目的对4例经由新生儿筛查发现的不同临床类型的3-甲基巴豆酰辅酶A羧化酶缺乏症(3-methylcrotonyl-coenzyme A carboxylase deficiency,MCCD)患儿,用尿气相色谱质谱和基因分析证实其诊断。方法对新生儿筛查中C4DC+C5OH>0.6μmol/L的...目的对4例经由新生儿筛查发现的不同临床类型的3-甲基巴豆酰辅酶A羧化酶缺乏症(3-methylcrotonyl-coenzyme A carboxylase deficiency,MCCD)患儿,用尿气相色谱质谱和基因分析证实其诊断。方法对新生儿筛查中C4DC+C5OH>0.6μmol/L的新生儿召回复查,同时检测其母亲的C4DC+C5OH浓度。用尿气相色谱质谱分析对MCCD疑诊病例进行临床诊断,再通过基因分析进一步证实。结果通过基因诊断确诊MCCD 3例,包括MCCD患儿1例,父源性MCCD 1例,母源性MCCD 1例。另有1例临床诊断的MCCD患儿经基因检测仅找到1个致病位点。结论对新生儿筛查中发现的C4DC+C5OH增高的新生儿家系(包括母亲和父亲)应行MS/MS检测。疑似MCCD患者基因检测仅发现1个致病位点时不要轻易否定MCCD的诊断,建议定期随访。展开更多
CDV3 is correlated with tumorigenesis and may affect some biological process in cancer.In this study,we explore the role of CDV3 in HCC.According to the TCGA data base,CDV3 is over-expressed in HCC tissues.Up-regulati...CDV3 is correlated with tumorigenesis and may affect some biological process in cancer.In this study,we explore the role of CDV3 in HCC.According to the TCGA data base,CDV3 is over-expressed in HCC tissues.Up-regulation of CDV3 is correlated with lower over-all survival rate in HCC patients.In HCC samples from our hospital,CDV3 is also enriched in cancer tissues and CDV3 expression associated with HCC pathological T stage.What is more,higher CDV3 expression could forecast poor survival rate in HCC patients.In conclusion,CDV3 is a biomarker of HCC and could be a potential therapeutic target.展开更多
基金This study was funded by The National Natural Science Foundation of China(Grant No.81702408)the Science Foundation for Fostering Talents of The First Affiliated Hospital of Chongqing Medical University(Grant No.PYJJ2017-08)The Medical research program from Board of Health in Chongqing(Grant No.2013-2-009).
文摘CDV3 is correlated with tumorigenesis and may affect some biological process in cancer.In this study,we explore the role of CDV3 in HCC.According to the TCGA data base,CDV3 is over-expressed in HCC tissues.Up-regulation of CDV3 is correlated with lower over-all survival rate in HCC patients.In HCC samples from our hospital,CDV3 is also enriched in cancer tissues and CDV3 expression associated with HCC pathological T stage.What is more,higher CDV3 expression could forecast poor survival rate in HCC patients.In conclusion,CDV3 is a biomarker of HCC and could be a potential therapeutic target.