The 3,4,5 trimethoxytoluene(TMT) was systhesized using p cresol by three steps including bromination, methoxylation, and methylation with an overall yield of 84%. The structure of TMT was identified by NMR, GC/MS and ...The 3,4,5 trimethoxytoluene(TMT) was systhesized using p cresol by three steps including bromination, methoxylation, and methylation with an overall yield of 84%. The structure of TMT was identified by NMR, GC/MS and IR.“One pot”method was used in methoxylation and methylation for economical and convenient consideration. The mechanism for the methoxylation of 2,6 dibromo 4 methylphenol was discussed.展开更多
Trimethoxybenzaldehyde (TMB) was hydrogenated over Pd/C in H 2-AcOH,in H 2-MeOH and in NH 2NH 2-PhMe system respectively.In Pd/C-TMB-H 2-AcOH system,TMB was reduced into 3,4,5-trimethoxytoluene (TMT) via 3,4,5-trimeth...Trimethoxybenzaldehyde (TMB) was hydrogenated over Pd/C in H 2-AcOH,in H 2-MeOH and in NH 2NH 2-PhMe system respectively.In Pd/C-TMB-H 2-AcOH system,TMB was reduced into 3,4,5-trimethoxytoluene (TMT) via 3,4,5-trimethoxybenzyl acetate and (1′-hydroxy)ethyl (3,4,5-trimethoxy)benzyl ether.In Pd/C-TMB-H 2-MeOH system,TMB was reduced into TMT via 3,4,5-trimethoxybenzyl alcohol,methyl(3,4,5-trimethoxy)benzyl ether and bis(3,4,5-trimethoxy)benzyl ether.In Pd/C-TMB-NH 2NH 2-PhMe system,TMB was reduced into TMT directly with mild manner and higher selectivity.展开更多
文摘The 3,4,5 trimethoxytoluene(TMT) was systhesized using p cresol by three steps including bromination, methoxylation, and methylation with an overall yield of 84%. The structure of TMT was identified by NMR, GC/MS and IR.“One pot”method was used in methoxylation and methylation for economical and convenient consideration. The mechanism for the methoxylation of 2,6 dibromo 4 methylphenol was discussed.
文摘Trimethoxybenzaldehyde (TMB) was hydrogenated over Pd/C in H 2-AcOH,in H 2-MeOH and in NH 2NH 2-PhMe system respectively.In Pd/C-TMB-H 2-AcOH system,TMB was reduced into 3,4,5-trimethoxytoluene (TMT) via 3,4,5-trimethoxybenzyl acetate and (1′-hydroxy)ethyl (3,4,5-trimethoxy)benzyl ether.In Pd/C-TMB-H 2-MeOH system,TMB was reduced into TMT via 3,4,5-trimethoxybenzyl alcohol,methyl(3,4,5-trimethoxy)benzyl ether and bis(3,4,5-trimethoxy)benzyl ether.In Pd/C-TMB-NH 2NH 2-PhMe system,TMB was reduced into TMT directly with mild manner and higher selectivity.