目的:探讨3.0 T MR扩散张量成像在颈椎病诊断中的应用效果。方法:从2013年1月开始,至2015年1月结束,一共80例颈椎病患者,采用MR诊断仪对患者进行检查,比较颈椎病患者、健康体检者不同颈髓水平ADC值、FA值、颈髓长轴、前后径、左右径。结...目的:探讨3.0 T MR扩散张量成像在颈椎病诊断中的应用效果。方法:从2013年1月开始,至2015年1月结束,一共80例颈椎病患者,采用MR诊断仪对患者进行检查,比较颈椎病患者、健康体检者不同颈髓水平ADC值、FA值、颈髓长轴、前后径、左右径。结果:(1)在健康体检者中,C2-3、C4-5、C6-7之间ADC值、FA值、颈髓长轴、前后径、左右径无明显差异,无统计学意义,P>0.05;颈髓长轴、前后径、左右径之间两两对比,颈髓长轴值高于前后径和左右径,数据比较差异具有统计学意义,P<0.05。前后径和左右径之间对比,无明显差异,无统计学意义,P>0.05。(2)和对照组对比,A组ADC、FA、a1颈髓长轴无明显差异(P>0.05);a2前后径、a3左右径明显更大(P<0.05)。B组、C组、D组ADC值、FA值、颈髓长轴、前后径、左右径明显更大,数据比较差异明显,存在统计学意义,P<0.05.结论:采用扩散张量成像技术对颈椎病患者进行诊断,能够有效地显示颈椎压迫所致的脊髓微结构变化,具有较高的敏感性,3.0 T MR扩散张量成像在颈椎病诊断中的应用效果显著,能够弥补常规MRI难以定量分析颈椎微结构受压情况的缺点。展开更多
AIM:To retrospectively and prospectively compare diffusion-weighted(DW)images in the abdomen in a1.5T system and 3.0T systems with and without twochannel functionality for B1shimming.METHODS:DW images of the abdomen w...AIM:To retrospectively and prospectively compare diffusion-weighted(DW)images in the abdomen in a1.5T system and 3.0T systems with and without twochannel functionality for B1shimming.METHODS:DW images of the abdomen were obtained on 1.5T and 3.0T(with and without two-channel functionality for B1shimming)scanners on 150 patients(retrospective study population)and 10 volunteers(prospective study population).Eight regions were selected for clinical significance or artifact susceptibility(at higher field strengths).Objective grading quantified signal-to-noise ratio(SNR),and subjective evaluation qualified image quality,ghosting artifacts,anddiagnostic value.Statistical significance was calculated usingχ2tests(categorical variables)and independent two-sided t tests or Mann-Whitney U tests(continuous variables).RESULTS:The 3.0T using dual-source parallel transmit(dpTX 3.0T)provided the significantly highest SNRs in nearly all regions.In regions susceptible to artifacts at higher field strengths(left lobe of liver,head of pancreas),the SNR was better or similar to the 1.5T system.Subjectively,both dpTX 3.0T and 1.5T systems provided higher image quality,diagnostic value,and less ghosting artifact(P【0.01,most values)compared to the 3.0T system without dual-source parallel transmit(non-dpTX 3.0T).CONCLUSION:The dpTX 3.0T scanner provided the highest SNR.Its image quality,lack of ghosting,and diagnostic value were equal to or outperformed most currently used systems.展开更多
目的探讨应用3.0 T磁共振动态增强(MRI-DCE)及扩散加权成像(DWI)诊断浸润性乳腺癌腋窝淋巴结(ALN)转移的价值。方法我院收治的143例早期浸润性乳腺癌患者,均接受MRI-DCE及DWI评估ALN转移情况,分析两者在ALN转移中诊断价值。结果以病理...目的探讨应用3.0 T磁共振动态增强(MRI-DCE)及扩散加权成像(DWI)诊断浸润性乳腺癌腋窝淋巴结(ALN)转移的价值。方法我院收治的143例早期浸润性乳腺癌患者,均接受MRI-DCE及DWI评估ALN转移情况,分析两者在ALN转移中诊断价值。结果以病理诊断为金标准,MRI-DCE联合DWI诊断ALN灵敏度、特异度、阳性预测值与阴性预测值分别为94.59%、96.23%、89.74%与98.08%;ALN转移与无ALN转移患者边界、早期强化模式、DWI信号、长径、短径、早期强化率、最大强化率、皮质厚度、表观扩散系数(ADC)值等MRI表现比较,差异有统计学意义(P<0.05);DWI高信号、短径及ADC值是ALN转移的影响因素(P<0.05);DWI信号、短径及ADC值诊断ALN转移曲线下面积(AUC)为0.619、0.745、0.734,各指标联合诊断ALN转移AUC值为0.835。结论3.0 T MR动态增强及扩散加权成像可以有效检出早期浸润性乳腺癌ALN转移,测定DWI信号、短径及ADC值联合有助于提高患者ALN转移诊断价值。展开更多
Objective:To achieve precision medicine,the use of imaging methods to help the clinical detection of cerebral infarction is conducive to the clinical development of a treatment plan and increase of the cure rate and i...Objective:To achieve precision medicine,the use of imaging methods to help the clinical detection of cerebral infarction is conducive to the clinical development of a treatment plan and increase of the cure rate and improvement of the prognosis of patients.Methods:In this work,T2-weighted imaging(T2WI),diffusion-weighted imaging(DWI),susceptibility-weighted imaging(SWI),and diffusion tensor imaging(DTI)examinations were performed on 34 patients with clinically diagnosed cerebral infarction to measure the difference in signal intensity between the lesion and its mirror area and make a comparative analysis by means of the Student-Newman-Keuls method.Results:The detection rate of T2WI was 79%(27/34),the detection rate of DWI was 97%(33/34),the detection rate of SWI was 88%(30/34),and the detection rate of DTI was 94%(32/34).Conclusion:The imaging performance was in the order DWI>DTI>SWI>T2WI for the diagnosis of cerebral infarction,and combined imaging is better than single imaging.展开更多
According to clinical statistics,the mortality of patients with early brainstem hemorrhage is high.In this study,we established rat models of brainstem hemorrhage by injecting type Ⅶ collagenase into the right basote...According to clinical statistics,the mortality of patients with early brainstem hemorrhage is high.In this study,we established rat models of brainstem hemorrhage by injecting type Ⅶ collagenase into the right basotegmental pontine and investigated the pathological changes of early brainstem hemorrhage using multi-sequence magnetic resonance imaging and histopathological methods.We found that brainstem hematoma gradually formed in the injured rats over the first 3 days and then reduced after 7 days.The edema that occurred was mainly of the vasogenic type.No complete myelin sheath structure was found around the focus of the brainstem hemorrhage.The integrity and continuity of nerve fibers gradually deteriorated over the first 7 days.Neuronal degeneration was mild in the first 3 days and then obviously aggravated on the 7^(th)day.Inflammatory cytokines,interleukin-1β,and tumor necrosis factorαappeared on the 1st day after intracerebral hemorrhage,reached peak levels on the 3^(rd)day,and decreased from the 7^(th)day.Our findings show the characteristics of the progression of early brainstem hemorrhage.展开更多
Rotenone and 6-hydroxydopamine are two drugs commonly used to generate Parkinson＇s disease animal models.They not only achieve degenerative changes of dopaminergic neurons in the substantia nigra,but also satisfy the...Rotenone and 6-hydroxydopamine are two drugs commonly used to generate Parkinson＇s disease animal models.They not only achieve degenerative changes of dopaminergic neurons in the substantia nigra,but also satisfy the requirements for iron deposition.However,few studies have compared the characteristics of these two models by magnetic resonance imaging.In this study,rat models of Parkinson＇s disease were generated by injection of 3 μg rotenone or 10 μg 6-hydroxydopamine into the right substantia nigra.At 1,2,4,and 6 weeks after injection,coronal whole-brain T2-weighted imaging,transverse whole-brain T2-weighted imaging,and coronal diffusion tensor weighted imaging were conducted to measure fractional anisotropy and T2＊ values at the injury site.The fractional anisotropy value on the right side of the substantia nigra was remarkably lower at 6 weeks than at other time points in the rotenone group.In the 6-hydroxydopamine group,the fractional anisotropy value was decreased,but T2＊ values were increased on the right side of the substantia nigra at 1 week.Our findings confirm that the 6-hydroxydopamine-induced model is suitable for studying dopaminergic neurons over short periods,while the rotenone-induced model may be appropriate for studying the pathological and physiological processes of Parkinson＇s disease over long periods.展开更多
文摘目的:探讨3.0 T MR扩散张量成像在颈椎病诊断中的应用效果。方法:从2013年1月开始,至2015年1月结束,一共80例颈椎病患者,采用MR诊断仪对患者进行检查,比较颈椎病患者、健康体检者不同颈髓水平ADC值、FA值、颈髓长轴、前后径、左右径。结果:(1)在健康体检者中,C2-3、C4-5、C6-7之间ADC值、FA值、颈髓长轴、前后径、左右径无明显差异,无统计学意义,P>0.05;颈髓长轴、前后径、左右径之间两两对比,颈髓长轴值高于前后径和左右径,数据比较差异具有统计学意义,P<0.05。前后径和左右径之间对比,无明显差异,无统计学意义,P>0.05。(2)和对照组对比,A组ADC、FA、a1颈髓长轴无明显差异(P>0.05);a2前后径、a3左右径明显更大(P<0.05)。B组、C组、D组ADC值、FA值、颈髓长轴、前后径、左右径明显更大,数据比较差异明显,存在统计学意义,P<0.05.结论:采用扩散张量成像技术对颈椎病患者进行诊断,能够有效地显示颈椎压迫所致的脊髓微结构变化,具有较高的敏感性,3.0 T MR扩散张量成像在颈椎病诊断中的应用效果显著,能够弥补常规MRI难以定量分析颈椎微结构受压情况的缺点。
文摘AIM:To retrospectively and prospectively compare diffusion-weighted(DW)images in the abdomen in a1.5T system and 3.0T systems with and without twochannel functionality for B1shimming.METHODS:DW images of the abdomen were obtained on 1.5T and 3.0T(with and without two-channel functionality for B1shimming)scanners on 150 patients(retrospective study population)and 10 volunteers(prospective study population).Eight regions were selected for clinical significance or artifact susceptibility(at higher field strengths).Objective grading quantified signal-to-noise ratio(SNR),and subjective evaluation qualified image quality,ghosting artifacts,anddiagnostic value.Statistical significance was calculated usingχ2tests(categorical variables)and independent two-sided t tests or Mann-Whitney U tests(continuous variables).RESULTS:The 3.0T using dual-source parallel transmit(dpTX 3.0T)provided the significantly highest SNRs in nearly all regions.In regions susceptible to artifacts at higher field strengths(left lobe of liver,head of pancreas),the SNR was better or similar to the 1.5T system.Subjectively,both dpTX 3.0T and 1.5T systems provided higher image quality,diagnostic value,and less ghosting artifact(P【0.01,most values)compared to the 3.0T system without dual-source parallel transmit(non-dpTX 3.0T).CONCLUSION:The dpTX 3.0T scanner provided the highest SNR.Its image quality,lack of ghosting,and diagnostic value were equal to or outperformed most currently used systems.
文摘目的探讨应用3.0 T磁共振动态增强(MRI-DCE)及扩散加权成像(DWI)诊断浸润性乳腺癌腋窝淋巴结(ALN)转移的价值。方法我院收治的143例早期浸润性乳腺癌患者,均接受MRI-DCE及DWI评估ALN转移情况,分析两者在ALN转移中诊断价值。结果以病理诊断为金标准,MRI-DCE联合DWI诊断ALN灵敏度、特异度、阳性预测值与阴性预测值分别为94.59%、96.23%、89.74%与98.08%;ALN转移与无ALN转移患者边界、早期强化模式、DWI信号、长径、短径、早期强化率、最大强化率、皮质厚度、表观扩散系数(ADC)值等MRI表现比较,差异有统计学意义(P<0.05);DWI高信号、短径及ADC值是ALN转移的影响因素(P<0.05);DWI信号、短径及ADC值诊断ALN转移曲线下面积(AUC)为0.619、0.745、0.734,各指标联合诊断ALN转移AUC值为0.835。结论3.0 T MR动态增强及扩散加权成像可以有效检出早期浸润性乳腺癌ALN转移,测定DWI信号、短径及ADC值联合有助于提高患者ALN转移诊断价值。
文摘Objective:To achieve precision medicine,the use of imaging methods to help the clinical detection of cerebral infarction is conducive to the clinical development of a treatment plan and increase of the cure rate and improvement of the prognosis of patients.Methods:In this work,T2-weighted imaging(T2WI),diffusion-weighted imaging(DWI),susceptibility-weighted imaging(SWI),and diffusion tensor imaging(DTI)examinations were performed on 34 patients with clinically diagnosed cerebral infarction to measure the difference in signal intensity between the lesion and its mirror area and make a comparative analysis by means of the Student-Newman-Keuls method.Results:The detection rate of T2WI was 79%(27/34),the detection rate of DWI was 97%(33/34),the detection rate of SWI was 88%(30/34),and the detection rate of DTI was 94%(32/34).Conclusion:The imaging performance was in the order DWI>DTI>SWI>T2WI for the diagnosis of cerebral infarction,and combined imaging is better than single imaging.
基金supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region, No. 2020D01A13 (to CWW)Chengdu Science and Technology Bureau, No. 2019-YF05-00511-SN (to MT)1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University, Nos. ZY2016102 (to MT), and ZY2016203 (to CY)
文摘According to clinical statistics,the mortality of patients with early brainstem hemorrhage is high.In this study,we established rat models of brainstem hemorrhage by injecting type Ⅶ collagenase into the right basotegmental pontine and investigated the pathological changes of early brainstem hemorrhage using multi-sequence magnetic resonance imaging and histopathological methods.We found that brainstem hematoma gradually formed in the injured rats over the first 3 days and then reduced after 7 days.The edema that occurred was mainly of the vasogenic type.No complete myelin sheath structure was found around the focus of the brainstem hemorrhage.The integrity and continuity of nerve fibers gradually deteriorated over the first 7 days.Neuronal degeneration was mild in the first 3 days and then obviously aggravated on the 7^(th)day.Inflammatory cytokines,interleukin-1β,and tumor necrosis factorαappeared on the 1st day after intracerebral hemorrhage,reached peak levels on the 3^(rd)day,and decreased from the 7^(th)day.Our findings show the characteristics of the progression of early brainstem hemorrhage.
基金supported by a grant from the Qinhuangdao Science-Technology Support Project of China,No.201402B036a grant from the Science and Technology Project of Hebei Province of China,No.1427777118D
文摘Rotenone and 6-hydroxydopamine are two drugs commonly used to generate Parkinson＇s disease animal models.They not only achieve degenerative changes of dopaminergic neurons in the substantia nigra,but also satisfy the requirements for iron deposition.However,few studies have compared the characteristics of these two models by magnetic resonance imaging.In this study,rat models of Parkinson＇s disease were generated by injection of 3 μg rotenone or 10 μg 6-hydroxydopamine into the right substantia nigra.At 1,2,4,and 6 weeks after injection,coronal whole-brain T2-weighted imaging,transverse whole-brain T2-weighted imaging,and coronal diffusion tensor weighted imaging were conducted to measure fractional anisotropy and T2＊ values at the injury site.The fractional anisotropy value on the right side of the substantia nigra was remarkably lower at 6 weeks than at other time points in the rotenone group.In the 6-hydroxydopamine group,the fractional anisotropy value was decreased,but T2＊ values were increased on the right side of the substantia nigra at 1 week.Our findings confirm that the 6-hydroxydopamine-induced model is suitable for studying dopaminergic neurons over short periods,while the rotenone-induced model may be appropriate for studying the pathological and physiological processes of Parkinson＇s disease over long periods.
