To search for more potent and less toxic antifungal agents,Four 2(2,4Diflurophenyl)1(4alkylpiperazine1yl)3(1,2,4triazole1yl)2propanols were designed and synthesized,and their antifungal act...To search for more potent and less toxic antifungal agents,Four 2(2,4Diflurophenyl)1(4alkylpiperazine1yl)3(1,2,4triazole1yl)2propanols were designed and synthesized,and their antifungal activities in vitro were determined.All title compounds exhibited mild activities against yeast.展开更多
Thermoanalysis study has been carried out on the complex of bis[1 (2 thienyl) 4,4,4 trifluoro butanedione 1,3]copper? and its adducts with pyridine, 2,2′ bipyridine, quinoline and dimethyl sulfoxide in a dynamic nitr...Thermoanalysis study has been carried out on the complex of bis[1 (2 thienyl) 4,4,4 trifluoro butanedione 1,3]copper? and its adducts with pyridine, 2,2′ bipyridine, quinoline and dimethyl sulfoxide in a dynamic nitrogen atmosphere by simultaneous TG DTG DSC technique. The experimental results showed that the decomposition modes of the solvent molecules were various according to the different structures of the complex, in general, the decomposition of them was ahead of the decomposition of the ligand 1 (2 thienyl) 4,4,4 triflurobu tanedione 1,3. Among them the adduct with 2,2 bipyridine showed a quite unique thermal behavior. Several methods have been jointly used to study the kinetics of all the thermal decomposition stages for title compounds, which showed that the evolution of the solvent molecules was controlled mainly by Rn mechanism (or Am mechanism for 2,2 bipyridine adduct) with lower activation energy; while the release of 1 (2 thienyl) 4,4,4 trifluro butane dione 1,3 was gove rned by D2 or D3 mode with higher activation energy.展开更多
The fused triazole derivatives,which is an important inhibitors of the dipeptidyl peptidase-Ⅳ enzyme(DPP-Ⅳ),can be used for the treatment or prevention of type 2 diabetes.A new fused triazole derivatives of 3-oxo-3-...The fused triazole derivatives,which is an important inhibitors of the dipeptidyl peptidase-Ⅳ enzyme(DPP-Ⅳ),can be used for the treatment or prevention of type 2 diabetes.A new fused triazole derivatives of 3-oxo-3-[3-trifluoromethyl-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-phenylpropan-1-amine was synthesized from 2-chloropyrazine and benzaldehyde by hydrazinolysis,trifluoroacetylation,cyclization,hydrogenation,condensation and deprotection reaction.The structures of the compound and its intermediates were determined by IR,NMR,and MS.展开更多
文摘To search for more potent and less toxic antifungal agents,Four 2(2,4Diflurophenyl)1(4alkylpiperazine1yl)3(1,2,4triazole1yl)2propanols were designed and synthesized,and their antifungal activities in vitro were determined.All title compounds exhibited mild activities against yeast.
文摘Thermoanalysis study has been carried out on the complex of bis[1 (2 thienyl) 4,4,4 trifluoro butanedione 1,3]copper? and its adducts with pyridine, 2,2′ bipyridine, quinoline and dimethyl sulfoxide in a dynamic nitrogen atmosphere by simultaneous TG DTG DSC technique. The experimental results showed that the decomposition modes of the solvent molecules were various according to the different structures of the complex, in general, the decomposition of them was ahead of the decomposition of the ligand 1 (2 thienyl) 4,4,4 triflurobu tanedione 1,3. Among them the adduct with 2,2 bipyridine showed a quite unique thermal behavior. Several methods have been jointly used to study the kinetics of all the thermal decomposition stages for title compounds, which showed that the evolution of the solvent molecules was controlled mainly by Rn mechanism (or Am mechanism for 2,2 bipyridine adduct) with lower activation energy; while the release of 1 (2 thienyl) 4,4,4 trifluro butane dione 1,3 was gove rned by D2 or D3 mode with higher activation energy.
文摘The fused triazole derivatives,which is an important inhibitors of the dipeptidyl peptidase-Ⅳ enzyme(DPP-Ⅳ),can be used for the treatment or prevention of type 2 diabetes.A new fused triazole derivatives of 3-oxo-3-[3-trifluoromethyl-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-phenylpropan-1-amine was synthesized from 2-chloropyrazine and benzaldehyde by hydrazinolysis,trifluoroacetylation,cyclization,hydrogenation,condensation and deprotection reaction.The structures of the compound and its intermediates were determined by IR,NMR,and MS.
