G protein-coupled receptor 37 (GPR37), also known as parkin associated endothelin-like (Pael) receptor, is an orphan G protein- coupled receptor, which suffers a defective parking ubiquitination in autosomal recessive...G protein-coupled receptor 37 (GPR37), also known as parkin associated endothelin-like (Pael) receptor, is an orphan G protein- coupled receptor, which suffers a defective parking ubiquitination in autosomal recessive Parkinson’s disease promoting its endoplasmic reticulum aggregation and stress, neurotoxicity and neuronal death (Takahashi and Imai, 2003). Interestingly, we have demonstrated previously that GPR37 heteromerizes with adenosine A2A receptor (A2AR) in the striatum (Morato et al., 2017;Sokolina et al., 2017).展开更多
基金Fondo Europeo de Desarrollo Regional(FEDER)/Ministerio de Ciencia,Innovacion y Universidades–Agencia Estatal de Investigacion(SAF2017-87349-R)Instituto de Salud Carlos Ⅲ(ISCⅢ)(PIE14/00034)+3 种基金the Catalan government(2017 SGR 1604)Fundaciola Maratode TV3(Grant 20152031)Fonds Wetenschappelijk Onderzoek(FWO)(SBO-140028)to FC and Centro 2020(projects CENTRO-01-0145-FEDER-000008:BrainHealth 2020 and CENTRO-01-0246-FEDER-000010)Fundacao para a Ciencia e a Tecnologia(FCT)(projects PTDC/NEU-NMC/4154/2014 and POCI-01-0145-FEDER-031274) to RAC
文摘G protein-coupled receptor 37 (GPR37), also known as parkin associated endothelin-like (Pael) receptor, is an orphan G protein- coupled receptor, which suffers a defective parking ubiquitination in autosomal recessive Parkinson’s disease promoting its endoplasmic reticulum aggregation and stress, neurotoxicity and neuronal death (Takahashi and Imai, 2003). Interestingly, we have demonstrated previously that GPR37 heteromerizes with adenosine A2A receptor (A2AR) in the striatum (Morato et al., 2017;Sokolina et al., 2017).
