虽然Voodoo2推出时间已有一年,但是为了证明使用SLI连卡Voodoo2也有不错的表现,我们特别使用2张赋泽公司的Magic 3D ⅡVoodoo2显卡,进行Voodoo2的连卡测试。市面上还有其它厂牌Voodoo2的显卡,使用者可自行选购,并建议搭配同一厂牌的Vood...虽然Voodoo2推出时间已有一年,但是为了证明使用SLI连卡Voodoo2也有不错的表现,我们特别使用2张赋泽公司的Magic 3D ⅡVoodoo2显卡,进行Voodoo2的连卡测试。市面上还有其它厂牌Voodoo2的显卡,使用者可自行选购,并建议搭配同一厂牌的Voodoo2进行连卡使用。测试时虽然1600×1200分辨率和32bit模式都无法支持,但是在1024×762×16bit模式时。展开更多
BACKGROUND Ulcerative colitis(UC)is a chronic,nonspecific intestinal inflammatory disease with undefined pathogenesis.Non-SMC condensin I complex subunit D2(NCAPD2)and non-SMC condensin II complex subunit D3(NCAPD3)pl...BACKGROUND Ulcerative colitis(UC)is a chronic,nonspecific intestinal inflammatory disease with undefined pathogenesis.Non-SMC condensin I complex subunit D2(NCAPD2)and non-SMC condensin II complex subunit D3(NCAPD3)play pivotal roles in chromosome assembly and segregation during both mitosis and meiosis.To date,there has been no relevant report about the functional role of NCAPD2 and NCAPD3 in UC.AIM To determine the level of NCAPD2/3 in intestinal mucosa and explore the mechanisms of NCAPD2/3 in UC.METHODS Levels of NCAPD2/3 in intestinal tissue were detected in 30 UC patients and 30 healthy individuals with in situ hybridization(ISH).In vitro,NCM60 cells were divided into the NC group,model group,si-NCAPD2 group,si-NCAPD3 group and si-NCAPD2+si-NCAPD3 group.Inflammatory cytokines were measured by ELISA,IKK and NF-κB were evaluated by western blot,and IKK nucleation and NF-κB volume were analyzed by immunofluorescence assay.RESULTS Compared with expression in healthy individuals,NCAPD2 and NCAPD3 expression in intestinal tissue was significantly upregulated(P<0.001)in UC patients.Compared with levels in the model group,IL-1β,IL-6 and TNF-αin the si-NCAPD2,si-NCAPD3 and si-NCAPD2+si-NCAPD3 groups were significantly downregulated(P<0.01).IKK and NF-κB protein expression in the si-NCAPD2,si-NCAPD3 and si-NCAPD2+si-NCAPD3 groups was significantly decreased(P<0.01).Moreover,IKK nucleation and NF-κB volume were suppressed upon si-NCAPD2,si-NCAPD3 and si-NCAPD2+si-NCAPD3 transfection.CONCLUSION NCAPD2/3 is highly expressed in the intestinal mucosa of patients with active UC.Overexpression of NCAPD2/3 promotes the release of pro-inflammatory cytokines by modulating the IKK/NF-κB signaling pathway.展开更多
A new Zn（Ⅱ） compound, namely {Zn（BTA）（pdc）0.5}n（1, HBTA = 1,2,3-benzotriazole, H2pdc = terephthalic acid）, has been hydrothermally synthesized and characterized by elemental analysis, infrared analysis, powde...A new Zn（Ⅱ） compound, namely {Zn（BTA）（pdc）0.5}n（1, HBTA = 1,2,3-benzotriazole, H2pdc = terephthalic acid）, has been hydrothermally synthesized and characterized by elemental analysis, infrared analysis, powder X-ray diffraction analysis and single-crystal X-ray structural analysis. The crystal structure is of monoclinic system, space group P21/c with a = 10.751（3）, b = 9.792（3）, c = 9.292（3）A, β = 95.391（4）°, V = 973.9（5） A^3, C10H6N3O2 Zn, Mr = 265.57, Z = 4, Dc = 1.811 g/cm3, F（000） = 532, μ = 2.506 mm-1, R = 0.0221 and w R = 0.0605 for 2075 observed reflections（I 〉 2s（I））. Single-crystal X-ray structural analysis reveals that compound 1 features a three-dimensional（3D） framework with 4-connected bbf topology. Moreover, the thermogravimetric（TG） analysis and photoluminescent property of 1 were also discussed.展开更多
A new Cd（Ⅱ） coordination polymer, namely {Cd_2（L）（biimpy）（H_2O）}_n（1, H4 L = 3-（3？,5？-dicarboxylphenoxy）phthalic acid, biimpy = 2,6-bis（1-imdazoly）pyridine）, has been successfully synthesized via the ...A new Cd（Ⅱ） coordination polymer, namely {Cd_2（L）（biimpy）（H_2O）}_n（1, H4 L = 3-（3？,5？-dicarboxylphenoxy）phthalic acid, biimpy = 2,6-bis（1-imdazoly）pyridine）, has been successfully synthesized via the hydrothermal reactions of Cd（Ⅱ） ions, H_4L and biimpy. The crystal structure is of triclinic, space group P1 with a = 7.7874（5）, b = 9.9716（5）, c = 18.5278（6） ？, α = 91.327（4）, β = 96.689（4）, γ = 111.896（5）o, V = 1322.39（12） ？~3, C_（27）H_（17）Cd_2N_5O_（10）, M_r = 796.26, Z = 2,D_c = 2.000 g/cm^3, F（000） = 780, μ = 1.679 mm^（-1）, R = 0.0345 and wR = 0.0767 for 3890 observed reflections（I 〉 2s（I））. Single-crystal X-ray structural analysis reveals that compound 1 features a three-dimensional（3D） framework based on two different dinuclear [Cd_2（COO）_2] building subunits, and topological analysis shows that it can be simplified into a binodal（4,6）-connected topological network with the point symbol of {3.4~2.5~2.6}{3~2.4~2.5~2.6~4.7~4.8}. Moreover, the thermal stability and luminescent property of compound 1 were also studied.展开更多
A novel complex, [Zn（L）]2·H2O（1, H2 L = 4-aminophthalic acid）, has been hydrothermally prepared and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and PXRD. Complex 1 c...A novel complex, [Zn（L）]2·H2O（1, H2 L = 4-aminophthalic acid）, has been hydrothermally prepared and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and PXRD. Complex 1 crystallizes in monoclinic, space group C2/c with a = 12.4267（6）, b = 7.7482（3）, c = 18.6983（8） A, β = 110.437（3）°, V = 1687.04（13） A3, Z = 4, C16H12N2O9Zn2, Mr = 507.06, Dc = 1.996 g/cm3, μ = 2.903 mm-1, S = 0.989, F（000） = 1016, the final R = 0.0304 and w R = 0.0720 for 12618 observed reflections（I 〉 2σ（I））. Single-crystal X-ray structural analysis reveals that compound 1 features a three-dimensional（3D） framework with 4-connected umc topology. Moreover, the thermogravimetric（TG） analysis and photoluminescent property of 1 were also discussed.展开更多
文摘虽然Voodoo2推出时间已有一年,但是为了证明使用SLI连卡Voodoo2也有不错的表现,我们特别使用2张赋泽公司的Magic 3D ⅡVoodoo2显卡,进行Voodoo2的连卡测试。市面上还有其它厂牌Voodoo2的显卡,使用者可自行选购,并建议搭配同一厂牌的Voodoo2进行连卡使用。测试时虽然1600×1200分辨率和32bit模式都无法支持,但是在1024×762×16bit模式时。
基金Supported by National Natural Science Foundation of China,No.81673973Natural Science Foundation of Jiangsu Province,China,No.BK20161577the Developing Program for Highlevel Academic Talent from Jiangsu Hospital of Chinese Medicine,No.y2018rc16
文摘BACKGROUND Ulcerative colitis(UC)is a chronic,nonspecific intestinal inflammatory disease with undefined pathogenesis.Non-SMC condensin I complex subunit D2(NCAPD2)and non-SMC condensin II complex subunit D3(NCAPD3)play pivotal roles in chromosome assembly and segregation during both mitosis and meiosis.To date,there has been no relevant report about the functional role of NCAPD2 and NCAPD3 in UC.AIM To determine the level of NCAPD2/3 in intestinal mucosa and explore the mechanisms of NCAPD2/3 in UC.METHODS Levels of NCAPD2/3 in intestinal tissue were detected in 30 UC patients and 30 healthy individuals with in situ hybridization(ISH).In vitro,NCM60 cells were divided into the NC group,model group,si-NCAPD2 group,si-NCAPD3 group and si-NCAPD2+si-NCAPD3 group.Inflammatory cytokines were measured by ELISA,IKK and NF-κB were evaluated by western blot,and IKK nucleation and NF-κB volume were analyzed by immunofluorescence assay.RESULTS Compared with expression in healthy individuals,NCAPD2 and NCAPD3 expression in intestinal tissue was significantly upregulated(P<0.001)in UC patients.Compared with levels in the model group,IL-1β,IL-6 and TNF-αin the si-NCAPD2,si-NCAPD3 and si-NCAPD2+si-NCAPD3 groups were significantly downregulated(P<0.01).IKK and NF-κB protein expression in the si-NCAPD2,si-NCAPD3 and si-NCAPD2+si-NCAPD3 groups was significantly decreased(P<0.01).Moreover,IKK nucleation and NF-κB volume were suppressed upon si-NCAPD2,si-NCAPD3 and si-NCAPD2+si-NCAPD3 transfection.CONCLUSION NCAPD2/3 is highly expressed in the intestinal mucosa of patients with active UC.Overexpression of NCAPD2/3 promotes the release of pro-inflammatory cytokines by modulating the IKK/NF-κB signaling pathway.
基金Supported by the 973 Program of China(2011CBA00505)the "Strategic Priority Research Program" of the Chinese Academy of Sciences(XDA07070200,XDA09030102)the Science Foundation of the Fujian Province(2006L2005)
文摘A new Zn（Ⅱ） compound, namely {Zn（BTA）（pdc）0.5}n（1, HBTA = 1,2,3-benzotriazole, H2pdc = terephthalic acid）, has been hydrothermally synthesized and characterized by elemental analysis, infrared analysis, powder X-ray diffraction analysis and single-crystal X-ray structural analysis. The crystal structure is of monoclinic system, space group P21/c with a = 10.751（3）, b = 9.792（3）, c = 9.292（3）A, β = 95.391（4）°, V = 973.9（5） A^3, C10H6N3O2 Zn, Mr = 265.57, Z = 4, Dc = 1.811 g/cm3, F（000） = 532, μ = 2.506 mm-1, R = 0.0221 and w R = 0.0605 for 2075 observed reflections（I 〉 2s（I））. Single-crystal X-ray structural analysis reveals that compound 1 features a three-dimensional（3D） framework with 4-connected bbf topology. Moreover, the thermogravimetric（TG） analysis and photoluminescent property of 1 were also discussed.
基金Supported by the 973 Program of China(2011CBA00505)the"Strategic Priority Research Program"of the Chinese Academy of Sciences(XDA07070200,XDA09030102)the Science Foundation of Fujian Province(2006L2005)
文摘A new Cd（Ⅱ） coordination polymer, namely {Cd_2（L）（biimpy）（H_2O）}_n（1, H4 L = 3-（3？,5？-dicarboxylphenoxy）phthalic acid, biimpy = 2,6-bis（1-imdazoly）pyridine）, has been successfully synthesized via the hydrothermal reactions of Cd（Ⅱ） ions, H_4L and biimpy. The crystal structure is of triclinic, space group P1 with a = 7.7874（5）, b = 9.9716（5）, c = 18.5278（6） ？, α = 91.327（4）, β = 96.689（4）, γ = 111.896（5）o, V = 1322.39（12） ？~3, C_（27）H_（17）Cd_2N_5O_（10）, M_r = 796.26, Z = 2,D_c = 2.000 g/cm^3, F（000） = 780, μ = 1.679 mm^（-1）, R = 0.0345 and wR = 0.0767 for 3890 observed reflections（I 〉 2s（I））. Single-crystal X-ray structural analysis reveals that compound 1 features a three-dimensional（3D） framework based on two different dinuclear [Cd_2（COO）_2] building subunits, and topological analysis shows that it can be simplified into a binodal（4,6）-connected topological network with the point symbol of {3.4~2.5~2.6}{3~2.4~2.5~2.6~4.7~4.8}. Moreover, the thermal stability and luminescent property of compound 1 were also studied.
基金supported by the National Natural Science Foundation of China(Nos.21171040 and 21302019)excellent organic teaching and research project(No.2013JCJS01)National Undergraduates Innovation Project(201510371010)
文摘A novel complex, [Zn（L）]2·H2O（1, H2 L = 4-aminophthalic acid）, has been hydrothermally prepared and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and PXRD. Complex 1 crystallizes in monoclinic, space group C2/c with a = 12.4267（6）, b = 7.7482（3）, c = 18.6983（8） A, β = 110.437（3）°, V = 1687.04（13） A3, Z = 4, C16H12N2O9Zn2, Mr = 507.06, Dc = 1.996 g/cm3, μ = 2.903 mm-1, S = 0.989, F（000） = 1016, the final R = 0.0304 and w R = 0.0720 for 12618 observed reflections（I 〉 2σ（I））. Single-crystal X-ray structural analysis reveals that compound 1 features a three-dimensional（3D） framework with 4-connected umc topology. Moreover, the thermogravimetric（TG） analysis and photoluminescent property of 1 were also discussed.
