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变饱和带数值模拟软件VS2DI介绍 被引量:3
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作者 冯建国 李云峰 +1 位作者 张新江 史春梅 《地下水》 2007年第1期24-27,共4页
介绍了数值模拟软件VS2DI,从软件模拟过程入手,依次对关键问题的处理方法、数据要求、输出操作、系统要求、版本升级过程作了说明,指出该软件在水污染模拟方面有着广泛的应用前景。
关键词 数值模拟 VS2di软件 介绍
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君悦Hi-end:SM2di千禧二号小音箱
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作者 韦仁 《实用影音技术》 1999年第9期33-34,共2页
纵观国内外音响,高档进口音箱特别是极品音箱中书架式较多。这可能与造价相对较低、瞬态好、定位准、易于摆位有关。这些书架箱追求小口径、小箱体、高级工艺、高音质的综合表现。这当中5寸单元几乎已成开发极限,采用4英寸低音单元者,... 纵观国内外音响,高档进口音箱特别是极品音箱中书架式较多。这可能与造价相对较低、瞬态好、定位准、易于摆位有关。这些书架箱追求小口径、小箱体、高级工艺、高音质的综合表现。这当中5寸单元几乎已成开发极限,采用4英寸低音单元者,实在不多见。君悦以1英寸和4英寸扬声器单元组成的小书架箱就是以科技及工艺向声音重放的极限挑战。 展开更多
关键词 音箱 设计 箱体 SM2di
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北京牌8305—2DI型彩色电视机电路特点及生产调试简介
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作者 刘国材 《通信与电视》 1990年第3期40-67,共28页
关键词 北京牌 彩电 电路 调试 8305-2di
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极限挑战者君悦SM 2di千禧二号音箱
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作者 曹昕 《高保真音响》 1999年第9期10-11,共2页
关键词 君悦SM2di 音箱 设计
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结直肠癌中RhoGDI2的表达与肿瘤侵袭、转移及预后的关系 被引量:2
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作者 陈颖 杨希夷 +3 位作者 姜昊声 马俐君 吴伟琪 徐庆 《现代肿瘤医学》 CAS 2016年第2期257-261,共5页
目的:探讨RhoG DI2在结直肠癌中的表达与肿瘤侵袭、转移及预后的关系。方法:应用Northern blot和Western blot检测具有不同侵袭、转移潜能的人结直肠癌细胞系(SW620、SW480)中RhoG DI2 mRNA及蛋白的表达。收集行手术切除并随访满5年的... 目的:探讨RhoG DI2在结直肠癌中的表达与肿瘤侵袭、转移及预后的关系。方法:应用Northern blot和Western blot检测具有不同侵袭、转移潜能的人结直肠癌细胞系(SW620、SW480)中RhoG DI2 mRNA及蛋白的表达。收集行手术切除并随访满5年的结直肠癌患者原发灶癌组织石蜡标本80例及相应的癌旁非癌组织、转移性淋巴结癌组织石蜡标本各20例。应用免疫组化法检测上述120例标本中RhoG DI2蛋白的表达,分析其与临床病理特征及预后的关系。结果:SW620、SW480人结直肠癌细胞系中RhoG DI2 mRNA及蛋白的表达具有统计学差异(P<0.01),前者表达均高于后者。结直肠癌相关组织中RhoG DI2蛋白存在差异性表达(转移淋巴结癌组织>原发灶癌组织>癌旁非癌组织,P<0.01)。RhoG DI2蛋白在结直肠癌组织中的表达与肿瘤的浸润深度、淋巴结转移、远处转移、周围淋巴管浸润、周围神经浸润、TNM分期显著相关(P<0.05)。RhoG DI2高表达的结直肠癌患者5年生存率显著低于低表达者(P<0.01)。高RhoG DI2表达是结直肠癌的独立预后因素之一(P<0.05)。结论:RhoG DI2在结直肠癌中的高表达与肿瘤的侵袭、转移及预后不良密切相关,可能是一个有效的结直肠癌预后标志物。 展开更多
关键词 结直肠癌 RHOG DI2 预后
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邻苯二甲酸二(2-丙基庚)酯分子印迹固相萃取剂的制备及其应用 被引量:3
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作者 韦寿莲 郭小君 +2 位作者 严子军 刘永 汪洪武 《色谱》 CAS CSCD 北大核心 2014年第5期458-463,共6页
以邻苯二甲酸二辛酯( DOP)为虚拟模板分子,α-甲基丙烯酸( MAA)为功能单体,乙二醇二甲基丙烯酸酯( EDMA)为交联剂,采用沉淀聚合法制备了对邻苯二甲酸二(2-丙基庚)酯( DPHP)具有高选择性的分子印迹聚合物( MIP)。用紫外... 以邻苯二甲酸二辛酯( DOP)为虚拟模板分子,α-甲基丙烯酸( MAA)为功能单体,乙二醇二甲基丙烯酸酯( EDMA)为交联剂,采用沉淀聚合法制备了对邻苯二甲酸二(2-丙基庚)酯( DPHP)具有高选择性的分子印迹聚合物( MIP)。用紫外分光光度法探索了不同功能单体与模板分子的结合能力,与功能单体丙烯酸( AA)相比,MAA 与DOP的结合能力更强,其最佳结合的物质的量比为6:1。考察 MIP 对 DOP、DPHP、邻苯二甲酸二甲酯( DMP)、邻苯二甲酸二丁酯( DBP)的选择吸附性能,发现该聚合物对 DPHP具有更高的选择吸附性。以制备的聚合物为固相萃取填料,结合 HPLC分析,考察了淋洗剂与洗脱剂的种类和用量对 DPHP 回收率的影响。将 DPHP 甲醇溶液加载至萃取柱后用1 mL甲醇-水(1:9,v/v)淋洗,5 mL甲醇-乙酸(9:1,v/v)洗脱,DPHP在分子印迹固相萃取( MI-SPE)柱上的回收率达到96.8%,而在非印迹固相萃取( NISPE)柱上的回收率仅为52.9%。将建立的 MISPE-HPLC方法应用于测定兔口服 DPHP后不同时间点兔血清中 DPHP的浓度,发现其血药浓度的最大值为5.88μg/mL,达峰值时间为4 h,DPHP加标回收率为90.0%~92.0%,相对标准偏差小于5%。 展开更多
关键词 虚拟模板 分子印迹聚合物 固相萃取 邻苯二甲酸二(2-丙基庚)酯 兔血清 molecular imprinted polymer( MIP ) SOLID-PHASE extraction (SPE) di(2-propylheptyl)phthalate(DPHP)
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DEK推出全新HawkEye自动印刷验证系统
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《电子产品与技术》 2004年第4期86-86,共1页
关键词 DEK公司 HawkEye 自动印刷验证系统 2di
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Glycerin Monostearate Aggravates Male Reproductive Toxicity Caused by Di(2-ethylhexyl)Phthalate in Rats 被引量:6
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作者 Hai-tao GAO Hong-yi SHI +5 位作者 Qi-meng DAI An-qi LI Liu YANG Yue SUN Si-yi JIN Ling-zi XIA 《Current Medical Science》 SCIE CAS 2019年第6期1003-1008,共6页
Human beings are increasingly exposed to phthalates,which are a group of chemicals used to make plastics more flexible and harder to break,and simultaneously ingesting abundant food emulsifiers via daily diet.The purp... Human beings are increasingly exposed to phthalates,which are a group of chemicals used to make plastics more flexible and harder to break,and simultaneously ingesting abundant food emulsifiers via daily diet.The purpose of this study was to investigate the effect of the food emulsifier glycerin monostearate(GMS)on male reproductive toxicity caused by di(2-ethylhexyl)phthalate(DEHP,one of the phthalates)and explore the underlying mechanism.Thirty male Sprague-Dawley rats were randomly divided into control group,DEHP group and DEHP+GMS group.Rats in the DEHP group and DEHP+GMS group were orally administered with 200 mg/kg/d DEHP with or without 20 mg/kg/d GMS.After 30 days of continuous intervention,it was found that the serum testosterone level was significantly lowered in DEHP group and DEHP+GMS group than that in control group(P<0.01).The serum testosterone level and the relative testis weight were significantly decreased in the DEHP+GMS group as compared with those in the DEHP group and control group(P<0.05).More spermatids were observed to be shed off in DEHP+GMS group than in DEHP group.The expression levels of cell cycle checkpoint kinase 1(Chkl),cell division cycle gene 2(Cdc2),and cyclin-dependent kinase 2(CDK2)were down-regulated in DEHP group,and this tendency was more significant in DEHP+GMS group(P<0.05 or P<0.01).There was no significant difference in the P-glycoprotein(P-gp)expression between DEHP group and control group.However,P-gp was markedly down-regulated in DEHP+GMS group(P<O.Ol).The results indicated that the food emulsifier GMS aggravated the toxicity of DEHP on male reproduction by inhibiting the cell cycle of testicular cells and the expression of P-gp in testis tissues. 展开更多
关键词 glycerin monostearate di(2-ethylhexyl)phthalate reproductive toxicity cell cycle P-GLYCOPROTEIN
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Separation of nickel, cobalt and copper by solvent extraction with P204 被引量:4
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作者 钱东 王开毅 +3 位作者 潘春跃 唐有根 蔡春林 蒋金枝 《中国有色金属学会会刊:英文版》 CSCD 2001年第5期803-805,共3页
Nickel, cobalt and copper were separated by solvent extraction with P204. The experimental results show that [Co(NH 3) 6] 3+ is an inert complex in extraction kinetics, therefore cobalt can be separated from nickel an... Nickel, cobalt and copper were separated by solvent extraction with P204. The experimental results show that [Co(NH 3) 6] 3+ is an inert complex in extraction kinetics, therefore cobalt can be separated from nickel and copper by non equilibrium solvent extraction. Under the conditions of temperature 25?℃, contact time of two phases 10?min, phase ratio 1∶1, aqueous pH 10.10 and concentration of P204 20%, [Co(NH 3) 6] 3+ is hardly extracted by P204, while the percentage extractions of nickel and copper are 79.3% and 93.9% respectively. Nickel and copper are separated by equilibrium solvent extraction with P204. Under the conditions of temperature 25?℃, contact time of two phases 1?min, phase ratio 1∶1, equilibrium pH 4.01 and concentration of P204 20%, the separation factor of copper and nickel is 216. 展开更多
关键词 non equilibrium solvent extraction equilibrium solvent extraction NICKEL COBALT COPPER di(2 ethylhexyl) phosphate
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An Estimation of the Daily Intake of Di(2-ethlhexyl) Phthalate(DEHP) among Workers in Flavoring Factories 被引量:2
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作者 LU Jie ZHANG Jing +1 位作者 WANG Zhu Tian FAN Yong Xiang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2014年第6期419-425,共7页
Objective To estimate the daily intake of DEHP among workers in flavoring factories. Methods 71 workers in two flavoring manufacturers, 27 administrators in those factories and 31 laboratory technicians in a research ... Objective To estimate the daily intake of DEHP among workers in flavoring factories. Methods 71 workers in two flavoring manufacturers, 27 administrators in those factories and 31 laboratory technicians in a research institute were recruited and assigned to exposure group, control group 1 and control group 2 respectively. Their urinary DEHP metabolites, mono(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), were detected by isotope dilution-ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS). The urinary metabolites concentrations were converted into DEHP intake levels using two pharmacokinetic models: the urine creatinine-excretion (UCE) one and the urine volume (UV) one. Results No significant differences were found among the three groups. Based on the urinary concentrations of Z3MEHP, we got a median daily DEHP intake of 3.22 or 1.85 μg/kg body-weight/day applying the UV or UCE models respectively. Depending on the UV model, three subjects (2.34%) exceeded the RfD value given by US EPA and the P50 of estimate daily DEHP intakes accounted for 16.10% of the RfD value. No subjects exceeded the limitation depending on the UCE model. Conclusion The workers in flavoring factories were not supposed to be the high DEHP exposure ones and their exposure level remained at a low risk. 展开更多
关键词 Di (2-ethylhexyl) phthalate (DEHP) Estimate daily intake BIOMONITORING Occupationa exposure
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Tb(III) Transport in Dispersion Supported Liquid Membrane System with D2EHPA as Carrier in Kerosene 被引量:2
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作者 PEI Liang YAO Bing-hua +1 位作者 WANG Li-ming MA Zhan-ying 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2011年第1期132-139,共8页
The transport of Tb(III) in dispersion supported liquid membrane(DSLM) with polyvinylidene fluoride membrane(PVDF) as the support and dispersion solution including HCl solution as the stripping solution and di(... The transport of Tb(III) in dispersion supported liquid membrane(DSLM) with polyvinylidene fluoride membrane(PVDF) as the support and dispersion solution including HCl solution as the stripping solution and di(2-ethylhexyl) phosphoric acid(D2EHPA) dissolved in kerosene as the membrane solution, has been studied. The effects of pH value, initial concentration of Tb(III) and different ionic strength in the feed phase, volume ratio of membrane solution to stripping solution, concentration of HCl solution, concentration of carrier, different stripping agents in the dispersion phase on the transport of Tb(III) have also been investigated, respectively. As a result, the optimum transport conditions of Tb(III) were obtained, i.e., the concentration of HCl solution was 4.0 mol/L, the concentration of D2EHPA was 0.16 mol/L, the volume ratio of membrane solution to stripping solution was 30:30 in the dispersion phase and pH value was 4.5 in the feed phase. Ionic strength had no obvious effect on the transport of Tb(III). Under the optimum conditions, the transport percentage of Tb(III) was up to 96.1% in a transport time of 35 min when the initial concentration of Tb(IIl) was 1.0× 10 -4 mol/L. The diffusion coefficient of Tb(III) in the membrane and the thickness of diffusion layer between feed phase and membrane phase were obtained and the values were 1.82×10 -8 m2/s and 5.61 um, respectively. The calculated results were in good agreement with the literature data. 展开更多
关键词 Dispersion supported liquid membrane Di(2-ethylhexyl) phosphoric acid Terbium(III) Dispersion phase Transport flux Transport percentage
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Solvent Extraction of Alkaline Earth Metals with Alkylphosphorus Acids 被引量:1
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作者 许新 朱屯 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2002年第1期25-32,共8页
Solvent extraction equilibria of four main alkaline earth metals(magnesium, calcium, strontium and barium) with di (2-ethylhexyl)phosphoric acid (DEHPA), 2-ethylhexyl phosphonic acidmono-(2-ethylhexyl) esters, di (2, ... Solvent extraction equilibria of four main alkaline earth metals(magnesium, calcium, strontium and barium) with di (2-ethylhexyl)phosphoric acid (DEHPA), 2-ethylhexyl phosphonic acidmono-(2-ethylhexyl) esters, di (2, 4, 4-tri-methylpentyl) phosphinicacid and IR spectra of the extracts have been studied. Theselectivity order is dependent on the e/r value and hydration energyof the metal ions. The minor shift of the P→O in IR absorption ofthe alkaline earth metal extracts indicates that the interactionbetween the metal ions and P→O is much weaker for alkaline earthmetals than for transitional metals. 展开更多
关键词 solvent extraction alkaline earth metals di(2-ethylhexyl) phosphoricacid (DEHPA)
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Study on the Process for Removal of Samarium from NdCl_3 Solution by Solvent Extraction with DEHPA 被引量:2
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作者 黄小卫 顾保江 +2 位作者 张国成 陈秀昆 赵春辉 《Rare Metals》 SCIE EI CAS CSCD 1996年第2期81-86,共6页
The process for removal of samarium from NdCl_3 solution containing a little samarium by solvent extrac-tion with unsaponated Di (2-ethyl hexyl) orthosphoric acid (DEHPA) at acidic range is reported. The in-dustri... The process for removal of samarium from NdCl_3 solution containing a little samarium by solvent extrac-tion with unsaponated Di (2-ethyl hexyl) orthosphoric acid (DEHPA) at acidic range is reported. The in-dustrial experiments have been completed on a production line of 150 t Nd_2O_3 per annum in the Baotou ThirdRare Earth Factory. As a result of 9 step counter current extraction , Sm_2 O_3 content in Nd_2 O_3 drops down to0. 08 % from 0. 5% , the purity of neodymium oxide is over 99. 5% and the direct recovery of Nd_2O_3 is 92%~ 93% . 展开更多
关键词 Di(2-ethyl hexyl) orthophcophoric acid (DEHPA) Extraction Samarium chloride Needymium chloride
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DIS3基因在肿瘤中的研究进展
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作者 魏堯 解春宝 +2 位作者 蒋灵晰 何阳军 石毅 《实用医院临床杂志》 2023年第4期181-185,共5页
随着医学诊治技术的发展,较多的肿瘤将从基因层面进行分析。DIS3蛋白是一种保守的核糖核酸酶,作为外泌体的催化亚基在细胞核与细胞质RNA加工降解过程中起重要作用。研究显示DIS3基因的异常表达与多种肿瘤发生发展相关,在多发性骨髓瘤患... 随着医学诊治技术的发展,较多的肿瘤将从基因层面进行分析。DIS3蛋白是一种保守的核糖核酸酶,作为外泌体的催化亚基在细胞核与细胞质RNA加工降解过程中起重要作用。研究显示DIS3基因的异常表达与多种肿瘤发生发展相关,在多发性骨髓瘤患者中检出DIS3基因突变的频率较高。DIS3基因及其功能蛋白的结构和生理作用相对清晰,但是DIS3基因突变与肿瘤的相关性还未探究清楚。本文将对DIS3的结构、分型、同系物DIS3L2和DIS3的部分生理功能,以及DIS3在肿瘤中的研究进展作一综述。 展开更多
关键词 DIS3基因 多发性骨髓瘤 DIS3L2基因
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Extraction of Gold by Di(2-ethylhexyl)Sulfoxide and N-Octyl Sulfoxide
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作者 Lu Zhong’e, Que Haoquan, Liu Guoxing, Wang Hanzhang and Zhu Qinhua (Department of Chemistry, Suzhou University, Suzhou) 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 1989年第3期231-236,共6页
A long chain aliphatic sulfoxide can be used as an extractant.It can extract almost all metallic ions which can be extracted by tributylphosphate (TBP).The extraction of gold was studied by Chekushin,V. S. and Mojski,... A long chain aliphatic sulfoxide can be used as an extractant.It can extract almost all metallic ions which can be extracted by tributylphosphate (TBP).The extraction of gold was studied by Chekushin,V. S. and Mojski,M.using petroleum sulfoxide and n-dioctyl sulfoxide(DOSO) as an extractant respectively. 展开更多
关键词 EXTRACTION Di(2-ethyl hexyl)sulfoxide N-octyl sulfoxide GOLD
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Aquatic toxicity of di (2-eihylhexyl) phthalate to duckweeds
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作者 徐刚 刘宁 +4 位作者 吴明红 郭瑞云 周佳欣 施文彦 李发生 《Journal of Shanghai University(English Edition)》 CAS 2010年第2期100-105,共6页
This study is concerned with the effects of di (2-ethylhexyl) phthalate (DEHP) on two kinds of duckweeds (Spirodela polyrhiza and Lemna minor).The results indicate that DEHP has aquatic toxicity to Spirodela pol... This study is concerned with the effects of di (2-ethylhexyl) phthalate (DEHP) on two kinds of duckweeds (Spirodela polyrhiza and Lemna minor).The results indicate that DEHP has aquatic toxicity to Spirodela polyrhiza at 0.4 mg/L and to Lemna minor at over 0.1 mg/L by changing their physiologic-biochemical characteristics.The contents of duckweed chlorophyll and soluble protein decrease with increasing DEHP concentration after 7 d of exposure.DEHP shows the stimulating role in catalase (CAT) and superoxide dismutase (SOD) systems at relative low levels.At 0.01 mg/L and 0.005 mg/L,SOD activities of Spirodela polyrhiza and Lemna minor reach their peak values respectively,while CAT activity reaches its maximum value at 0.05 mg/L and 0.01 mg/L.When DEHP levels are too high,the protection enzyme system would be destroyed and plant growth is inhibited.The analysis of malondialdehyde (MDA) and Fourier transform infrared spectroscopy manifest that DEHP could affect the tested duckweeds by destroying its cell membranes,and Spirodela polyrhiza is more resistant to DEHP exposure than Lemna minor. 展开更多
关键词 di (2-ethylhexyl) phthalate (DEHP) DUCKWEED aquatic toxicity antioxidant enzyme
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Intensified reactive extraction of 4-hydroxypyridine with di(2-ethylhexyl) phosphoric acid in 1-octanol by using tributyl phosphate
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作者 Zhixian Chang Xiangfeng Zhou +2 位作者 Huihua Bai Deliang Li Ling Zhang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第2期199-205,共7页
The efficient separation of amphoteric organic compounds from dilute solutions is of great importance in the industrial field. In the present work, the reactive extractions of 4-hydroxypyridine(4-HP) with tributyl pho... The efficient separation of amphoteric organic compounds from dilute solutions is of great importance in the industrial field. In the present work, the reactive extractions of 4-hydroxypyridine(4-HP) with tributyl phosphate(TBP), di(2-ethylhexyl) phosphoric acid(D2EHPA) and TBP + D2EHPA dissolved in 1-octanol were investigated, respectively. The influences of the initial concentrations of TBP, D2EHPA and TBP + D2EHPA on distribution ratio(D) were discussed, as well as the reactive extraction mechanism were proposed. The obvious intensification effect was observed when the mixture of TBP and D2EHPA was used as extractant. The best extraction conditions were found to be of the molar ratio of D2EHPA and TBP at 2:1 and the equilibrium aqueous pH at 3.50-4.50. D values increased with the increase of the total concentration of TBP and D2EHPA in 1-octanol. Especially, the analysis on the extraction mechanisms clearly indicate(i) TBP in 1-octanol shows negligible reactive extraction toward 4-HP,(ii) D2EHPA in 1-octanol exhibits moderate extraction effect by forming 4-HP:D2EHPA(1:1) and 4-HP:2D2EHPA(1:2) type complexes, while(iii) D2EHPA in TBP/1-octanol demonstrates the maximum distribution ratio with the 4-HP:D2EHPA(1:1) type complex domination. The discussion provides new insights on the mechanism and opens a new way for the intensified extraction of amphoteric organic compounds by using the mixture of multiple extractants in the diluent. 展开更多
关键词 4-Hydroxypyridine Di(2-ethylhexyl)phosphoric acid Tributyl phosphate Reactive extraction Intensified extraction
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Impairment of Di(2-Ethylhexyl) Phthalate on Cellular Immunity in Kunming Mice
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作者 Yufen Tian Deli Xu +6 位作者 Shengqun Zhang Jinyan Zhang Zhicun Sun Xiangfang Liu Xin Wang Xia Wang Daqian Meng 《Open Journal of Animal Sciences》 2015年第3期270-276,共7页
Immunity is crucial to the health of animals and it can determine their survival and fitness. Di(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer and hence is the most abundant phthalate in the environme... Immunity is crucial to the health of animals and it can determine their survival and fitness. Di(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer and hence is the most abundant phthalate in the environment. Exposure to DEHP is of great concern for human health. In the present study, we tested the hypothesis that exposure to DEHP would suppress T cell-mediated immunity in mice. Twenty adult male Kunming mice were randomly assigned into the control (n = 10) and the DEHP treatment (n = 10) groups. Both groups have free access to food and water, while the mice in the latter group drank DEHP solution (2000 mg/L) for 42 days. T cell-mediated immunity assessed by phytohaemagglutinin (PHA) response was depressed in the DEHP treated mice compared with the controls, however, wet thymus and spleen mass, white blood cells were not influenced by DEHP treatment. Taken together, different immunological parameters responded differently to DEHP treatment in Kunming mice. 展开更多
关键词 Di(2-Ethylhexyl) PHTHALATE (DEHP) Kunming MICE PHYTOHAEMAGGLUTININ Response
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Structure Reactivity Studies on the Extraction of Rare Earths by Di(2-ethylhexyl)chloroalkyl Phosphonates
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作者 叶伟贞 严金英 《Journal of Rare Earths》 SCIE EI CAS CSCD 1992年第3期179-182,共4页
The extractive separation properties and the extractive regularity of the lanthanide elements by five di(2-ethylhexyl)alkyl phosphonates with various alkyl structure:di(2-ethylhexyl)chloromethyl phosphonate CH_2ClP(O)... The extractive separation properties and the extractive regularity of the lanthanide elements by five di(2-ethylhexyl)alkyl phosphonates with various alkyl structure:di(2-ethylhexyl)chloromethyl phosphonate CH_2ClP(O) (OC_8H_(17)-i)_2(1),di(2-ethylhexyl)β-chloroethyl phosphonate ClCH_2CH_2P(O) (OC_8H_(17)-i)_2 (2),di(2-ethylhexyl)α-chloroethyl phosphonate CH_3CHClP(O)(OC_8H_(17)-i)_2 (3),and corresponding di(2-ethylhexyl)methyl phosphonate CH_3P(O)(OC_8H_(17)-i)_2 (4),di(2-ethylhexyl)ethyl phosphonate C_2H_5P(O) (OC_8H_(17)-i)_2 (5),in nitrate system have been studied.The coordination compounds were prepared. The structure of these extractants and their coordination compounds were further explored by IR and ^(31)P NMR spectra. 展开更多
关键词 RE Y EXTRACTION IR ^(31)P NMR Di(2-ethylhexyl)chloroalkyl phosphonate
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Green tea polyphenols alleviate di-(2-ethylhexyl)phthalate-induced liver injury in mice
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作者 Heng Shi Xin-Hai Zhao +6 位作者 Qin Peng Xian-Ling Zhou Si-Si Liu Chuan-Chuan Sun Qiu-Yu Cao Shi-Ping Zhu Sheng-Yun Sun 《World Journal of Gastroenterology》 SCIE CAS 2023年第34期5054-5074,共21页
BACKGROUND Di(2-ethylhexyl)phthalate(DEHP)is a common plasticizer known to cause liver injury.Green tea is reported to exert therapeutic effects on heavy metal exposureinduced organ damage.However,limited studies have... BACKGROUND Di(2-ethylhexyl)phthalate(DEHP)is a common plasticizer known to cause liver injury.Green tea is reported to exert therapeutic effects on heavy metal exposureinduced organ damage.However,limited studies have examined the therapeutic effects of green tea polyphenols(GTPs)on DEHP-induced liver damage.AIM To evaluate the molecular mechanism underlying the therapeutic effects of GTPs on DEHP-induced liver damage.METHODS C57BL/6J mice were divided into the following five groups:Control,model[DEHP(1500 mg/kg bodyweight)],treatment[DEHP(1500 mg/kg bodyweight)+GTP(70 mg/kg bodyweight),oil,and GTP(70 mg/kg bodyweight)]groups.After 8 wk,the liver function,blood lipid profile,and liver histopathology were examined.Differentially expressed micro RNAs(miRNAs)and mRNAs in the liver tissues were examined using high-throughput sequencing.Additionally,functional enrichment analysis and immune infiltration prediction were performed.The miRNA-mRNA regulatory axis was elucidated using the starBase database.Protein expression was evaluated using immunohistochemistry.RESULTS GTPs alleviated DHEP-induced liver dysfunction,blood lipid dysregulation,fatty liver disease,liver fibrosis,and mitochondrial and endoplasmic reticulum lesions in mice.The infiltration of macrophages,mast cells,and natural killer cells varied between the model and treatment groups.mmu-miR-141-3p(a differentially expressed miRNA),Zcchc24(a differentially expressed mRNA),and Zcchc24(a differentially expressed protein)constituted the miRNA-mRNA-protein regulatory axis involved in mediating the therapeutic effects of GTPs on DEHP-induced liver damage in mice.CONCLUSION This study demonstrated that GTPs mitigate DEHP-induced liver dysfunction,blood lipid dysregulation,fatty liver disease,and partial liver fibrosis,and regulate immune cell infiltration.Additionally,an important miRNAmRNA-protein molecular regulatory axis involved in mediating the therapeutic effects of GTPs on DEHP-induced liver damage was elucidated. 展开更多
关键词 Green tea polyphenols Di(2-ethylhexyl)phthalate Liver fibrosis Fatty liver disease MITOCHONDRIA IMMUNE
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