Acylation of 5-methyl-3-hydroxyisoxazole (1) with 3-substituted cyclopropanecarboxylic chlorides (3) in the presence of triethylamine (TEA) in acetonitrile yields predominantly O-acylated products (4).The N-acyl isome...Acylation of 5-methyl-3-hydroxyisoxazole (1) with 3-substituted cyclopropanecarboxylic chlorides (3) in the presence of triethylamine (TEA) in acetonitrile yields predominantly O-acylated products (4).The N-acyl isomers (5) are afforded regiospecifically using trimethylsilyl ether of 3-hydroxyisoxazole (2).展开更多
Keeping in view the biological activities of 3-hydroxyisoxa- zole and cyclic phosphate derivatives,some compounds possessing these two moieties have been synthesized,the structural elucidation of these diastereomers w...Keeping in view the biological activities of 3-hydroxyisoxa- zole and cyclic phosphate derivatives,some compounds possessing these two moieties have been synthesized,the structural elucidation of these diastereomers was made depending on spectral analyses.The mechanism could be illustrated by the theories of trigonal bipyramide intermediate and pseudorotation.展开更多
文摘Acylation of 5-methyl-3-hydroxyisoxazole (1) with 3-substituted cyclopropanecarboxylic chlorides (3) in the presence of triethylamine (TEA) in acetonitrile yields predominantly O-acylated products (4).The N-acyl isomers (5) are afforded regiospecifically using trimethylsilyl ether of 3-hydroxyisoxazole (2).
文摘Keeping in view the biological activities of 3-hydroxyisoxa- zole and cyclic phosphate derivatives,some compounds possessing these two moieties have been synthesized,the structural elucidation of these diastereomers was made depending on spectral analyses.The mechanism could be illustrated by the theories of trigonal bipyramide intermediate and pseudorotation.
