3-dimension(3-D)printing technology is growing strongly with many applications,one of which is the garment industry.The application of human body models to the garment industry is necessary to respond to the increasin...3-dimension(3-D)printing technology is growing strongly with many applications,one of which is the garment industry.The application of human body models to the garment industry is necessary to respond to the increasing personalization demand and still guarantee aesthetics.This paper proposes amethod to construct 3-D human models by applying deep learning.We calculate the location of the main slices of the human body,including the neck,chest,belly,buttocks,and the rings of the extremities,using pre-existing information.Then,on the positioning frame,we find the key points(fixed and unaltered)of these key slices and update these points tomatch the current parameters.To add points to a star slice,we use a deep learning model tomimic the form of the human body at that slice position.We use interpolation to produce sub-slices of different body sections based on the main slices to create complete body parts morphologically.We combine all slices to construct a full 3-D representation of the human body.展开更多
Purpose: Patient-specific quality assurance (PSQA) requires manual operation of different workstations, which is time-consuming and error-prone. Therefore, developing automated solutions to improve efficiency and accu...Purpose: Patient-specific quality assurance (PSQA) requires manual operation of different workstations, which is time-consuming and error-prone. Therefore, developing automated solutions to improve efficiency and accuracy is a priority. The purpose of this study was to develop a general software interface with scripting on a human interactive device (HID) for improving the efficiency and accuracy of manual quality assurance (QA) procedures. Methods: As an initial application, we aimed to automate our PSQA workflow that involves Varian Eclipse treatment planning system, Elekta MOSAIQ oncology information system and PTW Verisoft application. A general platform, the AutoFrame interface with two imbedded subsystems—the AutoFlow and the PyFlow, was developed with a scripting language for automating human operations of aforementioned systems. The interface included three functional modules: GUI module, UDF script interpreter and TCP/IP communication module. All workstations in the PSQA process were connected, and most manual operations were automated by AutoFrame sequentially or in parallel. Results: More than 20 PSQA tasks were performed both manually and using the developed AutoFrame interface. On average, 175 (±12) manual operations of the PSQA procedure were eliminated and performed by the automated process. The time to complete a PSQA task was 8.23 (±0.78) minutes for the automated workflow, in comparison to 13.91 (±3.01) minutes needed for manual operations. Conclusion: We have developed the AutoFrame interface framework that successfully automated our PSQA procedure, and significantly reduced the time, human (control/clicking/typing) errors, and operators’ stress. Future work will focus on improving the system’s flexibility and stability and extending its operations to other QA procedures.展开更多
A 3-Dimensional computer aided garment design (CAGD) system has been developed andimplemented on a high-performance workstation. We studied various approaches to the func-tional modelling of garment designs for the sy...A 3-Dimensional computer aided garment design (CAGD) system has been developed andimplemented on a high-performance workstation. We studied various approaches to the func-tional modelling of garment designs for the system. According to the characteristic data of a hu-man body, the models of human body and the garment are displayed on the screen, then we canmodify the garment with various styles and different sizes. The system can transform the 3-Dgarment to the 2-D pieces. The system has improved design efficiency. Various potential alterna-tives and improvement of the system have also been studied and explored.展开更多
This paper describes a method of the computer aided garment design,and discusses 3-D humanbody,wire frame modelling,approaches of expressing and a shading model of the 3-D garment.
A new series of 3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives was synthesized. The structures of the new derivatives were confirmed by the spectral data and elemental analyses. The antitumor activit...A new series of 3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives was synthesized. The structures of the new derivatives were confirmed by the spectral data and elemental analyses. The antitumor activity of this series against human breast adenocarcinoma cell line MCF7 was evaluated. Out of twenty new derivatives, ten were revealed mild to moderate activity compared with doxorubicin as a reference antitumor. Among this new series N-(2-chlorophenyl)-2-(3-(methylthio)-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamide (13a) was found the most active one with IC50 equal to 23 μM.展开更多
Recovering 3D human meshes from monocular images is an inherently ill-posed and challenging task due to depth ambiguity,joint occlusion,and truncation.However,most existing approaches do not model such uncertainties,t...Recovering 3D human meshes from monocular images is an inherently ill-posed and challenging task due to depth ambiguity,joint occlusion,and truncation.However,most existing approaches do not model such uncertainties,typically yielding a single reconstruction for one input.In contrast,the ambiguity of the reconstruction is embraced and the problem is considered as an inverse problem for which multiple feasible solutions exist.To address these issues,the authors propose a multi-hypothesis approach,multi-hypothesis human mesh recovery(MH-HMR),to efficiently model the multi-hypothesis representation and build strong relationships among the hypothetical features.Specifically,the task is decomposed into three stages:(1)generating a reasonable set of initial recovery results(i.e.,multiple hypotheses)given a single colour image;(2)modelling intra-hypothesis refinement to enhance every single-hypothesis feature;and(3)establishing inter-hypothesis communication and regressing the final human meshes.Meanwhile,the authors take further advantage of multiple hypotheses and the recovery process to achieve human mesh recovery from multiple uncalibrated views.Compared with state-of-the-art methods,the MH-HMR approach achieves superior performance and recovers more accurate human meshes on challenging benchmark datasets,such as Human3.6M and 3DPW,while demonstrating the effectiveness across a variety of settings.The code will be publicly available at https://cic.tju.edu.cn/faculty/likun/projects/MH-HMR.展开更多
By utilizing a 3-D atmospheric circulation resolving method, the authors studied the air-sea interactive linkages between the tropical Indian Ocean and the Pacific Ocean in 1979-2008 E1 Nifio-Southern Oscillation （E...By utilizing a 3-D atmospheric circulation resolving method, the authors studied the air-sea interactive linkages between the tropical Indian Ocean and the Pacific Ocean in 1979-2008 E1 Nifio-Southern Oscillation （ENSO） events. Their findings showed that evident 3-D gear-coupling characteristics existed in the 1979-2008 ENSO events. Their resolving analyses also suggested that the general circulation showed stronger and wider sinking motions over the eastern Indian Ocean-western Pacific during the mature phase of 1979-2008 ENSO events, compared with the vertical velocities from the U.S. National Centers for Enviornmental Prediction （NCEP） reanalysis data. With their 3-D analysis method, the vertical velocity was resolved by two components, i.e. zonal and meridional components. It was found that the zonal component of the vertical velocities showed a strong sinking motion while the meridional components showed an upward motion during the prevailing phases of the ENSO events. In the tropics, the zonal component of the vertical velocities was found greater than the meridional component, reflecting the dominant characteristics of the vertical velocity, and the overall outcomes showed a strong sinking motion, although the two components also partially offset each other in the processes. Compared with the vertical velocities from NCEP reanalysis, the vertical motions calculated with the 3-D resolving analysis method demonstrate some advantages.展开更多
Methamphetamine is one of the most prevalent drugs abused in the world.Methamphetamine abusers usually present with hyperpyrexia (39℃),hallucination and other psychiatric symptoms.However,the detailed mechanism under...Methamphetamine is one of the most prevalent drugs abused in the world.Methamphetamine abusers usually present with hyperpyrexia (39℃),hallucination and other psychiatric symptoms.However,the detailed mechanism underlying its neurotoxic action remains elusive.This study investigated the effects of methamphetamine + 39℃ on primary cortical neurons from the cortex of embryonic Sprague-Dawley rats.Primary cortex neurons were exposed to 1 mM methamphetamine + 39℃.Propidium iodide staining and lactate dehydrogenase release detection showed that methamphetamine + 39℃ triggered obvious necrosis-like death in cultured primary cortical neurons,which could be partially inhibited by receptor-interacting protein-1 (RIP1) inhibitor Necrostatin-1 partially.Western blot assay results showed that there were increases in the expressions of receptor-interacting protein-3 (RIP3) and mixed lineage kinase domain-like protein (MLKL) in the primary cortical neurons treated with 1 mM methamphetamine + 39℃ for 3 hours.After pre-treatment with RIP3 inhibitor GSK’872,propidium iodide staining and lactate dehydrogenase release detection showed that neuronal necrosis rate was significantly decreased;RIP3 and MLKL protein expression significantly decreased.Immunohistochemistry staining results also showed that the expressions of RIP3 and MLKL were up-regulated in brain specimens from humans who had died of methamphetamine abuse.Taken together,the above results suggest that methamphetamine + 39℃ can induce RIP3/MLKL regulated necroptosis,thereby resulting in neurotoxicity.The study protocol was approved by the Medical Ethics Committee of the Third Xiangya Hospital of Central South University,China (approval numbers: 2017-S026 and 2017-S033) on March 7,2017.展开更多
基金Funding for this study from Sai Gon University(Grant No.CSA2021–08).
文摘3-dimension(3-D)printing technology is growing strongly with many applications,one of which is the garment industry.The application of human body models to the garment industry is necessary to respond to the increasing personalization demand and still guarantee aesthetics.This paper proposes amethod to construct 3-D human models by applying deep learning.We calculate the location of the main slices of the human body,including the neck,chest,belly,buttocks,and the rings of the extremities,using pre-existing information.Then,on the positioning frame,we find the key points(fixed and unaltered)of these key slices and update these points tomatch the current parameters.To add points to a star slice,we use a deep learning model tomimic the form of the human body at that slice position.We use interpolation to produce sub-slices of different body sections based on the main slices to create complete body parts morphologically.We combine all slices to construct a full 3-D representation of the human body.
文摘Purpose: Patient-specific quality assurance (PSQA) requires manual operation of different workstations, which is time-consuming and error-prone. Therefore, developing automated solutions to improve efficiency and accuracy is a priority. The purpose of this study was to develop a general software interface with scripting on a human interactive device (HID) for improving the efficiency and accuracy of manual quality assurance (QA) procedures. Methods: As an initial application, we aimed to automate our PSQA workflow that involves Varian Eclipse treatment planning system, Elekta MOSAIQ oncology information system and PTW Verisoft application. A general platform, the AutoFrame interface with two imbedded subsystems—the AutoFlow and the PyFlow, was developed with a scripting language for automating human operations of aforementioned systems. The interface included three functional modules: GUI module, UDF script interpreter and TCP/IP communication module. All workstations in the PSQA process were connected, and most manual operations were automated by AutoFrame sequentially or in parallel. Results: More than 20 PSQA tasks were performed both manually and using the developed AutoFrame interface. On average, 175 (±12) manual operations of the PSQA procedure were eliminated and performed by the automated process. The time to complete a PSQA task was 8.23 (±0.78) minutes for the automated workflow, in comparison to 13.91 (±3.01) minutes needed for manual operations. Conclusion: We have developed the AutoFrame interface framework that successfully automated our PSQA procedure, and significantly reduced the time, human (control/clicking/typing) errors, and operators’ stress. Future work will focus on improving the system’s flexibility and stability and extending its operations to other QA procedures.
文摘A 3-Dimensional computer aided garment design (CAGD) system has been developed andimplemented on a high-performance workstation. We studied various approaches to the func-tional modelling of garment designs for the system. According to the characteristic data of a hu-man body, the models of human body and the garment are displayed on the screen, then we canmodify the garment with various styles and different sizes. The system can transform the 3-Dgarment to the 2-D pieces. The system has improved design efficiency. Various potential alterna-tives and improvement of the system have also been studied and explored.
文摘This paper describes a method of the computer aided garment design,and discusses 3-D humanbody,wire frame modelling,approaches of expressing and a shading model of the 3-D garment.
文摘A new series of 3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives was synthesized. The structures of the new derivatives were confirmed by the spectral data and elemental analyses. The antitumor activity of this series against human breast adenocarcinoma cell line MCF7 was evaluated. Out of twenty new derivatives, ten were revealed mild to moderate activity compared with doxorubicin as a reference antitumor. Among this new series N-(2-chlorophenyl)-2-(3-(methylthio)-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamide (13a) was found the most active one with IC50 equal to 23 μM.
基金National Key R&D Program of China(2023YFC3082100)National Natural Science Foundation of China(62122058 and 62171317)Science Fund for Distinguished Young Scholars of Tianjin(22JCJQJC00040).
文摘Recovering 3D human meshes from monocular images is an inherently ill-posed and challenging task due to depth ambiguity,joint occlusion,and truncation.However,most existing approaches do not model such uncertainties,typically yielding a single reconstruction for one input.In contrast,the ambiguity of the reconstruction is embraced and the problem is considered as an inverse problem for which multiple feasible solutions exist.To address these issues,the authors propose a multi-hypothesis approach,multi-hypothesis human mesh recovery(MH-HMR),to efficiently model the multi-hypothesis representation and build strong relationships among the hypothetical features.Specifically,the task is decomposed into three stages:(1)generating a reasonable set of initial recovery results(i.e.,multiple hypotheses)given a single colour image;(2)modelling intra-hypothesis refinement to enhance every single-hypothesis feature;and(3)establishing inter-hypothesis communication and regressing the final human meshes.Meanwhile,the authors take further advantage of multiple hypotheses and the recovery process to achieve human mesh recovery from multiple uncalibrated views.Compared with state-of-the-art methods,the MH-HMR approach achieves superior performance and recovers more accurate human meshes on challenging benchmark datasets,such as Human3.6M and 3DPW,while demonstrating the effectiveness across a variety of settings.The code will be publicly available at https://cic.tju.edu.cn/faculty/likun/projects/MH-HMR.
基金Key knowledge innovation research project (KZCX2-YW-Q11-01)973 project (2006CB403600)National Natural Science Foundation of China project (40805034)
文摘By utilizing a 3-D atmospheric circulation resolving method, the authors studied the air-sea interactive linkages between the tropical Indian Ocean and the Pacific Ocean in 1979-2008 E1 Nifio-Southern Oscillation （ENSO） events. Their findings showed that evident 3-D gear-coupling characteristics existed in the 1979-2008 ENSO events. Their resolving analyses also suggested that the general circulation showed stronger and wider sinking motions over the eastern Indian Ocean-western Pacific during the mature phase of 1979-2008 ENSO events, compared with the vertical velocities from the U.S. National Centers for Enviornmental Prediction （NCEP） reanalysis data. With their 3-D analysis method, the vertical velocity was resolved by two components, i.e. zonal and meridional components. It was found that the zonal component of the vertical velocities showed a strong sinking motion while the meridional components showed an upward motion during the prevailing phases of the ENSO events. In the tropics, the zonal component of the vertical velocities was found greater than the meridional component, reflecting the dominant characteristics of the vertical velocity, and the overall outcomes showed a strong sinking motion, although the two components also partially offset each other in the processes. Compared with the vertical velocities from NCEP reanalysis, the vertical motions calculated with the 3-D resolving analysis method demonstrate some advantages.
基金funded by the National Natural Science Foundation of China,No.81971891(to KX),81571939(to KX),81772134(to KX),81772024(to JY),and 81860781(to FXL)the Key Research and Development Program of Hunan Province of China,No.2018SK2091(to KX)+1 种基金the Natural Science Foundation of Hunan Province of China,No.2017JJ2339(to JY)the Wu Jie-Ping Medical Foundation of the Minister of Health of China,No.320.6750.14118(to KX)
文摘Methamphetamine is one of the most prevalent drugs abused in the world.Methamphetamine abusers usually present with hyperpyrexia (39℃),hallucination and other psychiatric symptoms.However,the detailed mechanism underlying its neurotoxic action remains elusive.This study investigated the effects of methamphetamine + 39℃ on primary cortical neurons from the cortex of embryonic Sprague-Dawley rats.Primary cortex neurons were exposed to 1 mM methamphetamine + 39℃.Propidium iodide staining and lactate dehydrogenase release detection showed that methamphetamine + 39℃ triggered obvious necrosis-like death in cultured primary cortical neurons,which could be partially inhibited by receptor-interacting protein-1 (RIP1) inhibitor Necrostatin-1 partially.Western blot assay results showed that there were increases in the expressions of receptor-interacting protein-3 (RIP3) and mixed lineage kinase domain-like protein (MLKL) in the primary cortical neurons treated with 1 mM methamphetamine + 39℃ for 3 hours.After pre-treatment with RIP3 inhibitor GSK’872,propidium iodide staining and lactate dehydrogenase release detection showed that neuronal necrosis rate was significantly decreased;RIP3 and MLKL protein expression significantly decreased.Immunohistochemistry staining results also showed that the expressions of RIP3 and MLKL were up-regulated in brain specimens from humans who had died of methamphetamine abuse.Taken together,the above results suggest that methamphetamine + 39℃ can induce RIP3/MLKL regulated necroptosis,thereby resulting in neurotoxicity.The study protocol was approved by the Medical Ethics Committee of the Third Xiangya Hospital of Central South University,China (approval numbers: 2017-S026 and 2017-S033) on March 7,2017.
