This paper reports that in the presence of cetyltrimethyl ammonium bromide as phase transfer catalyst,D-glucosamine hydrochloride reacts with 2,4-dinitrophenol to synthesize 1-O-(2’,4’-dinitrophenyl)-2-acetamido-β-...This paper reports that in the presence of cetyltrimethyl ammonium bromide as phase transfer catalyst,D-glucosamine hydrochloride reacts with 2,4-dinitrophenol to synthesize 1-O-(2’,4’-dinitrophenyl)-2-acetamido-β-D-glucoside.Chemical structure of the new compound was confirmed by elemental analysis,IR and UV.展开更多
目的探讨α-L-岩藻糖苷酶(AFU)、N-乙酰β-D-氨基葡萄糖苷酶(NAG)和β2-微球蛋白(β2-MG)检测对高血压早期肾损伤的诊断价值。方法 160例原发性高血压患者作为实验组,根据血压测试结果将高血压患者分为Ⅰ组[血压140-159/90-99 mm...目的探讨α-L-岩藻糖苷酶(AFU)、N-乙酰β-D-氨基葡萄糖苷酶(NAG)和β2-微球蛋白(β2-MG)检测对高血压早期肾损伤的诊断价值。方法 160例原发性高血压患者作为实验组,根据血压测试结果将高血压患者分为Ⅰ组[血压140-159/90-99 mm Hg(1 mm Hg=0.133 kPa),72例],Ⅱ组(血压≥160/100 mm Hg,84例);根据病程将高血压患者分为A组(〈10年,43例),B组(10-20年,70例C组(〉20年,47例);根据尿常规检查将高血压患者分为无蛋白尿组(60例)和有蛋白尿组(96例)。本院同期健康体检人群160例作为对照组,测定各组研究对象尿液中AFU、NAG、β2-MG及血清中血尿素氮(BUN)、血肌酐(Cr)含量并进行比较,分析各组人群中AFU、NAG、β2-MG、BUN、Cr异常检出率。结果实验组各亚组患者AFU、NAG和β2-MG含量均高于对照组(P〈0.05),BUN、Cr各组间比较差异无统计学意义(P〉0.05)。AFU、NAG和β2-MG在160例高血压患者中单项异常检出率分别为70.00%65.63%、66.88%;三项指标联合异常检出率为95.63%,明显高于各单项检出阳性率(P〈0.05)。结论 AFU NAG及β2-MG是早期肾损伤的标志物,三者联合检测可提高高血压肾脏早期病变的灵敏度。展开更多
文摘This paper reports that in the presence of cetyltrimethyl ammonium bromide as phase transfer catalyst,D-glucosamine hydrochloride reacts with 2,4-dinitrophenol to synthesize 1-O-(2’,4’-dinitrophenyl)-2-acetamido-β-D-glucoside.Chemical structure of the new compound was confirmed by elemental analysis,IR and UV.
文摘目的探讨α-L-岩藻糖苷酶(AFU)、N-乙酰β-D-氨基葡萄糖苷酶(NAG)和β2-微球蛋白(β2-MG)检测对高血压早期肾损伤的诊断价值。方法 160例原发性高血压患者作为实验组,根据血压测试结果将高血压患者分为Ⅰ组[血压140-159/90-99 mm Hg(1 mm Hg=0.133 kPa),72例],Ⅱ组(血压≥160/100 mm Hg,84例);根据病程将高血压患者分为A组(〈10年,43例),B组(10-20年,70例C组(〉20年,47例);根据尿常规检查将高血压患者分为无蛋白尿组(60例)和有蛋白尿组(96例)。本院同期健康体检人群160例作为对照组,测定各组研究对象尿液中AFU、NAG、β2-MG及血清中血尿素氮(BUN)、血肌酐(Cr)含量并进行比较,分析各组人群中AFU、NAG、β2-MG、BUN、Cr异常检出率。结果实验组各亚组患者AFU、NAG和β2-MG含量均高于对照组(P〈0.05),BUN、Cr各组间比较差异无统计学意义(P〉0.05)。AFU、NAG和β2-MG在160例高血压患者中单项异常检出率分别为70.00%65.63%、66.88%;三项指标联合异常检出率为95.63%,明显高于各单项检出阳性率(P〈0.05)。结论 AFU NAG及β2-MG是早期肾损伤的标志物,三者联合检测可提高高血压肾脏早期病变的灵敏度。