The solvents for the separation of diphenyl and 4-phenylacetophenone were screened with computer according to the solid-liquid equilibrium equation based on UNIFAC.With the predicted separation factor values and selec...The solvents for the separation of diphenyl and 4-phenylacetophenone were screened with computer according to the solid-liquid equilibrium equation based on UNIFAC.With the predicted separation factor values and selection principle for feasible solvents,the candidates of better solvents were determined as n-heptane,n-hexane,cyclohexane and diisopropyl ether.The solubility and separation factor of the two solid solutes in n-heptane,n-hexane,cyclohexane,diisopropyl ether and ethanol were measured by static equilibrium method.The average relative deviation between the calculated separation factor and experimental data is 16.73%,indicating that the solid-liquid equilibrium equation based on UNIFAC is suitable to select the separation solvent for solid solute mixtures with similar molecule stereoscopic structures.展开更多
以联苯和乙酰氯为原料,通过傅克酰基化反应合成4-联苯乙酮,在醋酸体系中,4-联苯乙酮经Co-Mn-Br常压催化氧化,得目标产物联苯-4-甲酸。详细考察了催化剂用量、物料配比、氧气流速和反应温度对氧化反应的影响,确定较佳的工艺条件:n(Co)∶n...以联苯和乙酰氯为原料,通过傅克酰基化反应合成4-联苯乙酮,在醋酸体系中,4-联苯乙酮经Co-Mn-Br常压催化氧化,得目标产物联苯-4-甲酸。详细考察了催化剂用量、物料配比、氧气流速和反应温度对氧化反应的影响,确定较佳的工艺条件:n(Co)∶n(Mn)=1∶1,n(Co+Mn)∶n(Br)=1∶1,催化剂的用量为1.5%(原料的重量比),氧气流速为150 m L/min,反应温度80℃。在此条件下,联苯-4-甲酸产品收率为92.9%(以原料联苯计),纯度为99.5%(HPLC面积归一化法)。产物结构经过熔点、1H-NMR和MS表征。展开更多
文摘The solvents for the separation of diphenyl and 4-phenylacetophenone were screened with computer according to the solid-liquid equilibrium equation based on UNIFAC.With the predicted separation factor values and selection principle for feasible solvents,the candidates of better solvents were determined as n-heptane,n-hexane,cyclohexane and diisopropyl ether.The solubility and separation factor of the two solid solutes in n-heptane,n-hexane,cyclohexane,diisopropyl ether and ethanol were measured by static equilibrium method.The average relative deviation between the calculated separation factor and experimental data is 16.73%,indicating that the solid-liquid equilibrium equation based on UNIFAC is suitable to select the separation solvent for solid solute mixtures with similar molecule stereoscopic structures.
文摘以联苯和乙酰氯为原料,通过傅克酰基化反应合成4-联苯乙酮,在醋酸体系中,4-联苯乙酮经Co-Mn-Br常压催化氧化,得目标产物联苯-4-甲酸。详细考察了催化剂用量、物料配比、氧气流速和反应温度对氧化反应的影响,确定较佳的工艺条件:n(Co)∶n(Mn)=1∶1,n(Co+Mn)∶n(Br)=1∶1,催化剂的用量为1.5%(原料的重量比),氧气流速为150 m L/min,反应温度80℃。在此条件下,联苯-4-甲酸产品收率为92.9%(以原料联苯计),纯度为99.5%(HPLC面积归一化法)。产物结构经过熔点、1H-NMR和MS表征。
