An automatic generation method of geological cross-sections in dredging engineering based on 3D geological solid models is presented.The 3D geological models are built applying the non-uniform rational B-splines(NURBS...An automatic generation method of geological cross-sections in dredging engineering based on 3D geological solid models is presented.The 3D geological models are built applying the non-uniform rational B-splines(NURBS) technique,and a 2D profile can be calculated and generated automatically through Boolean operation to meet the demands of dredging projects.Moreover,an automatic marking method for geological attributes is put forward based on database technology,and the geological attributes include the profile name,scale,horizontal and vertical relative coordinates,geological lithology,and 2D standard lithology legend.At the same time,the automatic marking method can also provide an interactive mode for geological engineers to edit and modify the profile in the modeling system.Practical engineering applications show that the automatic generation method is a simple,flexible,fast and precise visual graphics rendering process that can create 2D standard profiles automatically and efficiently.This method also provides a convenient support tool for geological engineering digital analysis.展开更多
Background Deep 3D morphable models(deep 3DMMs)play an essential role in computer vision.They are used in facial synthesis,compression,reconstruction and animation,avatar creation,virtual try-on,facial recognition sys...Background Deep 3D morphable models(deep 3DMMs)play an essential role in computer vision.They are used in facial synthesis,compression,reconstruction and animation,avatar creation,virtual try-on,facial recognition systems and medical imaging.These applications require high spatial and perceptual quality of synthesised meshes.Despite their significance,these models have not been compared with different mesh representations and evaluated jointly with point-wise distance and perceptual metrics.Methods We compare the influence of different mesh representation features to various deep 3DMMs on spatial and perceptual fidelity of the reconstructed meshes.This paper proves the hypothesis that building deep 3DMMs from meshes represented with global representations leads to lower spatial reconstruction error measured with L_(1) and L_(2) norm metrics and underperforms on perceptual metrics.In contrast,using differential mesh representations which describe differential surface properties yields lower perceptual FMPD and DAME and higher spatial fidelity error.The influence of mesh feature normalisation and standardisation is also compared and analysed from perceptual and spatial fidelity perspectives.Results The results presented in this paper provide guidance in selecting mesh representations to build deep 3DMMs accordingly to spatial and perceptual quality objectives and propose combinations of mesh representations and deep 3DMMs which improve either perceptual or spatial fidelity of existing methods.展开更多
Engineering excavation GIS (E 2 GIS) is a real-3D GIS serving for geosciences related to geo-engineering, civil engineering and mining engineering based on generalized tri-prism (GTP) model. As two instances of GTP mo...Engineering excavation GIS (E 2 GIS) is a real-3D GIS serving for geosciences related to geo-engineering, civil engineering and mining engineering based on generalized tri-prism (GTP) model. As two instances of GTP model, G\|GTP is used for the real\|3D modeling of subsurface geological bodies, and E\|GTP is used for the real\|3D modeling of subsurface engineering excavations.In the light of the discussions on the features and functions of E 2 GIS, the modeling principles of G\|GTP and E\|GTP are introduced. The two models couple together seamlessly to form an integral model for subsurface spatial objects including both geological bodies and excavations. An object\|oriented integral real\|3D data model and integral spatial topological relations are discussed.展开更多
To reuse and share the valuable knowledge embedded in repositories of engineering models for accelerating the design process, improving product quality, and reducing costs, it is crucial to devise search engines capab...To reuse and share the valuable knowledge embedded in repositories of engineering models for accelerating the design process, improving product quality, and reducing costs, it is crucial to devise search engines capable of matching 3D models efficiently and effectively. In this paper, an enhanced shape distributions-based technique of using geometrical and topological information to search 3D engineering models represented by polygonal meshes was presented. A simplification method of polygonal meshes was used to simplify engineering model as the pretreatment for generation of sample points. The method of sampling points was improved and a pair of functions that was more sensitive to shape was employed to construct a 2D shape distribution. Experiments were conducted to evaluate the proposed algorithm utilizing the Engineering Shape Benchmark (ESB) database. The experiential results suggest that the search effectiveness is significantly improved by enforcing the simplification and enhanced shape distributions to engineering model retrieval.展开更多
In this paper, we conduct research on the computer and 3D modeling technology with the applications on the modem civil engineering. Civil engineering is an important technology of the people to transform nature, the c...In this paper, we conduct research on the computer and 3D modeling technology with the applications on the modem civil engineering. Civil engineering is an important technology of the people to transform nature, the civil engineering in the actual construction technology for the human production and living provides a favorable safeguard and production needs, the human life has very important significance. After years of development and practice, in today' s society, civil engineering has become a comprehensive discipline, with multiple branches, played an indispensable role in all aspects. And after years of development and technological innovation, civil engineering technology not only has improved, but also spawned many other technologies have great effect on the human production and living. Our research starts from the general analysis on the corresponding issues with the general applications that are innovative.展开更多
Tissue engineering is an emerging means for resolving the problems of tissue repair and organ replacement in regenerative medicine.Insufficient supply of nutrients and oxygen to cells in large-scale tissues has led to...Tissue engineering is an emerging means for resolving the problems of tissue repair and organ replacement in regenerative medicine.Insufficient supply of nutrients and oxygen to cells in large-scale tissues has led to the demand to prepare blood vessels.Scaffold-based tissue engineering approaches are effective methods to form new blood vessel tissues.The demand for blood vessels prompts systematic research on fabrication strategies of vascular scaffolds for tissue engineering.Recent advances in 3D printing have facilitated fabrication of vascular scaffolds,contributing to broad prospects for tissue vascularization.This review presents state of the art on modeling methods,print materials and preparation processes for fabrication of vascular scaffolds,and discusses the advantages and application fields of each method.Specially,significance and importance of scaffold-based tissue engineering for vascular regeneration are emphasized.Print materials and preparation processes are discussed in detail.And a focus is placed on preparation processes based on 3D printing technologies and traditional manufacturing technologies including casting,electrospinning,and Lego-like construction.And related studies are exemplified.Transformation of vascular scaffolds to clinical application is discussed.Also,four trends of 3D printing of tissue engineering vascular scaffolds are presented,including machine learning,near-infrared photopolymerization,4D printing,and combination of self-assembly and 3D printing-based methods.展开更多
Catastrophic geological disasters frequently occur on slopes with obliquely inclined bedding structures(also referred to as obliquely inclined bedding slopes),where the apparent dip sliding is not readily visible.This...Catastrophic geological disasters frequently occur on slopes with obliquely inclined bedding structures(also referred to as obliquely inclined bedding slopes),where the apparent dip sliding is not readily visible.This phenomenon has become a focal point in landslide research.Yet,there is a lack of studies on the failure modes and mechanisms of hidden,steep obliquely inclined bedding slopes.This study investigated the Shanyang landslide in Shaanxi Province,China.Using field investigations,laboratory tests of geotechnical parameters,and the 3DEC software,this study developed a numerical model of the landslide to analyze the failure process of such slopes.The findings indicate that the Shanyang landslide primarily crept along a weak interlayer under the action of gravity.The landslide,initially following a dip angle with the support of a stable inclined rock mass,shifted direction under the influence of argillization in the weak interlayer,moving towards the apparent dip angle.The slide resistance effect of the karstic dissolution zone was increasingly significant during this process,with lateral friction being the primary resistance force.A reduction in the lateral friction due to karstic dissolution made the apparent dip sliding characteristics of the Shanyang landslide more pronounced.Notably,deformations such as bending and uplift at the slope’s foot suggest that the main slide resistance shifts from lateral friction within the karstic dissolution zone to the slope foot’s resistance force,leading to the eventual buckling failure of the landslide.This study unveils a novel failure mode of apparent dip creep-buckling in the Shanyang landslide,highlighting the critical role of lateral friction from the karstic dissolution zone in its failure mechanism.These insights offer a valuable reference for mitigating risks and preventing disasters related to obliquely inclined bedding landslides.展开更多
In view of the limitations of traditional measurement methods in the field of building information,such as complex operation,low timeliness and poor accuracy,a new way of combining three-dimensional scanning technolog...In view of the limitations of traditional measurement methods in the field of building information,such as complex operation,low timeliness and poor accuracy,a new way of combining three-dimensional scanning technology and BIM(Building Information Modeling)model was discussed.Focused on the efficient acquisition of building geometric information using the fast-developing 3D point cloud technology,an improved deep learning-based 3D point cloud recognition method was proposed.The method optimised the network structure based on RandLA-Net to adapt to the large-scale point cloud processing requirements,while the semantic and instance features of the point cloud were integrated to significantly improve the recognition accuracy and provide a precise basis for BIM model remodeling.In addition,a visual BIM model generation system was developed,which systematically transformed the point cloud recognition results into BIM component parameters,automatically constructed BIM models,and promoted the open sharing and secondary development of models.The research results not only effectively promote the automation process of converting 3D point cloud data to refined BIM models,but also provide important technical support for promoting building informatisation and accelerating the construction of smart cities,showing a wide range of application potential and practical value.展开更多
Three-dimensional(3D)printing technology has opened a new paradigm to controllably and reproducibly fabricate bioengineered neural constructs for potential applications in repairing injured nervous tissues or producin...Three-dimensional(3D)printing technology has opened a new paradigm to controllably and reproducibly fabricate bioengineered neural constructs for potential applications in repairing injured nervous tissues or producing in vitro nervous tissue models.However,the complexity of nervous tissues poses great challenges to 3D-printed bioengineered analogues,which should possess diverse architectural/chemical/electrical functionalities to resemble the native growth microenvironments for functional neural regeneration.In this work,we provide a state-of-the-art review of the latest development of 3D printing for bioengineered neural constructs.Various 3D printing techniques for neural tissue-engineered scaffolds or living cell-laden constructs are summarized and compared in terms of their unique advantages.We highlight the advanced strategies by integrating topographical,biochemical and electroactive cues inside 3D-printed neural constructs to replicate in vivo-like microenvironment for functional neural regeneration.The typical applications of 3D-printed bioengineered constructs for in vivo repair of injured nervous tissues,bio-electronics interfacing with native nervous system,neural-on-chips as well as brain-like tissue models are demonstrated.The challenges and future outlook associated with 3D printing for functional neural constructs in various categories are discussed.展开更多
Great advancement has been made on natural gas hydrates exploration and test production in the northern South China Sea.However,there remains a lot of key questions yet to be resolved,particularly about the mechanisms...Great advancement has been made on natural gas hydrates exploration and test production in the northern South China Sea.However,there remains a lot of key questions yet to be resolved,particularly about the mechanisms and the controls of gas hydrates enrichment.Numerical simulaution would play signficant role in addressing these questions.This study focused on the gas hydrate exploration in the Shenhu Area,Northern South China Sea.Based on the newly obtained borehole and multichannel reflection seismic data,the authors conducted an integrated 3D basin modeling study on gas hydrate.The results indicate that the Shenhu Area has favorable conditions for gas hydrate accumulation,such as temperature,pressure,hydrocarbon source,and tectonic setting.Gas hydrates are most concentrated in the Late Miocene strata,particularly in the structual highs between the Baiyun Sag and the Liwan Sag,and area to the south of it.It also proved the existence of overpressure in the main sag of source rocks,which was subject to compaction disequilibrium and hydrocarbon generation.It also shown that the regional fault activity is not conducive to gas hydrate accumulation due to excess gas seepage.The authors conjecture that fault activity may slightly weaken overpressure for the positive effect of hydrocarbon expulsion and areas lacking regional fault activity have better potential.展开更多
Reverse Engineering (RE) involves the use of techniques aimed to retrieve information about manufactured products, not only regarding geometries, but also materials and functionality. Today, even if several RE techniq...Reverse Engineering (RE) involves the use of techniques aimed to retrieve information about manufactured products, not only regarding geometries, but also materials and functionality. Today, even if several RE techniques are known, many of them still leave the object unusable to analyze. Nevertheless, other alternatives to this problem allows for obtaining a Digital or Virtual Model (VM) via the three-dimen- sional scanning. Getting the VM of an item, via scanning or not, can offer many possibilities to digital analysis (FEM). Furthermore, starting from VM, it is possible to achieve the physical reproduction of an element, part or workpiece—in the same or different materials—using Additive Manufacturing (AM) technologies. This enables to improve the product through a redesign process. In this paper, a RE based methodology is proposed for redesigning a tool for contour milling, after comparing different microscopy based techniques, 3D-Scanner tools and CAD-CAGD utilities for generating a Virtual Model of the newly designed mill.展开更多
Nowadays,additive manufacturing,or 3D printing(3DP),though not a new technology in many industrial fields,is still relatively novel in mining engineering.This study explored the application of 3D metal printing,3D pol...Nowadays,additive manufacturing,or 3D printing(3DP),though not a new technology in many industrial fields,is still relatively novel in mining engineering.This study explored the application of 3D metal printing,3D polylactic acid/acrylonitrile butadiene styrene printing,and 3D concrete printing in coal mining.Some examples of physical models established via 3DP technologies were studied in detail,namely,3DP bolts,3DP steel ladder beams,3DP face plates,and 3DP metal arches,which were installed in scaled 3DP concrete prototype models of coal mine excavation.Through the comprehensive laboratory loading tests,the models could simulate the damage scenario highly similar to the real failures.The results show that the 3D printed physical models greatly improved the accuracy and reliability of experiments.On this basis,the conceptual design of a 3DP machine for physical models was proposed,which had the potential of resembling the strata deformation/collapse in natural scenarios.Through assessing the applicability of the additive manufacturing technology in mining engineering,this study aimed to further explore its potential applicability in other engineering contexts such as slope controlling,large underground engineering,and underground space stability.展开更多
Viral infections cause damage to various organ systems by inducing organ-specific symptoms or systemic multi-organ damage.Depending on the infection route and virus type,infectious diseases are classified as respirato...Viral infections cause damage to various organ systems by inducing organ-specific symptoms or systemic multi-organ damage.Depending on the infection route and virus type,infectious diseases are classified as respiratory,nervous,immune,digestive,or skin infections.Since these infectious diseases can widely spread in the com-munity and their catastrophic effects are severe,identification of their causative agent and mechanisms un-derlying their pathogenesis is an urgent necessity.Although infection-associated mechanisms have been studied in two-dimensional(2D)cell culture models and animal models,they have shown limitations in organ-specific or human-associated pathogenesis,and the development of a human-organ-mimetic system is required.Recently,three-dimensional(3D)engineered tissue models,which can present human organ-like physiology in terms of the 3D structure,utilization of human-originated cells,recapitulation of physiological stimuli,and tight cell–cell interactions,were developed.Furthermore,recent studies have shown that these models can recapitulate infection-associated pathologies.In this review,we summarized the recent advances in 3D engineered tissue models that mimic organ-specific viral infections.First,we briefly described the limitations of the current 2D and animal models in recapitulating human-specific viral infection pathology.Next,we provided an overview of recently reported viral infection models,focusing particularly on organ-specific infection pathologies.Finally,a future perspective that must be pursued to reconstitute more human-specific infectious diseases is presented.展开更多
Design of internal combustion engine (ICE) components is one of the earliest and also the most active areas in which computer aided modeling techniques are applied. Computer aided modeling techniques could provide req...Design of internal combustion engine (ICE) components is one of the earliest and also the most active areas in which computer aided modeling techniques are applied. Computer aided modeling techniques could provide requisite information for follow up designing segments such as structural analysis, design of technological process and manufacturing etc, and thereby lead to the reduction of product design period and the quality and reliability improvement of ICE components. So the developing situations of ICE components' 2 D drafting, 3 D modeling of ICE, overall CAD of ICE as well as component design expert system etc. are surveyed, which are the typical applications of computer aided modeling techniques in ICE component design process, and some existent problems and tasks are pointed out so as to make some references for the further research work.展开更多
基金Supported by the Science Fund for Creative Research Groups of National Natural Science Foundation of China(No.51021004)Tianjin Research Program of Application Foundation and Advanced Technology(No.12JCZDJC29200)National Key Technology R and D Program in the 12th Five-Year Plan of China(No.2011BAB10B06)
文摘An automatic generation method of geological cross-sections in dredging engineering based on 3D geological solid models is presented.The 3D geological models are built applying the non-uniform rational B-splines(NURBS) technique,and a 2D profile can be calculated and generated automatically through Boolean operation to meet the demands of dredging projects.Moreover,an automatic marking method for geological attributes is put forward based on database technology,and the geological attributes include the profile name,scale,horizontal and vertical relative coordinates,geological lithology,and 2D standard lithology legend.At the same time,the automatic marking method can also provide an interactive mode for geological engineers to edit and modify the profile in the modeling system.Practical engineering applications show that the automatic generation method is a simple,flexible,fast and precise visual graphics rendering process that can create 2D standard profiles automatically and efficiently.This method also provides a convenient support tool for geological engineering digital analysis.
基金Supported by the Centre for Digital Entertainment at Bournemouth University by the UK Engineering and Physical Sciences Research Council(EPSRC)EP/L016540/1 and Humain Ltd.
文摘Background Deep 3D morphable models(deep 3DMMs)play an essential role in computer vision.They are used in facial synthesis,compression,reconstruction and animation,avatar creation,virtual try-on,facial recognition systems and medical imaging.These applications require high spatial and perceptual quality of synthesised meshes.Despite their significance,these models have not been compared with different mesh representations and evaluated jointly with point-wise distance and perceptual metrics.Methods We compare the influence of different mesh representation features to various deep 3DMMs on spatial and perceptual fidelity of the reconstructed meshes.This paper proves the hypothesis that building deep 3DMMs from meshes represented with global representations leads to lower spatial reconstruction error measured with L_(1) and L_(2) norm metrics and underperforms on perceptual metrics.In contrast,using differential mesh representations which describe differential surface properties yields lower perceptual FMPD and DAME and higher spatial fidelity error.The influence of mesh feature normalisation and standardisation is also compared and analysed from perceptual and spatial fidelity perspectives.Results The results presented in this paper provide guidance in selecting mesh representations to build deep 3DMMs accordingly to spatial and perceptual quality objectives and propose combinations of mesh representations and deep 3DMMs which improve either perceptual or spatial fidelity of existing methods.
文摘Engineering excavation GIS (E 2 GIS) is a real-3D GIS serving for geosciences related to geo-engineering, civil engineering and mining engineering based on generalized tri-prism (GTP) model. As two instances of GTP model, G\|GTP is used for the real\|3D modeling of subsurface geological bodies, and E\|GTP is used for the real\|3D modeling of subsurface engineering excavations.In the light of the discussions on the features and functions of E 2 GIS, the modeling principles of G\|GTP and E\|GTP are introduced. The two models couple together seamlessly to form an integral model for subsurface spatial objects including both geological bodies and excavations. An object\|oriented integral real\|3D data model and integral spatial topological relations are discussed.
基金The Basic Research of COSTIND,China (No.D0420060521)
文摘To reuse and share the valuable knowledge embedded in repositories of engineering models for accelerating the design process, improving product quality, and reducing costs, it is crucial to devise search engines capable of matching 3D models efficiently and effectively. In this paper, an enhanced shape distributions-based technique of using geometrical and topological information to search 3D engineering models represented by polygonal meshes was presented. A simplification method of polygonal meshes was used to simplify engineering model as the pretreatment for generation of sample points. The method of sampling points was improved and a pair of functions that was more sensitive to shape was employed to construct a 2D shape distribution. Experiments were conducted to evaluate the proposed algorithm utilizing the Engineering Shape Benchmark (ESB) database. The experiential results suggest that the search effectiveness is significantly improved by enforcing the simplification and enhanced shape distributions to engineering model retrieval.
基金supported by the National Basic Research Program of China (973 Program, No. 2013CB035904)the Innovative Research Groups of the National Natural Science Foundation of China (No. 51321065)the National Natural Science Foundation of China (No. 51439005)
文摘In this paper, we conduct research on the computer and 3D modeling technology with the applications on the modem civil engineering. Civil engineering is an important technology of the people to transform nature, the civil engineering in the actual construction technology for the human production and living provides a favorable safeguard and production needs, the human life has very important significance. After years of development and practice, in today' s society, civil engineering has become a comprehensive discipline, with multiple branches, played an indispensable role in all aspects. And after years of development and technological innovation, civil engineering technology not only has improved, but also spawned many other technologies have great effect on the human production and living. Our research starts from the general analysis on the corresponding issues with the general applications that are innovative.
文摘Tissue engineering is an emerging means for resolving the problems of tissue repair and organ replacement in regenerative medicine.Insufficient supply of nutrients and oxygen to cells in large-scale tissues has led to the demand to prepare blood vessels.Scaffold-based tissue engineering approaches are effective methods to form new blood vessel tissues.The demand for blood vessels prompts systematic research on fabrication strategies of vascular scaffolds for tissue engineering.Recent advances in 3D printing have facilitated fabrication of vascular scaffolds,contributing to broad prospects for tissue vascularization.This review presents state of the art on modeling methods,print materials and preparation processes for fabrication of vascular scaffolds,and discusses the advantages and application fields of each method.Specially,significance and importance of scaffold-based tissue engineering for vascular regeneration are emphasized.Print materials and preparation processes are discussed in detail.And a focus is placed on preparation processes based on 3D printing technologies and traditional manufacturing technologies including casting,electrospinning,and Lego-like construction.And related studies are exemplified.Transformation of vascular scaffolds to clinical application is discussed.Also,four trends of 3D printing of tissue engineering vascular scaffolds are presented,including machine learning,near-infrared photopolymerization,4D printing,and combination of self-assembly and 3D printing-based methods.
基金jointly supported by the projects of the China Geological Survey(DD20230092,DD20201119)。
文摘Catastrophic geological disasters frequently occur on slopes with obliquely inclined bedding structures(also referred to as obliquely inclined bedding slopes),where the apparent dip sliding is not readily visible.This phenomenon has become a focal point in landslide research.Yet,there is a lack of studies on the failure modes and mechanisms of hidden,steep obliquely inclined bedding slopes.This study investigated the Shanyang landslide in Shaanxi Province,China.Using field investigations,laboratory tests of geotechnical parameters,and the 3DEC software,this study developed a numerical model of the landslide to analyze the failure process of such slopes.The findings indicate that the Shanyang landslide primarily crept along a weak interlayer under the action of gravity.The landslide,initially following a dip angle with the support of a stable inclined rock mass,shifted direction under the influence of argillization in the weak interlayer,moving towards the apparent dip angle.The slide resistance effect of the karstic dissolution zone was increasingly significant during this process,with lateral friction being the primary resistance force.A reduction in the lateral friction due to karstic dissolution made the apparent dip sliding characteristics of the Shanyang landslide more pronounced.Notably,deformations such as bending and uplift at the slope’s foot suggest that the main slide resistance shifts from lateral friction within the karstic dissolution zone to the slope foot’s resistance force,leading to the eventual buckling failure of the landslide.This study unveils a novel failure mode of apparent dip creep-buckling in the Shanyang landslide,highlighting the critical role of lateral friction from the karstic dissolution zone in its failure mechanism.These insights offer a valuable reference for mitigating risks and preventing disasters related to obliquely inclined bedding landslides.
文摘In view of the limitations of traditional measurement methods in the field of building information,such as complex operation,low timeliness and poor accuracy,a new way of combining three-dimensional scanning technology and BIM(Building Information Modeling)model was discussed.Focused on the efficient acquisition of building geometric information using the fast-developing 3D point cloud technology,an improved deep learning-based 3D point cloud recognition method was proposed.The method optimised the network structure based on RandLA-Net to adapt to the large-scale point cloud processing requirements,while the semantic and instance features of the point cloud were integrated to significantly improve the recognition accuracy and provide a precise basis for BIM model remodeling.In addition,a visual BIM model generation system was developed,which systematically transformed the point cloud recognition results into BIM component parameters,automatically constructed BIM models,and promoted the open sharing and secondary development of models.The research results not only effectively promote the automation process of converting 3D point cloud data to refined BIM models,but also provide important technical support for promoting building informatisation and accelerating the construction of smart cities,showing a wide range of application potential and practical value.
基金financially supported by the National Natural Science Foundation of China (52125501)OPEN Project (BHJ17C019)+4 种基金the Key Research Project of Shaanxi Province (2021LLRH-08)the Program for Innovation Team of Shaanxi Province (2023-CX-TD-17)the Natural Science Basic Research Program of Shaanxi Province (2023-JCQN-0543)the China Postdoctoral Science Foundation (2021M702597)the Fundamental Research Funds for the Central Universities
文摘Three-dimensional(3D)printing technology has opened a new paradigm to controllably and reproducibly fabricate bioengineered neural constructs for potential applications in repairing injured nervous tissues or producing in vitro nervous tissue models.However,the complexity of nervous tissues poses great challenges to 3D-printed bioengineered analogues,which should possess diverse architectural/chemical/electrical functionalities to resemble the native growth microenvironments for functional neural regeneration.In this work,we provide a state-of-the-art review of the latest development of 3D printing for bioengineered neural constructs.Various 3D printing techniques for neural tissue-engineered scaffolds or living cell-laden constructs are summarized and compared in terms of their unique advantages.We highlight the advanced strategies by integrating topographical,biochemical and electroactive cues inside 3D-printed neural constructs to replicate in vivo-like microenvironment for functional neural regeneration.The typical applications of 3D-printed bioengineered constructs for in vivo repair of injured nervous tissues,bio-electronics interfacing with native nervous system,neural-on-chips as well as brain-like tissue models are demonstrated.The challenges and future outlook associated with 3D printing for functional neural constructs in various categories are discussed.
基金funded by Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(GML2019ZD0201,GML2019ZD0104)Finance Science and Technology Project of Hainan Province(ZDKJ202019).
文摘Great advancement has been made on natural gas hydrates exploration and test production in the northern South China Sea.However,there remains a lot of key questions yet to be resolved,particularly about the mechanisms and the controls of gas hydrates enrichment.Numerical simulaution would play signficant role in addressing these questions.This study focused on the gas hydrate exploration in the Shenhu Area,Northern South China Sea.Based on the newly obtained borehole and multichannel reflection seismic data,the authors conducted an integrated 3D basin modeling study on gas hydrate.The results indicate that the Shenhu Area has favorable conditions for gas hydrate accumulation,such as temperature,pressure,hydrocarbon source,and tectonic setting.Gas hydrates are most concentrated in the Late Miocene strata,particularly in the structual highs between the Baiyun Sag and the Liwan Sag,and area to the south of it.It also proved the existence of overpressure in the main sag of source rocks,which was subject to compaction disequilibrium and hydrocarbon generation.It also shown that the regional fault activity is not conducive to gas hydrate accumulation due to excess gas seepage.The authors conjecture that fault activity may slightly weaken overpressure for the positive effect of hydrocarbon expulsion and areas lacking regional fault activity have better potential.
文摘Reverse Engineering (RE) involves the use of techniques aimed to retrieve information about manufactured products, not only regarding geometries, but also materials and functionality. Today, even if several RE techniques are known, many of them still leave the object unusable to analyze. Nevertheless, other alternatives to this problem allows for obtaining a Digital or Virtual Model (VM) via the three-dimen- sional scanning. Getting the VM of an item, via scanning or not, can offer many possibilities to digital analysis (FEM). Furthermore, starting from VM, it is possible to achieve the physical reproduction of an element, part or workpiece—in the same or different materials—using Additive Manufacturing (AM) technologies. This enables to improve the product through a redesign process. In this paper, a RE based methodology is proposed for redesigning a tool for contour milling, after comparing different microscopy based techniques, 3D-Scanner tools and CAD-CAGD utilities for generating a Virtual Model of the newly designed mill.
基金National Natural Science Foundation of China,Grant/Award Number:51804296China Scholarship Council Grant,Grant/Award Number:CSC#202006425019。
文摘Nowadays,additive manufacturing,or 3D printing(3DP),though not a new technology in many industrial fields,is still relatively novel in mining engineering.This study explored the application of 3D metal printing,3D polylactic acid/acrylonitrile butadiene styrene printing,and 3D concrete printing in coal mining.Some examples of physical models established via 3DP technologies were studied in detail,namely,3DP bolts,3DP steel ladder beams,3DP face plates,and 3DP metal arches,which were installed in scaled 3DP concrete prototype models of coal mine excavation.Through the comprehensive laboratory loading tests,the models could simulate the damage scenario highly similar to the real failures.The results show that the 3D printed physical models greatly improved the accuracy and reliability of experiments.On this basis,the conceptual design of a 3DP machine for physical models was proposed,which had the potential of resembling the strata deformation/collapse in natural scenarios.Through assessing the applicability of the additive manufacturing technology in mining engineering,this study aimed to further explore its potential applicability in other engineering contexts such as slope controlling,large underground engineering,and underground space stability.
基金National Research Foundation of Korea(NRF)grant(Nos.2021R1A2B5B02086828 and 2022M3A9B6082678)(H.N.K)funded by the Korean Government(MSIT)Korea Environment Industry&Technology Institute(KEITI)through Technology Development Project for Biological Hazards Management in Indoor Air Program(or Project),funded by Korea Ministry of Environment(MOE)(No.2021003370005).
文摘Viral infections cause damage to various organ systems by inducing organ-specific symptoms or systemic multi-organ damage.Depending on the infection route and virus type,infectious diseases are classified as respiratory,nervous,immune,digestive,or skin infections.Since these infectious diseases can widely spread in the com-munity and their catastrophic effects are severe,identification of their causative agent and mechanisms un-derlying their pathogenesis is an urgent necessity.Although infection-associated mechanisms have been studied in two-dimensional(2D)cell culture models and animal models,they have shown limitations in organ-specific or human-associated pathogenesis,and the development of a human-organ-mimetic system is required.Recently,three-dimensional(3D)engineered tissue models,which can present human organ-like physiology in terms of the 3D structure,utilization of human-originated cells,recapitulation of physiological stimuli,and tight cell–cell interactions,were developed.Furthermore,recent studies have shown that these models can recapitulate infection-associated pathologies.In this review,we summarized the recent advances in 3D engineered tissue models that mimic organ-specific viral infections.First,we briefly described the limitations of the current 2D and animal models in recapitulating human-specific viral infection pathology.Next,we provided an overview of recently reported viral infection models,focusing particularly on organ-specific infection pathologies.Finally,a future perspective that must be pursued to reconstitute more human-specific infectious diseases is presented.
文摘Design of internal combustion engine (ICE) components is one of the earliest and also the most active areas in which computer aided modeling techniques are applied. Computer aided modeling techniques could provide requisite information for follow up designing segments such as structural analysis, design of technological process and manufacturing etc, and thereby lead to the reduction of product design period and the quality and reliability improvement of ICE components. So the developing situations of ICE components' 2 D drafting, 3 D modeling of ICE, overall CAD of ICE as well as component design expert system etc. are surveyed, which are the typical applications of computer aided modeling techniques in ICE component design process, and some existent problems and tasks are pointed out so as to make some references for the further research work.