目的探讨神经营养素-3基因(NT-3)基因甘氨酸(Gly) /谷氨酸(Glu)多态性与儿童精神分裂症及其脑室扩大的关系。方法分析218例儿童精神分裂症患者和210名正常儿童对照的NT-3基因Gly/Glu多态性;患者进行阳性与阴性症状量表(PANSS)评定,采用A...目的探讨神经营养素-3基因(NT-3)基因甘氨酸(Gly) /谷氨酸(Glu)多态性与儿童精神分裂症及其脑室扩大的关系。方法分析218例儿童精神分裂症患者和210名正常儿童对照的NT-3基因Gly/Glu多态性;患者进行阳性与阴性症状量表(PANSS)评定,采用Andreason阳性与阴性精神分裂症分型标准分为阴性症状为主型(阴性组)和阳性症状为主型(阳性组)。结果①患者组NT-3基因Gly/Gly频率高于对照组,差异有统计学意义(75.2% vs 64.3%, X2=6.86,P<0.05),等位基因Gly频率高于对照组,差异有统计学意义(86.2% vs 81.0%, X2=4.37,P<0.05)。②阴性组与阳性组患者基因型和等位基因频率差异均无统计学意义(P>0.05);③不同基因型患者之间各脑室值、PANSS量表总分及因子分的差异均无统计学意义(P>0.05);④患者阴性症状分与哈氏值、三脑室宽度呈正相关(r=0.38,P<0.01;r=0.16,P<0.05),与脑室指数和前角指数呈负相关(r=-0.16,P<0.05;r=-0.19,P<0.05)。结论 NT-3基因Gly/Glu多态性与儿童精神分裂症有关,与患者的脑室扩大无关。展开更多
A 38-year-old man experienced double vision with pupillary abnormalities and convergence retraction nystagmus. A mass, which responded to radiation therapy, was seen as the cause of his dorsal midbrain syndrome. The n...A 38-year-old man experienced double vision with pupillary abnormalities and convergence retraction nystagmus. A mass, which responded to radiation therapy, was seen as the cause of his dorsal midbrain syndrome. The neural control of vertical eye movements is reviewed and the management of a third ventricular-pineal region mass discussed.展开更多
文摘目的探讨神经营养素-3基因(NT-3)基因甘氨酸(Gly) /谷氨酸(Glu)多态性与儿童精神分裂症及其脑室扩大的关系。方法分析218例儿童精神分裂症患者和210名正常儿童对照的NT-3基因Gly/Glu多态性;患者进行阳性与阴性症状量表(PANSS)评定,采用Andreason阳性与阴性精神分裂症分型标准分为阴性症状为主型(阴性组)和阳性症状为主型(阳性组)。结果①患者组NT-3基因Gly/Gly频率高于对照组,差异有统计学意义(75.2% vs 64.3%, X2=6.86,P<0.05),等位基因Gly频率高于对照组,差异有统计学意义(86.2% vs 81.0%, X2=4.37,P<0.05)。②阴性组与阳性组患者基因型和等位基因频率差异均无统计学意义(P>0.05);③不同基因型患者之间各脑室值、PANSS量表总分及因子分的差异均无统计学意义(P>0.05);④患者阴性症状分与哈氏值、三脑室宽度呈正相关(r=0.38,P<0.01;r=0.16,P<0.05),与脑室指数和前角指数呈负相关(r=-0.16,P<0.05;r=-0.19,P<0.05)。结论 NT-3基因Gly/Glu多态性与儿童精神分裂症有关,与患者的脑室扩大无关。
文摘A 38-year-old man experienced double vision with pupillary abnormalities and convergence retraction nystagmus. A mass, which responded to radiation therapy, was seen as the cause of his dorsal midbrain syndrome. The neural control of vertical eye movements is reviewed and the management of a third ventricular-pineal region mass discussed.
