Synthesis and Crystal Structure of (Z)-Methyl-3-methoxy-2-{2-[(4-(E-3-p-tolylacryloyl)phenoxy)methyl]phenyl}acrylate

The title compound,(Z)-methyl-3-methoxy-2-{2-[(4-(E-3-p-tolylacryloyl)phenoxy)-methyl]phenyl}acrylate,was synthesized and determined by X-ray single-crystal diffraction.The crystal belongs to the triclinic system,space group P1 with a=8.0157(8),b=12.5748(13),c=13.3768(14)Å,α=64.770(2),β=75.720(2),γ=89.784(2)°,μ=0.085 mm^(-1),Mr=442.49,V=1174.1(2)Å3,Z=2,Dc=1.252 g/cm^(3),F(000)=468,T=294(2)K,R=0.0603 and wR=0.1498 for 2644 observed reflections with I〉2σ(I).X-ray diffraction analysis reveals that the single crystal contains strong non-classical hydrogen bonds.The preliminary bioassay showed that the title compound exhibits inhibitory activity against the Pseudoperoniospora cubensis and Rhizoctonia solani at the test concentration of 200 mg/L.

Synthesis of 1-Bromo-3-methoxy-4-propoxy-5-iodobenzene——A Novel Efficient Process for the Synthesis of Brominated Aromatic Compound

The reaction of aromatic carboxylic acid with oxalyl chloride gives rise to the corres- ponding acid chloride which without purification is treated with the sodium salt of mercapto- pyridine oxide in the presence of 2,2-azo-bisisobutyronitrile (AIBN), radical initiator to give a brominated aromatic compound. After etherification and oxidation, 5-iodovaniline was converted to trisubstituted benzene carboxylic acid which give 1-bromo-3-methoxy-4-propoxy-5-iodo- benzene by this new brominating process with a yield of 74 %.

Synthesis, Crystal Structure and Antitumor Activity of (E)-1-(7-Methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5- yl)-3-(2-methoxyphenyl)-2-(1H-1,2,4-triazol-1-yl)propenol

The title compound, （E）-1-（7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl）- 3-（2-methoxyphenyl）-2-（1H-1,2,4-triazol-1-yl）propenol （3a）, was synthesized by the Aldol con- densation reaction of 1-（7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl）-2-（1,2,4-triazol- 1-yl）ethanone with 2-methoxybenzaldehyde and then reduced with NaBH4, and its crystal structure was determined by single-crystal X-ray diffraction： monoclinic system, space group P21 with a = 6.2002（3）, b = 12.8452（7）, c = 13.2257（7） ？, Z = 2, V = 1031.23（9） ？3, Mr = 407.46, Dc = 1.312 Mg/m3, S = 1.054, μ = 0.091 mm-1, F（000） = 432, the final R = 0.0353 and wR = 0.0769 for 3161 observed reflections （I 〉 2σ（I））. X-ray analysis displays that the title compound adopts an E configuration for the C（7）=C（8） double bond and S configuration for the chirality center with the specific rotation of –63.75°. Furthermore, the stability of the crystal was maintained through the intermolecular hydrogen bond O（1）–H？？？N（3）. The antitumor assay exhibits that the title compound 3a （E configuration） has a good antitumor activity against the Hela cell line with the IC50 value of 36.9 μM, which is better than that of 3b （Z configuration）.

Synthesis and Crystal Structure of(E)-Ethyl 2-(4-(2,4-dimethoxybenzylideneamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate

The crystal structure of the title compound(E)-ethyl 2-(4-(2,4-dimethoxy benzylide-neamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate(4,C_(24)H_(28)N_(4)O_(7)S,Mr=516.17)was synthesized and determined by X-ray single-crystal diffraction.The crystal belongs to the monoclinic system,space group P2_(1)/n with a=13.162(2),b=8.4506(13),c=22.602(4)Å,β=99.888(3)°,μ=0.183 mm^(-1),V=2476.5(7)Å^(3),Z=4,D_(c)=1.385 g/cm^(3),F(000)=1088,T=110(2)K,R=0.0426 and wR=0.1216 for 3859 observed reflections with I 2σ(Ⅰ).

团花树皮的化学成分研究

采用硅胶、MCI和Sephadex LH-20层析方法对团花树皮的化学成分进行分离纯化,运用现代波谱技术鉴定了10个化合物:4-carboxy-3-hydroxy-5-methylphenyl 3-methoxy-4-hydroxy-5-methylbenzoate(1),谷甾醇-3-O-(6'-O-棕榈酰基)-β-D-葡萄糖苷(2),喹诺酸-3-O-α-L-鼠李糖苷(3),clethric acid(4),常春藤苷元(5),钩藤苷元C(6),morolic acid(7),咖啡酸甲酯(8),卡丹宾(9)和3α-二氢卡丹宾(10)。其中化合物1为一个新的酚性成分,化合物2～8首次从该属植物中分离得到。

青蕨植物化学成分的研究(英文)

从青蕨根部的乙酸乙酯提取物中分离得到4个化合物.通过化学及波谱分析鉴定其结构为:saucerneolD1,dehydrogoniothalamin2,1-acetoxyl-2-piperonyl-6-[6-methoxyl-piperonyl]-3,7-dioxabicyclo-[3,3,0]-octane3and5,5′-dihydroxy-3-methoxy-6,8,3″,3″-tetramethylpyran-3′,4′flavone-7-O-[β-D-apiofuranosyl-1→6]-β-D-glucopyranoside4.其中化合物4为新化合物,化合物1为首次从该属植物中分离得到.

冰糖草化学成分的分离与鉴定

目的研究冰糖草(Scoparia dulcis L.)全草乙醇提取物的正丁醇萃取部位的化学成分。方法运用硅胶、Sephadex LH-20和半制备HPLC等各种方法进行分离纯化,根据理化性质和波谱数据等鉴定化合物结构。结果分离得到16个化合物,分别鉴定为(2S)-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-O-β-glucopyranoside(1)、(2R)-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-O-β-glucopyranoside(2)、对羟基苯甲酸甲酯(3)、对羟基苯甲醛(4)、2-唑啉酮(5)、对羟基苯乙酮(6)、薏苡素(7)、苯甲酸(8)、对羟基肉桂酸甲酯(9)、黑麦草内酯(10)、异黑麦草内酯(11)、橙酰胺乙酸酯(12)、apigenin 7-O-rutinoside(13)、hispidulin-7-O-rutinoside(14)、isoschaftoside(15)和schaftoside(16)。结论化合物1为新化合物,化合物13~16为首次从冰糖草中分离得到。

A New Quinolizidine Alkaloid from Boehmeria siamensis

A new quinolizidine alkaloid. 3-(4-hydroxyphenyl)-4-(3-methoxy-4-hydroxyphenyl)-3,4-dihydroquinolizidine (1). was isolated from the ethanol extract of the whole plants of Boehmeria siamensis Craib. Its structure was elucidated on the analysis of ID NMR and 2D NMR spectrum.

Two New Diarylheptanoids from the Rhizomes of Zingiber officinale

Two new diaryheptanoids, (5S)-5-acetoxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3- heptanone (1) and (3S,5S)-3,5-diacetoxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptane (2) were isolated from the rhizomes of Zingiber officinale. Their structures were elucidated by spectral methods.

Two New Flavonoid Glycosides from Chrysanthemum morifolium

Two new flavonoid glycosides were isolated from the flowering heads of Chrysanthemum morifolium. Their structures were determined to be luteolin 4＇-methoxy-7- O-（6＂-O-acetyl）-β-D-glucopyranoside （1） and acacetin 7-O-（3＂-O-acetyl）-β-D-glucopyranoside （2） by means of 1H and 13C NMR spectroscopic analysis, including 2D NMR technique.

Altered serous levels of monoamine neurotransmitter metabolites in patients with refractory and non-refractory depression

The study examined plasma metabolite changes of monoamine neurotransmitters in patients with treatment-resistant depression （TRD） and non-TRD before and after therapy. All 30 TRD and 30 non-TRD patients met the diagnostic criteria for a depressive episode in accordance with the International Classification of Diseases, Tenth Revision. Before treatment, and at 4, 6, and 8 weeks after treatment, the plasma metabolite products of monoamine neurotransmitters in TRD group, including 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenyl ethylene glycol and homovanillic acid, were significantly lower than those in the non-TRD group. After two types of anti-depressive therapy with 5-serotonin and norepinephrine reuptake inhibitor, combined with psychotherapy, the Hamilton Depression Rating Scale scores were significantly reduced in both groups of patients, and the serous levels of 5-hydroxyindoleacetic acid and 3-methoxy-4-hydroxyphenyl ethylene glycol were significantly increased. In contrast, the homovanillic acid level exhibited no significant change. The levels of plasma metabolite products of peripheral monoamine neurotransmitters in depressive patients may predict the degree of depression and the therapeutic effects of treatment.

匙叶八角中的酚性成分

目的研究匙叶八角Illicium spathulatum枝叶的化学成分。方法匙叶八角枝叶的甲醇提取物经醋酸乙酯和正丁醇萃取部分经过反复的硅胶柱色谱、反相柱色谱及Sephadex LH-20凝胶色谱等方法分离,用波谱分析法鉴定化合物结构。结果分离得到了13个酚性化合物,分别鉴定为苏式-(1,2-二羟基丙基)-3,5-二甲氧基苯-4-O-β-D-葡萄糖苷(1)、5,7,3′,4′-tetrahydroxy-2-methoxy-3-flavanone-3-hydrate(2)、4-O-(2-hydroxy-1-hydroxymethylethyl)-dihydroconierylalcohol(3)、2,3-dihydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-propanone(4)、槲皮素(5)、槲皮素-3-O-α-L-吡喃鼠李糖苷(6)、山柰酚(7)、山柰酚-3-O-α-L-吡喃鼠李糖苷(8)、儿茶素(9)、丁香酸-4-O-β-D-吡喃葡萄糖苷(10)、丁香酸甲酯-4-O-β-D-吡喃葡萄糖苷(11)、3,4-二羟基苯甲酸(12)、羟基酪醇(13),同时还分离到大量的莽草酸(14)。结论化合物1是一个新苯丙素葡萄糖苷类化合物,命名为匙叶八角苷。化合物2是首次从植物中分离得到的黄酮醇类物质氧化的水合物,可能是一人工产物,其余化合物均为首次从匙叶八角中分离得到。

红葱的化学成分研究

目的研究红葱Eleutherine americana的化学成分。方法采用硅胶柱色谱、Sephadex LH-20柱色谱及重结晶等方法,分离纯化红葱的化学成分,通过MS、NMR等波谱技术确定化合物结构。结果确定了7个化合物的结构,分别为9-hydroxy-8-methoxy-1-methyl-1,3-dihydronaphtho[2,3-c]furan-4-O-β-D-glucopyranoside(1)、eleutherinoside A(2)、豆甾醇-3-O-β-D-葡萄糖苷(3)、kadsuric acid(4)、豆甾醇(5)、1,2-二羟基-8-甲氧基-3-甲基蒽醌(6)、9-methoxy-1,3-dimethyl-1H-naphtho[2,3-c]pyran-5,10-dione(7)。结论化合物1为新化合物,命名为红葱新苷。化合物3～5为首次从该植物中分离得到,化合物6和7为首次获得的新天然产物。

湖北麦冬地下部分化学成分

目的：研究百合科山麦冬属植物湖北麦冬Liriope spicata var.prolifera地下部分的化学成分,进一步丰富该植物的化学信息并为其开发和利用提供理论指导。方法：采用60%乙醇对湖北麦冬地下部分进行提取,综合利用大孔吸附树脂,正、反向硅胶,小孔树脂（MCI）及葡聚糖凝胶等柱色谱法对提取物进行分离和纯化,并根据化合物的理化性质及谱学数据鉴定其结构。结果：从湖北麦冬地下部分共分离并鉴定了12个化合物,其中包括4个黄酮类成分（化合物1~4）,4个酚类及苯甲酸类衍生物（化合物5~8）,2个酰胺类生物碱（化合物9,10）及2个其他类成分（化合物11,12）。分别鉴定为2＇,4,4＇-三羟基查耳酮（1）,木犀草素（2）,槲皮苷（3）,3,5-dihydroxy-7-methoxy-6-methyl-3-（4-hydroxybenzyl）chroman-4-one（4）,2,6-二甲氧基-4-硝基苯酚（5）,烯丙基焦儿茶酚（6）,3,4-dihydroxyallylbenzene 4-O-[α-L-rhamnopyranosyl（1→6）]-β-D-glucopyranoside（7）,丁香酸（8）,E-阿魏酰酪胺（9）,反式对羟基桂皮酸（10）,（1S,4S,5R,6R,7S,10S）-1,4,6-trihydroxyeudesmane-6-O-β-Dglucopyranoside（11）和5-羟甲基糠醛（12）。结论：其中化合物1~3,5~8及化合物10~12均为首次从山麦冬属植物中分离得到,化合物4和9为首次从该植物中分离得到。

Isolation and characterization of a bacterial strain that efficiently degrades sex steroid hormones

A bacterial strain,ZY3,growing on sex steroid hormones as the sole source of carbon and energy was isolated from the sewage treatment plant of a prophylactic steroids factory.ZY3 degrades the 3-methoxy-17b-hydroxy-1,3,5(10),8(9)-d-4-estren(MHE).This strain was preli-minarily identified as Raoultella sp.ZY3 according to its morphology and its 16S rRNA gene sequence.During the experimental period(72 h),the optimum temperature,pH and 3-MHE concentration for the degradation of hydride by the strain ZY3 were 35°C,10 and 10 mg/L,respectively.The degradation rate of the sex steroid hormones increased to 87%and 85% after the addition of maltose and peptone,respectively.

New Isoflavonoid Glycosides from the Rhizomes of Iris leptophylla Lingelsh.

Two new isoflavonoid glucosides, 5-hydroxy-6,7-methylenedioxy-isoflavone-4＇-O-D-glucopyranosyl （2→〉l）-L-rhamnoside （irilone-bioside） （compound 1） and 5,4＇-methoxy-6,7-methylenedioxyisoflavone-3＇-O-β-D-glucoside （irisleptophyllidin） （compound 2）, together with five known compounds, nigricanin- 4＇-O-β-D-glucoside （compound 3）, irifloside （compound 4）, irigenin （compound 5）, 5, 3＇, 4＇-trimethoxy-6,7-methylenedioxyisoflavone （compound 6）, and nigricanin （compound 7） were isolated from the alcoholic extract of rhizomes of Iris leptophylla Lingelsh. Their structures were elucidated by spectroscopic methods.