Estimation of the anisotropy of hydraulic conductivity through 3D fracture networks using the directional geological entropy

With an extension of the geological entropy concept in porous media,the approach called directional entrogram is applied to link hydraulic behavior to the anisotropy of the 3D fracture networks.A metric called directional entropic scale is used to measure the anisotropy of spatial order in different directions.Compared with the traditional connectivity indexes based on the statistics of fracture geometry,the directional entropic scale is capable to quantify the anisotropy of connectivity and hydraulic conductivity in heterogeneous 3D fracture networks.According to the numerical analysis of directional entrogram and fluid flow in a number of the 3D fracture networks,the hydraulic conductivities and entropic scales in different directions both increase with spatial order(i.e.,trace length decreasing and spacing increasing)and are independent of the dip angle.As a result,the nonlinear correlation between the hydraulic conductivities and entropic scales from different directions can be unified as quadratic polynomial function,which can shed light on the anisotropic effect of spatial order and global entropy on the heterogeneous hydraulic behaviors.

Investigation on the Thermal Conductivity of 3-Dimensional and 4-Directional Braided Composites

It is vital to choose a factual and reasonable micro-structural model of braided composites for improving the calculating precision of thermal property of 3-D braided composites by finite element method （FEM）. On the basis of new microstructure model of braided composites proposed recently, the model of FEM calculation for thermal conductivity of 3-dimennsional and 4-directional braided composites is set up in this paper. The curves of coefficient of effective thermal conductivity versus fiber volume ratio and interior braiding angle are obtained. Furthermore, comparing the results of FEM with the available experimental data, the reasonability and veracity of calculation are confirmed at the same time.

Wide color gamut switchable autostereoscopic 3D display based on directional quantum-dot backlight

A switchable autostereoscopic 3-dimensional(3D) display device with wide color gamut is introduced in this paper. In conjunction with a novel directional quantum-dot(QD) backlight, the precise scanning control strategy, and the eye-tracking system, this spatial-sequential solution enables our autostereoscopic display to combine all the advantages of full resolution,wide color gamut, low crosstalk, and switchable 2D/3D. And also, we fabricated an autostereoscopic display prototype and demonstrated its performances effectively. The results indicate that our system can both break the limitation of viewing position and provide high-quality 3D images. We present two working modes in this system. In the spatial-sequential mode,the crosstalk is about 6%. In the time-multiplexed mode, the viewer should wear auxiliary and the crosstalk is about 1%,just next to that of a commercial 3D display(BENQ XL2707-B and View Sonic VX2268 WM). Additionally, our system is also completely compatible with active shutter glasses and its 3D resolution is same as its 2D resolution. Because of the excellent properties of the QD material, the color gamut can be widely extended to 77.98% according to the ITU-R recommendation BT.2020(Rec.2020).

(1-3)-β-D葡聚糖联合降钙素原、CD4^(+)T淋巴细胞多指标在艾滋病患者马尔尼菲篮状菌感染早期诊断临床研究

目的探讨(1-3)-β-D葡聚糖联合降钙素原(procalcitonin,PCT)、CD4^(+)T淋巴细胞多指标在艾滋病患者马尔尼菲篮状菌感染早期诊断临床研究。方法回顾性选取我院2020年1月—2022年6月住院的120例艾滋病患者为研究对象。依据实验室结果,将其分为马尔尼菲篮状菌感染确诊组(血或组织液培育养出马尔尼菲篮状菌),简称A组(62例),及马尔尼菲篮状菌感染临床诊断组[根据临床症状、体征、血常规及(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞多指标诊断],简称B组(58例)。检测患者(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞的表达水平,采用受试者工作特征(receiver-operating characteristic,ROC)曲线下面积(area under the curve,AUC)评估上述指标联合检测对艾滋病患者感染马尔尼菲篮状菌的诊断效能。结果A组的(1-3)-β-D葡聚糖和PCT水平均高于B组,CD4^(+)T淋巴细胞个数低于B组(P<0.05);(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞联合检测的AUC为0.933,(1-3)-β-D葡聚糖单独检测的AUC是0.812,PCT单独检测的AUC为0.883,CD4^(+)T淋巴细胞单独检测的AUC是0.810,(1-3)-β-D葡聚糖、PCT和CD4^(+)T淋巴细胞联合检测的AUC皆优于三项单独检测,表明(1-3)-β-D葡聚糖、PCT和CD4^(+)T淋巴细胞联合检测的诊断价值皆优于单一指标诊断,且联合检测的特异度、约登指数分别为92.43%和0.580,均高于三项单独检测。结论(1-3)-β-D葡聚糖联合PCT和CD4^(+)T淋巴细胞多指标对艾滋病马尔尼菲篮状菌感染具有非常高的临床诊断价值,能够帮助医生分析出高危风险患者,及时制定治疗方案,同时也承担预后效果的判断依据,对治疗艾滋病马尔尼菲篮状菌感染具有非常重要的研究价值。

老年COPD继发肺部真菌感染患者外周血(1-3)-β-D葡聚糖、淋巴细胞水平变化的临床意义

目的分析老年慢性阻塞性肺疾病(COPD)继发肺部真菌感染(PFI)患者外周血(1-3)-β-D葡聚糖、淋巴细胞水平变化的临床意义。方法选取老年COPD继发PFI患者108例(PFI组)和老年COPD未继发PFI患者80例(非PFI组)。分析PFI组痰液病原菌分布情况;比较两组临床资料、外周血(1-3)-β-D葡聚糖、淋巴细胞亚群水平。分析COPD继发PFI的影响因素及(1-3)-β-D葡聚糖与淋巴细胞水平的相关性。结果PFI组患者痰液病原菌主要为曲霉菌、假丝酵母菌和白念珠菌。PFI组(1-3)-β-D葡聚糖、CD3^(+)CD8^(+)高于非PFI组,CD3^(+)CD4^(+)、CD3^(+)CD4^(+)/CD3^(+)CD8^(+)低于非PFI组(P<0.05)。外周血(1-3)-β-D葡聚糖与CD3^(+)CD4^(+)、CD3^(+)CD4^(+)/CD3^(+)CD8^(+)呈负相关,与CD3^(+)CD8^(+)呈正相关(P<0.001);(1-3)-β-D葡聚糖、CD3^(+)CD4^(+)、CD3^(+)CD4^(+)/CD3^(+)CD8^(+)均为老年COPD患者继发PFI的独立影响因素(P<0.05)。结论(1-3)-β-D葡聚糖、CD3^(+)CD4^(+)、CD3^(+)CD4^(+)/CD3^(+)CD8^(+)是老年COPD患者继发PFI的影响因素,可为其临床治疗提供参考。

Interactions between γ-TiAl melt and Y_2O_3 ceramic material during directional solidification process

A γ-TiAl alloy with nominal composition of Ti-47%Al（molar fraction） was directionally solidified in an alumina mould with an Y2O3 protective coating.The effects of processing parameters（melting temperature and interaction time） on the metal-coating interface,microstructure and chemical composition of the alloy were evaluated.The result shows that the Y2O3 protective coating exhibits an effective barrier capability to avoid direct contact between the mould base material and the TiAl melt,although the Y2O3 coating is found to suffer some erosion and be slightly dissolved by the molten TiAl due to the coating-metal interactions.The directionally solidified alloys were contaminated with Y and O,and Y2O3 inclusions were dispersed in the metal matrix.The reason for this metal contamination is the Y2O3 coating dissolution by the TiAl melt.One mode of the interaction between Y2O3 and the TiAl melt is dissolution of yttrium and atomic oxygen in the melt by reaction Y2O3（s）=2Y（in TiAl melt）＋3O（in TiAl melt）.Both the extent of alloy contamination and the volume fractions of Y2O3 inclusions depend on the melting temperature and the interaction time.

1例RHD-CE(3-7)-D基因重组与RHCE变异型患者的血清学与分子生物学分析

目的 研究分析1例Rh血型弱D、弱cE患者的血清学与分子生物学特征,为该类患者的临床安全输血提供实验依据。方法 采用微柱凝胶卡法对患者红细胞进行ABO、RhDCcEe抗原的鉴定,同时采用试管法进行血型复核,抗人球蛋白卡法筛查不规则抗体;采用PCR-SSP法对RhDCcEe(RhD、RhC、Rhc、RhE、Rhe)基因型进行检测;三代全长测序技术对RHD/RHCE基因序列进行测序分析。结果 微柱凝胶卡法鉴定ABO、RhD、RhCcEe血型抗原的结果为:A抗原(-)、B抗原(-)、RhD(1+)、RhC(4+)、Rhc(1+)、RhE(1+)、Rhe(4+)、对照孔(-);试管法ABO、RhD、RhCcEe抗原鉴定该患者表型为:A抗原(-)、B抗原(-)、RhD(w+)、RhC(4+)、Rhc(w+)、RhE(w+)、Rhe(4+),对照管(-);抗人球蛋白卡法筛查患者不规则抗体阴性;PCR-SSP法血型基因分型RhDCcEe结果:RhD(+)、RhC(+)、Rhc(+)、RhE(+)、Rhe(+);RHD/RHCE基因结果:RHD单倍体1为外显子1-10全缺失,而单倍体2为外显子RHD-CE基因重组融合,且确认其重组类型为RHD-CE(3-7)-D,起点在外显子2(g.20238-20312之间),终点在外显子8(g49184-50480之间),同时RHCE基因第6外显子存在新碱基点突变RHCE*cE(827C>A)。结论RHD-CE(3-7)-D基因重组融合与RHCE*cE(827C>A)新等位基因突变可能引起D、cE血型抗原弱表达,为临床安全输血提供了重要的实验数据支持。

EFFECT OF YTTRIUM ON PERFORMANCE OF DIRECTIONALLY SOLIDIFIED Ni 3Al BASE ALLOY IC6

The effect of different amounts of rare earth element yttrium on the microstructure of the directionally solidified (DS) Ni 3Al base alloy IC6 was studied with scanning electron microscope(SEM). The results showed that the microstructure of alloys with addition of 0.04%～0.12%Y had no obvious difference compared with that of IC6 without yttrium, and a bulk shape phase rich in Ni, Mo and Y was formed within large size γ′ phase in interdendritic area in the alloy with 0.20%Y, and the volume of large size γ′ phase in interdendritic area increased when the adding amounts of yttrium increased to 0.3%. The stress rupture properties at 1 100 ℃, 80 MPa were improved by adding 0.04%～0.20%Y. The oxidation resistance and thermal fatigue property of the alloys with different amounts of yttrium were tested at 1 100 ℃. The results showed that the oxidation resistance and thermal fatigue property were substantially improved by adding proper amounts of yttrium.

3D printing of poly(ethyleneimine)-functionalized Mg-Al mixed metal oxide monoliths for direct air capture of CO_(2)

Direct air capture(DAC)of CO_(2)plays an indispensable role in achieving carbon-neutral goals as one of the key negative emission technologies.Since large air flows are required to capture the ultradilute CO_(2)from the air,lab-synthesized adsorbents in powder form may cause unacceptable gas pressure drops and poor heat and mass transfer efficiencies.A structured adsorbent is essential for the implementation of gas-solid contactors for cost-and energy-efficient DAC systems.In this study,efficient adsorbent poly(ethyleneimine)(PEI)-functionalized Mg-Al-CO_(3)layered double hydroxide(LDH)-derived mixed metal oxides(MMOs)are three-dimensional(3D)printed into monoliths for the first time with more than 90%adsorbent loadings.The printing process has been optimized by initially printing the LDH powder into monoliths followed by calcination into MMO monoliths.This structure exhibits a 32.7%higher specific surface area and a 46.1%higher pore volume,as compared to the direct printing of the MMO powder into a monolith.After impregnation of PEI,the monolith demonstrates a large adsorption capacity(1.82 mmol/g)and fast kinetics(0.7 mmol/g/h)using a CO_(2)feed gas at 400 ppm at 25℃,one of the highest values among the shaped DAC adsorbents.Smearing of the amino-polymers during the post-printing process affects the diffusion of CO_(2),resulting in slower adsorption kinetics of pre-impregnation monoliths compared to post-impregnation monoliths.The optimal PEI/MeOH ratio for the post-impregnation solution prevents pores clogging that would affect both adsorption capacity and kinetics.

Relations of 3D directional derivatives and expressions of typical differential operators

Relations of the 3D multi-directional derivatives are studied in this paper. These relations are applied to a geeral second-order linear elliptical operator and the corresponding expression are obtained. These relations and expressions play important roles in the meshless finite point method.

Spatiotemporal Evolution Analysis of the 3-D Deformation Field of Land Subsidence in Beijing after the South-to-North Water Diversion Project

The implementation of the South-to-North Water Diversion Project (SNWDP) has alleviated groundwater resource pressure in North China to some extent, resulting in a gradual deceleration of land subsidence and even rebound in some areas. To investigate the spatiotemporal evolution characteristics of land subsidence in the eastern plain of Beijing following the SNWDP, this study employs Ascending (ASC) and Descending (DES) InSAR data combined with a Strain Model (SM) to obtain a Three-Dimensional (3-D) deformation field from 2016 to 2018. Through analysis of the 3-D deformation characteristics and spatiotemporal evolution of land subsidence in this region from 2016 to 2018, the results reveal a shift in the distribution of subsiding areas after the South-to-North Water Diversion, with a marked decrease in subsidence rates in certain areas. The maximum subsidence rate in the Beijing area has decreased to 110 mm/yr, accompanied by horizontal deformation at a rate of 12 mm/yr. Additionally, by examining the spatial relationship between major active faults and subsidence deformation in this region, the study further elucidates the influence of fault activity on the spatial distribution of subsidence deformation.

基于二萘并[2,3-B∶2′,3′-D]呋喃基团的高效窄发射蓝光OLED器件

高效率窄光谱蓝色有机电致发光器件(OLED)是柔性显示领域的研究重点之一。本文以二萘并[2,3-B∶2′,3′-D]呋喃为弱电子受体、N-(4-联苯基)-1-萘胺作为电子给体设计合成了一种D-A-D型蓝光分子DPF-NA,其在正己烷溶液中的发射峰位于441 nm。理论计算与光物理测试结果显示DPF-NA具有杂化局域电荷转移激发态(HLCT)特性,兼具局域态(LE)高发光效率与电荷转移态(CT)高激子利用率特征,在二氯甲烷溶液中的光致发光量子效率(PLQY)为81.2%。基于质量分数3%DPF-NA掺杂浓度的OLED器件电致发光(EL)峰位于455 nm,半峰宽(FWHM)仅为26 nm,CIE(x,y)坐标为(0.14,0.08),最大外量子效率(EQEmax)为6.76%。

谷氨酸棒杆菌3-磷酸甘油酸脱氢酶的定向进化改造研究

3-磷酸甘油酸脱氢酶(3-phosphoglycerate dehydrogenase,PGDH)是L-丝氨酸生物合成途径的限速酶,是影响L-丝氨酸高效合成的关键。该研究以来源于谷氨酸棒杆菌(Corynebacterium glutamicum)的PGDH为研究对象,通过对其酶学性质进行测试分析发现,Cg-PGDH的酶活性仅为1.98 U/mg,而且热稳定性较差,严重制约了L-丝氨酸的高效生物合成。针对这一关键问题,该研究采用定向进化和高通量筛选的方法对Cg-PGDH进行改造,提高酶的催化活性和热稳定性。通过多轮筛选,最终获得了5个催化活性显著提升的突变体,P85Q、D365Y、A389T、A183V、I231V。其中,突变体P85Q的酶活性提升了1.55倍,并显著提高了酶的温度稳定性,最适催化温度达到60℃。随后该研究对P85Q、D365Y、A389T、A183V、I231V等5个突变体的突变位点进行组合突变,获得了温度稳定性进一步提高的突变体P85Q-D365Y。通过对Cg-PGDH突变位点的三维结构解析和分子动力学模拟实验发现,尽管突变体P85Q与D365Y的突变位点不位于Cg-PGDH催化活性中心,但是可通过蛋白结构形变增强Cg-PGDH活性中心130~140区间loop的稳定性,从而增加了酶的底物亲和性和催化活性。相关研究成果为进一步解析PGDH催化机制,提高PGDH催化活性提供了重要的研究基础和方向。

DPGL:The Direct3D9-based Parallel Graphics Library for Multi-display Environment

The emergence of high performance 3D graphics cards has opened the way to PC clusters for high performance multi- display environment. In order to exploit the rendering ability of PC clusters, we should design appropriate parallel rendering algorithms and parallel graphics library interfaces. Due to the rapid development of Direct3D, we bring forward DPGL, the Direct3D9-based parallel graphics library in D3DPR parallel rendering system, which implements Direct3D9 interfaces to support existing Direct3D9 application parallelization with no modification. Based on the parallelism analysis of Direct3D9 rendering pipeline, we briefly introduce D3DPR parallel rendering system. DPGL is the fundamental component of D3DPR. After presenting DPGL three layers architecture, we discuss the rendering resource interception and management. Finally, we describe the design and implementation of DPGL in detail, including rendering command interception layer, rendering command interpretation layer and rendering resource parallelization layer.

New 4-imino-4H-Chromeno[2,3-d]Pyrimidin-3(5H)-Amine: Synthesis, Cytotoxic Effects on Tumoral Cell Lines and in Silico ADMET Properties

The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, MDA-MB231, MDA-MB468, HCT116, PC3 and MCF7) and also on fibroblasts. Among them, only the compounds 6c showed micromolar cytotoxic activity on tumor cell lines (1.8 50 50 > 25 μM). Finally, in silico ADMET studies ware performed to investigate the possibility of using of the identified compound 6c as potential anti-tumor compound.

1-D Directional Filter Based Texture Descriptor in Fractional Fourier Domain

Texture analysis is a fundamental field in computer vision. However,it is also a particularly difficult problem for no universal mathematical model of real world textures. By extending a new application of the fractional Fourier transform( Fr FT) in the field of texture analysis,this paper proposes an Fr FT-based method for describing textures. Firstly,based on the Radon-Wigner transform,1-D directional Fr FT filters are designed to two types of texture features,i. e.,the coarseness and directionality. Then,the frequencies with maximum and median amplitudes of the Fr FT of the input signal are regarded as the output of the 1-D directional Fr FT filter. Finally,the mean and the standard deviation are used to compose of the feature vector. Compared to the WD-based method,three benefits can be achieved with the proposed Fr FT-based method,i. e.,less memory size,lower computational load,and less disturbed by the cross-terms. The proposed method has been tested on16 standard texture images. The experimental results show that the proposed method is superior to the popular Gabor filtering-based method.

血浆(1-3)-β-D葡聚糖诊断新生儿侵袭性真菌感染的价值

探讨在针对新生儿侵袭性真菌感染的诊断中使用血浆(1-3)-β-D葡聚糖能够产生的诊断效能。方法 选取2021年1月到2022年2月因为侵袭性真菌感染于医院寻求医疗干预的新生儿总共60例作为本次研究的一部分研究对象记为1组;另外选取60例健康婴儿作为2组;统计、对比两组患者的血浆(1-3)-β-D葡聚糖水平、CD4+T淋巴细胞数水平;整理PCR技术针对1组患者诊断结果,将其与血浆(1-3)-β-D葡聚糖诊断侵袭性真菌感染的诊断效能进行对比。结果 研究结果显示1组患者的血浆(1-3)-β-D葡聚糖水平、CD4+T淋巴细胞数水平较之于2组患者存在明显差异,1组患者血浆(1-3)-β-D葡聚糖水平更高,而CD4+T淋巴细胞数水平明显更低;P<0.05。在针对诊断效能的考察上,血浆(1-3)-β-D葡聚糖诊断效能和PCR诊断结果之间在灵敏度、特异度方面差异不大,P>0.05。结论 针对罹患侵袭性真菌感染的新生儿使用血浆(1-3)-β-D葡聚糖进行检查,一定程度上能够确保诊断结果的严谨程度,可使用。

血浆(1,3)-β-D葡聚糖检测在侵袭性真菌感染诊断中的价值分析

研究血浆(1,3)-β-D葡聚糖检测技术(G实验)应用于侵袭性真菌感染(IFI)诊断中的应用价值。方法 选择我院在2023年1月至2024年1月期间收治的100例高危型侵袭型真菌感染患者,应用MB-80微生物快速检测动态系统以及对应的试剂对患者的血浆(1,3)-β-D葡聚糖进行检测,分析真菌培养、G实验和联合检测结果;三种方法的诊断效能;三种方法的ROC曲线。结果 确诊IFI阳性共28例,阴性共72例;联合检测的诊断效能高于真菌培养或者G实验。联合检测面积高于单一检测。结论 在侵袭性真菌感染的诊断中,应用血浆(1,3)-β-D葡聚糖检测,诊断效能良好,在和传统真菌培养技术联合检测下,可进一步提升诊断效能。

DUCTILITY ENHANCEMENT OF Al RICH Ni_3Al BY DIRECTIONAL SOLIDIFICATION

Stoichiometric (25.0% Al in mole) and hyperstoichiometric (26.5% Al in mole) Ni 3Al alloy can be made ductile by directional solidification in ceramic mould. In the stoichiometric alloy, texture formation varies between samples and more than 20% plastic elongation can be obtained. In the hyper stoichiometric alloy, strong 〈110〉 texture forms and 12% plastic elongation can be obtained. The high plastic elongation of the directionally solidified alloy is attributed to the suppression of intergranular fracture by reducing the portion of the transverse boundaries. The texture and microstructure formation mechanism were proposed.

A New 3D Wireless Directional Sensing Model and Coverage Enhancement Algorithm

Coverage control for each sensor is based on a 2D directional sensing model in directional sensor networks conventionally. But the 2D model cannot accurately characterize the real environment. In order to solve this problem,a new 3D directional sensor model and coverage enhancement algorithm is proposed. We can adjust the pitch angle and deviation angle to enhance the coverage rate. And the coverage enhancement algorithm is based on an improved gravitational search algorithm. In this paper the two improved strategies of GSA are directional mutation strategy and individual evolution strategy. A set of simulations show that our coverage enhancement algorithm has a good performance to improve the coverage rate of the wireless directional sensor network on different number of nodes,different virtual angles and different sensing radius.