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Multi-scale Modeling and Finite Element Analyses of Thermal Conductivity of 3D C/SiC Composites Fabricating by Flexible-Oriented Woven Process
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作者 Zheng Sun Zhongde Shan +5 位作者 Hao Huang Dong Wang Wang Wang Jiale Liu Chenchen Tan Chaozhong Chen 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第3期275-288,共14页
Thermal conductivity is one of the most significant criterion of three-dimensional carbon fiber-reinforced SiC matrix composites(3D C/SiC).Represent volume element(RVE)models of microscale,void/matrix and mesoscale pr... Thermal conductivity is one of the most significant criterion of three-dimensional carbon fiber-reinforced SiC matrix composites(3D C/SiC).Represent volume element(RVE)models of microscale,void/matrix and mesoscale proposed in this work are used to simulate the thermal conductivity behaviors of the 3D C/SiC composites.An entirely new process is introduced to weave the preform with three-dimensional orthogonal architecture.The 3D steady-state analysis step is created for assessing the thermal conductivity behaviors of the composites by applying periodic temperature boundary conditions.Three RVE models of cuboid,hexagonal and fiber random distribution are respectively developed to comparatively study the influence of fiber package pattern on the thermal conductivities at the microscale.Besides,the effect of void morphology on the thermal conductivity of the matrix is analyzed by the void/matrix models.The prediction results at the mesoscale correspond closely to the experimental values.The effect of the porosities and fiber volume fractions on the thermal conductivities is also taken into consideration.The multi-scale models mentioned in this paper can be used to predict the thermal conductivity behaviors of other composites with complex structures. 展开更多
关键词 3D C/SiC composites Finite element analyses Multi-scale modeling Thermal conductivity
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Contribution to the Full 3D Finite Element Modelling of a Hybrid Stepping Motor with and without Current in the Coils
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作者 Belemdara Dingamadji Hilaire Mbaïnaïbeye Jérôme Guidkaya Golam 《Journal of Electromagnetic Analysis and Applications》 2024年第2期11-23,共13页
The paper presents our contribution to the full 3D finite element modelling of a hybrid stepping motor using COMSOL Multiphysics software. This type of four-phase motor has a permanent magnet interposed between the tw... The paper presents our contribution to the full 3D finite element modelling of a hybrid stepping motor using COMSOL Multiphysics software. This type of four-phase motor has a permanent magnet interposed between the two identical and coaxial half stators. The calculation of the field with or without current in the windings (respectively with or without permanent magnet) is done using a mixed formulation with strong coupling. In addition, the local high saturation of the ferromagnetic material and the radial and axial components of the magnetic flux are taken into account. The results obtained make it possible to clearly observe, as a function of the intensity of the bus current or the remanent induction, the saturation zones, the lines, the orientations and the magnetic flux densities. 3D finite element modelling provide more accurate numerical data on the magnetic field through multiphysics analysis. This analysis considers the actual operating conditions and leads to the design of an optimized machine structure, with or without current in the windings and/or permanent magnet. 展开更多
关键词 MODELLING 3D Finite elements Magnetic Flux Hybrid Stepping Motor
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Al_(2)O_(3)-Ce_(2)O_(3)复合薄膜对304不锈钢抗高温氧化性能的影响
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作者 马静 王铁凝 +3 位作者 姜秋月 冯志浩 张欣 李建辉 《材料保护》 CAS CSCD 2024年第10期19-26,共8页
为提高304不锈钢的抗高温氧化性能,采用溶胶-凝胶法以异丙醇铝和CeCl_3·7H_(2)O为原料,在304不锈钢表面分别制备了Al_(2)O_(3)薄膜和Al_(2)O_(3)-Ce_(2)O_(3)复合薄膜,通过氧化动力学曲线、XRD、SEM和EDS分析,研究了不同Ce/Al比例... 为提高304不锈钢的抗高温氧化性能,采用溶胶-凝胶法以异丙醇铝和CeCl_3·7H_(2)O为原料,在304不锈钢表面分别制备了Al_(2)O_(3)薄膜和Al_(2)O_(3)-Ce_(2)O_(3)复合薄膜,通过氧化动力学曲线、XRD、SEM和EDS分析,研究了不同Ce/Al比例(摩尔比,下同)的Al_(2)O_(3)-Ce_(2)O_(3)复合薄膜对304不锈钢900℃抗高温氧化性能的影响。结果表明,涂覆Ce∶Al=1∶10的薄膜试样在900℃循环氧化100 h后的氧化增重与氧化剥落量仅为未涂覆试样的34.1%和51.8%,抗高温氧化性能最佳。Al_(2)O_(3)-Ce_(2)O_(3)复合薄膜降低了304不锈钢基体表面的氧分压,有利于生成保护性的Cr_2O_(3)氧化层,有效抑制了Cr_2O_(3)的挥发;添加Ce_(2)O_(3)降低了氧化层中的热应力,提高了其附着力;Ce_(2)O_(3)起到了活性元素效应,改变了氧化膜的生长机制,因此显著提高了不锈钢的抗高温氧化性能。 展开更多
关键词 溶胶-凝胶法 Al_(2)O_(3)-Ce_(2)O_(3)复合薄膜 高温氧化 活性元素效应
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冠心病患者血清环磷酸腺苷反应元件结合蛋白调节转录辅激活因子3及氧化应激指标与颈动脉粥样硬化的相关性
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作者 李馨 程国杰 +1 位作者 刘佳 王文斌 《实用临床医药杂志》 CAS 2024年第15期31-35,共5页
目的探讨冠心病患者血清环磷酸腺苷反应元件结合蛋白调节转录辅激活因子3(CRTC3)及氧化应激指标与颈动脉粥样硬化的相关性。方法选取2021年6月—2023年6月本院收治的154例冠心病患者为研究组,根据颈动脉粥样硬化程度分为轻度硬化组、中... 目的探讨冠心病患者血清环磷酸腺苷反应元件结合蛋白调节转录辅激活因子3(CRTC3)及氧化应激指标与颈动脉粥样硬化的相关性。方法选取2021年6月—2023年6月本院收治的154例冠心病患者为研究组,根据颈动脉粥样硬化程度分为轻度硬化组、中度硬化组和重度硬化组;另选取154例同期健康体检者为对照组。采用Pearson法分析血清CRTC3及氧化应激指标与颈动脉粥样硬化指标的相关性。结果研究组血清CRTC3、丙二醛(MDA)、颈动脉斑块面积和中层内膜厚度(IMT)高于或大于对照组,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平低于对照组,差异有统计学意义(P<0.05)。轻度硬化组、中度硬化组和重度硬化组血清CRTC3、MDA、颈动脉斑块面积和IMT依次升高或增大,SOD、GSH-Px水平依次降低,差异有统计学意义(P<0.05)。Pearson相关性分析显示,血清CRTC3、MDA水平与颈动脉斑块面积、IMT呈正相关(P<0.05),SOD、GSH-Px与颈动脉斑块面积、IMT呈负相关(P<0.05)。受试者工作特征(ROC)曲线显示,CRTC3、SOD、MDA和GSH-Px联合诊断重度颈动脉粥样硬化的曲线下面积(AUC)为0.990(95%CI:0.982~0.998),灵敏度为96.27%,特异度为76.28%。4项指标联合诊断的价值高于各指标单独诊断,差异有统计学意义(Z_(联合-CRTC3)=2.723,Z_(联合-SOD)=2.698,Z_(联合-MDA)=2.673,Z_(联合-GSH-Px)=2.803,P均<0.05)。结论冠心病患者血清CRTC3、MDA水平显著升高,SOD、GSH-Px水平显著降低;血清CRTC3、氧化应激水平均与颈动脉粥样硬化密切相关。 展开更多
关键词 冠心病 环磷酸腺苷反应元件结合蛋白调节转录辅激活因子3 氧化应激 颈动脉粥样硬化
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Histone H3K27me3 methylation regulates the expression of secreted proteins distributed at fast-evolving regions through transcriptional repression of transposable elements 被引量:1
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作者 XIE Jia-hui TANG Wei +4 位作者 LU Guo-dong HONG Yong-he ZHONG Zhen-hui WANG Zong-hua ZHENG Hua-kun 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2023年第10期3059-3068,共10页
The fine-tuned expression dynamics of the effector genes are pivotal for the transition from vegetative growth to host colonization of pathogenic filamentous fungi.However,mechanisms underlying the dynamic regulation ... The fine-tuned expression dynamics of the effector genes are pivotal for the transition from vegetative growth to host colonization of pathogenic filamentous fungi.However,mechanisms underlying the dynamic regulation of these genes remain largely unknown.Here,through comparative transcriptome and chromatin immunoprecipitation sequencing(ChIP-seq)analyses of the methyltransferase PoKmt6 in rice blast fungus Pyricularia oryzae(syn.Magnaporthe oryzae),we found that PoKmt6-mediated H3K27me3 deposition was enriched mainly at fast-evolving regions and contributed to the silencing of a subset of secreted proteins(SP)and transposable element(TE)families during the vegetative growth of P.oryzae.Intriguingly,we observed that a group of SP genes,which were depleted of H3K27me3 modification,could also be silenced via the H3K27me3-mediated repression of the nearby TEs.In conclusion,our results indicate that H3K27me3 modification mediated by PoKmt6 regulates the expression of some SP genes in fast-evolving regions through the suppression of nearby TEs. 展开更多
关键词 secreted protein transposable elements fast-evolving regions H3K27me3
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Effect of surface retaining elements on rock stability:laboratory investigation with sand powder 3D printing
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作者 Hao Feng Lishuai Jiang +3 位作者 Qingwei Wang Peng Tang Atsushi Sainoki Hani S.Mitri 《International Journal of Coal Science & Technology》 EI CAS CSCD 2023年第4期305-324,共20页
This study aims to investigate the benefcial efects of surface retaining elements (SREs) on the mechanical behaviors of bolted rock and roadway stability. 3D printing (3DP) technology is utilized to create rock analog... This study aims to investigate the benefcial efects of surface retaining elements (SREs) on the mechanical behaviors of bolted rock and roadway stability. 3D printing (3DP) technology is utilized to create rock analogue prismatic specimens for conducting this investigation. Uniaxial compression tests with acoustic emission (AE) and digital image correlation techniques have been conducted on 3DP specimens bolted with diferent SREs. The results demonstrate that the strength and modulus of elasticity of the bolted specimens show a positive correlation with the area of the SRE;the AE characteristics of the bolted specimens are higher than those of the unbolted specimen, but they decrease with an increase in SRE area, thus further improving the integrity of the bolted specimens. The reinforcement efect of SREs on the surrounding rock of roadways is further analyzed using numerical modelling and feld test. The results provide a better understanding of the role of SREs in rock bolting and the optimization of rock bolting design. Furthermore, they verify the feasibility of 3DP for rock analogues in rock mechanics tests. 展开更多
关键词 Roadway stability Surface retaining element Sand-powder 3D printing Rock bolting Numerical modelling
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3D DEM simulation of hard rock fracture in deep tunnel excavation induced by changes in principal stress magnitude and orientation 被引量:1
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作者 Weiqi Wang Xia-Ting Feng +2 位作者 Qihu Wang Rui Kong Chengxiang Yang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第10期3870-3884,共15页
To achieve the loading of the stress path of hard rock,the spherical discrete element model(DEM)and the new flexible membrane technology were utilized to realize the transient loading of three principal stresses with ... To achieve the loading of the stress path of hard rock,the spherical discrete element model(DEM)and the new flexible membrane technology were utilized to realize the transient loading of three principal stresses with arbitrary magnitudes and orientations.Furthermore,based on the deep tunnel of China Jinping Underground Laboratory II(CJPL-II),the deformation and fracture evolution characteristics of deep hard rock induced by excavation stress path were analyzed,and the mechanisms of transient loading-unloading and stress rotation-induced fractures were revealed from a mesoscopic perspective.The results indicated that the stressestrain curve exhibits different trends and degrees of sudden changes when subjected to transient changes in principal stress,accompanied by sudden changes in strain rate.Stress rotation induces spatially directional deformation,resulting in fractures of different degrees and orientations,and increasing the degree of deformation anisotropy.The correlation between the degree of induced fracture and the unloading magnitude of minimum principal stress,as well as its initial level is significant and positive.The process of mechanical response during transient unloading exhibits clear nonlinearity and directivity.After transient unloading,both the minimum principal stress and minimum principal strain rate decrease sharply and then tend to stabilize.This occurs from the edge to the interior and from the direction of the minimum principal stress to the direction of the maximum principal stress on theε1-ε3 plane.Transient unloading will induce a tensile stress wave.The ability to induce fractures due to changes in principal stress magnitude,orientation and rotation paths gradually increases.The analysis indicates a positive correlation between the abrupt change amplitude of strain rate and the maximum unloading magnitude,which is determined by the magnitude and rotation of principal stress.A high tensile strain rate is more likely to induce fractures under low minimum principal stress. 展开更多
关键词 Deep hard rock tunnel Three-dimensional(3D)discrete element model(DEM) Magnitude and orientation of principal stress Transient unloading Fracture mechanism
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过渡金属元素掺杂对SmCo_(3)合金结构和磁性能影响的第一性原理计算
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作者 严志 方诚 +1 位作者 王芳 许小红 《物理学报》 SCIE EI CAS CSCD 北大核心 2024年第3期250-257,共8页
在稀土永磁材料中,Sm-Co基合金具有优异的高温磁性能,是目前最有发展前景的永磁材料.然而,这些合金在高温环境的实际应用中,由于其相对较低的饱和磁化强度和结构稳定性而受到限制.本研究采用Fe,Ni,Cu,Zr作为代表的过渡金属元素,通过第... 在稀土永磁材料中,Sm-Co基合金具有优异的高温磁性能,是目前最有发展前景的永磁材料.然而,这些合金在高温环境的实际应用中,由于其相对较低的饱和磁化强度和结构稳定性而受到限制.本研究采用Fe,Ni,Cu,Zr作为代表的过渡金属元素,通过第一性原理计算,研究掺杂元素对SmCo_(3)合金结构稳定性、磁性能和电子结构的影响.计算结果表明,元素Ni,Cu和Fe的掺杂有利于提升SmCo_(3)体系结构稳定性,而元素Zr的掺杂不利于体系结构稳定性.磁性能计算表明,掺杂非磁性元素在一定程度上会降低SmCo_(3)体系的总磁矩,而掺杂磁性元素可以增大SmCo_(3)体系的总磁矩,在SmCo_(3)体系中并不是掺杂所有的磁性元素都可以增大体系总磁矩,并通过电子结构的分析阐明了其微观机制.最后筛选出了过渡元素Fe有利于提升SmCo_(3)的磁性能和结构稳定性,并在其原胞中掺杂原子百分比为0—22.22%范围内,预测了其最佳掺杂原子百分比为18.52%. 展开更多
关键词 SmCo_(3)型永磁合金 第一性原理计算 过渡元素掺杂 综合磁性能
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元素引发对Na_(2)CO_(3)胁迫下膜荚黄芪种子萌发的影响
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作者 尹琦翔 刘霞 《东北师大学报(自然科学版)》 CAS 北大核心 2024年第3期111-120,共10页
为研究元素引发对Na_(2)CO_(3)胁迫下膜荚黄芪种子及幼苗生长的影响,以膜荚黄芪种子为研究对象,利用2×10^(-2)mol/L浓度的Na_(2)CO_(3)溶液提供胁迫环境,使用B,Si,Fe,Zn_(4)种元素处理胁迫下的种子,测定了种子的发芽指标、幼苗的... 为研究元素引发对Na_(2)CO_(3)胁迫下膜荚黄芪种子及幼苗生长的影响,以膜荚黄芪种子为研究对象,利用2×10^(-2)mol/L浓度的Na_(2)CO_(3)溶液提供胁迫环境,使用B,Si,Fe,Zn_(4)种元素处理胁迫下的种子,测定了种子的发芽指标、幼苗的生物量、叶绿素含量、渗透调节物质含量和抗氧化酶活力.结果表明:3×10^(-5)mol/L的B元素、6.5×10^(-5)mol/L的Si元素、1.8×10^(-4)mol/L的Fe元素和1.2×10^(-4)mol/L的Zn元素对种子及幼苗的生长发育促进效果显著,可缓解Na_(2)CO_(3)对植物的胁迫作用、提高种子发芽率、增加幼苗生物量的积累、增强幼苗的光合作用、提高幼苗的抗氧化能力.引发浓度较低时,对种子及幼苗生长的促进效果不显著,引发浓度较高时则会抑制种子及幼苗生长. 展开更多
关键词 膜荚黄芪 Na_(2)CO_(3)胁迫 元素 种子引发
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气象条件对合肥市O_(3)质量浓度变化的影响
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作者 邓鹏 林保国 +2 位作者 夏晓宇 陈公名 朱承驻 《合肥工业大学学报(自然科学版)》 CAS 北大核心 2024年第8期1009-1014,共6页
文章基于2016-2020年合肥市大气污染物逐时监测数据及同期逐日气象数据,利用KZ(Kolmogorov-Zurbenko)滤波法将合肥市O_(3)质量浓度及各气象要素逐日序列分解为长期、季节以及短期分量,并针对分解浓度序列建立气象因子回归模型,综合评估... 文章基于2016-2020年合肥市大气污染物逐时监测数据及同期逐日气象数据,利用KZ(Kolmogorov-Zurbenko)滤波法将合肥市O_(3)质量浓度及各气象要素逐日序列分解为长期、季节以及短期分量,并针对分解浓度序列建立气象因子回归模型,综合评估合肥市O_(3)质量浓度变化趋势及气象条件对O_(3)质量浓度的影响。结果表明:季节变化是引起O_(3)质量浓度原始序列波动的最主要因素,合肥市O_(3)质量浓度的长期变化趋势为先增长后下降;在长期分量中,相对湿度可能是影响O_(3)质量浓度的最主要气象要素,且呈现显著负相关(r=-0.581),而在原始序列以及其余分量中,太阳净辐射对O_(3)质量浓度的影响最为重要,呈现为显著正相关(r最高为0.911);聚类分析发现O_(3)在较重污染时对应的日最高温度和相对湿度的均值分别为30.9℃和71%;气象条件在2019年中期以前对O_(3)污染起促进作用,使ρ(O_(3))平均上升了2.19μg/m^(3),而在2019年中期以后对O_(3)污染起抑制作用,使ρ(O_(3))平均下降了3.91μg/m^(3)。 展开更多
关键词 合肥市 O_(3)污染 Kolmogorov-Zurbenko滤波法 气象要素
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3He管探测器前端处理电路设计与实现
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作者 王蕾 张校尧 +2 位作者 史涛 郑其斌 金钻明 《电子元件与材料》 CAS 北大核心 2024年第9期1104-1112,共9页
面向3 He管中子探测器的测量需求,设计了一款前端处理电路,主要由信号成形模块和高压供电模块组成。信号成形模块采用分立元件方法,集成电荷灵敏放大、极零相消、多级滤波、基线恢复等功能电路,实现了信号的快速放大成形,可满足高计数... 面向3 He管中子探测器的测量需求,设计了一款前端处理电路,主要由信号成形模块和高压供电模块组成。信号成形模块采用分立元件方法,集成电荷灵敏放大、极零相消、多级滤波、基线恢复等功能电路,实现了信号的快速放大成形,可满足高计数率、微弱信号的测量需求;高压供电模块的核心器件选用国产高压元件,结合外控电压调节电路,为探测器提供合适的偏置高压,在0~2 kV范围内实现线性控制。测试表明,该前端电路输出信号的脉宽小于1μs,电荷测量的动态范围为-100~0 fC,等效输入噪声优于0.25 fC。 展开更多
关键词 前端电路 分立元件 整形滤波 高压器件 3 He管中子探测器
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PBX-3造型粉颗粒压制成型过程仿真分析
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作者 赵海波 李自胜 +3 位作者 肖晓萍 卢洋 刘宇宸 刘聪 《火工品》 CAS CSCD 北大核心 2024年第6期48-54,共7页
为了探究3号高聚物粘结炸药(PBX-3)压制成型过程中的颗粒演变行为和密度演化规律,采用多颗粒有限元法(MPFEM)结合Johnson-Cook(J-C)模型对PBX-3粉末在压制过程中的致密化行为进行了模拟仿真;将仿真结果与Heckel方程拟合,分析了压制过程... 为了探究3号高聚物粘结炸药(PBX-3)压制成型过程中的颗粒演变行为和密度演化规律,采用多颗粒有限元法(MPFEM)结合Johnson-Cook(J-C)模型对PBX-3粉末在压制过程中的致密化行为进行了模拟仿真;将仿真结果与Heckel方程拟合,分析了压制过程中粉体的温度与压紧力大小对粉体颗粒致密化质量的影响,并讨论了粉末颗粒中的应力和应变分布。结果表明:在PBX-3致密化过程的滑移阶段、变形阶段以及压实阶段中,升高压制温度能有效减小压制过程中所需的压紧力,并提高药柱成型密度。 展开更多
关键词 PBX-3 致密化过程 仿真 多颗粒有限元法(MPFEM) 药柱成型密度
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基于AE中Element 3D插件的三维特效制作思路与实例分析
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作者 杨乃健 《影视制作》 2023年第9期51-56,共6页
AE中Element 3D是一款具有real time rendering(实时渲染)特性的插件,即在制作3D效果过程中可以直接在屏幕上看到渲染效果,CG运算的效率得以大幅提升,是AE中为数不多的支持完全3D渲染特性的插件之一。本文结合两个具有代表性的实例分析... AE中Element 3D是一款具有real time rendering(实时渲染)特性的插件,即在制作3D效果过程中可以直接在屏幕上看到渲染效果,CG运算的效率得以大幅提升,是AE中为数不多的支持完全3D渲染特性的插件之一。本文结合两个具有代表性的实例分析了该插件实现三维特效制作的方法。 展开更多
关键词 After Effects element 3D 三维特效
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Three-dimensional Modeling of Ore-forming Elements and Mineralization Prognosis for the Yechangping Mo Deposit,Henan Province,China
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作者 DING Gaoming JI Genyuan +5 位作者 YAN Guolong XU Yongzhong WANG Kunming XIAO Chun WANG Quanle GUO Dongbao 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2024年第3期736-752,共17页
Three-dimensional geochemical modeling of ore-forming elements is crucial for predicting deep mineralization.This approach provides key information for the quantitative prediction of deep mineral localization,three-di... Three-dimensional geochemical modeling of ore-forming elements is crucial for predicting deep mineralization.This approach provides key information for the quantitative prediction of deep mineral localization,three-dimensional fine interpolation,analysis of spatial distribution patterns,and extraction of quantitative mineral-seeking markers.The Yechangping molybdenum(Mo)deposit is a significant and extensive porphyry-skarn deposit in the East Qinling-Dabie Mo polymetallic metallogenic belt at the southern margin of the North China Block.Abundant borehole data on oreforming elements underpin deep geochemical predictions.The methodology includes the following steps:(1)Threedimensional geological modeling of the deposit was established.(2)Correlation,cluster,and factor analyses post delineation of mineralization stages and determination of mineral generation sequence to identify(Cu,Pb,Zn,Ag)and(Mo,W,mfe)assemblages.(3)A three-dimensional geochemical block model was constructed for Mo,W,mfe,Cu,Zn,Pb,and Ag using the ordinary kriging method,and the variational function was developed.(4)Spatial distribution and enrichment characteristics analysis of ore-forming elements are performed to extract geological information,employing the variogram and w(Cu+Pb+Zn+Ag)/w(Mo+W)as predictive indicators.(5)Identifying the western,northwestern,and southwestern areas of the mine with limited mineralization potential,contrasted by the northeastern and southeastern areas favorable for mineral exploration. 展开更多
关键词 3D geochemical model ore-forming elements GEOSTATISTICS deep mineralization prediction Yechangping Mo deposit
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Numerical Study of the Biomechanical Behavior of a 3D Printed Polymer Esophageal Stent in the Esophagus by BP Neural Network Algorithm
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作者 Guilin Wu Shenghua Huang +7 位作者 Tingting Liu Zhuoni Yang Yuesong Wu Guihong Wei Peng Yu Qilin Zhang Jun Feng Bo Zeng 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第3期2709-2725,共17页
Esophageal disease is a common disorder of the digestive system that can severely affect the quality of life andprognosis of patients. Esophageal stenting is an effective treatment that has been widely used in clinica... Esophageal disease is a common disorder of the digestive system that can severely affect the quality of life andprognosis of patients. Esophageal stenting is an effective treatment that has been widely used in clinical practice.However, esophageal stents of different types and parameters have varying adaptability and effectiveness forpatients, and they need to be individually selected according to the patient’s specific situation. The purposeof this study was to provide a reference for clinical doctors to choose suitable esophageal stents. We used 3Dprinting technology to fabricate esophageal stents with different ratios of thermoplastic polyurethane (TPU)/(Poly-ε-caprolactone) PCL polymer, and established an artificial neural network model that could predict the radial forceof esophageal stents based on the content of TPU, PCL and print parameter. We selected three optimal ratios formechanical performance tests and evaluated the biomechanical effects of different ratios of stents on esophagealimplantation, swallowing, and stent migration processes through finite element numerical simulation and in vitrosimulation tests. The results showed that different ratios of polymer stents had different mechanical properties,affecting the effectiveness of stent expansion treatment and the possibility of postoperative complications of stentimplantation. 展开更多
关键词 Finite element method 3D printing polymer esophageal stent artificial neural network
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基于CREB3L1探讨矾冰纳米乳对兔耳增生性瘢痕模型相关蛋白及炎症因子的影响
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作者 沈乐乐 范洪桥 刘丽芳 《中药新药与临床药理》 CAS CSCD 北大核心 2024年第8期1142-1151,共10页
目的观察矾冰纳米乳对兔耳增生性瘢痕组织环腺苷酸应答元件结合蛋白3样1(CREB3L1)及炎症损伤的影响,探讨其预防增生性瘢痕的作用机制。方法将30只新西兰大耳白兔随机分为空白组、模型组、积雪草苷组及矾冰纳米乳低、中、高剂量组(8.15、... 目的观察矾冰纳米乳对兔耳增生性瘢痕组织环腺苷酸应答元件结合蛋白3样1(CREB3L1)及炎症损伤的影响,探讨其预防增生性瘢痕的作用机制。方法将30只新西兰大耳白兔随机分为空白组、模型组、积雪草苷组及矾冰纳米乳低、中、高剂量组(8.15、16.3、32.6 mg·mL^(-1))。采用热力烫伤法进行造模,深Ⅱ度烧伤造模成功后第14天给予相应药物外用,空白组、模型组外用等量生理盐水,每日2次,连续给药至第35天。苏木素-伊红(HE)染色观察兔耳瘢痕组织病理学改变;马松(Masson)染色观察瘢痕组织胶原沉积情况;免疫荧光双标法检测兔耳瘢痕组织CREB3L1/α-平滑肌肌动蛋白(α-SMA)共表达情况;酶联免疫吸附测定法(ELISA)检测瘢痕组织白细胞介素6(IL-6)、白细胞介素10(IL-10)等炎性因子表达;实时荧光定量聚合酶链式反应(Real-time PCR)检测CREB3L1、Ⅰ型胶原蛋白(COL-Ⅰ)、Ⅲ型胶原蛋白(COL-Ⅲ)、α-SMA mRNA表达;蛋白免疫印迹法(Western Bolt)检测CREB3L1、COL-Ⅰ、COL-Ⅲ、α-SMA的蛋白表达情况。结果与空白组比较,模型组瘢痕增生指数明显升高(P<0.01);病理学改变包括真皮层增厚,形成致密的网状纤维,伴见炎症细胞浸润;Masson染色可见真皮层增厚,蓝染的胶原纤维大量沉积排列紊乱;免疫荧光双标结果显示,瘢痕组织中CREB3L1阳性表达增加,α-SMA阳性表达增加,IL-6含量明显升高(P<0.01),IL-10含量明显降低(P<0.01),兔耳瘢痕组织中的CREB3L1、COL-Ⅰ、COL-Ⅲ、α-SMA mRNA相对表达量明显增加(P<0.01),CREB3L1、COL-Ⅰ、COL-Ⅲ、α-SMA蛋白的表达明显增加(P<0.01)。与模型组比较,矾冰纳米乳中、高剂量组及积雪草苷组治疗后瘢痕增生指数均明显下降(P<0.05,P<0.01),病理改变可见真皮层变薄,炎性细胞均有不同程度减少,蓝染的胶原纤维减少,免疫荧光双染可见瘢痕组织中CREB3L1阳性表达降低,α-SMA阳性表达降低,IL-6含量明显降低(P<0.01),IL-10含量明显升高(P<0.01),矾冰纳米乳中、高剂量组和积雪草苷组均能够明显下调CREB3L1、COL-Ⅰ、COL-Ⅲ、α-SMA mRNA的表达(均P<0.01),降低CREB3L1、COL-Ⅰ、COL-Ⅲ、α-SMA蛋白的表达(P<0.05,P<0.01)。结论矾冰纳米乳能够通过调节CREB3L1及相关纤维化蛋白的表达,降低炎症水平,从而预防增生性瘢痕形成,丰富了中医“既病防变”“治未病”思想的科学内涵。 展开更多
关键词 增生性瘢痕 矾冰纳米乳 环腺苷酸应答元件结合蛋白3样1(CREB3L1) 炎症 纤维化 新西兰大耳白兔
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光电催化材料Ce_(2)O_(3)@ZnO/TNTs的制备及其性能的研究
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作者 关高明 滕雨薇 +2 位作者 刘慧琳 王键 蒋辽川 《广州化工》 CAS 2024年第20期16-19,22,共5页
采用阳极氧化法制备出TiO_(2)纳米管阵列(TNTs),再以方波脉冲沉积法在TNTs修饰ZnO,最后以阴极恒电流沉积在ZnO/TNTs表面沉积Ce,经煅烧处理后得到Ce_(2)O_(3)@ZnO/TNTs纳米复合材料。X-射线衍射仪(XRD)测试表明该材料中TiO_(2)、ZnO和Ce_... 采用阳极氧化法制备出TiO_(2)纳米管阵列(TNTs),再以方波脉冲沉积法在TNTs修饰ZnO,最后以阴极恒电流沉积在ZnO/TNTs表面沉积Ce,经煅烧处理后得到Ce_(2)O_(3)@ZnO/TNTs纳米复合材料。X-射线衍射仪(XRD)测试表明该材料中TiO_(2)、ZnO和Ce_(2)O_(3)共存。扫描电镜(SEM)分析显示在TNTs管口及管壁表面均匀生长了ZnO和Ce_(2)O_(3)。莫特-肖特基曲线(M-S曲线)测试表明其为n型半导体,紫外-可见漫反射(UV-vis)光谱分析证实其最大吸收波长可以达到448 nm。光电催化降解刚果红染料实验结果表明:Ce_(2)O_(3)@ZnO/TNTs光电催化降解效率高达82.09%,高于TNTs(21.32%)、ZnO/TNTs(51.96%)和Ce_(2)O_(3)/TNTs(75.3%)。 展开更多
关键词 Ce_(2)O_(3)@ZnO/TNTs 光电催化 稀土元素 过渡金属
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新时代我国0~3岁婴幼儿照护政策工具选择的优化路径——基于对166份国家和省级政策文本的分析
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作者 董雅楠 江夏 《成都师范学院学报》 2024年第3期32-42,共11页
为探析国家和省级层面婴幼儿照护政策工具选择与发展关注,构建政策工具和发展要素二维分析框架对2018—2023年7月间颁布的166份国家及省级层面婴幼儿照护政策文件进行文本分析。结果发现:目前我国婴幼儿照护政策存在的主要问题有政策工... 为探析国家和省级层面婴幼儿照护政策工具选择与发展关注,构建政策工具和发展要素二维分析框架对2018—2023年7月间颁布的166份国家及省级层面婴幼儿照护政策文件进行文本分析。结果发现:目前我国婴幼儿照护政策存在的主要问题有政策工具使用不均衡,系统变革工具和激励工具使用程度偏低;婴幼儿照护服务被窄化为托育机构服务,政府对机构的监督管理力度较弱;部分发展要素与政策工具匹配失衡,数据利用与创新维度政策工具使用数量偏少;省级层面发展关注重点与国家有所偏差,领导与投资过度依赖国家等。因此,为推动婴幼儿照护服务系统稳定发展,提出如下建议:结合实际需求,优化政策工具组合结构;优化顶层设计,进一步强化有效监管;加强对托育数据利用与创新,推动托育服务智能化发展;构建财权与事权相适应的政府间关系,增加婴幼儿照护财政投入。 展开更多
关键词 托育服务 0~3岁婴幼儿 婴幼儿照护政策 政策文本分析 政策工具 发展要素
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大口径天线3-RPS驱动机构结构优化设计与分析
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作者 吴凯 郑飞 梅贵凤 《现代机械》 2024年第5期14-19,86,共7页
采用并联机构替换现有的方位-俯仰式串联机构作为反射面天线的驱动机构可以满足其位姿调整的功能,并有效改善反射面天线整体结构的轻量化效果。目前少有将并联机构应用于大口径天线的分析与实际工程应用案例,故需要对承受较大载荷的并... 采用并联机构替换现有的方位-俯仰式串联机构作为反射面天线的驱动机构可以满足其位姿调整的功能,并有效改善反射面天线整体结构的轻量化效果。目前少有将并联机构应用于大口径天线的分析与实际工程应用案例,故需要对承受较大载荷的并联机构展开力学分析并对其结构进行优化,从而使其满足承载与运动精度的要求。针对3-RPS并联机构承受较大载荷时支链的结构方案展开优化设计并进行有限元仿真分析。首先,对3-RPS并联机构展开静力学分析,得到在动平台承受一定载荷的情况下机构各个支链的受力特性;其次,在给定机构基本尺寸参数及活动范围要求下,对3-RPS并联机构支链的结构方案进行设计,针对并联机构支链弯曲变形较为严重的情况提出了并联液压缸的结构方案;最后,对并联液压缸结构方案进行了优化以及稳定性分析。结果表明,优化后的并联液压缸方案各项性能指标均优于原有方案,且满足稳定性安全性要求,为实际的工程应用提供参考。 展开更多
关键词 3-RPS并联机构 多级液压缸 有限元分析 优化设计
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微RNA-196a-1-3p靶向Ras响应元件结合蛋白调控胆管癌细胞增殖的机制研究 被引量:1
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作者 丁敬健 张升涛 +3 位作者 郭永锋 王尚毓 罗孔亮 董伟 《安徽医药》 CAS 2024年第7期1399-1403,I0004,共6页
目的探讨转化生长因子β(TGF-β)调控人胆管癌细胞系RBE细胞增殖的关键微RNA(miRNA)及其潜在的机制。方法该研究起止时间为2020年1月至2022年1月。磷酸盐缓冲液(PBS)处理为对照组,TGF-β处理为TGF-β组,TGF-β抗体处理为抗体组。检测三... 目的探讨转化生长因子β(TGF-β)调控人胆管癌细胞系RBE细胞增殖的关键微RNA(miRNA)及其潜在的机制。方法该研究起止时间为2020年1月至2022年1月。磷酸盐缓冲液(PBS)处理为对照组,TGF-β处理为TGF-β组,TGF-β抗体处理为抗体组。检测三组RBE细胞的增殖水平。miRNA高通量测序检测三组RBE细胞的miRNA调控变化,并进行miRNA模拟物过表达筛选鉴定受TGF-β调控的影响RBE细胞增殖水平的关键miRNA。miRNA数据库(miRDB)在线分析miRNA的潜在底物,并通过小干扰RNA(siRNA)敲低筛选鉴定影响RBE细胞增殖水平的关键底物。结果相比于对照组,TGF-β组RBE细胞的增殖水平上升(1.62±0.07比2.35±0.09,P<0.05),抗体组RBE细胞的增殖水平下降(1.62±0.07比1.11±0.08,P<0.05)。过表达微RNA-196a-1-3p(miR-196a-1-3p)时,RBE细胞的增殖水平下降(P<0.05)。敲低Ras响应元件结合蛋白(RREB1)时,RBE细胞的增殖水平下降(P<0.05)。过表达miR-196a-1-3p后,RBE细胞中RREB1的信使RNA(mRNA)和蛋白水平下降(P<0.05)。敲低miR-196a-1-3p后,RBE细胞中RREB1与SMAD家族蛋白3(SMAD3)的相互作用增加。敲低SMAD3后,RBE细胞的增殖水平下降(P<0.05)。与仅敲低SMAD3相比,敲低SMAD3的同时过表达RREB1的RBE细胞的增殖水平无显著变化,并且同时敲低SMAD3和miR-196a-1-3p的RBE细胞的增殖水平无显著变化。结论TGF-β能够通过miR-196a-1-3p/RREB1/SMAD3轴促进RBE细胞增殖;miR-196a-1-3p和RREB1可作为潜在的治疗胆管癌的靶标,为针对该靶标的新药研发奠定了基础。 展开更多
关键词 胆管肿瘤 转化生长因子β 细胞增殖 微RNA-196a-1-3p Ras反应元件结合蛋白1 SMAD家族成员3
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