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吉林特低渗油藏长岩心CO_(2)驱替微观动用规律研究
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作者 张辉 李忠诚 +4 位作者 祝孝华 李金龙 李海波 姚兰兰 肖前华 《中国科技论文》 CAS 2024年第1期50-56,共7页
针对松辽盆地莫里青油田特低渗储层动用困难的问题,利用物理模拟实验和核磁共振技术相结合的实验方法,开展长岩心CO_(2)驱替研究。结果表明:岩样CO_(2)驱替驱油效率介于72.30%~80.40%。大孔喉(>33 ms)平均赋存占比为33.65%,小孔喉(&l... 针对松辽盆地莫里青油田特低渗储层动用困难的问题,利用物理模拟实验和核磁共振技术相结合的实验方法,开展长岩心CO_(2)驱替研究。结果表明:岩样CO_(2)驱替驱油效率介于72.30%~80.40%。大孔喉(>33 ms)平均赋存占比为33.65%,小孔喉(<33 ms)平均赋存占比为18.01%;1 PV的CO_(2)驱替后,岩样大孔喉平均相对采出程度为80.67%,小孔喉平均相对采出程度为17.45%;5 PV的CO_(2)驱替后,岩样大孔喉平均相对采出程度为95.68%,小孔喉平均相对采出程度为39.82%,大PV驱替可有效动用小孔喉的油。研究成果可为莫里青油田储层CO_(2)驱替提供理论支撑,同时也为同类油藏开展注气先导试验提供科学指导。 展开更多
关键词 特低渗油藏 核磁共振 CO_(2)驱替 采出程度
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不同CO_(2)压力下黄铁矿与煤制气耦合机制研究
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作者 夏大平 廖佳佳 +4 位作者 王心义 李赛赛 顾朋涛 袁筱莹 简阔 《河南理工大学学报(自然科学版)》 CAS 北大核心 2024年第3期101-106,134,共7页
目的为了研究不同CO_(2)压力下黄铁矿与煤制气的耦合机制,方法利用压力为1,3,5 MPa的高压罐进行煤和黄铁矿厌氧发酵产气试验。结果结果表明:(1)压力1 MPa时产气量较好,最终产气量为1.26 mmol/g;压力增加,罐中产气量减少,压力5 MPa时产... 目的为了研究不同CO_(2)压力下黄铁矿与煤制气的耦合机制,方法利用压力为1,3,5 MPa的高压罐进行煤和黄铁矿厌氧发酵产气试验。结果结果表明:(1)压力1 MPa时产气量较好,最终产气量为1.26 mmol/g;压力增加,罐中产气量减少,压力5 MPa时产气量仅0.02 mmol/g。(2)随着压力增加,水溶液中HCO-3质量浓度和氧化还原电位(Eh)逐渐上升,pH逐渐下降,5 MPa试验组反应末期pH最低,为4.02,1 MPa压力罐内总铁有消耗,波动较大;反应前期,3,5 MPa压力罐中总铁质量浓度持续增加,说明反应前期3,5 MPa压力下黄铁矿溶解量增加较多;(3)高压条件下,化学需氧量(chemical oxygen deman,COD)和短链脂肪酸浓度水平的显著减少反映了厌氧发酵程度的减弱和黄铁矿酸化程度的增强;(4)压力增加,功能菌种丰度和多样性降低,硫杆菌属逐渐处于优势地位,厌氧发酵过程基本停滞。结论适宜的CO_(2)压力条件可促进煤储层条件下的微生物生长代谢,同时添加黄铁矿发生氧化产生的铁离子,可促进菌群酶活,使煤生物产气反应顺利进行。研究结果可为原位条件富集营养液注入后的产气机制研究提供理论支撑。 展开更多
关键词 CO_(2)压力 煤生物产气 黄铁矿 总铁 酸化程度
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基于三维点云计算的CO_(2)-水-岩反应程度量化表征方法
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作者 蒋长宝 程岳 +5 位作者 李春梅 侯典东 杨毅毫 焦冰洋 赵冬 邓博知 《实验技术与管理》 CAS 北大核心 2024年第6期9-19,共11页
CO_(2)地质封存是减少大气中CO_(2)排放,降低温室效应的重要途径,CO_(2)注入含水地层中时,CO_(2)-水-岩反应可能引起岩石矿物的侵蚀,对CO_(2)地质封存安全性产生显著影响。在室内实验中,通过表征岩石表面的形貌特征可以有效地评估CO_(2)... CO_(2)地质封存是减少大气中CO_(2)排放,降低温室效应的重要途径,CO_(2)注入含水地层中时,CO_(2)-水-岩反应可能引起岩石矿物的侵蚀,对CO_(2)地质封存安全性产生显著影响。在室内实验中,通过表征岩石表面的形貌特征可以有效地评估CO_(2)-水-岩反应程度,为CO_(2)地质封存的安全性评估提供科学依据。通过三维点云计算可以精确量化地表征CO_(2)-水-岩反应程度,这种方法首先运用三维激光扫描技术,构建岩石表面的三维模型,确定CO_(2)-水处理前岩石表面三维模型的基准面,并基于处理前的均方根粗糙度确定处理后岩石表面三维模型的基准面。基于三维模型点云信息,提出了两种不同的体积计算新方法,并通过对规则模型体积的计算比较了两种计算方法的准确性与适用性,可根据实际情况选择两种计算方法量化表征CO_(2)-水处理前后岩石表面的侵蚀体积。最后,以陕西省咸阳市某煤矿煤样为例,开展了CO_(2)-水-岩反应模拟试验,验证了计算的可行性。试验结果表明:该文提出的侵蚀体积计算方法可有效地量化表征CO_(2)-水-岩反应程度,CO_(2)-水处理后岩石表面不同区域的侵蚀差异性明显,岩石表面的侵蚀体积与均方根粗糙度之间存在显著的正比关系,随着均方根粗糙度的增大,侵蚀体积也相应上升。 展开更多
关键词 三维点云 CO_(2)-水-岩 基准面 均方根粗糙度 反应程度
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机械硕士专业学位研究生“1+2+3”培养模式研究
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作者 赵建国 李久熙 +3 位作者 桑永英 李建平 李建昌 郝建军 《农机使用与维修》 2024年第7期155-158,共4页
针对当前机械硕士专业学位研究生实践能力难以满足国家高水平工程技术人才需要,以及院校与企业之间合作不够深入,共同培养研究生机制不健全等问题。该文对以学生能力培养为中心,校企联动培养为路径,学科互融、课堂贯通、双导师制为保障... 针对当前机械硕士专业学位研究生实践能力难以满足国家高水平工程技术人才需要,以及院校与企业之间合作不够深入,共同培养研究生机制不健全等问题。该文对以学生能力培养为中心,校企联动培养为路径,学科互融、课堂贯通、双导师制为保障的1个中心、2个主体、3重保障的“1+2+3”人才培养模式进行了研究。通过理论与实践、高校与企业的有机融合,增强了机械硕士专业学位研究生的实践与创新能力,提高了机械专业学生的就业率和就业质量,满足了当下企业对复合型人才的需求。 展开更多
关键词 机械 专业学位 研究生培养 “1+2+3”培养模式 复合型人才
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急性心肌梗死患者血清ANGPTL8、KLF2表达与冠脉病变程度及主要心脏不良事件发生的关系
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作者 梁亚鹏 张朝普 +1 位作者 张浩 王中群 《实用医学杂志》 CAS 北大核心 2024年第13期1827-1832,共6页
目的探讨急性心肌梗死(AMI)患者血清血管生成素样蛋白8(ANGPTL8)、Kruppel样因子2(KLF2)表达与冠脉病变程度及主要心脏不良事件(MACE)发生的关系。方法选取106例AMI患者为研究对象,根据冠脉病变程度将患者分为轻度组(52例)和重度组(54... 目的探讨急性心肌梗死(AMI)患者血清血管生成素样蛋白8(ANGPTL8)、Kruppel样因子2(KLF2)表达与冠脉病变程度及主要心脏不良事件(MACE)发生的关系。方法选取106例AMI患者为研究对象,根据冠脉病变程度将患者分为轻度组(52例)和重度组(54例),根据MACE发生情况将患者分为MACE组(18例)和非MACE组(88例)。收集患者一般资料,酶联免疫吸附试验(ELISA)法检测血清ANGPTL8、KLF2水平,Spearman相关分析AMI患者血清ANGPTL8、KLF2水平与Gensini评分的相关性,多因素Logistic回归分析AMI患者冠脉病变程度的影响因素;绘制受试者工作特征(ROC)曲线分析血清ANGPTL8、KLF2水平预测AMI患者发生MACE的价值。结果重度组AMI患者高血压史、高血脂史患者比例,收缩压、舒张压、三酰甘油(TG)、N-末端B型利钠肽原(NT-proBNP)、心肌肌钙蛋白I(cTnI)水平,Gensini评分以及血清ANGPTL8水平高于轻度组(P<0.05),高密度脂蛋白胆固醇(HDL-C)水平以及血清KLF2水平低于轻度组(P<0.05);且轻度组和重度组AMI患者病变支数比较,差异有统计学意义(P<0.05)。AMI患者血清ANGPTL8水平与Gensini评分呈正相关(r=0.638,P<0.05),血清KLF2水平与Gensini评分呈负相关(r=-0.612,P<0.05)。高血压史、高血脂史、cTnI、ANGPTL8是AMI患者冠脉病变进展为重度的危险因素(P<0.05),而HDL-C、KLF2是保护因素(P<0.05)。MACE组血清ANGPTL8水平高于非MACE组(P<0.05),而血清KLF2水平低于非MACE组(P<0.05)。血清ANGPTL8、KLF2水平及二者联合预测AMI患者发生MACE的曲线下面积分别为0.740(95%CI:0.646~0.820)、0.799(95%CI:0.710~0.870)、0.806(95%CI:0.717~0.876)。结论血清ANGPTL8、KLF2表达均与AMI患者冠脉病变程度密切相关,且对MACE发生具有一定预测价值。 展开更多
关键词 急性心肌梗死 冠脉病变程度 主要心脏不良事件 血管生成素样蛋白8 Kruppel样因子2
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Changes of heating and cooling degree days over China in response toglobal warming of 1.5℃, 2℃, 3℃ and 4℃ 被引量:7
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作者 SHI Ying ZHANG Dong-Feng +1 位作者 XU Ying ZHOU Bo-Tao 《Advances in Climate Change Research》 SCIE CSCD 2018年第3期192-200,共9页
Future changes of heating degree days (HDD) and cooling degree days (CDD) in the 21st century with and without considering populationfactor are investigated based on four sets of climate change simulations over Ea... Future changes of heating degree days (HDD) and cooling degree days (CDD) in the 21st century with and without considering populationfactor are investigated based on four sets of climate change simulations over East Asia using the regional climate model version 4.4 (RegCM4.4)driven by the global models of CSIRO-Mk3-6-0, EC-EARTH, HadGEM2-ES, and MPI-ESM-MR. Under global warming of 1.5℃, 2℃, 3℃,and 4℃, significant decrease of HDD can be found over China without considering population factor, with greater decrease over high elevationand high latitude regions, including the Tibetan Plateau, the northern part of Northeast China, and Northwest China; while population-weightedHDD increased in areas where population will increase in the future, such as Beijing, Tianjin, parts of southern Hebei, northern Shandong andHenan provinces. Similarly, the CDD projections with and without considering population factor are largely different. Specifically, withoutconsidering population, increase of CDD were observed over most parts of China except the Tibetan Plateau where the CDD remained zerobecause of the cold climate even under global warming; while considering population factor, the future CDD decreases in South China andincreases in North China, the Sichuan Basin, and the southeastern coastal areas, which is directly related to the population changes. The differentfuture changes of HDD and CDD when considering and disregarding the effects of population show that population distribution plays animportant role in energy consumption, which should be considered in future research. 展开更多
关键词 REGIONAL CLIMATE model Global WARMING of 1.5 2 3℃ and 4℃ Heating degree DAYS Cooling degree DAYS China
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o2突变引起糯玉米籽粒淀粉积累差异研究
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作者 韩洁楠 张泽 +11 位作者 刘晓丽 李冉 上官小川 周婷芳 潘越 郝转芳 翁建峰 雍洪军 周志强 徐晶宇 李新海 李明顺 《作物学报》 CAS CSCD 北大核心 2024年第5期1207-1222,共16页
糯玉米是主要鲜食玉米类型,opaque2(o2)基因导入可增加籽粒赖氨酸含量,但同时引起籽粒皱缩、淀粉含量下降等,限制了其育种应用。为发掘优良糯玉米受体,以籽粒饱满圆型o2近等基因系(o2-NIL)糯2/wx1wx1o2o2和皱缩型黄糯2/wx1wx1o2o2为研... 糯玉米是主要鲜食玉米类型,opaque2(o2)基因导入可增加籽粒赖氨酸含量,但同时引起籽粒皱缩、淀粉含量下降等,限制了其育种应用。为发掘优良糯玉米受体,以籽粒饱满圆型o2近等基因系(o2-NIL)糯2/wx1wx1o2o2和皱缩型黄糯2/wx1wx1o2o2为研究材料,通过对鲜食期、成熟期的百粒重和籽粒成分测定,发现淀粉和可溶性糖含量不同可能是导致2份糯玉米o2-NILs表型差异的主要原因。利用实时荧光定量PCR技术分析,发现授粉后10~24 d两糯玉米o2-NILs中6个淀粉合成基因动态表达模式不同,其中Sh1、Sh2、SSIIIa和SBEIIb差异较大。分析胚乳转录组数据,发现两糯玉米o2-NILs中24个海藻糖和糖基水解酶编码基因和48个o2胚乳修饰基因变化不同,以上结果表明淀粉合成关键基因前期表达量高,后期与对照无差异,且糖代谢基因表达变化有利于淀粉合成可能是糯2/wx1wx1o2o2淀粉含量和百粒重不受o2突变影响,籽粒性状明显优于黄糯2/wx1wx1o2o2的重要原因,同时多个胚乳修饰基因的差异表达可能与该结果直接相关。本研究结果可为o2突变体在玉米育种中的应用提供重要参考。 展开更多
关键词 糯玉米 2/wx1wx1o2o2 黄糯2/wx1wx1o2o2 籽粒饱满度 淀粉 糖代谢 差异基因
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The risks, degree of malignancy and clinical progression of prostate cancer associated with the MDM2 T309G polymorphism: a meta-analysis 被引量:4
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作者 Jie Yang Wen Gao +5 位作者 Ning-Hong Song Wei Wang Jie-Xiu Zhang Pei Lu Li-Xin Hua Min Gu 《Asian Journal of Andrology》 SCIE CAS CSCD 2012年第5期726-731,共6页
To determine the risk, malignant degree and clinical progression of prostate cancer (PCa) associated with mouse double-minute 2 protein (MDM2) T309G variants, a meta-analysis was performed on all eligible publishe... To determine the risk, malignant degree and clinical progression of prostate cancer (PCa) associated with mouse double-minute 2 protein (MDM2) T309G variants, a meta-analysis was performed on all eligible published studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess these associations in seven studies that included 5151 cases and 1003 controls. In the overall analysis, the 309G allele was significantly associated with a decreased PCa risk (0R=0.85, 95% CI: 0.74-0.97); this was also the case for the homozygous comparison (0R--0.72, 95% Ch 0.55-0.95) and the dominant genetic model (0R=0.79, 95% Ch 0.65-0.96). The 309G allele was also found to be significantly associated with lower degrees of PCa malignancy (0R=0.85, 95% Ch 0.75-0.96) in the overall analysis, as well as in the heterozygous comparison (0R=0.79, 95% Ch 0.65-0.96), homozygous comparison (0R=0.76, 95% Ch 0.58-0.98) and dominant genetic model (0R=0.81, 95% CI: 0.68-0.96). Furthermore, grouping analysis showed that the 309G allele in Caucasians was significantly correlated with a decreased PCa risk (0R=0.77, 95% Ch 0.61-0.96); this was also the case in the homozygous comparison (0R=0.51, 95% Ch 0.31-0.86). The grouping analysis also showed that the 309G variant in Caucasians was significantly associated with a lower degree of PCa malignancy in all of the genetic models. In addition, we found that the 309G variant in Caucasians was significantly associated with a slower PCa clinical progression in all of the genetic models. In summary, our meta-analysis showed that the MDM2 309G variant was significantly associated with a decreased PCa risk, lower malignant degree and slower clinical progression in Caucasians, but there was no obvious association in the Asian population. 展开更多
关键词 clinical progression malignant degree MDM2 META-ANALYSIS POLYMORPHISM prostate cancer risk
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Severity of the metabolic syndrome as a predictor of prediabetes and type 2 diabetes in first degree relatives of type 2 diabetic patients:A 15-year prospective cohort study 被引量:2
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作者 Rokhsareh Meamar Masoud Amini +3 位作者 Ashraf Aminorroaya Maryam Nasri Majid Abyar Awat Feizi 《World Journal of Diabetes》 SCIE CAS 2020年第5期202-212,共11页
BACKGROUND Type 2 diabetes mellitus(T2DM)has high morbidity and mortality worldwide,therefore there is of paramount importance to identify the risk factors in the populations at risk early in the course of illness.A s... BACKGROUND Type 2 diabetes mellitus(T2DM)has high morbidity and mortality worldwide,therefore there is of paramount importance to identify the risk factors in the populations at risk early in the course of illness.A strong correlation between severity of metabolic syndrome(MetS)and HbA1c,fasting insulin and insulin resistance has been reported.Accordingly,the MetS severity score(or MestS Zscore)can potentially be used to predict the risk of T2DM progression over time.AIM To evaluate the association the of MestS Z-score in first degree relatives(FDRs)of T2DM with the risk of prediabetes and type 2 diabetes in future.METHODS A prospective open cohort study was conducted between 2003-2018.At baseline,the sample comprised of 1766 FDRs of patients with T2DM who had a normal glucose tolerance test.Relative risk(RR)and 95%confidence interval were calculated based on logistic regression.The receiver-operator characteristic analysis and area under the curve based on MetS Z-score were used to evaluate the risk of prediabetes and diabetes among the FDR population.RESULTS Baseline MetS Z-scores were associated with the its latest values(P<0.0001).Compared with individuals who were T2DM free at the end of follow up,those who developed T2DM had higher MetS Z-score at baseline(P<0.001).In multivariable logistic regression analyses for every unit elevation in MetS Z-score at the baseline,the RR for developing future T2DM and prediabetes was(RR=1.94,RR=3.84),(RR=1.5,RR=2.17)in total population and female group,respectively(P<0.05).The associations remained significant after adjusting the potential confounding variables.A cut off value of 0.97 and 0.94 was defined in the receiver-operator characteristic curve based on the MetS Z-score for differentiating female patients with diabetes and prediabetes from the normal population,respectively.CONCLUSION The MetS Z-score was associated with an increased risk of future T2DM.Appropriate interventions at earlier stages for preventing and attenuating MetS effects may be considered as an effective strategy for FDR as at-risk population. 展开更多
关键词 Insulin resistance Metabolic syndrome Risk Type 2 diabetes mellitus PREDIABETES First degree relative
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Multi-Degree Reduction of Bézier Curves with Distance and Energy Optimization 被引量:2
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作者 Xuli Han Jing Yang 《Journal of Applied Mathematics and Physics》 2016年第1期8-15,共8页
In this paper, we propose a new approach to the problem of degree reduction of Bézier curves based on the given endpoint constraints. A differential term is added for the purpose of controlling the smoothness to ... In this paper, we propose a new approach to the problem of degree reduction of Bézier curves based on the given endpoint constraints. A differential term is added for the purpose of controlling the smoothness to a certain extent. Considering the adjustment of second derivative in curve design, a modified objective function including two parts is constructed here. One part is a kind of measure of the distance between original high order Bézier curve and degree-reduced curve. The other part represents the second derivative of degree-reduced curve. We tackle two kinds of conditions which are position vector constraint and tangent vector constraint respectively. The explicit representations of unknown points are presented. Some examples are illustrated to show the influence of the differential terms to approximation and smoothness effect. 展开更多
关键词 Bézier Curve degree Reduction Endpoint Constraint Differential Constraint L2-Norm
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Increased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients 被引量:5
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作者 Jin-Ting Zhang ing-Wei Wang, +5 位作者 Zhen-Long Zhu Xiao-Hui Huo Jian-Kun Chu Dong-Sheng Cui Liang Qiao Jun Yu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第31期4918-4922,共5页
AIM: To study the expression of cyclooxygenase-2 (COX-2)in human gastric cancer tissues and their paired adjacent mucosa, as well as mucosa from gastric antrum and corpus of the first-degree relatives of the recruited... AIM: To study the expression of cyclooxygenase-2 (COX-2)in human gastric cancer tissues and their paired adjacent mucosa, as well as mucosa from gastric antrum and corpus of the first-degree relatives of the recruited cancer patients.METHODS: The expression of COX-2 mRNA in 38 patients with gastric cancer and their 29 first-degree relatives and 18 healthy controls was assessed by the real time RT-PCR.The expression of COX-2 protein was determined by Western blot.RESULTS: A marked increase in COX-2 mRNA expression was found in 20 of 37 (54%) cancerous tissues compared to their respective paired normal mucosa (P<0.001).Interestingly, increased COX-2 mRNA expression was also found in mucosa of the corpus (6/29) and antrum (13/29)of their first-degree relatives. Increased COX-2 mRNA expression was more frequently observed in the antrum biopsies from cancer patients than in the antrum biopsies from healthy controls (P<0.05). In addition, 3 of 23 (13%)patients with atrophic mucosa and 6 of 35 (17%) patients with intestinal metaplasia showed increased COX-2 mRNA expression. Furthermore, COX-2 expression increased in H pylori-positive tissues, especially in antrum mucosa.CONCLUSION: Increased COX-2 expression is involved in gastric carcinogenesis, and may be necessary for maintenance of the malignant phenotype and contribute to Helicobacterpylori-associated malignant transformation. 展开更多
关键词 基因表达 环氧合酶-2 胃癌 病理机制
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吉林油田致密油藏不同CO_(2)注入方式驱替效果实验
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作者 黄天杰 许建国 +2 位作者 吴俊 宋宜磊 宋兆杰 《断块油气田》 CAS CSCD 北大核心 2024年第4期740-745,共6页
利用吉林油田扶余致密油藏岩心和油样,开展CO_(2)吞吐、CO_(2)驱替、表面活性剂+CO_(2)复合吞吐、表面活性剂+CO_(2)复合驱替实验,分析了不同CO_(2)注入方式的驱油效果差异,结合核磁共振扫描技术监测剩余油分布,明确了原油动用程度。结... 利用吉林油田扶余致密油藏岩心和油样,开展CO_(2)吞吐、CO_(2)驱替、表面活性剂+CO_(2)复合吞吐、表面活性剂+CO_(2)复合驱替实验,分析了不同CO_(2)注入方式的驱油效果差异,结合核磁共振扫描技术监测剩余油分布,明确了原油动用程度。结果表明,CO_(2)吞吐提高采收率效果最好,表面活性剂+CO_(2)复合驱替次之,CO_(2)驱替稍差,表面活性剂+CO_(2)复合吞吐最差。4个吞吐轮次后,复合吞吐的原油采出程度明显低于CO_(2)吞吐,但复合吞吐单轮次原油采出程度下降幅度较小,后续仍有提高采收率的潜力。根据孔隙尺寸和饱和油量将孔隙分为大孔、中孔、小孔、微孔,大孔和中孔是原油采出程度的主要贡献者。相比CO_(2)吞吐和CO_(2)驱替,表面活性剂+CO_(2)复合吞吐和表面活性剂+CO_(2)复合驱替显著提高了微孔内原油采出程度。 展开更多
关键词 致密油藏 CO_(2)吞吐 CO_(2)驱替 表面活性剂 动用程度
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IL-17 mRNA和PGE2 mRNA在口腔扁平苔藓患者中的表达水平及临床意义
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作者 李阳 王珑 《检验医学与临床》 CAS 2024年第8期1103-1106,共4页
目的探讨白细胞介素17(IL-17)信使RNA(mRNA)和前列腺素E2(PGE2)mRNA在口腔扁平苔藓(OLP)患者中的表达水平及临床意义。方法选取2020年3月至2021年3月宁夏医科大学总医院口腔医院收治的35例OLP患者作为试验组,另选取同期在宁夏医科大学... 目的探讨白细胞介素17(IL-17)信使RNA(mRNA)和前列腺素E2(PGE2)mRNA在口腔扁平苔藓(OLP)患者中的表达水平及临床意义。方法选取2020年3月至2021年3月宁夏医科大学总医院口腔医院收治的35例OLP患者作为试验组,另选取同期在宁夏医科大学总医院口腔医院进行阻生牙拔除的20例患者作为对照组,根据组织是否糜烂,将试验组患者分为糜烂型OLP组和非糜烂型OLP组。检测并比较糜烂型OLP组和非糜烂型OLP组患者口腔黏膜病损组织及对照组患者口腔黏膜组织的IL-17 mRNA和PGE2 mRNA表达水平,并通过视觉模拟评分法(VAS)评估OLP患者的疼痛程度,比较不同疼痛程度的OLP患者IL-17 mRNA和PGE2 mRNA表达水平。采用Pearson相关分析OLP患者IL-17 mRNA与PGE2 mRNA表达水平的相关性。采用Spearman相关分析OLP患者IL-17 mRNA和PGE2 mRNA表达水平与疼痛程度的相关性。结果非糜烂型OLP组有19例患者,糜烂型OLP组有16例患者。糜烂型OLP组IL-17 mRNA和PGE2 mRNA表达水平均高于非糜烂型OLP组和对照组,且非糜烂型OLP组均高于对照组,差异均有统计学意义(P<0.05)。试验组中无疼痛患者有5例,轻度疼痛患者有6例,中度疼痛患者有16例,重度疼痛患者有8例。无疼痛OLP患者IL-17 mRNA和PGE2 mRNA表达水平均低于轻度、中度、重度疼痛OLP患者,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,OLP患者IL-17 mRNA表达水平与PGE2 mRNA表达水平呈正相关(r=0.505,P=0.002)。Spearman相关分析结果显示,OLP患者IL-17 mRNA、PGE2 mRNA表达水平与疼痛程度均呈正相关(r=0.710、0.570,P<0.05)。结论IL-17 mRNA和PGE2 mRNA参与了OLP的发生、发展过程,并且其表达水平与OLP患者疼痛程度呈正相关。 展开更多
关键词 口腔扁平苔藓 白细胞介素17 前列腺素2 疼痛程度 信使RNA
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无托槽隐形矫治2型糖尿病伴错[牙合]畸形患者的治疗效果分析
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作者 赵秀敏 侯萍 赵秀梅 《中国美容医学》 CAS 2024年第8期143-146,共4页
目的:探讨无托槽隐形矫治技术对2型糖尿病(Type 2 diabetes mellitus,T2DM)伴错[牙合]畸形患者的治疗效果。方法:回顾性分析2019年1月-2022年1月在笔者医院行无托槽隐形矫正器治疗的43例T2DM伴错[牙合]畸形患者临床资料,分析其矫治效果... 目的:探讨无托槽隐形矫治技术对2型糖尿病(Type 2 diabetes mellitus,T2DM)伴错[牙合]畸形患者的治疗效果。方法:回顾性分析2019年1月-2022年1月在笔者医院行无托槽隐形矫正器治疗的43例T2DM伴错[牙合]畸形患者临床资料,分析其矫治效果、矫治疗程、牙周健康指标、美观效果、生活质量及并发症发生情况。结果:43例患者经治疗后总有效率达95.35%。矫正治疗后,患者的牙龈指数、菌斑指数、龈沟出血指数及探诊深度均降低,口腔健康影响程度量表各维度得分均降低,矫治美观效果评分得分均升高,差异有统计学意义(均P<0.05);43例患者并发症发生率为2.33%。结论:对T2DM伴错[牙合]畸形患者使用无托槽隐形矫治技术行矫正治疗具有较好临床效果,能改善患者牙周指标,提高其舒适度与美观度,且安全性较好。 展开更多
关键词 无托槽隐形矫治 2型糖尿病 错[牙合]畸形 舒适度 美观度 并发症
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A New Proof for Congruent Number’s Problem via Pythagorician Divisors
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作者 Léopold Dèkpassi Keuméan François Emmanuel Tanoé 《Advances in Pure Mathematics》 2024年第4期283-302,共20页
Considering Pythagorician divisors theory which leads to a new parameterization, for Pythagorician triplets ( a,b,c )∈ ℕ 3∗ , we give a new proof of the well-known problem of these particular squareless numbers n∈ ℕ... Considering Pythagorician divisors theory which leads to a new parameterization, for Pythagorician triplets ( a,b,c )∈ ℕ 3∗ , we give a new proof of the well-known problem of these particular squareless numbers n∈ ℕ ∗ , called congruent numbers, characterized by the fact that there exists a right-angled triangle with rational sides: ( A α ) 2 + ( B β ) 2 = ( C γ ) 2 , such that its area Δ= 1 2 A α B β =n;or in an equivalent way, to that of the existence of numbers U 2 , V 2 , W 2 ∈ ℚ 2∗ that are in an arithmetic progression of reason n;Problem equivalent to the existence of: ( a,b,c )∈ ℕ 3∗ prime in pairs, and f∈ ℕ ∗ , such that: ( a−b 2f ) 2 , ( c 2f ) 2 , ( a+b 2f ) 2 are in an arithmetic progression of reason n;And this problem is also equivalent to that of the existence of a non-trivial primitive integer right-angled triangle: a 2 + b 2 = c 2 , such that its area Δ= 1 2 ab=n f 2 , where f∈ ℕ ∗ , and this last equation can be written as follows, when using Pythagorician divisors: (1) Δ= 1 2 ab= 2 S−1 d e ¯ ( d+ 2 S−1 e ¯ )( d+ 2 S e ¯ )=n f 2;Where ( d, e ¯ )∈ ( 2ℕ+1 ) 2 such that gcd( d, e ¯ )=1 and S∈ ℕ ∗ , where 2 S−1 , d, e ¯ , d+ 2 S−1 e ¯ , d+ 2 S e ¯ , are pairwise prime quantities (these parameters are coming from Pythagorician divisors). When n=1 , it is the case of the famous impossible problem of the integer right-angled triangle area to be a square, solved by Fermat at his time, by his famous method of infinite descent. We propose in this article a new direct proof for the numbers n=1 (resp. n=2 ) to be non-congruent numbers, based on an particular induction method of resolution of Equation (1) (note that this method is efficient too for general case of prime numbers n=p≡a ( ( mod8 ) , gcd( a,8 )=1 ). To prove it, we use a classical proof by induction on k , that shows the non-solvability property of any of the following systems ( t=0 , corresponding to case n=1 (resp. t=1 , corresponding to case n=2 )): ( Ξ t,k ){ X 2 + 2 t ( 2 k Y ) 2 = Z 2 X 2 + 2 t+1 ( 2 k Y ) 2 = T 2 , where k∈ℕ;and solutions ( X,Y,Z,T )=( D k , E k , f k , f ′ k )∈ ( 2ℕ+1 ) 4 , are given in pairwise prime numbers.2020-Mathematics Subject Classification 11A05-11A07-11A41-11A51-11D09-11D25-11D41-11D72-11D79-11E25 . 展开更多
关键词 Prime Numbers-Diophantine Equations of degree 2 & 4 Factorization Greater Common Divisor Pythagoras Equation Pythagorician Triplets Congruent Numbers Inductive Demonstration Method Infinite Descent BSD Conjecture
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Temperature-dependent Gilbert damping in Co2 FeAl thin films with different B2 ordering degrees
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作者 格桑顿珠 赵逸冰 +2 位作者 金莹 周偲 蒋长军 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第12期414-418,共5页
The temperature-dependent Gilbert damping in Co2FeAl thin film grown on a Pb(Mg1/3Nb2/3)O3-30%PbTiO3 substrate is investigated by the systematic measurement of physical property measurement system(PPMS) on a series of... The temperature-dependent Gilbert damping in Co2FeAl thin film grown on a Pb(Mg1/3Nb2/3)O3-30%PbTiO3 substrate is investigated by the systematic measurement of physical property measurement system(PPMS) on a series of samples with different substrate temperatures. Varying the substrate temperatures from 350℃ to 500℃, the B2 ordering degrees of Co2FeAl thin films increase, which can lead the Gilbert damping to decrease, indicated by the field-sweep in-plane PPMS measurements. In addition, the measurement result of PPMS demonstrates that the Gilbert damping decreases first with measurement temperature decreasing down to about 150 K, then increases at a measurement temperature of ~ 50 K, and decreases again with the measurement temperature decreasing. There are two independent damping manners, namely bulk damping and surface damping, which contribute to the Gilbert damping. Moreover, the observed peak of Gilbert damping at ~ 50 K can be attributed to the spin re-orientation transition at the Co2FeAl surface, which is similar to the result of the effective magnetization as a function of measurement temperature. The result presents the evidence for further studying the Gilbert damping in Co2FeAl thin film. 展开更多
关键词 Gilbert damping Co2FeAl thin film B2 ordering degree
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Fermat and Pythagoras Divisors for a New Explicit Proof of Fermat’s Theorem:a4 + b4 = c4. Part I
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作者 Prosper Kouadio Kimou François Emmanuel Tanoé Kouassi Vincent Kouakou 《Advances in Pure Mathematics》 2024年第4期303-319,共17页
In this paper we prove in a new way, the well known result, that Fermat’s equation a<sup>4</sup> + b<sup>4</sup> = c<sup>4</sup>, is not solvable in ℕ , when abc≠0 . To show this ... In this paper we prove in a new way, the well known result, that Fermat’s equation a<sup>4</sup> + b<sup>4</sup> = c<sup>4</sup>, is not solvable in ℕ , when abc≠0 . To show this result, it suffices to prove that: ( F 0 ): a 1 4 + ( 2 s b 1 ) 4 = c 1 4 , is not solvable in ℕ , (where a 1 , b 1 , c 1 ∈2ℕ+1 , pairwise primes, with necessarly 2≤s∈ℕ ). The key idea of our proof is to show that if (F<sub>0</sub>) holds, then there exist α 2 , β 2 , γ 2 ∈2ℕ+1 , such that ( F 1 ): α 2 4 + ( 2 s−1 β 2 ) 4 = γ 2 4 , holds too. From where, one conclude that it is not possible, because if we choose the quantity 2 ≤ s, as minimal in value among all the solutions of ( F 0 ) , then ( α 2 ,2 s−1 β 2 , γ 2 ) is also a solution of Fermat’s type, but with 2≤s−1<s , witch is absurd. To reach such a result, we suppose first that (F<sub>0</sub>) is solvable in ( a 1 ,2 s b 1 , c 1 ) , s ≥ 2 like above;afterwards, proceeding with “Pythagorician divisors”, we creat the notions of “Fermat’s b-absolute divisors”: ( d b , d ′ b ) which it uses hereafter. Then to conclude our proof, we establish the following main theorem: there is an equivalence between (i) and (ii): (i) (F<sub>0</sub>): a 1 4 + ( 2 s b 1 ) 4 = c 1 4 , is solvable in ℕ , with 2≤s∈ℕ , ( a 1 , b 1 , c 1 )∈ ( 2ℕ+1 ) 3 , coprime in pairs. (ii) ∃( a 1 , b 1 , c 1 )∈ ( 2ℕ+1 ) 3 , coprime in pairs, for wich: ∃( b ′ 2 , b 2 , b ″ 2 )∈ ( 2ℕ+1 ) 3 coprime in pairs, and 2≤s∈ℕ , checking b 1 = b ′ 2 b 2 b ″ 2 , and such that for notations: S=s−λ( s−1 ) , with λ∈{ 0,1 } defined by c 1 − a 1 2 ≡λ( mod2 ) , d b =gcd( 2 s b 1 , c 1 − a 1 )= 2 S b 2 and d ′ b = 2 s−S b ′ 2 = 2 s B 2 d b , where ( 2 s B 2 ) 2 =gcd( b 1 2 , c 1 2 − a 1 2 ) , the following system is checked: { c 1 − a 1 = d b 4 2 2+λ = 2 2−λ ( 2 S−1 b 2 ) 4 c 1 + a 1 = 2 1+λ d ′ b 4 = 2 1+λ ( 2 s−S b ′ 2 ) 4 c 1 2 + a 1 2 =2 b ″ 2 4;and this system implies: ( b 1−λ,2 4 ) 2 + ( 2 4s−3 b λ,2 4 ) 2 = ( b ″ 2 2 ) 2;where: ( b 1−λ,2 , b λ,2 , b ″ 2 )={ ( b ′ 2 , b 2 , b ″ 2 )  if λ=0 ( b 2 , b ′ 2 , b ″ 2 )  if λ=1;From where, it is quite easy to conclude, following the method explained above, and which thus closes, part I, of this article. . 展开更多
关键词 Factorisation in Greatest Common Divisor Pythagoras Equation Pythagorician Triplets Fermat's Equations Pythagorician Divisors Fermat's Divisors Diophantine Equations of degree 2 4-Integral Closure of in
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引起2型糖尿病患者慢性牙周炎发病的相关因素分析
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作者 黄翠香 施莹芬 苏婷玉 《糖尿病新世界》 2024年第6期35-37,47,共4页
目的探究2型糖尿病(Type 2 diabetes mellitus,T2DM)患者慢性牙周炎的形成机制及独立危险因素。方法回顾性选取2021年10月—2023年10月晋江市医院收治的82例2型糖尿病患者的临床资料,根据患者是否合并慢性牙周炎,划分为无牙周炎组(n=54... 目的探究2型糖尿病(Type 2 diabetes mellitus,T2DM)患者慢性牙周炎的形成机制及独立危险因素。方法回顾性选取2021年10月—2023年10月晋江市医院收治的82例2型糖尿病患者的临床资料,根据患者是否合并慢性牙周炎,划分为无牙周炎组(n=54)以及牙周炎组(n=28);采用单因素分析可能影响T2DM引起慢性牙周炎的因素,多因素分析可能造成T2DM引起慢性牙周炎的独立危险因素。结果单因素分析结果显示,2型糖尿病合并慢性牙周炎患者的口腔菌斑指数(Plaque Index,PLI)、附着丧失(Apparatus Loss,AL)、空腹血糖(Fasting Plasma Glucose,FPG)、糖化血红蛋白(Hemoglobin A1c,HbA1c)、牙周探诊深度(Probing Depth,PD)水平显著高于无牙周炎组患者,差异有统计学意义(P均<0.05);多因素分析研究结果显示,FPG、HbA1c、PD与AL值偏高是2型糖尿病患者发生慢性牙周炎的独立危险因素(P均<0.05)。结论较高的FPG、HbA1c、PD与AL水平是2型糖尿病患者发生慢性牙周炎的独立危险因素。 展开更多
关键词 2型糖尿病 慢性牙周炎 疾病程度 糖代谢 影响因素分析
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2型糖尿病患者血糖控制水平对复发性阿弗他溃疡严重程度的相关性分析
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作者 徐明罡 杨安常 《系统医学》 2024年第6期176-179,共4页
目的分析2型糖尿病患者血糖控制水平与复发性阿弗他溃疡(Recurrent Aphthous Ulcer,RAU)严重程度的相关性,为2型糖尿病合并RAU患者的诊治提供依据。方法选取2022年1—12月山东济宁市泗水县人民医院收治的2型糖尿病合并RAU的患者200例作... 目的分析2型糖尿病患者血糖控制水平与复发性阿弗他溃疡(Recurrent Aphthous Ulcer,RAU)严重程度的相关性,为2型糖尿病合并RAU患者的诊治提供依据。方法选取2022年1—12月山东济宁市泗水县人民医院收治的2型糖尿病合并RAU的患者200例作为研究对象,根据RAU的严重程度分为两组,A组轻型RAU 98例,B组重型RAU 102例。对比两组患者血糖指标,用Pearson检验分析血糖指标水平与RAU严重程度的相关性。结果A组4项血糖指标均低于B组,差异有统计学意义(P均<0.05)。4项血糖指标与RAU严重程度均呈正相关(r=0.801,0.714,0.648,0.688,P均<0.05)。结论血糖水平与RAU严重程度呈正相关。 展开更多
关键词 2型糖尿病 血糖控制水平 复发性阿弗他溃疡 严重程度 相关性分析
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2型糖尿病患者下肢血管病变(PAD)程度与血清生化指标的关系研究
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作者 崔帆 刘化学 《糖尿病新世界》 2024年第7期32-35,共4页
目的探讨血清生化指标与2型糖尿病(Type 2 Diabetes mellitus,T2DM)下肢血管病变(Peripheral Arte-rial Disease,PAD)程度的相关性。方法回顾性选取2021年11月—2023年8月临沂市中医医院内分泌科收治的80例T2DM-PAD患者的临床资料,依据... 目的探讨血清生化指标与2型糖尿病(Type 2 Diabetes mellitus,T2DM)下肢血管病变(Peripheral Arte-rial Disease,PAD)程度的相关性。方法回顾性选取2021年11月—2023年8月临沂市中医医院内分泌科收治的80例T2DM-PAD患者的临床资料,依据PAD严重程度不同分为轻度PAD组(29例)、中度PAD组(26例)和重度PAD组(25例)。比较3组血清生化指标肌酐(Creatinine,Cr)、空腹血糖(Fasting Plasma Glucose,FPG)、总胆固醇(Total Cholesterol,TC)、糖化血红蛋白(Glycated Hemoglobin A1c,HbA1c)、高密度脂蛋白胆固醇(High Density Lipoprotein-Cholesterol,HDL-C)、甘油三酯(Triacylglyceride,TG)、低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol,LDL-C)与缺氧诱导因子-1α(Hypoxia-Inducible Factor-1α,HIF-1α),利用Pearson相关系数分析指标与PAD程度的相关性。结果3组TC、TG、LDL-C、FPG、HbA1c、HIF-1α与HDL-C比较,差异有统计学意义(P均<0.05)。经Pearson分析,TC、TG、LDL-C与HDL-C与PAD程度无明显相关性(P均>0.05),FPG、HbA1c与HIF-1α与PAD呈正相关(P均<0.05)。结论FPG、HIF-1α、HbA1c与T2DM患者PAD严重程度存在相关性,可以为PAD早期筛查和预防提供参考。 展开更多
关键词 2型糖尿病 下肢血管病变程度 血清生化指标
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