Due to the attractive performances such as the ability of beam focus,broadband,multi-beam scanning and other features,Luneburg lens antennas are applied in multi-beam antenna,which overcomes the problem of gain loss p...Due to the attractive performances such as the ability of beam focus,broadband,multi-beam scanning and other features,Luneburg lens antennas are applied in multi-beam antenna,which overcomes the problem of gain loss produced by multi-beam parabolic antenna.Based on 3-D printing technique,Luneburg lens antennas by drilling holes are studied.Permittivity and loss tangent of the equivalent lens materials can be influenced by original materials,hole shapes,hole directions,and porosity.After tests,polystyrene with waxes may be the most appropriate materials for Luneburg lens with high strength.Permittivity with the shape of triangle is the lowest due to the homogeneity.Relative permittivities with the direction at a range of 15°-45°are lower while loss tangent at a range of 0°-30°.Radial directional holes are more appropriate for Luneburg lens.The relative permittivity is decreased with the increment of porosity.After calculations,the forecasts calculated by Looyenga and A-BG theory are more precise.Finally,Luneburg lens with two layers is fabricated by 3-D printing.展开更多
Objective: To investigate the value of 3D printing techniques in the treatment of complex tibial plateau fractures. Methods: From September 2016 to September 2018, 28 patients with complex tibial plateau fractures wer...Objective: To investigate the value of 3D printing techniques in the treatment of complex tibial plateau fractures. Methods: From September 2016 to September 2018, 28 patients with complex tibial plateau fractures were treated in our hospital. According to the odevity of hospitalized order, the patients were divided into two groups. Group A used 3D reconstruction, virtually reduction, 3D printing and demonstration of individual fracture model before operation while group B only received conventional process by use X-rays or CT image. Comparison between the two groups was made in operation time, operative blood loss, radiation frequency, surgery instrument cost and knee function score. Results: The follow-up was 14.4 months on average (ranged 6 to 22 months). There was no statistical difference of the surgery instrument cost between the 2 groups (P > 0.05). The operation time of group A was significantly shorter than that of group B (P χ2 = 0.373, P = 0.54). Conclusion: 3D printing techniques can improve surgery effect in complex tibial plateau fractures.展开更多
This paper presents the preclinical evaluation of a novel immobilization system for patients undergoing external beam radiation treatment of head and neck tumors. An immobilization mask is manufactured directly from a...This paper presents the preclinical evaluation of a novel immobilization system for patients undergoing external beam radiation treatment of head and neck tumors. An immobilization mask is manufactured directly from a 3-D model, built using the CT data routinely acquired for treatment planning so there is no need to take plaster of Paris moulds. Research suggests that many patients find the mould room visit distressing and so rapid prototyping could potentially improve the overall patient experience. Evaluation of a computer model of the immobilization system using an anthropomorphic phantom shows that >99% of vertices are within a tolerance of ±0.2 mm. Hausdorff distance was used to analyze CT slices obtained by rescanning the phantom with a printed mask in position. These results show that for >80% of the slices the median “worse-case” tolerance is approximately 4 mm. These measurements suggest that printed masks can achieve similar levels of immobilization to those of systems currently in clinical use.展开更多
Enterocutaneous fistulas(ECFs) are great challenges during the open abdomen. The loss of digestive juice, water-electrolyte imbalance and malnutrition are intractable issues during management of ECF. Techniques such a...Enterocutaneous fistulas(ECFs) are great challenges during the open abdomen. The loss of digestive juice, water-electrolyte imbalance and malnutrition are intractable issues during management of ECF. Techniques such as "fistula patch" and vacuumassisted closure therapy have been applied to prevent contamination of open abdominal wounds by intestinal fistula drainage. However, failures are encountered due to high-output fistula and anatomical complexity. Here, we report 3 D-printed patient-personalized fistula stent for ECF treatment based on 3 D reconstruction of the fistula image. Subsequent follow-up demonstrated that this stent was well-implanted and effective to reduce the volume of enteric fistula effluent.展开更多
BACKGROUND Open abdomen(OA) has been generally accepted for its magnificent superiority and effectiveness in patients with severe trauma, severe intra-abdominal infection, and abdominal compartment syndrome. In the me...BACKGROUND Open abdomen(OA) has been generally accepted for its magnificent superiority and effectiveness in patients with severe trauma, severe intra-abdominal infection, and abdominal compartment syndrome. In the meantime, OA calls for a mass of nursing and the subsequent enteroatomospheric fistula(EAF), which is one of the most common complications of OA therapy, remains a thorny challenge.CASE SUMMARY Our team applied thermoplastic polyurethane as a befitting material for producing a 3 D-printed "fistula stent" in the management of an EAF patient,who was initially admitted to local hospital because of abdominal pain and distension and diagnosed with bowel obstruction. After a series of operations and OA therapy, the patient developed an EAF.CONCLUSION Application of this novel "fistula stent" resulted in a drastic reduction in the amount of lost enteric effluent and greatly accelerated rehabilitation processes.展开更多
The quantitative characterization of the full-field stress and displacement is significant for analyzing the failure and instability of engineering materials.Various optical measurement techniques such as photoelastic...The quantitative characterization of the full-field stress and displacement is significant for analyzing the failure and instability of engineering materials.Various optical measurement techniques such as photoelasticity,moiréand digital image correlation methods have been developed to achieve this goal.However,these methods are difficult to incorporate to determine the stress and displacement fields simultaneously because the tested models must contain particles and grating for displacement measurement;however,these elements will disturb the light passing through the tested models using photoelasticity.In this study,by combining photoelasticity and the sampling moirémethod,we developed a method to determine the stress and displacement fields simultaneously in a three-dimensional(3D)-printed photoelastic model with orthogonal grating.Then,the full-field stress was determined by analyzing 10 photoelastic patterns,and the displacement fields were calculated using the sampling moirémethod.The results indicate that the developed method can simultaneously determine the stress and displacement fields.展开更多
Long-span bridges are special structures that require advanced analysis techniques to examine their performance. This paper presents a procedure developed to model the Confederation Bridge using 3-D beam elements. The...Long-span bridges are special structures that require advanced analysis techniques to examine their performance. This paper presents a procedure developed to model the Confederation Bridge using 3-D beam elements. The model was validated using the data collected before the opening of the bridge to the public. The bridge was instrumented to conduct fullscale static and dynamic tests. The static tests were to measure the deflection of the bridge pier while the dynamic tests to measure the free vibrations of the pier due to a sudden release of the static load. Confederation Bridge is one of the longest reinforced concrete bridges in the world. It connects the province of Prince Edward Island and the province of New Brunswick in Canada. Due to its strategic location and vital role as a transportation link between these two provinces, it was designed using higher safety factors than those for typical highway bridges. After validating the present numerical model, a procedure was developed to evaluate the performance of similar bridges subjected to traffic and seismic loads. It is of interest to note that the foundation stiffness and the modulus of elasticity of the concrete have significant effects on the structural responses of the Confederation Bridge.展开更多
This nanoprinting process allows researchers to 3D print more material on a biochip than ever before,making it easier to study biomedical issues.Making biochips,a key technology in studying disease,just got a little e...This nanoprinting process allows researchers to 3D print more material on a biochip than ever before,making it easier to study biomedical issues.Making biochips,a key technology in studying disease,just got a little easier.This new nanoprinting process?uses gold-plated pyramids,an LED light,and photochemical reactions to print more organic material on the surface of one single biochip than ever before.The technique uses an array of polymer pyramids that are covered in gold and mounted onto an atomic force mi-展开更多
Processing biomaterials into porous scaffolds for bone tissueengineering is a critical and a key step in defining and controlling their physicochemical,mechanical,and biological properties.Biomaterials such as polymer...Processing biomaterials into porous scaffolds for bone tissueengineering is a critical and a key step in defining and controlling their physicochemical,mechanical,and biological properties.Biomaterials such as polymers are commonlyprocessed into porous scaffolds using conventional processing techniques,e.g.,saltleaching.However,these traditional techniques have shown unavoidable limitations andseveral shortcomings.For instance,tissue-engineered porous scaffolds with a complexthree-dimensional(3D)geometric architecture mimicking the complexity of theextracellular matrix of native tissues and with the ability to fit into irregular tissue defectscannot be produced using the conventional processing techniques.3D printing hasrecently emerged as an advanced processing technology that enables the processing ofbiomaterials into 3D porous scaffolds with highly complex architectures and tunableshapes to precisely fit into irregular and complex tissue defects.3D printing providescomputer-based layer-by-layer additive manufacturing processes of highly precise andcomplex 3D structures with well-defined porosity and controlled mechanical propertiesin a highly reproducible manner.Furthermore,3D printing technology provides anaccurate patient-specific tissue defect model and enables the fabrication of a patientspecifictissue-engineered porous scaffold with pre-customized properties.展开更多
The advent of three-dimensional （3-D） printed technique provides great possibility in the fabrication of customized porous titanium （Ti） implant. However, the bioinert property of the printed Ti poses an out- stan...The advent of three-dimensional （3-D） printed technique provides great possibility in the fabrication of customized porous titanium （Ti） implant. However, the bioinert property of the printed Ti poses an out- standing problem. Hybrid micro-arc oxidation and hydrothermal （MAO-HT） treatment on porous metals is able to produce multi-scaled hierarchical orthopedic implant, showing great potential for surface mod- ification of 3-D printed implant. In this study, cylindrical porous Ti6Al4V （Ti64） scaffolds with pore size of 640 lure, porosity of ？3% were 3-D printed by electron beam melting process, and their surfaces were left untreated or treated by a combined MAO-HT procedure. In vitro bioactivity was tested by immer- sion in simulated body fluid for different time points. Then, 12 scaffolds in each group were implanted into the femoral condyles of New Zealand rabbit for 8 weeks. Osseointegration was evaluated by qual- itative and quantitative histological analysis, and the bone ingrowth features were probed by sequential fluorescent labeling at 3 and 6 weeks post-surgery, Following the MAO-HT treatment, the porous Ti64 scaffold was endowed with multi-scaled micro/nano-topographies and high amounts of CaP on its surface. The treated scaffold exhibited drastically enhanced apatite forming ability compared with the un- treated one. In vivo test revealed significantly that a higher amount of bone ingrowth and bone implant contact at the treated scaffold. The 2 types of scaffolds had different patterns of bone ingrowth; the treated scaffold exhibited a pattern of contact osteogenesis, by which bone formed directly on the treated implant surface, whereas bone formed distal to the implant surface of the untreated scaffold. MAO-HT treat- ment can significantly enhance the in vitro apatite-inducing ability and in vivo osseointegration capacity of 3-D porous Ti64 scaffold and may provide as a viable approach for the fabrication of bioactive 3-D printed porous implant for orthopedic applications.展开更多
Bioresorbable scaffolds have emerged as a new generation of vascular implants for the treatment of atherosclerosis,and designed to provide a temporary scaffold that is subsequently absorbed by blood vessels over time....Bioresorbable scaffolds have emerged as a new generation of vascular implants for the treatment of atherosclerosis,and designed to provide a temporary scaffold that is subsequently absorbed by blood vessels over time.Presently,there is insufficient data on the biological and mechanical responses of blood vessels accompanied by bioresorbable scaffolds(BRS)degradation.Therefore,it is necessary to investigate the inflexion point of degradation,the response of blood vessels,and the pathophysiological process of vascular,as results of such studies will be of great value for the design of next generation of BRS.In this study,abdominal aortas of SD rats were received 3-D printed poly-l-actide vascular scaffolds(PLS)for various durations up to 12 months.The response of PLS implanted aorta went through two distinct processes:(1)the neointima with desirable barrier function was obtained in 1 month,accompanied with slow degradation,inflammation,and intimal hyperplasia;(2)significant degradation occurred from 6 months,accompanied with decreasing inflammation and intimal hyperplasia,while the extracellular matrix recovered to normal vessels which indicate the positive remodeling.These in vivo results indicate that 6 months is a key turning point.This“two-stage degradation and vascular characteristics”is proposed to elucidate the long-term effects of PLS on vascular repair and demonstrated the potential of PLS in promoting endothelium function and positive remodeling,which highlights the benefits of PLS and shed some light in the future researches,such as drug combination coatings design.展开更多
基金supported by the Science and Technology Programme of Shijiazhuang under Grant 151130081A
文摘Due to the attractive performances such as the ability of beam focus,broadband,multi-beam scanning and other features,Luneburg lens antennas are applied in multi-beam antenna,which overcomes the problem of gain loss produced by multi-beam parabolic antenna.Based on 3-D printing technique,Luneburg lens antennas by drilling holes are studied.Permittivity and loss tangent of the equivalent lens materials can be influenced by original materials,hole shapes,hole directions,and porosity.After tests,polystyrene with waxes may be the most appropriate materials for Luneburg lens with high strength.Permittivity with the shape of triangle is the lowest due to the homogeneity.Relative permittivities with the direction at a range of 15°-45°are lower while loss tangent at a range of 0°-30°.Radial directional holes are more appropriate for Luneburg lens.The relative permittivity is decreased with the increment of porosity.After calculations,the forecasts calculated by Looyenga and A-BG theory are more precise.Finally,Luneburg lens with two layers is fabricated by 3-D printing.
文摘Objective: To investigate the value of 3D printing techniques in the treatment of complex tibial plateau fractures. Methods: From September 2016 to September 2018, 28 patients with complex tibial plateau fractures were treated in our hospital. According to the odevity of hospitalized order, the patients were divided into two groups. Group A used 3D reconstruction, virtually reduction, 3D printing and demonstration of individual fracture model before operation while group B only received conventional process by use X-rays or CT image. Comparison between the two groups was made in operation time, operative blood loss, radiation frequency, surgery instrument cost and knee function score. Results: The follow-up was 14.4 months on average (ranged 6 to 22 months). There was no statistical difference of the surgery instrument cost between the 2 groups (P > 0.05). The operation time of group A was significantly shorter than that of group B (P χ2 = 0.373, P = 0.54). Conclusion: 3D printing techniques can improve surgery effect in complex tibial plateau fractures.
文摘This paper presents the preclinical evaluation of a novel immobilization system for patients undergoing external beam radiation treatment of head and neck tumors. An immobilization mask is manufactured directly from a 3-D model, built using the CT data routinely acquired for treatment planning so there is no need to take plaster of Paris moulds. Research suggests that many patients find the mould room visit distressing and so rapid prototyping could potentially improve the overall patient experience. Evaluation of a computer model of the immobilization system using an anthropomorphic phantom shows that >99% of vertices are within a tolerance of ±0.2 mm. Hausdorff distance was used to analyze CT slices obtained by rescanning the phantom with a printed mask in position. These results show that for >80% of the slices the median “worse-case” tolerance is approximately 4 mm. These measurements suggest that printed masks can achieve similar levels of immobilization to those of systems currently in clinical use.
基金Supported by the National Natural Science Foundation of China,No.81571881
文摘Enterocutaneous fistulas(ECFs) are great challenges during the open abdomen. The loss of digestive juice, water-electrolyte imbalance and malnutrition are intractable issues during management of ECF. Techniques such as "fistula patch" and vacuumassisted closure therapy have been applied to prevent contamination of open abdominal wounds by intestinal fistula drainage. However, failures are encountered due to high-output fistula and anatomical complexity. Here, we report 3 D-printed patient-personalized fistula stent for ECF treatment based on 3 D reconstruction of the fistula image. Subsequent follow-up demonstrated that this stent was well-implanted and effective to reduce the volume of enteric fistula effluent.
文摘BACKGROUND Open abdomen(OA) has been generally accepted for its magnificent superiority and effectiveness in patients with severe trauma, severe intra-abdominal infection, and abdominal compartment syndrome. In the meantime, OA calls for a mass of nursing and the subsequent enteroatomospheric fistula(EAF), which is one of the most common complications of OA therapy, remains a thorny challenge.CASE SUMMARY Our team applied thermoplastic polyurethane as a befitting material for producing a 3 D-printed "fistula stent" in the management of an EAF patient,who was initially admitted to local hospital because of abdominal pain and distension and diagnosed with bowel obstruction. After a series of operations and OA therapy, the patient developed an EAF.CONCLUSION Application of this novel "fistula stent" resulted in a drastic reduction in the amount of lost enteric effluent and greatly accelerated rehabilitation processes.
基金financial support from the National Natural Science Foundation of China(Nos.52004137,52121003,51727807,12032013 and 11972209)Fundamental Research Funds for the Central Universities(No.2022XJAQ01)。
文摘The quantitative characterization of the full-field stress and displacement is significant for analyzing the failure and instability of engineering materials.Various optical measurement techniques such as photoelasticity,moiréand digital image correlation methods have been developed to achieve this goal.However,these methods are difficult to incorporate to determine the stress and displacement fields simultaneously because the tested models must contain particles and grating for displacement measurement;however,these elements will disturb the light passing through the tested models using photoelasticity.In this study,by combining photoelasticity and the sampling moirémethod,we developed a method to determine the stress and displacement fields simultaneously in a three-dimensional(3D)-printed photoelastic model with orthogonal grating.Then,the full-field stress was determined by analyzing 10 photoelastic patterns,and the displacement fields were calculated using the sampling moirémethod.The results indicate that the developed method can simultaneously determine the stress and displacement fields.
文摘Long-span bridges are special structures that require advanced analysis techniques to examine their performance. This paper presents a procedure developed to model the Confederation Bridge using 3-D beam elements. The model was validated using the data collected before the opening of the bridge to the public. The bridge was instrumented to conduct fullscale static and dynamic tests. The static tests were to measure the deflection of the bridge pier while the dynamic tests to measure the free vibrations of the pier due to a sudden release of the static load. Confederation Bridge is one of the longest reinforced concrete bridges in the world. It connects the province of Prince Edward Island and the province of New Brunswick in Canada. Due to its strategic location and vital role as a transportation link between these two provinces, it was designed using higher safety factors than those for typical highway bridges. After validating the present numerical model, a procedure was developed to evaluate the performance of similar bridges subjected to traffic and seismic loads. It is of interest to note that the foundation stiffness and the modulus of elasticity of the concrete have significant effects on the structural responses of the Confederation Bridge.
文摘This nanoprinting process allows researchers to 3D print more material on a biochip than ever before,making it easier to study biomedical issues.Making biochips,a key technology in studying disease,just got a little easier.This new nanoprinting process?uses gold-plated pyramids,an LED light,and photochemical reactions to print more organic material on the surface of one single biochip than ever before.The technique uses an array of polymer pyramids that are covered in gold and mounted onto an atomic force mi-
文摘Processing biomaterials into porous scaffolds for bone tissueengineering is a critical and a key step in defining and controlling their physicochemical,mechanical,and biological properties.Biomaterials such as polymers are commonlyprocessed into porous scaffolds using conventional processing techniques,e.g.,saltleaching.However,these traditional techniques have shown unavoidable limitations andseveral shortcomings.For instance,tissue-engineered porous scaffolds with a complexthree-dimensional(3D)geometric architecture mimicking the complexity of theextracellular matrix of native tissues and with the ability to fit into irregular tissue defectscannot be produced using the conventional processing techniques.3D printing hasrecently emerged as an advanced processing technology that enables the processing ofbiomaterials into 3D porous scaffolds with highly complex architectures and tunableshapes to precisely fit into irregular and complex tissue defects.3D printing providescomputer-based layer-by-layer additive manufacturing processes of highly precise andcomplex 3D structures with well-defined porosity and controlled mechanical propertiesin a highly reproducible manner.Furthermore,3D printing technology provides anaccurate patient-specific tissue defect model and enables the fabrication of a patientspecifictissue-engineered porous scaffold with pre-customized properties.
基金the Beijing AKEC Medical Co.,LtdMedical Research Center of Peking University Third Hospitalsupported by the Project of Scientific and Technical Plan of Beijing(Nos.Z121100005312005 and Z141100002814008)
文摘The advent of three-dimensional （3-D） printed technique provides great possibility in the fabrication of customized porous titanium （Ti） implant. However, the bioinert property of the printed Ti poses an out- standing problem. Hybrid micro-arc oxidation and hydrothermal （MAO-HT） treatment on porous metals is able to produce multi-scaled hierarchical orthopedic implant, showing great potential for surface mod- ification of 3-D printed implant. In this study, cylindrical porous Ti6Al4V （Ti64） scaffolds with pore size of 640 lure, porosity of ？3% were 3-D printed by electron beam melting process, and their surfaces were left untreated or treated by a combined MAO-HT procedure. In vitro bioactivity was tested by immer- sion in simulated body fluid for different time points. Then, 12 scaffolds in each group were implanted into the femoral condyles of New Zealand rabbit for 8 weeks. Osseointegration was evaluated by qual- itative and quantitative histological analysis, and the bone ingrowth features were probed by sequential fluorescent labeling at 3 and 6 weeks post-surgery, Following the MAO-HT treatment, the porous Ti64 scaffold was endowed with multi-scaled micro/nano-topographies and high amounts of CaP on its surface. The treated scaffold exhibited drastically enhanced apatite forming ability compared with the un- treated one. In vivo test revealed significantly that a higher amount of bone ingrowth and bone implant contact at the treated scaffold. The 2 types of scaffolds had different patterns of bone ingrowth; the treated scaffold exhibited a pattern of contact osteogenesis, by which bone formed directly on the treated implant surface, whereas bone formed distal to the implant surface of the untreated scaffold. MAO-HT treat- ment can significantly enhance the in vitro apatite-inducing ability and in vivo osseointegration capacity of 3-D porous Ti64 scaffold and may provide as a viable approach for the fabrication of bioactive 3-D printed porous implant for orthopedic applications.
基金supported by National Key R&D Program of China(2016YFC1102305)National Natural Science Foundation of China(12032007,31971242)+1 种基金the Natural Science Foundation of Chongqing(cstc2019jcyj-msxmX0307,cstc2019jcyj-19zdxmX0009,cstc2019jcyj-zdxmX0028)the Fundamental Research Funds for the Central Universities(2019CDYGZD002,2021CDJCGJ007).
文摘Bioresorbable scaffolds have emerged as a new generation of vascular implants for the treatment of atherosclerosis,and designed to provide a temporary scaffold that is subsequently absorbed by blood vessels over time.Presently,there is insufficient data on the biological and mechanical responses of blood vessels accompanied by bioresorbable scaffolds(BRS)degradation.Therefore,it is necessary to investigate the inflexion point of degradation,the response of blood vessels,and the pathophysiological process of vascular,as results of such studies will be of great value for the design of next generation of BRS.In this study,abdominal aortas of SD rats were received 3-D printed poly-l-actide vascular scaffolds(PLS)for various durations up to 12 months.The response of PLS implanted aorta went through two distinct processes:(1)the neointima with desirable barrier function was obtained in 1 month,accompanied with slow degradation,inflammation,and intimal hyperplasia;(2)significant degradation occurred from 6 months,accompanied with decreasing inflammation and intimal hyperplasia,while the extracellular matrix recovered to normal vessels which indicate the positive remodeling.These in vivo results indicate that 6 months is a key turning point.This“two-stage degradation and vascular characteristics”is proposed to elucidate the long-term effects of PLS on vascular repair and demonstrated the potential of PLS in promoting endothelium function and positive remodeling,which highlights the benefits of PLS and shed some light in the future researches,such as drug combination coatings design.
