.05)。观察组AFP水平高于对照组,差异有统计学意义(P<0.05)。PHC血清患者25(OH)D3水平与中国肝癌分期(China live cancer staging,CNLC)、淋巴结转移有关,差异有统计学意义(P<0.05)。结论针对PHC患者,其血清25(OH)D3水平主要相关因素为CNLC分期、淋巴结转移,根据血清25(OH)D3水平可为疾病治疗及其预后评估提供依据。
基金supported by grants from Danone Institute,China Diet Nutrition Research & Communication (DIC2010-03)National Natural Science Foundation of China (81172669)+1 种基金Medical Scientific Research Foundation of Guangdong Province (A2012581)National Key Technology Research and Development Program of China (2012BAI02B02)
文摘Objective To study the effect of oral vitamin D （VD） supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men. Methods Twenty-one obese men with their body mass index （BMI）〉28 kg/m2 served as an obese group and 22 healthy normal-weight men with their BMI〈24 kg/m2 served as a control group in this study. After they were given 50 000 IU of oral VD, once a week for 8 weeks, the serum 25-hydroxyvitamin D [25（OH）D] concentration was measured with an enzyme-immunoassay kit. Results After oral VD supplementation, the serum 25（OH）D concentration significantly increased from 46.1＋9.1 nmol/L to 116.7_＋20.3 nmol/L in the obese subjects （P〈O.01） and from 52.8_＋17.8 nmol/L to 181.3_＋30.2 nmol/L in the control ones （P=0.13）. The serum high-density lipoprotein cholesterol （HDL-C） level was reduced within the normal reference range in the obese group. However, no significant change was observed in the level of other serum lipids （triglycerides, total cholesterol, and low-density lipoprotein cholesterol） in either of the two groups. Conclusion The effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group. High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.
文摘目的探讨非酒精性脂肪肝(NAFLD)患者血浆25-OH维生素D(25-OH Vit D)水平变化。方法随机入组NAFLD患者50例,年龄匹配的健康对照者50例,留取血清及血浆标本测定血糖及血脂。使用液相色谱-质谱法测定血清25-OH Vit D水平。用t检验比较两组间各指标间的差异,用Spearman相关分析检测血清25-OH Vit D水平与NAFLD之间的相关性。结果 NAFLD组血清25-OH Vit D水平较健康对照组显著下降(P=0.03);25-OH Vit D水平与NAFLD明显相关(r=-0.128,P=0.002)。结论NAFLD患者存在25-OH Vit D缺乏,且低25-OH Vit D水平与NAFLD显著相关。
