<strong>Background:</strong> Type 2 diabetes mellitus (T2DM) is a chronic disease that is characterized by <em>β</em>-cell dysfunction and resistance for insulin. Vitamin D is necessary for in...<strong>Background:</strong> Type 2 diabetes mellitus (T2DM) is a chronic disease that is characterized by <em>β</em>-cell dysfunction and resistance for insulin. Vitamin D is necessary for insulin secretion so it is a crucial factor in the development of T2DM. This study was done to investigate the association between serum 25-hydroxy Vitamin D [25(OH)3D], VDR (Vitamin D receptor) and VDBP (Vitamin D binding protein) with type 2 diabetic patients compared to control subjects.<strong> Subjects and Methods:</strong> This study carried out 110 female patients who were previously diagnosed with type 2 diabetes and 110 age, sex and weight matched as controls. All participants were subjected to full history taking, clinical examination and assessment of fasting blood glucose, HbA1c , lipid profile, 25-hydroxy Vitamin D [25(OH)3D], VDR and VDBP. <strong>Results:</strong> Results showed that the level of 25(OH)3D was significantly lower in diabetic group compared to controls and was significantly negatively correlated with glycated hemoglobin, serum total cholesterol and low density lipoprotein cholesterol in type 2 DM. Decreasing Vitamin D level was significantly associated with decreasing VDR. No significant association was found between Vit D and VDBP levels. <strong>Conclusions:</strong> Vitamin D deficiency is frequent in diabetic patients and associated with poor control and outcome. This suggests a role of Vitamin D in the pathogenesis and control of T2DM. Serum VDBP in diabetes may be independent to the level of 25(OH)3D and needs further studies.展开更多
目的观察原发性肝癌(primary hepatocellular carcinoma,PHC)与血清25(OH)维生素D水平的相关性。方法抽取2018年8月—2020年8月莆田市第一医院PHC患者50例作为观察组,抽取同时期健康体检者50例作为对照组。检测两组血清25(OH)D3水平以...目的观察原发性肝癌(primary hepatocellular carcinoma,PHC)与血清25(OH)维生素D水平的相关性。方法抽取2018年8月—2020年8月莆田市第一医院PHC患者50例作为观察组,抽取同时期健康体检者50例作为对照组。检测两组血清25(OH)D3水平以及甲胎蛋白(alpha fetoprotein,AFP)水平。结果观察组血清25(OH)D3水平低于对照组,差异有统计学意义(P<0.05)。观察组AFP水平高于对照组,差异有统计学意义(P<0.05)。PHC血清患者25(OH)D3水平与中国肝癌分期(China live cancer staging,CNLC)、淋巴结转移有关,差异有统计学意义(P<0.05)。结论针对PHC患者,其血清25(OH)D3水平主要相关因素为CNLC分期、淋巴结转移,根据血清25(OH)D3水平可为疾病治疗及其预后评估提供依据。展开更多
Background Hospitalized patients often have higher rate of vitamin D deficiency than healthy people. Vitamin D levels below normal are associated with hospital stay, increased incidence of adverse prognosis and increa...Background Hospitalized patients often have higher rate of vitamin D deficiency than healthy people. Vitamin D levels below normal are associated with hospital stay, increased incidence of adverse prognosis and increased mortality of a number of diseases. Whether there is a relationship between vitamin D levels and infection or sepsis in the critically ill is still unclear. This study will explore the relationship between vitamin D levels and risk of infection, assessment for disease severity, and predictor of mortality. Methods To evaluate the value of vitamin D in intensive care unit （ICU） cases to sepsis, severity and prognosis assessment, high performance liquid chromatography and tandem mass spectrometry were used to measure the concentrations of vitamin D in sera of critically ill patients. The serum samples were drawn within the first 24 hours of ICU admission. Results The study included 206 people, 50 healthy controls, 51 ICU control patients and 105 ICU diagnosed with sepsis. Critically ill ICU patients （ICU sepsis and ICU control group） had lower vitamin D concentration than normal people, but septic patients showed no significant reduction of vitamin D concentration when compared with critically ill patients with no positive etiological evidence. For assessment of disease severity, there were very low negative correlations between APACHE II, SAPS II and SOFA scores and vitamin D level. Additionally, patients of different 25-（OH）D levels showed no difference whether in terms of 28-day survival （χ2=1.78, P=0.776） or 90-day survival （χ2=4.12, P=0.369）. Multivariate Logistic regression demonstrated that APECHE II and SAPS II scores were independent risk factors to deaths caused by sepsis. Conclusion Clinically, serum concentration of vitamin D is not an indicator for diagnosis and assessment in critically ill patients （ClinicalTrial.gov identifier NCT01636232）.展开更多
文摘<strong>Background:</strong> Type 2 diabetes mellitus (T2DM) is a chronic disease that is characterized by <em>β</em>-cell dysfunction and resistance for insulin. Vitamin D is necessary for insulin secretion so it is a crucial factor in the development of T2DM. This study was done to investigate the association between serum 25-hydroxy Vitamin D [25(OH)3D], VDR (Vitamin D receptor) and VDBP (Vitamin D binding protein) with type 2 diabetic patients compared to control subjects.<strong> Subjects and Methods:</strong> This study carried out 110 female patients who were previously diagnosed with type 2 diabetes and 110 age, sex and weight matched as controls. All participants were subjected to full history taking, clinical examination and assessment of fasting blood glucose, HbA1c , lipid profile, 25-hydroxy Vitamin D [25(OH)3D], VDR and VDBP. <strong>Results:</strong> Results showed that the level of 25(OH)3D was significantly lower in diabetic group compared to controls and was significantly negatively correlated with glycated hemoglobin, serum total cholesterol and low density lipoprotein cholesterol in type 2 DM. Decreasing Vitamin D level was significantly associated with decreasing VDR. No significant association was found between Vit D and VDBP levels. <strong>Conclusions:</strong> Vitamin D deficiency is frequent in diabetic patients and associated with poor control and outcome. This suggests a role of Vitamin D in the pathogenesis and control of T2DM. Serum VDBP in diabetes may be independent to the level of 25(OH)3D and needs further studies.
文摘目的观察原发性肝癌(primary hepatocellular carcinoma,PHC)与血清25(OH)维生素D水平的相关性。方法抽取2018年8月—2020年8月莆田市第一医院PHC患者50例作为观察组,抽取同时期健康体检者50例作为对照组。检测两组血清25(OH)D3水平以及甲胎蛋白(alpha fetoprotein,AFP)水平。结果观察组血清25(OH)D3水平低于对照组,差异有统计学意义(P<0.05)。观察组AFP水平高于对照组,差异有统计学意义(P<0.05)。PHC血清患者25(OH)D3水平与中国肝癌分期(China live cancer staging,CNLC)、淋巴结转移有关,差异有统计学意义(P<0.05)。结论针对PHC患者,其血清25(OH)D3水平主要相关因素为CNLC分期、淋巴结转移,根据血清25(OH)D3水平可为疾病治疗及其预后评估提供依据。
文摘Background Hospitalized patients often have higher rate of vitamin D deficiency than healthy people. Vitamin D levels below normal are associated with hospital stay, increased incidence of adverse prognosis and increased mortality of a number of diseases. Whether there is a relationship between vitamin D levels and infection or sepsis in the critically ill is still unclear. This study will explore the relationship between vitamin D levels and risk of infection, assessment for disease severity, and predictor of mortality. Methods To evaluate the value of vitamin D in intensive care unit （ICU） cases to sepsis, severity and prognosis assessment, high performance liquid chromatography and tandem mass spectrometry were used to measure the concentrations of vitamin D in sera of critically ill patients. The serum samples were drawn within the first 24 hours of ICU admission. Results The study included 206 people, 50 healthy controls, 51 ICU control patients and 105 ICU diagnosed with sepsis. Critically ill ICU patients （ICU sepsis and ICU control group） had lower vitamin D concentration than normal people, but septic patients showed no significant reduction of vitamin D concentration when compared with critically ill patients with no positive etiological evidence. For assessment of disease severity, there were very low negative correlations between APACHE II, SAPS II and SOFA scores and vitamin D level. Additionally, patients of different 25-（OH）D levels showed no difference whether in terms of 28-day survival （χ2=1.78, P=0.776） or 90-day survival （χ2=4.12, P=0.369）. Multivariate Logistic regression demonstrated that APECHE II and SAPS II scores were independent risk factors to deaths caused by sepsis. Conclusion Clinically, serum concentration of vitamin D is not an indicator for diagnosis and assessment in critically ill patients （ClinicalTrial.gov identifier NCT01636232）.
