4substituted ethyl2methyl6,7methylenedioxy3quinolinecarboxylate was prepared from 3,4methylenedioxy-phenylketones Ⅳ,yield of Ⅳa-Ⅳd is 74～87%.The synthetic route consists of acylation,nitration,...4substituted ethyl2methyl6,7methylenedioxy3quinolinecarboxylate was prepared from 3,4methylenedioxy-phenylketones Ⅳ,yield of Ⅳa-Ⅳd is 74～87%.The synthetic route consists of acylation,nitration,reduction and condensation.Moleculor structures of Ⅳa～Ⅳd were determined by IR,1H NMR and MS.展开更多
Objective To investigate whether 3,4-methylenedioxymethamphetamine (MDMA) abuse produces another neurotoxicity which may significantly inhibit the acetylcholinesterase activity and result in severe oxidative damage an...Objective To investigate whether 3,4-methylenedioxymethamphetamine (MDMA) abuse produces another neurotoxicity which may significantly inhibit the acetylcholinesterase activity and result in severe oxidative damage and liperoxidative damage to MDMA abusers. Methods 120 MDMA abusers (MA) and 120 healthy volunteers (HV) were enrolled in an independent sample control design, in which the levels of lipoperoxide (LPO) in plasma and erythrocytes as well as the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and acetylcholinesterase (AChE) in erythrocytes were determined by spectrophotometric methods. Results Compared with the average values of biochemical parameters in the HV group, those of LPO in plasma and erythrocytes in the MA group were significantly increased (P<0.0001), while those of SOD, CAT, GPX and AChE in erythrocytes in the MA group were significantly decreased (P<0.0001). The Pearson product-moment correlation analysis between the values of AChE and biochemical parameters in 120 MDMA abusers showed that significant linear negative correlation was present between the activity of AChE and the levels of LPO in plasma and erythrocytes (P<0.0005-0.0001), while significant linear positive correlation was observed between the activity of AchE and the activities of SOD, CAT and GPX (P<0.0001). The reliability analysis for the above biochemical parameters reflecting oxidative and lipoperoxidative damages in MDMA abusers suggested that the reliability coefficient (alpha) was 0.8124, and that the standardized item alpha was 0.9453. Conclusion The findings in the present study suggest that MDMA abuse can induce another neurotoxicity that significantly inhibits acetylcholinesterase activity and aggravates a series of free radical chain reactions and oxidative stress in the bodies of MDMA abusers, thereby resulting in severe neural, oxidative and lipoperoxidative damages in MDMA abusers.展开更多
The title complex chloro(p-toluidine)[4-(p-tolyl)imino-2-pentanone-3-oximato]- palladium(Ⅱ), PdCl(p-CH3C6H4NH2)(p-CH3C6H4-iai), C19H22ClN3O2Pd, (p-CH3C6H4NH2 and p-CH3C6H4-iai- are p-toluidine and the anion of 4-(p-t...The title complex chloro(p-toluidine)[4-(p-tolyl)imino-2-pentanone-3-oximato]- palladium(Ⅱ), PdCl(p-CH3C6H4NH2)(p-CH3C6H4-iai), C19H22ClN3O2Pd, (p-CH3C6H4NH2 and p-CH3C6H4-iai- are p-toluidine and the anion of 4-(p-tolyl)imino-2-pentanone-3-oximato, respec- tively), crystallizes in the monoclinic system, space group C2/c with a = 26.082(5), b = 13.521(3), c = 12.578(3) ? b = 112.18(3), Mr = 466.25, V = 4108(2) 3, Dc = 1.508 g/cm3, F(000) = 1888, m(MoKa) = 1.051 mm-1, Z = 8, the final R = 0.0368 and wR = 0.0855 for 3243 observed reflections (I ≥ 2s(I)). The coordination environment around Pd is a distorted PdClN3 square-plane composed of imino- and oximo-nitrogen from the Schiff base ligand of p-CH3C6H4-iai-, and amino-nitrogen from p-toluidine and chlorine atom.展开更多
文摘4substituted ethyl2methyl6,7methylenedioxy3quinolinecarboxylate was prepared from 3,4methylenedioxy-phenylketones Ⅳ,yield of Ⅳa-Ⅳd is 74～87%.The synthetic route consists of acylation,nitration,reduction and condensation.Moleculor structures of Ⅳa～Ⅳd were determined by IR,1H NMR and MS.
文摘Objective To investigate whether 3,4-methylenedioxymethamphetamine (MDMA) abuse produces another neurotoxicity which may significantly inhibit the acetylcholinesterase activity and result in severe oxidative damage and liperoxidative damage to MDMA abusers. Methods 120 MDMA abusers (MA) and 120 healthy volunteers (HV) were enrolled in an independent sample control design, in which the levels of lipoperoxide (LPO) in plasma and erythrocytes as well as the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and acetylcholinesterase (AChE) in erythrocytes were determined by spectrophotometric methods. Results Compared with the average values of biochemical parameters in the HV group, those of LPO in plasma and erythrocytes in the MA group were significantly increased (P<0.0001), while those of SOD, CAT, GPX and AChE in erythrocytes in the MA group were significantly decreased (P<0.0001). The Pearson product-moment correlation analysis between the values of AChE and biochemical parameters in 120 MDMA abusers showed that significant linear negative correlation was present between the activity of AChE and the levels of LPO in plasma and erythrocytes (P<0.0005-0.0001), while significant linear positive correlation was observed between the activity of AchE and the activities of SOD, CAT and GPX (P<0.0001). The reliability analysis for the above biochemical parameters reflecting oxidative and lipoperoxidative damages in MDMA abusers suggested that the reliability coefficient (alpha) was 0.8124, and that the standardized item alpha was 0.9453. Conclusion The findings in the present study suggest that MDMA abuse can induce another neurotoxicity that significantly inhibits acetylcholinesterase activity and aggravates a series of free radical chain reactions and oxidative stress in the bodies of MDMA abusers, thereby resulting in severe neural, oxidative and lipoperoxidative damages in MDMA abusers.
基金Supported by the Natural Science Foundation of Fujian province (No. E0110010)
文摘The title complex chloro(p-toluidine)[4-(p-tolyl)imino-2-pentanone-3-oximato]- palladium(Ⅱ), PdCl(p-CH3C6H4NH2)(p-CH3C6H4-iai), C19H22ClN3O2Pd, (p-CH3C6H4NH2 and p-CH3C6H4-iai- are p-toluidine and the anion of 4-(p-tolyl)imino-2-pentanone-3-oximato, respec- tively), crystallizes in the monoclinic system, space group C2/c with a = 26.082(5), b = 13.521(3), c = 12.578(3) ? b = 112.18(3), Mr = 466.25, V = 4108(2) 3, Dc = 1.508 g/cm3, F(000) = 1888, m(MoKa) = 1.051 mm-1, Z = 8, the final R = 0.0368 and wR = 0.0855 for 3243 observed reflections (I ≥ 2s(I)). The coordination environment around Pd is a distorted PdClN3 square-plane composed of imino- and oximo-nitrogen from the Schiff base ligand of p-CH3C6H4-iai-, and amino-nitrogen from p-toluidine and chlorine atom.
