为了对即将发布的新一代全球重力场模型EGM2020(Earth Gravitational Model 2020)在似大地水准面精化上的提升进行评估,通过其试验版的全球重力场模型XGM2019(X Gravitational Model 2019)利用扰动位配合布隆斯公式计算出高程异常的长波...为了对即将发布的新一代全球重力场模型EGM2020(Earth Gravitational Model 2020)在似大地水准面精化上的提升进行评估,通过其试验版的全球重力场模型XGM2019(X Gravitational Model 2019)利用扰动位配合布隆斯公式计算出高程异常的长波项,以评估XGM2019(Earth Gravitational Model 2008)相较于EGM2008(Earth Gravitational Model 2008)在直接转换为正常高精度上的提升;利用"移去-恢复-拟合"法以及顾及由地形起伏变化引起高程异常的短波波分,通过内符合精度和外符合精度来对比其在似大地水准面精度上的提升。以河南省平顶山市某区域的实测数据为例验证了该模型和方法的GPS高程拟合精度。结果表明,在研究区域内使用XGM2019模型在计算高程异常长波精度上相比EGM2008有近1倍的提高,在应用"移去-拟合-恢复"法后两种模型的计算结果比较相近。展开更多
The first pandemic wave of coronavirus disease 2019(COVID-19)induced a considerable increase in several antivirals and antibiotics in surface water.The common symptoms of COVID-19 are viral and bacterial infections,wh...The first pandemic wave of coronavirus disease 2019(COVID-19)induced a considerable increase in several antivirals and antibiotics in surface water.The common symptoms of COVID-19 are viral and bacterial infections,while comorbidities(e.g.,hypertension and diabetes)and mental shock(e.g.,insomnia and anxiety)are nonnegligible.Nevertheless,little is known about the long-term impacts of comorbidities and mental shock on organic micropollutants(OMPs)in surface waters.Herein,we monitored 114 OMPs in surface water and wastewater treatment plants(WWTPs)in Wuhan,China,between 2019 and 2021.The pandemic-induced OMP pollution in surface water was confirmed by significant increases in 26 OMP concentrations.Significant increases in four antihypertensives and one diabetic drug suggest that the treatment of comorbidities may induce OMP pollution.Notably,cotinine(a metabolite of nicotine)increased 155 times to 187 ngL1,which might be associated with increased smoking.Additionally,the increases in zolpidem and sulpiride might be the result of worsened insomnia and depression.Hence,it is reasonable to note that mental-health protecting drugs/behavior also contributed to OMP pollution.Among the observed OMPs,telmisartan,lopinavir,and ritonavir were associated with significantly higher ecological risks because of their limited WWTP-removal rate and high ecotoxicity.This study provides new insights into the effects of comorbidities and mental shock on OMPs in surface water during a pandemic and highlights the need to monitor the fate of related pharmaceuticals in the aquatic environment and to improve their removal efficiencies in WWTPs。展开更多
BACKGROUND Many studies have revealed a link between non-alcoholic fatty liver disease(NA-FLD)and coronavirus disease 2019(COVID-19),making understanding the relationship between these two conditions an absolute requi...BACKGROUND Many studies have revealed a link between non-alcoholic fatty liver disease(NA-FLD)and coronavirus disease 2019(COVID-19),making understanding the relationship between these two conditions an absolute requirement.AIM To provide a qualitative synthesis on the currently present data evaluating COVID-19 and NAFLD.METHODS This systematic review was conducted in accordance with the guidelines pro-vided by preferred reporting items for systematic reviews and meta-analyses and the questionnaire utilized the population,intervention,comparison,and outcome framework.The search strategy was run on three separate databases,PubMed/MEDLINE,Scopus,and Cochrane Central,which were systematically searched from inception until March 2024 to select all relevant studies.In addition,ClinicalTrials.gov,Medrxiv.org,and Google Scholar were searched to identify grey literature.RESULTS After retrieval of 11 studies,a total of 39282 patients data were pooled.Mortality was found in 11.5%and 9.4%of people in NAFLD and non-NAFLD groups.In all,23.2%of NAFLD patients and 22%of non-NAFLD admissions diagnosed with COVID-19 were admitted to the intensive care unit,with days of stay varying.Ventilatory support ranged from 5%to 40.5%in the NAFLD cohort and from 3.1%to 20%in the non-NAFLD cohort.The incidence of acute liver injury showed significance.Clinical improvement on days 7 and 14 between the two classifications was significant.Hospitalization stay ranged from 9.6 days to 18.8 days and 7.3 days to 16.4 days in the aforementioned cohorts respectively,with 73.3%and 76.3%of patients being discharged.Readmission rates varied.CONCLUSION Clinical outcomes except mortality consistently showed a worsening trend in patients with NAFLD and concomitant COVID-19.Further research in conducting prospective longitudinal studies is essential for a more powerful conclusion.展开更多
The East African (EA) region highly experiences intra-seasonal and inter-annual variation in rainfall amounts. This study investigates the driving factors for anomalous rainfall events observed during the season of Oc...The East African (EA) region highly experiences intra-seasonal and inter-annual variation in rainfall amounts. This study investigates the driving factors for anomalous rainfall events observed during the season of October-November-December (OND) 2019 over the region. The study utilized daily rainfall data from Climate Hazards Group InfraRed Precipitation with Station Data Version 2 (CHIRPSv2) and the driving systems data. Statistical spatiotemporal analysis, correlation, and composite techniques were performed to investigate the teleconnection between OND 2019 seasonal rainfall and global synoptic climate systems. The findings showed that the OND 2019 experienced seasonal rainfall that was twice or greater than its seasonal climatology and varied with location. Further, the OND 2019 rainfall showed a positive correlation with the Indian Ocean Dipole (IOD) (0.81), Nino 3 (0.51), Nino 3.4 (0.47), Nino 4 (0.40), Pacific Decadal Oscillation (PDO) (0.22), and North Tropical Atlantic (NTA) (0.02), while El Nino-Southern Oscillation (ENSO) showed a negative correlation (−0.30). The region was dominated by southeasterly warming and humid winds that originated from the Indian Ocean, while the geopotential height, vertical velocity, and vorticity anomalies were closely related to the anomalous rainfall characteristics. The study deduced that the IOD was the major synoptic system that influenced maximum rainfall during the peak season of OND 2019. This study therefore provided insights on the diagnosis study of OND 2019 anomalous rainfall and its attribution over the EA. The findings of the study will contribute to improvements in forecasting seasonal rainfall by regional climate centers and national meteorological centers within the region.展开更多
文摘为了对即将发布的新一代全球重力场模型EGM2020(Earth Gravitational Model 2020)在似大地水准面精化上的提升进行评估,通过其试验版的全球重力场模型XGM2019(X Gravitational Model 2019)利用扰动位配合布隆斯公式计算出高程异常的长波项,以评估XGM2019(Earth Gravitational Model 2008)相较于EGM2008(Earth Gravitational Model 2008)在直接转换为正常高精度上的提升;利用"移去-恢复-拟合"法以及顾及由地形起伏变化引起高程异常的短波波分,通过内符合精度和外符合精度来对比其在似大地水准面精度上的提升。以河南省平顶山市某区域的实测数据为例验证了该模型和方法的GPS高程拟合精度。结果表明,在研究区域内使用XGM2019模型在计算高程异常长波精度上相比EGM2008有近1倍的提高,在应用"移去-拟合-恢复"法后两种模型的计算结果比较相近。
基金supported by the National Natural Science Foundation of China(52221004,52091542,and 51820105011)the Scientific Research Project of China Three Gorges Corporation(201903139)the Research Fund of Vanke School of Public Health(2021JC009),Tsinghua University.
文摘The first pandemic wave of coronavirus disease 2019(COVID-19)induced a considerable increase in several antivirals and antibiotics in surface water.The common symptoms of COVID-19 are viral and bacterial infections,while comorbidities(e.g.,hypertension and diabetes)and mental shock(e.g.,insomnia and anxiety)are nonnegligible.Nevertheless,little is known about the long-term impacts of comorbidities and mental shock on organic micropollutants(OMPs)in surface waters.Herein,we monitored 114 OMPs in surface water and wastewater treatment plants(WWTPs)in Wuhan,China,between 2019 and 2021.The pandemic-induced OMP pollution in surface water was confirmed by significant increases in 26 OMP concentrations.Significant increases in four antihypertensives and one diabetic drug suggest that the treatment of comorbidities may induce OMP pollution.Notably,cotinine(a metabolite of nicotine)increased 155 times to 187 ngL1,which might be associated with increased smoking.Additionally,the increases in zolpidem and sulpiride might be the result of worsened insomnia and depression.Hence,it is reasonable to note that mental-health protecting drugs/behavior also contributed to OMP pollution.Among the observed OMPs,telmisartan,lopinavir,and ritonavir were associated with significantly higher ecological risks because of their limited WWTP-removal rate and high ecotoxicity.This study provides new insights into the effects of comorbidities and mental shock on OMPs in surface water during a pandemic and highlights the need to monitor the fate of related pharmaceuticals in the aquatic environment and to improve their removal efficiencies in WWTPs。
文摘BACKGROUND Many studies have revealed a link between non-alcoholic fatty liver disease(NA-FLD)and coronavirus disease 2019(COVID-19),making understanding the relationship between these two conditions an absolute requirement.AIM To provide a qualitative synthesis on the currently present data evaluating COVID-19 and NAFLD.METHODS This systematic review was conducted in accordance with the guidelines pro-vided by preferred reporting items for systematic reviews and meta-analyses and the questionnaire utilized the population,intervention,comparison,and outcome framework.The search strategy was run on three separate databases,PubMed/MEDLINE,Scopus,and Cochrane Central,which were systematically searched from inception until March 2024 to select all relevant studies.In addition,ClinicalTrials.gov,Medrxiv.org,and Google Scholar were searched to identify grey literature.RESULTS After retrieval of 11 studies,a total of 39282 patients data were pooled.Mortality was found in 11.5%and 9.4%of people in NAFLD and non-NAFLD groups.In all,23.2%of NAFLD patients and 22%of non-NAFLD admissions diagnosed with COVID-19 were admitted to the intensive care unit,with days of stay varying.Ventilatory support ranged from 5%to 40.5%in the NAFLD cohort and from 3.1%to 20%in the non-NAFLD cohort.The incidence of acute liver injury showed significance.Clinical improvement on days 7 and 14 between the two classifications was significant.Hospitalization stay ranged from 9.6 days to 18.8 days and 7.3 days to 16.4 days in the aforementioned cohorts respectively,with 73.3%and 76.3%of patients being discharged.Readmission rates varied.CONCLUSION Clinical outcomes except mortality consistently showed a worsening trend in patients with NAFLD and concomitant COVID-19.Further research in conducting prospective longitudinal studies is essential for a more powerful conclusion.
文摘The East African (EA) region highly experiences intra-seasonal and inter-annual variation in rainfall amounts. This study investigates the driving factors for anomalous rainfall events observed during the season of October-November-December (OND) 2019 over the region. The study utilized daily rainfall data from Climate Hazards Group InfraRed Precipitation with Station Data Version 2 (CHIRPSv2) and the driving systems data. Statistical spatiotemporal analysis, correlation, and composite techniques were performed to investigate the teleconnection between OND 2019 seasonal rainfall and global synoptic climate systems. The findings showed that the OND 2019 experienced seasonal rainfall that was twice or greater than its seasonal climatology and varied with location. Further, the OND 2019 rainfall showed a positive correlation with the Indian Ocean Dipole (IOD) (0.81), Nino 3 (0.51), Nino 3.4 (0.47), Nino 4 (0.40), Pacific Decadal Oscillation (PDO) (0.22), and North Tropical Atlantic (NTA) (0.02), while El Nino-Southern Oscillation (ENSO) showed a negative correlation (−0.30). The region was dominated by southeasterly warming and humid winds that originated from the Indian Ocean, while the geopotential height, vertical velocity, and vorticity anomalies were closely related to the anomalous rainfall characteristics. The study deduced that the IOD was the major synoptic system that influenced maximum rainfall during the peak season of OND 2019. This study therefore provided insights on the diagnosis study of OND 2019 anomalous rainfall and its attribution over the EA. The findings of the study will contribute to improvements in forecasting seasonal rainfall by regional climate centers and national meteorological centers within the region.
