Background： Dietary canthaxanthin（CX）, 25-hydroxycholecalciferol（25-OH-D3） and vitamins have been widely reported to be involved in productive and reproductive performance of broiler breeders. However, limited in...Background： Dietary canthaxanthin（CX）, 25-hydroxycholecalciferol（25-OH-D3） and vitamins have been widely reported to be involved in productive and reproductive performance of broiler breeders. However, limited information is available for duck breeders. In this study, a total of 1,560 Cherry Valley SM3 duck breeder females and 312 males were used to assess if the addition of CX and 25-OH-D3 could increase the performance of duck breeders under two different dietary vitamin regimens. Four diets were used under a 2 × 2 factorial arrangement with 2 kinds of vitamin premixes（REGULAR and HIGH; HIGH premix had higher levels of all vitamins except K3 than REGULAR premix）, and with or without the supplementation of the mixture of CX（6 mg/kg） and 25-OH-D3（0.069 mg/kg）. The ducks were fed ad libitum with pelleted diets based on corn-soybean meal from 38 to 77 wk of age.Results： HIGH vitamin premix decreased malondialdehyde（MDA） level（P 〈 0.001） of egg yolk, increased hatchability of fertile eggs（P = 0.029）, increased hatchability of total eggs（P = 0.029）, and decreased serum protein carbonyl level（P = 0.037） of breeder males. The mixture of CX and 25-OH-D3 increased serum calcium of breeder females（P = 0.010）, decreased the cracked egg rate（P = 0.001）, increased the pigmentation of egg yolk（P 〈 0.001）and male bill（P 〈 0.001）, and decreased MDA level of egg yolk（P 〈 0.001） and male serum（P = 0.034）. Interactive effects were observed in cracked egg rate（P = 0.038）, shell thickness（P = 0.011） and serum phosphorus（P = 0.026）of breeder females. HIGH vitamin premix together with the mixture of CX and 25-OH-D3 decreased cracked egg rate and increased shell thickness of duck breeders. Serum phosphorus was decreased in duck breeder females fed REGULAR vitamin premix without the addition of the CX and 25-OH-D3 mixture.Conclusions： Dietary HIGH vitamin premix increased antioxidant status of eggs and breeder males, and increased hatchability. The mixture of CX and 25-OH-D3 enhanced egg shell quality, and promoted pigmentation and antioxidant status of eggs and breeder males.展开更多
In order to evaluate the effect of 25-OH-D3 on productive performance of broilers and bone mineralization, an experiment in which 10,000 newly born Cobb mixed was used. The animals were divided into two groups: experi...In order to evaluate the effect of 25-OH-D3 on productive performance of broilers and bone mineralization, an experiment in which 10,000 newly born Cobb mixed was used. The animals were divided into two groups: experimental received 25-OH-D3 at a dose of 50 mg/liter and a control group (0 mg/liter). Weight gain and European Production Efficiency Factor (EPEF) were higher (P < 0.05) for chickens that received 25-OH-D3. Mortality was lower (P < 0.05) for the group receiving 25-OH-D3. However feed conversion rate (FCR) and feed intake showed no significant difference between treatments. The amount of calcium in tibia was higher in the experimental group (P < 0.05). Based on the results obtained, it is concluded that the use of 25-OH-D3 improves production performance and bone mineral status broiler.展开更多
目的分析2型糖尿病患者25-羟维生素D[25(OH)D]水平,初步了解血清25(OH)D水平与2型糖尿病患者糖化血红蛋白(HbA1c)、胰岛功能等代谢指标的相关性。方法选择新乡市第一人民医院内分泌科2020年1月至2020年12月收治的459例2型糖尿病患者为...目的分析2型糖尿病患者25-羟维生素D[25(OH)D]水平,初步了解血清25(OH)D水平与2型糖尿病患者糖化血红蛋白(HbA1c)、胰岛功能等代谢指标的相关性。方法选择新乡市第一人民医院内分泌科2020年1月至2020年12月收治的459例2型糖尿病患者为研究对象。收集患者的临床资料,包括性别、年龄、血清25(OH)D、空腹胰岛素、C肽、HbA1c、空腹血糖、餐后血糖、尿微量白蛋白、尿白蛋白肌酐比值、血钙、血尿酸(UA)、三酰甘油(TG)、总胆固醇(TCH)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)等。根据血清25(OH)D水平将患者分为充足组[n=20,25(OH)D≥30μg·L^(-1)]、不足组[n=95,20μg·L^(-1)≤25(OH)D<30μg·L^(-1)]、缺乏组[n=231,10μg·L^(-1)≤25(OH)D<20μg·L^(-1)]、严重缺乏组[n=113,25(OH)D<10μg·L^(-1)]。比较4组患者各代谢指标的差异,采用Pearson相关分析25(OH)D与各代谢指标的相关性。结果2型糖尿病患者血清25(OH)D水平为3.00~46.59(15.75±0.35)μg·L^(-1),男性患者的血清25(OH)D水平显著高于女性患者(P<0.05)。2型糖尿病患者25(OH)D缺乏的患病率为74.9%(344/459),25(OH)D缺乏主要发生在1、2、3、4、11、12月份。不足组、缺乏组和严重缺乏组患者HbA1c显著高于充足组(P<0.05),缺乏组和严重缺乏组患者HbA1c显著高于不足组(P<0.05);缺乏组和严重缺乏组患者HbA1c比较差异无统计学意义(P>0.05)。充足组与不足组、缺乏组与严重缺乏组患者空腹血糖比较差异无统计学意义(P>0.05);缺乏组和严重缺乏组患者空腹血糖显著高于充足组、不足组(P<0.05)。充足组、不足组、缺乏组患者空腹胰岛素、尿微量白蛋白、日尿白蛋白总量、尿白蛋白肌酐比值比较差异无统计学意义(P>0.05);严重缺乏组患者空腹胰岛素显著低于充足组、不足组和缺乏组,尿微量白蛋白、日尿白蛋白总量、尿白蛋白肌酐比值显著高于充足组、不足组和缺乏组(P<0.05)。4组患者的稳态模型评估的胰岛素抵抗指数(HOMA-IR)、血清白蛋白、血肌酐、餐后1 h血糖、餐后2 h血糖、餐后3 h血糖、空腹C肽、餐后1 h C肽、餐后2 h C肽、餐后3 h C肽、TG、TCH、LDL、HDL、血UA、血钙比较差异均无统计学意义(P>0.05)。Pearson相关性分析结果显示,2型糖尿病患者血清25(OH)D水平与HbA1c、尿微量白蛋白、尿白蛋白肌酐比值呈负相关(r=-0.093、-0.166、-0.157,P<0.05),与空腹胰岛素呈正相关(r=0.089,P<0.05)。2型糖尿病患者血清25(OH)D水平与空腹血糖、HOMA-IR、血清白蛋白、血肌酐、餐后1 h血糖、餐后2 h血糖、餐后3 h血糖、空腹C肽、餐后1 h C肽、餐后2 h C肽、餐后3 h C肽、TG、TCH、LDL、HDL、血UA、血钙等无相关性(P>0.05)。结论2型糖尿病患者25(OH)D缺乏与不足普遍存在,女性患者缺乏更明显。2型糖尿病患者25(OH)D水平与空腹胰岛素呈正相关,与HbA1c、尿微量白蛋白、尿白蛋白肌酐比值呈负相关,25(OH)D缺乏的2型糖尿病患者主要分布在1、2、3、4、11、12月份。展开更多
基金National and Sichuan Provincial Science and Technology Projects(2014BAD13B02,2014NZ0030 and 2013NC0047)Academy of Kechuang Feed Industry in SichuanDSM(China)Ltd
文摘Background： Dietary canthaxanthin（CX）, 25-hydroxycholecalciferol（25-OH-D3） and vitamins have been widely reported to be involved in productive and reproductive performance of broiler breeders. However, limited information is available for duck breeders. In this study, a total of 1,560 Cherry Valley SM3 duck breeder females and 312 males were used to assess if the addition of CX and 25-OH-D3 could increase the performance of duck breeders under two different dietary vitamin regimens. Four diets were used under a 2 × 2 factorial arrangement with 2 kinds of vitamin premixes（REGULAR and HIGH; HIGH premix had higher levels of all vitamins except K3 than REGULAR premix）, and with or without the supplementation of the mixture of CX（6 mg/kg） and 25-OH-D3（0.069 mg/kg）. The ducks were fed ad libitum with pelleted diets based on corn-soybean meal from 38 to 77 wk of age.Results： HIGH vitamin premix decreased malondialdehyde（MDA） level（P 〈 0.001） of egg yolk, increased hatchability of fertile eggs（P = 0.029）, increased hatchability of total eggs（P = 0.029）, and decreased serum protein carbonyl level（P = 0.037） of breeder males. The mixture of CX and 25-OH-D3 increased serum calcium of breeder females（P = 0.010）, decreased the cracked egg rate（P = 0.001）, increased the pigmentation of egg yolk（P 〈 0.001）and male bill（P 〈 0.001）, and decreased MDA level of egg yolk（P 〈 0.001） and male serum（P = 0.034）. Interactive effects were observed in cracked egg rate（P = 0.038）, shell thickness（P = 0.011） and serum phosphorus（P = 0.026）of breeder females. HIGH vitamin premix together with the mixture of CX and 25-OH-D3 decreased cracked egg rate and increased shell thickness of duck breeders. Serum phosphorus was decreased in duck breeder females fed REGULAR vitamin premix without the addition of the CX and 25-OH-D3 mixture.Conclusions： Dietary HIGH vitamin premix increased antioxidant status of eggs and breeder males, and increased hatchability. The mixture of CX and 25-OH-D3 enhanced egg shell quality, and promoted pigmentation and antioxidant status of eggs and breeder males.
文摘In order to evaluate the effect of 25-OH-D3 on productive performance of broilers and bone mineralization, an experiment in which 10,000 newly born Cobb mixed was used. The animals were divided into two groups: experimental received 25-OH-D3 at a dose of 50 mg/liter and a control group (0 mg/liter). Weight gain and European Production Efficiency Factor (EPEF) were higher (P < 0.05) for chickens that received 25-OH-D3. Mortality was lower (P < 0.05) for the group receiving 25-OH-D3. However feed conversion rate (FCR) and feed intake showed no significant difference between treatments. The amount of calcium in tibia was higher in the experimental group (P < 0.05). Based on the results obtained, it is concluded that the use of 25-OH-D3 improves production performance and bone mineral status broiler.
文摘目的分析2型糖尿病患者25-羟维生素D[25(OH)D]水平,初步了解血清25(OH)D水平与2型糖尿病患者糖化血红蛋白(HbA1c)、胰岛功能等代谢指标的相关性。方法选择新乡市第一人民医院内分泌科2020年1月至2020年12月收治的459例2型糖尿病患者为研究对象。收集患者的临床资料,包括性别、年龄、血清25(OH)D、空腹胰岛素、C肽、HbA1c、空腹血糖、餐后血糖、尿微量白蛋白、尿白蛋白肌酐比值、血钙、血尿酸(UA)、三酰甘油(TG)、总胆固醇(TCH)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)等。根据血清25(OH)D水平将患者分为充足组[n=20,25(OH)D≥30μg·L^(-1)]、不足组[n=95,20μg·L^(-1)≤25(OH)D<30μg·L^(-1)]、缺乏组[n=231,10μg·L^(-1)≤25(OH)D<20μg·L^(-1)]、严重缺乏组[n=113,25(OH)D<10μg·L^(-1)]。比较4组患者各代谢指标的差异,采用Pearson相关分析25(OH)D与各代谢指标的相关性。结果2型糖尿病患者血清25(OH)D水平为3.00~46.59(15.75±0.35)μg·L^(-1),男性患者的血清25(OH)D水平显著高于女性患者(P<0.05)。2型糖尿病患者25(OH)D缺乏的患病率为74.9%(344/459),25(OH)D缺乏主要发生在1、2、3、4、11、12月份。不足组、缺乏组和严重缺乏组患者HbA1c显著高于充足组(P<0.05),缺乏组和严重缺乏组患者HbA1c显著高于不足组(P<0.05);缺乏组和严重缺乏组患者HbA1c比较差异无统计学意义(P>0.05)。充足组与不足组、缺乏组与严重缺乏组患者空腹血糖比较差异无统计学意义(P>0.05);缺乏组和严重缺乏组患者空腹血糖显著高于充足组、不足组(P<0.05)。充足组、不足组、缺乏组患者空腹胰岛素、尿微量白蛋白、日尿白蛋白总量、尿白蛋白肌酐比值比较差异无统计学意义(P>0.05);严重缺乏组患者空腹胰岛素显著低于充足组、不足组和缺乏组,尿微量白蛋白、日尿白蛋白总量、尿白蛋白肌酐比值显著高于充足组、不足组和缺乏组(P<0.05)。4组患者的稳态模型评估的胰岛素抵抗指数(HOMA-IR)、血清白蛋白、血肌酐、餐后1 h血糖、餐后2 h血糖、餐后3 h血糖、空腹C肽、餐后1 h C肽、餐后2 h C肽、餐后3 h C肽、TG、TCH、LDL、HDL、血UA、血钙比较差异均无统计学意义(P>0.05)。Pearson相关性分析结果显示,2型糖尿病患者血清25(OH)D水平与HbA1c、尿微量白蛋白、尿白蛋白肌酐比值呈负相关(r=-0.093、-0.166、-0.157,P<0.05),与空腹胰岛素呈正相关(r=0.089,P<0.05)。2型糖尿病患者血清25(OH)D水平与空腹血糖、HOMA-IR、血清白蛋白、血肌酐、餐后1 h血糖、餐后2 h血糖、餐后3 h血糖、空腹C肽、餐后1 h C肽、餐后2 h C肽、餐后3 h C肽、TG、TCH、LDL、HDL、血UA、血钙等无相关性(P>0.05)。结论2型糖尿病患者25(OH)D缺乏与不足普遍存在,女性患者缺乏更明显。2型糖尿病患者25(OH)D水平与空腹胰岛素呈正相关,与HbA1c、尿微量白蛋白、尿白蛋白肌酐比值呈负相关,25(OH)D缺乏的2型糖尿病患者主要分布在1、2、3、4、11、12月份。
