Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown extensively.In short,personalized medicine is a term that describes medical trea...Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown extensively.In short,personalized medicine is a term that describes medical treatment that is tuned to the individual.One possible way to realize personalized medicine is 3D printing.When using materials that can be tuned upon stimulation,4D printing is established.In recent years,many studies have been exploring a new field that combines 3D and 4D printing with therapeutics.This has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an individual.Moreover,the first 3D printed drug,Spritam®,has already found its way to the clinic.This review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.展开更多
The recently developed hard-magnetic soft(HMS)materials manufactured by embedding high-coercivity micro-particles into soft matrices have received considerable attention from researchers in diverse fields,e.g.,soft ro...The recently developed hard-magnetic soft(HMS)materials manufactured by embedding high-coercivity micro-particles into soft matrices have received considerable attention from researchers in diverse fields,e.g.,soft robotics,flexible electronics,and biomedicine.Theoretical investigations on large deformations of HMS structures are significant foundations of their applications.This work is devoted to developing a powerful theoretical tool for modeling and computing the complicated nonplanar deformations of flexible beams.A so-called quaternion beam model is proposed to break the singularity limitation of the existing geometrically exact(GE)beam model.The singularity-free governing equations for the three-dimensional(3D)large deformations of an HMS beam are first derived,and then solved with the Galerkin discretization method and the trustregion-dogleg iterative algorithm.The correctness of this new model and the utilized algorithms is verified by comparing the present results with the previous ones.The superiority of a quaternion beam model in calculating the complicated large deformations of a flexible beam is shown through several benchmark examples.It is found that the purpose of the HMS beam deformation is to eliminate the direction deviation between the residual magnetization and the applied magnetic field.The proposed new model and the revealed mechanism are supposed to be useful for guiding the engineering applications of flexible structures.展开更多
The article proposes an Equivalent Single Layer(ESL)formulation for the linear static analysis of arbitrarily-shaped shell structures subjected to general surface loads and boundary conditions.A parametrization of the...The article proposes an Equivalent Single Layer(ESL)formulation for the linear static analysis of arbitrarily-shaped shell structures subjected to general surface loads and boundary conditions.A parametrization of the physical domain is provided by employing a set of curvilinear principal coordinates.The generalized blendingmethodology accounts for a distortion of the structure so that disparate geometries can be considered.Each layer of the stacking sequence has an arbitrary orientation and is modelled as a generally anisotropic continuum.In addition,re-entrant auxetic three-dimensional honeycomb cells with soft-core behaviour are considered in the model.The unknown variables are described employing a generalized displacement field and pre-determined through-the-thickness functions assessed in a unified formulation.Then,a weak assessment of the structural problem accounts for shape functions defined with an isogeometric approach starting fromthe computational grid.Ageneralizedmethodology has been proposed to define two-dimensional distributions of static surface loads.In the same way,boundary conditions with three-dimensional features are implemented along the shell edges employing linear springs.The fundamental relations are obtained from the stationary configuration of the total potential energy,and they are numerically tackled by employing the Generalized Differential Quadrature(GDQ)method,accounting for nonuniform computational grids.In the post-processing stage,an equilibrium-based recovery procedure allows the determination of the three-dimensional dispersion of the kinematic and static quantities.Some case studies have been presented,and a successful benchmark of different structural responses has been performed with respect to various refined theories.展开更多
文摘Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown extensively.In short,personalized medicine is a term that describes medical treatment that is tuned to the individual.One possible way to realize personalized medicine is 3D printing.When using materials that can be tuned upon stimulation,4D printing is established.In recent years,many studies have been exploring a new field that combines 3D and 4D printing with therapeutics.This has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an individual.Moreover,the first 3D printed drug,Spritam®,has already found its way to the clinic.This review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.
基金Project supported by the National Key Research and Development Program of China(No.2018YFA0703200)the National Natural Science Foundation of China(Nos.52205594 and51820105008)+1 种基金the China National Postdoctoral Program for Innovative Talents(No.BX20220118)the China Postdoctoral Science Foundation(No.2021M701306)。
文摘The recently developed hard-magnetic soft(HMS)materials manufactured by embedding high-coercivity micro-particles into soft matrices have received considerable attention from researchers in diverse fields,e.g.,soft robotics,flexible electronics,and biomedicine.Theoretical investigations on large deformations of HMS structures are significant foundations of their applications.This work is devoted to developing a powerful theoretical tool for modeling and computing the complicated nonplanar deformations of flexible beams.A so-called quaternion beam model is proposed to break the singularity limitation of the existing geometrically exact(GE)beam model.The singularity-free governing equations for the three-dimensional(3D)large deformations of an HMS beam are first derived,and then solved with the Galerkin discretization method and the trustregion-dogleg iterative algorithm.The correctness of this new model and the utilized algorithms is verified by comparing the present results with the previous ones.The superiority of a quaternion beam model in calculating the complicated large deformations of a flexible beam is shown through several benchmark examples.It is found that the purpose of the HMS beam deformation is to eliminate the direction deviation between the residual magnetization and the applied magnetic field.The proposed new model and the revealed mechanism are supposed to be useful for guiding the engineering applications of flexible structures.
文摘The article proposes an Equivalent Single Layer(ESL)formulation for the linear static analysis of arbitrarily-shaped shell structures subjected to general surface loads and boundary conditions.A parametrization of the physical domain is provided by employing a set of curvilinear principal coordinates.The generalized blendingmethodology accounts for a distortion of the structure so that disparate geometries can be considered.Each layer of the stacking sequence has an arbitrary orientation and is modelled as a generally anisotropic continuum.In addition,re-entrant auxetic three-dimensional honeycomb cells with soft-core behaviour are considered in the model.The unknown variables are described employing a generalized displacement field and pre-determined through-the-thickness functions assessed in a unified formulation.Then,a weak assessment of the structural problem accounts for shape functions defined with an isogeometric approach starting fromthe computational grid.Ageneralizedmethodology has been proposed to define two-dimensional distributions of static surface loads.In the same way,boundary conditions with three-dimensional features are implemented along the shell edges employing linear springs.The fundamental relations are obtained from the stationary configuration of the total potential energy,and they are numerically tackled by employing the Generalized Differential Quadrature(GDQ)method,accounting for nonuniform computational grids.In the post-processing stage,an equilibrium-based recovery procedure allows the determination of the three-dimensional dispersion of the kinematic and static quantities.Some case studies have been presented,and a successful benchmark of different structural responses has been performed with respect to various refined theories.
