Aim and Method Comparative molecular field analysis (CoMFA), a threedimensional quantitative structure-activity relationship (3D-QSAR) method was applied to a novelseries of C-3 substituted 4, 6-dichloioindole-2-carbo...Aim and Method Comparative molecular field analysis (CoMFA), a threedimensional quantitative structure-activity relationship (3D-QSAR) method was applied to a novelseries of C-3 substituted 4, 6-dichloioindole-2-carboxylic acids to study the relationship betweentheir structure and the affinity for the glycine site of the NMDA receptor. Result Hie coefficientsof cross-validation q^2 and non cross-validation r^2 for the model established by the study are0.744 and 0.993, respectively, the value of variance ratio F is 261.343, and standard error estimate(SE) is 0.039. Conclusion These values indicate that the CoMFA model may have a good prediction forthe activity of C-3 substituted 4, 6-dichloroin-dole-2-carboxylic acids. As a consequence, thepredicted activity values of new designed compounds supports our conclusion from the model.展开更多
A developed stereo particle image velocimetry(stereo-PIV) system was proposed to measure three-dimensional(3D) soil deformation around a laterally loaded pile in sand.The stereo-PIV technique extended 2D measurement t...A developed stereo particle image velocimetry(stereo-PIV) system was proposed to measure three-dimensional(3D) soil deformation around a laterally loaded pile in sand.The stereo-PIV technique extended 2D measurement to 3D based on a binocular vision model,where two cameras with a well geometrical setting were utilized to image the same object simultaneously.This system utilized two open software packages and some simple programs in MATLAB,which can easily be adjusted to meet user needs at a low cost.The failure planes form an angle with the horizontal line,which are measured at 27°-29°,approximately three-fourths of the frictional angle of soil.The edge of the strain wedge formed in front of the pile is an arc,which is slightly different from the straight line reported in the literature.The active and passive influence zones are about twice and six times of the diameter of the pile,respectively.The test demonstrates the good performance and feasibility of this stereo-PIV system for more advanced geotechnical testing.展开更多
文摘Aim and Method Comparative molecular field analysis (CoMFA), a threedimensional quantitative structure-activity relationship (3D-QSAR) method was applied to a novelseries of C-3 substituted 4, 6-dichloioindole-2-carboxylic acids to study the relationship betweentheir structure and the affinity for the glycine site of the NMDA receptor. Result Hie coefficientsof cross-validation q^2 and non cross-validation r^2 for the model established by the study are0.744 and 0.993, respectively, the value of variance ratio F is 261.343, and standard error estimate(SE) is 0.039. Conclusion These values indicate that the CoMFA model may have a good prediction forthe activity of C-3 substituted 4, 6-dichloroin-dole-2-carboxylic acids. As a consequence, thepredicted activity values of new designed compounds supports our conclusion from the model.
基金Project(104244) supported by the Natural Sciences and Engineering Research Council of Canada
文摘A developed stereo particle image velocimetry(stereo-PIV) system was proposed to measure three-dimensional(3D) soil deformation around a laterally loaded pile in sand.The stereo-PIV technique extended 2D measurement to 3D based on a binocular vision model,where two cameras with a well geometrical setting were utilized to image the same object simultaneously.This system utilized two open software packages and some simple programs in MATLAB,which can easily be adjusted to meet user needs at a low cost.The failure planes form an angle with the horizontal line,which are measured at 27°-29°,approximately three-fourths of the frictional angle of soil.The edge of the strain wedge formed in front of the pile is an arc,which is slightly different from the straight line reported in the literature.The active and passive influence zones are about twice and six times of the diameter of the pile,respectively.The test demonstrates the good performance and feasibility of this stereo-PIV system for more advanced geotechnical testing.
