Three-dimensional time-of-flight magnetic resonance angiography combined with high resolution T2-weighted imaging in preoperative evaluation of microvascular decompression

BACKGROUND Neurovascular compression(NVC) is the main cause of primary trigeminal neuralgia(TN) and hemifacial spasm(HFS). Microvascular decompression(MVD) is an effective surgical method for the treatment of TN and HFS caused by NVC. The judgement of NVC is a critical step in the preoperative evaluation of MVD, which is related to the effect of MVD treatment. Magnetic resonance imaging(MRI) technology has been used to detect NVC prior to MVD for several years. Among many MRI sequences, three-dimensional time-of-flight magnetic resonance angiography(3D TOF MRA) is the most widely used. However, 3D TOF MRA has some shortcomings in detecting NVC. Therefore, 3D TOF MRA combined with high resolution T2-weighted imaging(HR T2WI) is considered to be a more effective method to detect NVC.AIM To determine the value of 3D TOF MRA combined with HR T2WI in the judgment of NVC, and thus to assess its value in the preoperative evaluation of MVD.METHODS Related studies published from inception to September 2022 based on PubMed, Embase, Web of Science, and the Cochrane Library were retrieved. Studies that investigated 3D TOF MRA combined with HR T2WI to judge NVC in patients with TN or HFS were included according to the inclusion criteria. Studies without complete data or not relevant to the research topics were excluded. The Quality Assessment of Diagnostic Accuracy Studies checklist was used to assess the quality of included studies. The publication bias of the included literature was examined by Deeks’ test. An exact binomial rendition of the bivariate mixed-effects regression model was used to synthesize data. Data analysis was performed using the MIDAS module of statistical software Stata 16.0. Two independent investigators extracted patient and study characteristics, and discrepancies were resolved by consensus. Individual and pooled sensitivities and specificities were calculated. The I_(2) statistic and Q test were used to test heterogeneity. The study was registered on the website of PROSERO(registration No. CRD42022357158).RESULTS Our search identified 595 articles, of which 12(including 855 patients) fulfilled the inclusion criteria. Bivariate analysis showed that the pooled sensitivity and specificity of 3D TOF MRA combined with HR T2WI for detecting NVC were 0.96 [95% confidence interval(CI): 0.92-0.98] and 0.92(95%CI: 0.74-0.98), respectively. The pooled positive likelihood ratio was 12.4(95%CI: 3.2-47.8), pooled negative likelihood ratio was 0.04(95%CI: 0.02-0.09), and pooled diagnostic odds ratio was 283(95%CI: 50-1620). The area under the receiver operating characteristic curve was 0.98(95%CI: 0.97-0.99). The studies showed no substantial heterogeneity(I2 = 0, Q = 0.001 P = 0.50).CONCLUSION Our results suggest that 3D TOF MRA combined with HR T2WI has excellent sensitivity and specificity for judging NVC in patients with TN or HFS. This method can be used as an effective tool for preoperative evaluation of MVD.

Ultra-high-field magnetic resonance:Why and when?

This paper briefly summarizes the development of magnetic resonance imaging and spectroscopy in medicine.Aspects of magnetic resonancephysics and-technology relevant at ultra-high magnetic fields as well as current limitations are highlighted.Based on the first promising studies,potential clinical applications at 7 Tesla are suggested.Other aims are to stimulate awareness of the potential of ultra-high field magnetic resonance and to stimulate active participation in much needed basic or clinical research at 7 Tesla or higher.

3.0 Tesla magnetic resonance imaging: A new standard in liver imaging?

An ever-increasing number of 3.0 Tesla(T) magnets are installed worldwide. Moving from the standard of 1.5 T to higher field strength implies a number of potential advantage and drawbacks, requiring careful optimization of imaging protocols or implementation of novel hardware components. Clinical practice and literature review suggest that state-of-the-art 3.0 T is equivalent to 1.5 T in the assessment of focal liver lesions and diffuse liver disease. Therefore, further technical improvements are needed in order to fully exploit the potential of higher field strength.

Patient’s Comfort and Technical Quality Exams at 1.5 and 3.0 T Magnetic Resonance Imaging

Increased interest of clinicians for using 3.0 T magnetic resonance imaging (MRI), as imaging modality of choice for their patients, has been evident in the past few years. The aim of this study was to compare the technical quality of the obtained tomography using 3.0 T and 1.5 T MRI, and to compare the subjective feeling of discomfort of patients and subjective acoustic noise experience during imaging using MRI at 3.0 T and 1.5 T. Brain MRI (1.5 and 3.0 T) was performed in 58 patients, according to a standardized protocol. All studies have been randomly described by independent two radiologists. The reference standard for the existence of technical artifact is established on the basis of both radiologists’ consensus. We also compared the subjective feelings of the discomfort and acoustic noise during the both MRI (1.5 T and 3.0 T) exams. Artifacts were significantly more common during 3.0 T MRI in comparison with the 1.5 T MRI (χ2 = 5.286, P < 0.05), as well as in male patients (χ2 = 8.841, P < 0.05), and sub-jective assessments of discomfort and acoustic noise were higher in patients who underwent imaging using 3.0 T MRI, (χ2 = 125.959, df = 1, P < 0.001) and in females (χ2 = 195.449, df = 1, P < 0.001). Additional research is needed to prove that appropriate information for patients about the discomfort during 3.0 T MRI and their psychological preparation is very important element for optimal use of 3.0 T MRI in daily clinical practice.

3.0 T proton magnetic resonance spectroscopy of the liver: Quantification of choline

AIM: To investigate the normal hepatic magnetic resonance spectroscopy findings choline/lipid2 (Cho/Lip2) associated with age and body mass index (BMI).METHODS: A total of 58 single-voxel proton spectra of the liver were acquired at 3.0 T using the eightchannel phased array abdominal coil as the receiver coil. Consecutive stacks of breath-hold spectra were acquired using the point resolved spectroscopy technique at a short echo time of 30 ms and a repetition time of 1500 ms. The spectra were processed with the SAGE software package. Areas and heights for metabolite resonance were obtained. Student's t test for unpaired data was used for comparisons of shimming, Cho/Lip2, and lipid content. RESULTS: There were significant negative correlations between the Cho/Lip2 peak height ratios and BMI (r=-0.615) and age (r=-0.398) (all P<0.01). Compared with the high-BMI group, the low-BMI group was younger (39.1±13.0 years vs 47.6±8.5 years, t=-2.954,P=0.005); had better water suppression (93.4%±1.4% vs 85.6%±11.6%, t=2.741, P=0.014); had higher Cho/Lip2 peak heights ratio (0.2±0.14 vs 0.05±0.04,t=6.033,P<0.000); and had lower lipid content (0.03±0.08 vs 0.29±0.31, t=-3.309, P=0.004). Compared with the older group, the younger group had better shimming effects (17.1±3.6 Hz vs 22.0±6.8 Hz, t=-2.919, P=0.008); higher Cho/Lip2 peak heights ratios (0.03±0.05vs 0.09±0.12,t=2.4, P=0.020); and lower lipid content (0.05±0.11 vs 0.23±0.32,t=-2.337,P=0.031). Compared with the lowcholine peak group, the high-choline peak group had lower lipid content (0.005±0.002 vs 0.13±0.23, t=-3.796,P<0.000); lower BMI (19.6±2.4vs 23.9±3.0, t=-4.410, P<0.000); and younger age (34.7±10.0 years vs 43.2±12.5 years, t=-2.088, P=0.041). CONCLUSION: Lipid accumulation could result from the increased fat in the body depending on age and BMI. Lipid can mask the resonance signal of choline.

7T超高场磁共振颅内血管壁成像在缺血性脑卒中病因分型中的研究进展

缺血性脑卒中的病因分型对临床治疗决策和预后判断有重要价值。近年来,随着高分辨率磁共振血管壁成像(high-resolution vessel wall magnetic resonance imaging,HR-VW-MRI)在脑卒中临床研究和实践中的应用增加,7 T MRI以其更高信噪比和更优图像质量,可发现脑血管早期、细微的病理变化,为深入了解各种脑血管疾病的病理机制提供了新思路。然而,超高场强也存在B1场不均、扫描时间长等技术挑战。本文就7 T HR-VW-MRI在缺血性卒中病因分型及临床应用中的进展进行综述,深入分析7 T HR-VW-MRI在提升临床诊断精确性与指导临床治疗中的潜在价值,为临床实践与科研探索提供参考。

飞利浦Ingenia 3.0 T磁共振成像仪射频系统故障三例

磁共振成像无电离辐射且软组织成像效果较好,已成为常规体检和疾病诊断非常重要的医学影像诊疗技术之一。磁共振设备结构复杂,维修及维护成本较高,长期高负荷的运转会导致磁共振设备故障率增加。本文总结了本院飞利浦Ingenia 3.0 T磁共振设备射频系统故障三例,包括de-tuned印刷电路板故障、射频放大器故障及体线圈故障。文中对三例飞利浦磁共振设备射频系统故障的表现进行了描述,对故障产生的原因进行了分析并介绍了故障排除过程,包括观察外观、提取后台日志参数、测量疑似受损部件指标、更换受损部件以及系统测试。通过深入分析射频系统故障案例,分享维修经验,以期提高设备使用率。

7T磁共振成像在脑小血管病中的应用进展

脑小血管病在老年人群具有很高的发病率,可显著增加脑卒中和痴呆的发生风险。迄今为止,该疾病尚无有效的临床和体液生物标志物,诊断鉴别高度依赖于MRI。然而,由于临床影像的空间分辨率所限,脑小血管损害难以直接评价,因此研究者们主要使用一些反映脑实质损害的影像标志物来评估小血管损伤。近年来,随着超高场(7T)MRI技术的不断成熟,其在脑小血管病领域的研究亦日趋广泛。7T-MRI能够直接评估脑小血管结构、功能,并显著提高微小脑实质病灶的检测敏感性,为脑小血管病机制研究和精准诊断提供了重要工具。本文将回顾近年来基于7T-MRI的脑小血管病研究,并讨论潜在的问题和未来研究方向,为相关研究工作者提供借鉴。

多模态高场MRI乳腺扫描对乳腺良恶性病变的诊断价值

目的 分析多模态高场磁共振成像(MRI)乳腺扫描诊断乳腺良恶性病变的临床价值。方法 收集2022年1月至2023年12月于河南科技大学第二附属医院进行乳腺MRI检查的79例乳腺患者的临床资料,所有患者入院后均接受高场MRI轴位T1加权成像(T1WI)、压脂T2加权成像(fs-T2WI)、扩散加权成像(DWI)、表观弥散系数(ADC)、动态对比增强(DCE),并将扫描的图像传至配套的后处理软件工作站建立病灶感兴趣区的动态增强曲线(DCE-TIC)及最大强度投影(MIP)图像、分析多模态高场MRI乳腺扫描在诊断乳腺良恶性病变方面的临床价值。结果 以组织病理学检查结果作为金标准,79例患者中发现81个病灶,其中良性病变44个,恶性病变37个,有2例患者存在2个病变并存的情况,1例是左乳纤维腺瘤,右乳微小粘液癌,1例是左乳发现2个病变,血管平滑肌瘤和叶状肿瘤并存。磁共振平扫、动态对比增强扫描和多模态高场MRI乳腺扫描诊断恶性病变的灵敏度分别为72.97%、86.49%、94.59%,特异度分别为54.55%、59.09%、81.82%,准确度分别为62.96%、71.60%、87.65%,约登指数分别为0.28、0.46、0.76。其中多模态高场MRI乳腺扫描诊断乳腺恶性病变效能最高,灵敏度、特异度、准确度及约等指数分别为94.59%、81.82%、87.65%,0.76,高于单一做乳腺磁共振平扫或单做动态对比增强成像。结论 多单一做乳腺平扫或DCE检查都有一定的不足,多模态高场MRI乳腺扫描诊断乳腺良恶性病变的诊断效能较好,对乳腺恶性病变诊断的准确性较高,对乳腺良恶性病变的诊断具有较高的临床价值。

肝硬化结节及小肝癌患者3.0T MRI检查结果分析

目的评价3.0 T MRI检查在肝硬化再生性结节(RN)、异型增生性结节(DN)和小肝癌(SHCC)诊断和鉴别诊断中价值。方法回顾性分析经病理检查确诊的69例RN、DN及SHCC患者的3.0 T MRI平扫及容积采集技术(LAVA)三期动态增强扫描特点。结果 RN主要表现为T2WI低信号,动态增强方式呈"缓慢上升型";DN主要表现为T2WI高、低信号,信号较均匀结节的动态方式以"速升缓降型"为主,可有"结中结"(特征表现);SHCC主要表现为T1WI低信号、T2WI高信号,动态增强方式为"速升速降型"。结论肝硬化结节及小肝癌在3.0 T MRI上各有较为典型的表现,临床可据此进行诊断与鉴别诊断;对其他强化类型的肝脏病灶应结合肿瘤血管的扭曲增粗及包膜等表现排除SHCC。

3.0T高分辨率MRI在直肠癌术前T分期中的应用价值

目的探讨3.0T高分辨率磁共振成像(HR-MRI)在直肠癌术前T分期中的应用价值。方法选取51例原发性直肠癌患者,术前均行HR-MRI检查,术后行病理检查,分析HR-MRI术前T分期与病理T分期的一致性和相关性,计算HR-MRI诊断各分期的灵敏度、特异度、准确度、阳性预测值、阴性预测值。结果 HR-MRI术前T分期与病理T分期具有较强的一致性(Kappa=0.740,P<0.01)和相关性(r=0.838,P<0.01),HR-MRI术前T分期的诊断符合率为84.3%。结论 HR-MRI可有效评估直肠癌肠壁外层的侵犯程度、环周切缘的受侵、腹膜受累和邻近器官的侵犯。HRMRI术前T分期与病理T分期具有较好的一致性和相关性,且诊断符合率较高。

3.0T磁共振高分辨联合扩散加权成像对直肠癌局部浸润的诊断价值

目的:探讨3.0T磁共振高分辨联合扩散加权成像(DWI)序列对直肠癌鉴别浸润深度的评估价值。方法:回顾性分析2017年3月—2018年10月四川省雅安市人民医院手术的34例直肠癌患者,患者术前均扫描了MRI高分辨序列和DWI序列,以病理学结果为金标准,分别计算单独高分辨MRI和高分辨MRI联合DWI对直肠癌T分期和环周切缘(CRM)诊断的准确度、敏感度、特异度。结果:34例直肠癌术后诊断T1期4例,T2期7例,T3期15例,T4期8例。MRI高分辨成像对直肠癌T1、T2、T3、T4期诊断的准确度分别为94.1%、88.2%、94.1%、94.1%,敏感度分别为50.0%、75.0%、92.9%、87.5%,特异度分别为100%、92.3%、95.0%、95.8%,对CRM评估的准确度、敏感度、特异度分别为85.7%、66.7%、87.5%。高分辨MRI联合DWI序列对直肠癌T1、T2、T3、T4期诊断的准确度分别为94.1%、91.2%、97.1%、100%,敏感度分别为50.0%、87.5%、100%、100%,特异度分别为100%、91.2%、95.0%、100%,对CRM评估的准确度、敏感度、特异度分别为92.8%、71.4%、85.7%。对2种成像方法诊断T分期的准确度、敏感度、特异度比较,高分辨MRI联合DWI较高,但差异无统计学意义(P>0.05)。结论:3.0T磁共振DWI序列是直肠癌分期诊断必要补充序列,可以为直肠癌局部浸润诊断提供更多帮助,为临床选择治疗方式提供依据。

7.0 T及以上的超高场MRI在骨骼肌肉系统的研究进展

随着磁共振磁场强度的不断提升、扫描技术的智能化、扫描序列的创新及优化、新技术的脱颖而出,骨骼肌肉系统在磁共振成像的应用也是日新月异。7.0 T及以上的超高场MRI在骨骼肌肉系统成像中信噪比的提升尤为显著,超高分辨率图像有利于软骨、骨、韧带、肌腱、半月板等解剖结构细节的观察、病变信息的显示和呈现,从而提高诊断的特异性及敏感度。超高场MRI有利于高级功能成像的实现,提供了组织生化和代谢信息。本综述通过进一步总结超高场MRI在临床诊断、疾病监测及科学研究中的不足,提出未来可向优化成像序列、降低伪影和提高磁场均匀性等方向发展,为临床医生和研究人员提供超高场MRI应用的最新进展和前景,以促进超高场MRI在医学中的广泛应用和发展。

超高场磁共振在骨肌系统的研究进展

超高场磁共振(ultra-high-field magnetic resonance,UHF-MR)对疾病诊断和细微结构显示一直是临床研究热点。但由于其固有特性,7 T UHF-MR的研究目前主要集中在中枢神经及部分骨肌系统疾病中。而5 T UHF-MR的问世,似乎为骨肌及全身系统的超高场成像带来了新的可能性。本文重点对UHF-MR的固有物理特性对骨肌系统疾病诊断的影响及UHF-MR在骨肌系统疾病中的临床研究进展展开综述,旨在增强医师对UHF-MR的了解,拓宽研究者的思路,进一步推动新型对比剂的开发、多模态成像技术的应用以及人工智能辅助诊断的结合,促进UHF-MR在骨肌系统疾病中的临床转化及应用。

3.0T MRI评估食管癌侵犯主动脉:多序列成像之间的比较

目的比较3.0T磁共振多序列成像评估食管鳞状细胞癌是否侵犯胸主动脉之间的差异,以判断最有价值的评价方法。方法收集我院经内镜活检证实的食管鳞状细胞癌患者50例,术前均行3.0T磁共振同相位(Inphase)T_1WI、脂肪抑制T_2WI及动态增强扫描,评价食管鳞状细胞癌与胸主动脉之间的关系,并与手术病理检查结果进行对照。结果若采用动态增强扫描成像序列判断胸段食管癌侵犯胸主动脉壁,灵敏度、特异度、准确度高达91.3%、100%、92%;采用Inphase T_1WI序列判断胸段食管癌侵犯胸主动脉壁,其灵敏度、特异度、准确度分别为87%、100%、88%;采用脂肪抑制T_2WI序列判断胸段食管癌侵犯胸主动脉壁,其灵敏度、特异度、准确度分别为91.3%、25%、86%。结论 3.0T磁共振多序列成像有助于判断胸段食管癌是否侵犯胸主动脉,以判断肿瘤的可切除性;其中以动态增强扫描成像序列最有价值。

3.0T磁共振颞颌关节扫描技术的探讨

目的探讨颞颌关节的磁共振(MR)扫描技术及扫描参数。方法 28例受检者行颞颌关节MR检查,分别扫描颞颌关节闭口位和开口位的斜矢状位和斜冠状位,扫描序列包括:T1W-Atse、T2W-TSE、T2-SPAIR、PDWI。结果受检者均能够得到很好的图像,其颞下颌关节的解剖形态显示清晰完整,所有成像序列均能够显示关节盘、关节窝、关节间隙、髁突骨质形态、盘周组织以及翼外肌等。结论 3.0TMR扫描序列及参数的优化组合、病人体位及扫描方位的正确选择均有助于检测引起临床症状或体征的颞颌关节盘及周围组织的解剖与病变损伤情况。

基于脑脊液冲刷规律探讨枣仁安神颗粒对大鼠睡眠作用机制研究

[目的]基于脑脊液分泌和冲刷作用规律探讨枣仁安神颗粒改善正常大鼠睡眠状态的作用机制。[方法]选取雄性SD大鼠44只,随机分为正常组和枣仁安神颗粒组,每组22只。连续8 d对枣仁安神颗粒组大鼠灌服枣仁安神颗粒水溶液,正常组以等量纯净水灌服作为对照。分析大鼠给药第6至8天脑电(EEG)、肌电(EMG)特征,觉醒期、非快眼动睡眠期(NREM)、快眼动睡眠期(REM)时长,给药8 d后,超高场强核磁共振成像设备检测大鼠中脑导水管中段处脑脊液平均流速,酶联免疫吸附(ELISA)法测定大鼠大脑前额叶皮质水通道蛋白1(AQP1)和钠离子(Na^(+))-钾离子(K^(+))-氯离子(Cl-)协同转运蛋白1(NKCC1)含量,蛋白免疫印迹(Western Blot)法检测大脑前额叶皮质AQP1、NKCC1蛋白表达(因EEG植入手术含金属,无法进行核磁共振监测,故每组用于EEG描述的有8只大鼠,核磁共振监测的有6只大鼠,检测蛋白表达情况的有8只大鼠)。[结果]与正常组相比,枣仁安神颗粒组觉醒期时间缩短(P<0.01),睡眠时间增加(P<0.01),NREM、REM时间增加(P<0.01),枣仁安神颗粒组第6、7、8天之间的觉醒时间逐日减少(P<0.01),睡眠时间逐日增加(P<0.01),NREM、REM时间增加(P<0.01),对大鼠24 h睡眠结构产生影响(P<0.01),中脑导水管中段处脑脊液平均流速加快(P<0.05),大脑前额叶皮质AQP1、NKCC1含量增加(P<0.05),大脑前额叶皮质AQP1、NKCC1蛋白表达升高(P<0.05)。[结论]枣仁安神颗粒可以显著缩短正常大鼠觉醒期,延长睡眠期,特别是NREM与REM,其机制可能与增加脑脊液分泌蛋白AQP1、NKCC1的蛋白表达从而促进脑脊液冲刷有关。

不同节段直肠癌T分期的多模态1.5T MRI评估与病理对照研究

目的探讨分析多模态1.5T磁共振成像(MRI)对不同节段直肠癌T分期的评估价值。方法选取我院2018年6月至2023年3月收治的经肠镜下活检确诊的160例直肠癌患者作为研究对象,所有患者术前均进行多模态1.5T MRI检查,并接受全直肠系膜切除术(TME)治疗及术后病理分析,以病理结果为金指标,分析1.5T MRI对直肠癌T分期的评估价值;依据肠镜测量的肿瘤距肛门距离将全部患者分为低位直肠癌、中位直肠癌、高位直肠癌,分析多模态1.5T MRI检查对不同节段直肠癌T分期的评估价值及效能分析。结果1.5T MRI分期的评估准确率为89.38%;MRI T_(1)分期的准确率、敏感性、特异性、阳性预测值及阴性预测值分别为98.75%、94.74%、100.00%、100.00%、98.39%;T2分期的各项评估结果分别为91.25%、86.49%、92.68%、78.05%、95.80%;T3分期的各项评估结果分别为90.63%、75.61%、95.80%、86.11%、91.94%;T4分期的各项评估结果分别为100.00%、100.00%、97.48%、93.62%、100.00%;1.5T MRI低位及中位直肠癌T_(1)分期的准确率、特异性及阳性预测值最高,T4分期的敏感性及阴性预测值最高;高位直肠癌T_(1)分期的的评估准确率、敏感性、特异性及阴性预测值,T4分期的敏感性及阴性预测值最高;且三个阶段其他T分期的各项效能分析均较高。结论1.5T MRI评估效果显著,且对于直肠癌患者T分期的各项效能指标评估分析参考价值都较高,有更为准确的评估结果,值得临床上使用推广。

基于专利的全球高端磁共振成像发展现状分析

目的从专利申请角度对全球高端磁共振成像(Magnetic Resonance Imaging,MRI)发展现状进行分析,并对国内发展状况提出针对性对策和建议。方法利用incoPat对2013—2022年全球高端MRI专利情况进行分析,从专利申请数量、质量及研究方向角度对检索到的专利进行分析,探讨国内外高端MRI技术研究态势。结果共检索到全球高端MRI相关专利申请6087件,从专利申请数量角度,我国申请数量位居世界首位,为1949件,全球占比32%,但从专利申请质量角度来看,我国的申请授权率略低,约为53.82%。全球高端MRI主要包括超高场MRI、超极化MRI、深度学习后处理的超快速MRI、多核MRI、AI+MRI和PET/MRI多模态一体化成像6个技术方向。我国的超高场、深度学习及AI、多核及超极化MRI研发实力均位于全球前列,其中中科院为主要贡献者;而我国的PET/MRI一体化MRI研发实力较弱,需进一步加强。结论国内企业要加强和中科院及高校的合作,将国家科研项目应用到产业中,促进科研成果转化,形成优势互补,提高我国在高端MRI领域的话语权。

7 T与3 T MRI对健康人脑内灰质核团铁沉积的定量比较

目的比较在7 T与3 T场强下应用定量磁化率成像(QSM)分析正常人脑深部灰质核团铁沉积的差异。方法前瞻性招募无神经系统疾病的健康青年志愿者10例,平均年龄(22±3)岁;均行7 T及3 T MRI扫描采集QSM数据。应用STI-suite算法进行QSM后处理,手动勾画12个感兴趣区(包括双侧的红核、黑质、苍白球、壳核、尾状核头及丘脑),并测量脑灰质核团内的磁化率值。以7 T QSM上总体核团的平均磁化率值为参考,将核团分为高磁化率组和低磁化率组。采用配对t检验或Wilcoxon秩和检验比较同一核团在2种场强下QSM的磁化率差异。采用线性回归模型和Bland-Altman图分析2种不同场强下各核团定量磁化率的拟合度及一致性。结果3 T上测得的脑内灰质核团总体磁化率值高于7 T(P<0.05)。高磁化率组(红核、黑质、苍白球)各个核团以及总体结果均在3 T上测得的磁化率值高于7 T(P<0.05),低磁化率组(尾状核、壳核、丘脑)各个核团以及总体结果在2种场强下测得的磁化率值差异均无统计学意义(P>0.05)。线性回归结果显示2种场强下,核团总体磁化率值(R^(2)为0.954)及各核团的磁化率值的拟合度(R^(2)为0.803~0.936)均较好;Bland-Altman图分析显示2种场强下低磁化率组中各核团的磁化率值的一致性均较高,高于高磁化率组各核团。低磁化率组在2种场强下测得的磁化率拟合度(R2=0.995)高于高磁化率组(R^(2)=0.862);且低磁化率组在2种场强下磁化率的一致性高于高磁化率组。结论7 T与3 T场强下测得的低磁化率核团的磁化率值一致性较高,而在高磁化率核团中两者的差异较大,进行QSM评估时应注意场强对定量不同磁化率组织铁沉积的影响。