FDM技术在熔模铸造生产中的运用

ProCAST模拟软件和3D打印技术可以用于熔模铸造新产品开发,有效改善成本高、周期长的现状。首先,采用UG软件建立零件和浇注系统三维模型,运用ProCAST软件对零件的工艺方案进行模拟;其次,采用FDM成型工艺ABS材质打印零件模型,并将ABS模型和蜡质浇注系统组树;最后,通过熔模铸造制壳、脱蜡、焙烧、浇注等流程制备铸件,用三坐标测量仪和粗超度仪检测铸件。结果表明,该工艺铸件尺寸精度达到CT6,表面粗糙度低于Ra6.8μm以下。

Fused deposition modeling 3D printed oral famotidine pulsatile release tablets

The aim of this study was to prepare pulsatile release tablets which provide different drug delayed-release time and realize personalized administration according to the needs of patients.Fused deposition modeling(FDM)3D printing technology was introduced into the field of pharmaceutics in this study,and the feasibility to prepare core-shell pulsatile release tablets was explored by combing 3D printing technology with the traditional manufacturing technology.The core of the pulsatile tablets was a commercial tablet obtained from the traditional technology,and the drug-free shell was prepared by the FDM 3D printing technology.Three kinds of tablet shells were designed using different parameters.Furthermore,the morphology,size,weight,hardness,and in vitro drug release of the 3D printed famotidine pusatile tablets were characterized and evaluated.The results showed that the 3D printed tablets appeared intact without any defects.Different parameters of outer shell affected the size,weight,hardness,and in vitro drug release of the tablets.The tablets achieved a personalized delayed release time varying from 5 to 7 h in vitro.In this way,a new method for preparing pulsatile release tablets and a new way for the personalized administration of pulsatile tablets were explored in this study.