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Synthesis and biological evaluation of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates against Eimeria tenella 被引量:5
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作者 Zhang, Yuan Yuan Zeng, Xing Yan +3 位作者 Nie, Kui Zhong, Zhi Cheng Wang, Yu Liang Wang, Yu Zhong 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第4期426-428,共3页
A series of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates were designed and synthesized.Their structures were confirmed by ~1H NMR,^(13)C NMR,IR and HRMS.The biological activities were primarily evaluated ... A series of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates were designed and synthesized.Their structures were confirmed by ~1H NMR,^(13)C NMR,IR and HRMS.The biological activities were primarily evaluated against Eimeria tenella according to Anticoccidial Index(ACI) method in vivo.The results showed that compounds 5e,5f and 5i exhibited anticoccidial activities against E.tenella at 27 mg kg^(-1). 展开更多
关键词 Ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylate Synthesis Anticoccidial activity Eimeria tenella
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Synthesis of Gingerenone C and 5-Hydroxy-1-(4′-hydroxy-3-methoxyphenyl)-7-(4′′-hydroxyphenyl)-3-heptanone 被引量:2
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作者 Shao Bai LI Yun Gen LIU 《Chinese Chemical Letters》 SCIE CAS CSCD 2003年第3期251-254,共4页
The two diarylheptanoids (E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) hept-4-en-3-one 1 (Gingerenone C) and (±)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4- hydroxyphenyl)-3-heptanone 2 were synthesized... The two diarylheptanoids (E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) hept-4-en-3-one 1 (Gingerenone C) and (±)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4- hydroxyphenyl)-3-heptanone 2 were synthesized from vanillin 3 and 4-hydroxybenzaldehyde 9. 展开更多
关键词 DIARYLHEPTANOIDS (E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hept- 4-en-3-one Gingerenone C (±)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxy- phenyl)-3-heptanone synthesis.
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Thermal Behavior, Non-isothermal Decomposition Reaction Kinetics of Copper(Ⅱ) Salt of 4-Hydroxy-3,5-dinitropyridine and Its Application in Propellant 被引量:2
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作者 CHENPei ZHAOFeng-qi +5 位作者 LUOyang HURong-zu GAOSheng-li ZHENGYu-mei DENGMin-zhi GAOYin 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2005年第1期100-103,共4页
The thermal behavior and kinetic parameters of the major exothermic decomposition reaction of the title compound in a temperature-programmed mode were studied by means of TG-DTG and DSC. The critical temperature of th... The thermal behavior and kinetic parameters of the major exothermic decomposition reaction of the title compound in a temperature-programmed mode were studied by means of TG-DTG and DSC. The critical temperature of thermal explosion was calculated. The effect of the title compound on the combustion characteristic of composition modifier double base propellant containing RDX was explored with a strand burner. The results show that the kinetic model function in differential forms, the apparent activation energy(E a) and the pre-exponential factor(A) of the major exothermic decomposition reaction are 3(1-α)[-ln(1-α)] 2/3, 190.56 kJ/mol and 10 13.39 s -1, respectively. The critical temperature of thermal explosion of the compound is 353.08 ℃. The kinetic equation of the major exothermic decomposition process of the title compound at 0.1 MPa could be expressed as dα/dT=10 14.65(1-α)[-ln(1-α)] 2/3 e -2.2920×104/T. As an auxiliary catalyzer, the title compound can help the main catalyzer of lead salt of 4-hydroxy-3,5-dinitropyridine to accelerate the burning rate and reduce the pressure exponent of RDX-CMDB propellant. 展开更多
关键词 Thermal behavior Decomposition kinetics Copper(Ⅱ) salt of 4-hydroxy-3 5-dinitropyridine Application PROPELLANT
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Synthesis of fused pyran and arylbis(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)methane in ionic liquid 被引量:2
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作者 Xue Sen Fan Ying Ying Qu Xin Ying Zhang Xia Wang Jian Ji Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第4期387-390,共4页
Promoted and mediated by an ionic liquid-[bmim][BF4], fused pyrans or arylbis(4-hydroxy-6-methyl-2-oxo-2H-pyran-3- yl)methanes were efficiently and selectively prepared from the reaction of aldehyde and 4-hydroxy-6-... Promoted and mediated by an ionic liquid-[bmim][BF4], fused pyrans or arylbis(4-hydroxy-6-methyl-2-oxo-2H-pyran-3- yl)methanes were efficiently and selectively prepared from the reaction of aldehyde and 4-hydroxy-6-methyl-2-oxo-pyran with or without acetic anhydride. By using these novel procedures, pyrimidine nucleoside-fused pyran and arylbis(pyranon-3-yl)methane hybrids with potential biological activities were constructed. 展开更多
关键词 Ionic liquid Fused pyran Arylbis(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)methane Pyrimidine nucleoside Green synthesis
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Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist inhibits apoptosis of retinal ganglion cells in a rabbit model of optic nerve injury 被引量:1
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作者 Ruijia Wang Xinping Luan Yiti Mu Hongyu Jia Jingxuan Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第10期731-735,共5页
A rabbit model of traumatic optic nerve injury, established by occlusion of the optic nerve using a vascular clamp, was used to investigate the effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid recep... A rabbit model of traumatic optic nerve injury, established by occlusion of the optic nerve using a vascular clamp, was used to investigate the effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist GYKI 52466 on apoptosis of retinal ganglion cells following nerve injury. Hematoxylin-eosin staining and a terminal deoxynucleotidyl transferase dUTP nick end labeling assay showed that retinal ganglion cells gradually decreased with increasing time of optic nerve injury, while GYKI 52466 could inhibit this process. The results demonstrate that following acute optic nerve injury, apoptosis of retinal ganglion cells is a programmed process, which can be inhibited by the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist. 展开更多
关键词 optic nerve injury retinal ganglion cells GLUTAMATE alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
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Optical 2-benzyl-5-hydroxy-4-oxopentanoic acids against carboxypeptidase A:Synthesis,kinetic evaluation and X-ray crystallographic study 被引量:1
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作者 Wang, Shou Feng Jin, Jing-Yi +1 位作者 Zeng, Zong Hao Tian, Guan Rong 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第2期159-162,共4页
2-Benzyl-5-hydroxy-4-oxopentanoic acid 1 and its enantiomers were designed,synthesized and assayed for inhibitory activity against carboxypeptidase A(CPA,EC 3.4.17.1).To verify the role of the terminal hydroxyl group ... 2-Benzyl-5-hydroxy-4-oxopentanoic acid 1 and its enantiomers were designed,synthesized and assayed for inhibitory activity against carboxypeptidase A(CPA,EC 3.4.17.1).To verify the role of the terminal hydroxyl group in 1 binding to CPA,2-benzyl-5- benzyloxy-4-oxopentanoic acid 2 was also synthesized and evaluated.The inhibition constants show that both L-1 and D-1 were shown to have strong binding affinity with L-1 being more potent than its enantiomer by 165-fold.On the other hand,the inhibition constant ... 展开更多
关键词 2-Benzyl-5-hydroxy-4-oxopentanoic acid Carboxypeptidase A X-ray crystallographic study
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Determination of trans-4-hydroxy-2-alkenals in thermally treated soybean oil by SPE-HPLC 被引量:1
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作者 Hongying Hua Shimin Wu Xin Ma 《Grain & Oil Science and Technology》 2022年第3期107-113,共7页
Trans-4-hydroxy-2-hexenal(4-HHE) and trans-4-hydroxy-2-nonenal(4-HNE) are secondary lipid peroxidation products in edible oils, which are cytotoxic and genotoxic. They could covalently bind with protein, phospholipids... Trans-4-hydroxy-2-hexenal(4-HHE) and trans-4-hydroxy-2-nonenal(4-HNE) are secondary lipid peroxidation products in edible oils, which are cytotoxic and genotoxic. They could covalently bind with protein, phospholipids and DNA, further disrupting the normal function of liver, lung and brain.Derivation process was generally conducted during pretreatment before detection and quantification of 4-HHE and 4-HNE. However, the derivation procedures were time consuming and chemical degradation may occur during the process. Hence, this paper aims to establish a simple solid phase extractionhigh performance liquid chromatography(SPE-HPLC) method to determine the 4-HHE and 4-HNE contents in thermally treated soybean oil. C18 solid phase extraction was applied in the pretreatment process. Firstly, the reliability of the method was evaluated. Good linearity was observed in the range of 0.1–0.5 μg/m L and 0.5–10 μg/m L for 4-HHE and 4-HNE. The limit of detection(LOD) of 4-HHE and 4-HNE were 0.0486 and 0.0129 μg/m L, respectively. And the limit of quantitation(LOQ) of4-HHE and 4-HNE were 0.1458 and 0.0431 μg/m L, respectively. Recovery rate were in the range of89.11%–91.58% and 71.83%–79.40% for 4-HHE and 4-HNE, respectively. The method achieved the extraction, purification and detection of 4-HHE and 4-HNE simultaneously and had the advantages of simple operation, effectiveness, high precision, good repeatability. Then, the method was applied to monitor the concentrations of 4-HHE and 4-HNE in soybean oil heated at 180 °C for 40 h. The contents of 4-HHE and 4-HNE were 0–0.32 μg/g and 0–6.97 μg/g, respectively, which provided guidance for evaluating health risks of thermally treated soybean oil during heating. 展开更多
关键词 Trans-4-hydroxy-2-hexenal Trans-4-hydroxy-2-nonenal Soybean oil
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Synthesis Hexadecyl 3-{4-[2-Hydroxy-3(isopropylamino)propoxy] phenyl}propionate as Potential Ligand for Liposome Targeting to Ischemic Myocardium 被引量:1
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作者 Yan Li HAO Ying Jie DENG +1 位作者 Yan CHEN You Cai HU 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第8期1004-1006,共3页
Novel hexadecyl 3-{4-[2-hydroxy-3(isopropylamino)propoxy]phenyl}propionate(HPP)was synthesized and its effect on delivery of liposomes into cultured cardiomyocytes was examined.The structure of HPP was characterized b... Novel hexadecyl 3-{4-[2-hydroxy-3(isopropylamino)propoxy]phenyl}propionate(HPP)was synthesized and its effect on delivery of liposomes into cultured cardiomyocytes was examined.The structure of HPP was characterized by IH NMR,1R and MS.The amount of cardiomyocytes uptake of HPP-liposome was 3.9-fold higher than plain-liposome,and the increase was 6.2-fold when hypoxia happens.It indicated that HPP was a potential ligand for liposome targeting to ischemic myocardium. 展开更多
关键词 Hexadecyl 3-{4-[2-hydroxy-3(isopropylamino)propoxy]phenyl}propionate liposome targeting ischemic myocardium.
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Localization of a defensive volatile 4-hydroxy-4-methylpentan-2-one in the capitate glandular trichomes of Oenothera glazioviana
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作者 Yanyun Tan Desen Li +3 位作者 Juan Hua Shihong Luo Yan Liu Shenghong Li 《Plant Diversity》 SCIE CAS CSCD 北大核心 2017年第3期154-159,共6页
Glandular trichomes of plants produce a wide variety of secondary metabolites which are considered as major defensive chemicals. The capitate glandular trichomes of Oenothera glazioviana(Onagraceae) were collected wit... Glandular trichomes of plants produce a wide variety of secondary metabolites which are considered as major defensive chemicals. The capitate glandular trichomes of Oenothera glazioviana(Onagraceae) were collected with laser microdissection and analyzed by gas chromatography-mass spectrometry. The volatile compound 4-hydroxy-4-methylpentan-2-one(1) was identified. We found that compound 1 displays antimicrobial, insecticidal, and phytotoxic activities. These results suggest that compound 1 might function as a defensive compound in the capitate glandular trichomes of O. glazioviana against pathogens, insect herbivores, and presumably competitive plants as well. 展开更多
关键词 Oenothera glazioviana Capitate glandular trichomes Laser microdissection 4-hydroxy-4-methylpentan-2-one Defensive functions
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First total synthesis of 10α-hydroxy-4-muurolen-3-one and its C_(10)-isomer
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作者 Fu Qiang Bi Li Jing Fang Chen Xi Zhang Yu Lin Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第11期1265-1267,共3页
An efficient synthetic route to muurolane type sesquiterpenes starting from (R)-carvone, employing allylic diazene rearrangement and the ring closing methesis (RCM) reaction as key steps, is described. The first a... An efficient synthetic route to muurolane type sesquiterpenes starting from (R)-carvone, employing allylic diazene rearrangement and the ring closing methesis (RCM) reaction as key steps, is described. The first asymmetric total synthesis of (-)-10α- hydroxy-4-muurolen-3-one 11 and (-)-10β-hydroxy-4-muurolen-3-one C was accomplished. Through the total synthesis, the absolute configurations of the natural products A, B and C were established. 展开更多
关键词 10α-hydroxy-4-muurolen-3-one 10β-hydroxy-4-muurolen-3-one Allylic diazene rearrangement RCM reaction Total synthesis
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Asymmetric Syntheses of Osmundalactones and 5-Hydroxy-2-hexen-4-olides from 4-Benzyloxy-5-hydroxy-2(E)-hexenoate
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作者 Xi Ying ZHAO Machiko ONO +1 位作者 Hiroyuki AKITA Yu Ming CHI 《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第6期727-729,共3页
(+)-(4S,5R)-and (-)-(4R,5S)-osmundalactones as well as (+)-(4R,5S)- and (-)-(4S,5R)- 5-hydroxy-2-hexen-4-olides were synthesized by a concise and efficient synthesis method starting from 4-benzyloxy-... (+)-(4S,5R)-and (-)-(4R,5S)-osmundalactones as well as (+)-(4R,5S)- and (-)-(4S,5R)- 5-hydroxy-2-hexen-4-olides were synthesized by a concise and efficient synthesis method starting from 4-benzyloxy-5-hydroxy-2(E)-hexenoate in good yield with over 99% e.e.. 展开更多
关键词 Osmundalactone 5-hydroxy-2-hexen-4-olide 4-benzyloxy-5-hydroxy-2(E)-hexenoate.
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Synthesis, Crystal Structure and Antitumor Activity of 4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)-N-(2-hydroxy-3,5-diiodinebenzyl)-thiazol-2-amine 被引量:1
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作者 叶姣 谢选青 +3 位作者 李康明 刘永超 孙利 胡艾希 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2015年第3期344-348,共5页
The title compound, 4-(tert-butyl)-5-(1 H- 1,2,4-triazol- 1 -yl)-N-(2-hydroxy-3,5-diio- dinebenzyl)thiazol-2-amine, was synthesized via the reduction of 4-(tert-butyl)-5-(1H-l,2,4- triazol-l-yl)-N-benzyliden... The title compound, 4-(tert-butyl)-5-(1 H- 1,2,4-triazol- 1 -yl)-N-(2-hydroxy-3,5-diio- dinebenzyl)thiazol-2-amine, was synthesized via the reduction of 4-(tert-butyl)-5-(1H-l,2,4- triazol-l-yl)-N-benzylidene-thiazol-2-amine with NaBH4, and its crystal structure was determined by single-crystal X-ray diffraction. The compound crystallizes in monoclinic system, space group P21/c with a = 7.91944(19), b = 10.5250(3), c = 24.4985(6) A, Z = 4, V = 2041.66(9) A3, Mr = 599.22, Dc = 1,949 Mg/m3, S = 1.120, p = 3.203 mm-1, F(000) = 1152, the final R = 0.0283 and wR = 0.0592 for 3490 observed reflections (I 〉 2σ(I)). X-ray analysis displays that the crystal water takes part in three intermolecular hydrogen bonds of O(2)-H(2A)…O(1), O(2)-H(2B)…N(I) and N(5)-H(5)…O(2), and an octatomic ring R^(8) is formed via intramolecular hydrogen bond of O(I)-H(IA)…N(4). Furthermore, the I…I contacts are involved in stabilizing the overall three-dimensional network structure. The preliminary biological test shows the title compound has good antitumor activity with the IC50 value of 26 μM against the Hela cell line. 展开更多
关键词 4-(tert-butyl)-5-(1H-1 2 4-triazol-1-yl)-N-(2-hydroxy-3-5-diiodinebenzyl)-thiazol-2-amine synthesis crystal structure antitumor activity
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A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl) butanoates from malic acid
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作者 Yong Zhang M. NaseerA. Khan +1 位作者 Ping Gong Yong Sup Lee 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第8期898-900,共3页
A synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates has been accomplished using Friedel-Crafts acylation of substituted benzenes with 2-acetoxybutanoyl chloride. The key feature of this strategy i... A synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates has been accomplished using Friedel-Crafts acylation of substituted benzenes with 2-acetoxybutanoyl chloride. The key feature of this strategy is that various 4-arylbutanoates can be obtained conveniently, which are important intermediates for the synthesis of biologically active compounds including ACE inhibitors.?2009 Yong Sup Lee. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. 展开更多
关键词 2-hydroxy-4-oxo-4-phcnylbutanoatcs Malic acid Fricdel-Crafts reaction
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Catalytic Dehydration of 4-Hydroxy-3-hexanone to 4-Hexen-3-one over HZSM-5 Zeolite
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作者 Huang Kai Zheng Haitao Tao Keyi 《China Petroleum Processing & Petrochemical Technology》 SCIE CAS 2013年第4期87-91,共5页
A study on catalytic dehydration of 4-hydroxy-3-hexanone (HH) to 4-hexen-3-one (HO) was carried out through conversion of HH over HZSM-5 zeolite catalyst in a fixed-bed reactor (FBR) operating under almospheric ... A study on catalytic dehydration of 4-hydroxy-3-hexanone (HH) to 4-hexen-3-one (HO) was carried out through conversion of HH over HZSM-5 zeolite catalyst in a fixed-bed reactor (FBR) operating under almospheric pressure. The test indicated a relatively high activity of the HZSM-5 zeolite capable of achieving a HH conversion of 99.2% and a HO yield of 83.5%. Catalyst deactivation could be prevented by increasing the reaction temperature by 10 "C for every 20 h and adding 2.0% of piperidine in the feed. A catalyst stability test (for 100 h) in FBR showed that the catalyst was active even after 100 h of time-on-stream with HH conversion remaining at 99.2% and HO yield still reaching over 83.5%. Regenera- tion experiment showed that the regenerated catalyst demonstrated a catalytic performance comparable to the fresh one. 展开更多
关键词 HZSM-5 DEHYDRATION 4-hydroxy-3-hexanone DEACTIVATION regeneration
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Highly efficient synthesis of(R)-1,3-butanediol via anti-Prelog reduction of 4-hydroxy-2-butanone with absolute stereoselectivity by a newly isolated Pichia kudriavzevii
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作者 Han Zu Hui Zhang +4 位作者 Anwen Fan Jie Gu Yao Nie Pengjie Luo Yan Xu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2020年第8期2160-2166,共7页
(R)-1,3-butanediol is an important pharmaceutical intermediate, and the synthesis of(R)-1,3-butanediol using green biological methods has recently been of interest for industrial application. Here, a novel strain QC-1... (R)-1,3-butanediol is an important pharmaceutical intermediate, and the synthesis of(R)-1,3-butanediol using green biological methods has recently been of interest for industrial application. Here, a novel strain QC-1 that efficiently transforms 4-hydroxy-2-butanone to(R)-1,3-butanediol was isolated from soil samples. Based on morphological, physiological, and biochemical tests and 5.8 S-internal transcribed spacer sequencing, the strain was identified as Pichia kudriavzevii QC-1. The reaction conditions were optimized to 35 ℃, pH 8.0, rotation speed 200 rpm, and 6:5 mass ratio of glucose to 4-hydroxy-2-butanone. Evaluation of the effects of 4-hydroxy-2-butanone concentrations on yield and cell survival rate showed that 85.60 g·L^-1 product accumulated, with an enantiomeric excess of more than 99%, when 30 g·L^-14-hydroxy-2-butanone was added at 0, 10, and 30 h in a 3-L bioreactor. Thus, strain QC-1 showed excellent catalytic activity and stereoselectivity for the synthesis of(R)-1,3-butanediol from 4-hydroxy-2-butanone. 展开更多
关键词 Asymmetric reduction STEREOSELECTIVITY (R)-1 3-butanediol 4-hydroxy-2-butanone Whole-cell catalysis
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The new antioxidant 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2- dihydroquinoline has a protective effect against carbon tetrachloride-induced hepatic injury in rats
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作者 Evgenii Dmitrievich Kryl'skii Darya Andreevna Sinitsyna +4 位作者 Tatyana Nikolaevna Popova Khidmet Safarovich Shikhaliev Svetlana Mikhajlovna Medvedeva Larisa Vladimirovna Matasova Valentina Olegovna Mittova 《The Journal of Biomedical Research》 CAS CSCD 2022年第6期423-434,共12页
Liver diseases with the central pathogenetic mechanism of oxidative stress are one of the main causes of mortality worldwide.Therefore,dihydroquinoline derivatives,which are precursors of hepatoprotectors and have ant... Liver diseases with the central pathogenetic mechanism of oxidative stress are one of the main causes of mortality worldwide.Therefore,dihydroquinoline derivatives,which are precursors of hepatoprotectors and have antioxidant activity,are of interest.We have previously found that some compounds in this class have the ability to normalize redox homeostasis under experimental conditions.Here,we initially analyzed the hepatoprotective potential of the dihydroquinoline derivative 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline(BHDQ)for carbon tetrachloride(CCl4)-induced liver injury in rats.Results suggested that BHDQ normalized the alanine aminotransferase,aspartate aminotransferase,and gamma-glutamyl transpeptidase in serum.We also observed an improvement in liver tissue morphology related to BHDQ.Animals with CCl4-induced liver injuries treated with BHDQ had less oxidative stress compared to animals with CCl4-induced liver injury.BHDQ promoted activation changes in superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase,and glutathione transferase on control values in animals with CCl4-induced liver injury.BHDQ also activated gene transcription in Sod1 and Gpx1 via nuclear factor erythroid 2-related factor 2 and forkhead box protein O1 factors.Therefore,the compound of concern has a hepatoprotective effect by inhibiting the development of necrotic processes in the liver tissue,through antioxidation. 展开更多
关键词 CCl4-induced hepatic injury oxidative stress 1-benzoyl-6-hydroxy-2 2 4-trimethyl-1 2-dihydroquinoline antioxidants
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Synthesis and Crystal Structure of [2-Hydroxy-5-(4-hydroxy-3-phenyliminomethyl-benzyl)-benzylidene]-phenyl-amine
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作者 丁瑜 库宗军 +2 位作者 周环波 余华莉 高大顺 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2009年第6期699-702,共4页
The title compound [2-hydroxy-5-(4-hydroxy-3-phenyliminomethyl-benzyl)-benzylidene]-phenyl-amine (C27H22N2O2, Mr = 406.47) was synthesized by 5,5′-methylene-bissalicylal- dehyde with aminobenezene, and its crysta... The title compound [2-hydroxy-5-(4-hydroxy-3-phenyliminomethyl-benzyl)-benzylidene]-phenyl-amine (C27H22N2O2, Mr = 406.47) was synthesized by 5,5′-methylene-bissalicylal- dehyde with aminobenezene, and its crystal structure was determined by single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group C2/c with a = 4.4026(6), b = 1.501(13), c = 0.95818(12) nm, β = 90.868(2)°, V= 4.2813(9) nm^3, Z= 8, Dc= 1.292 g/cm^3,μ = 0.010, F(000) = 1744, R = 0.0576 and wR = 0.1450 for 3766 observed reflections with I 〉 2σ(I). X-ray analysis reveals that the molecule has a pair of intramolecular OH…N hydrogen bonds. 展开更多
关键词 synthesis crystal structure [2-hydroxy-5-(4-hydroxy-3-phenyUminomethylbenzyl)- benzylidene]-phenyl-amine
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Synthesis of 1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one
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作者 Ming Zhao ZHU Shao Bat LI +1 位作者 Qiang GAO Guo Lin ZHANG(National Laboratory of Applied Organic Chemistry and institute of Organic Chemistry,Lanzhou University, Lanzhou 730000)(Laboratory of Materia Medica, Chengdu Institute of Biology, Chinese Academy of Sci 《Chinese Chemical Letters》 SCIE CAS CSCD 1999年第11期917-918,共2页
A facile synthesis of the analog of curcumin. 1,7-bis (4-hydroxyphenyl)-3-hydroxy-1.3-heptadien-5-one 1 was achieved. The key step was completed through the regioselective condensation of ketone 5 and acyl chloride 7.
关键词 1 7-bis(4-hydroxyphenyl)-3-hydroxy-1 3-heptadien-5-one regioselectivity synthesis
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A Facile Synthesis of 6β-Hydroxy-7α(H)-eudesma-4-en-3-one
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作者 Gang ZHOU Zhao Ming XIONG +1 位作者 Yong Gang CHEN Yu Lin LI (National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry,Lanzhou University, Lanzhou 730000) 《Chinese Chemical Letters》 SCIE CAS CSCD 1998年第9期817-818,共2页
A stereoselective total synthesis of 6β-hydroxy-7α(H)-eudesma-4-en-3- 1startingfrom (+)-dihydrocarvone 7 has been described.
关键词 synthesis SESQUITERPENE -hydroxy-7α(H)-eudesm-4-en-3-one sihydrocarvone
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Formation of (2E)-4-Hydroxy-2-nonenal and (2E)-4-Hydroxy-2-hexenal by Plant Enzymes: A Review Suggests a Role in the Physiology of Plants
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作者 Harold W. Gardner 《Advances in Enzyme Research》 CAS 2016年第2期56-61,共6页
It is demonstrated that (3Z)-nonenal (NON) and (3Z)-hexenal (HEX) are oxidized in a cascade by lipoxygenase (LOX) and hydroperoxide peroxygenase (HP peroxygenase) into (2E)-4-hydroxy-2- nonenal (HNE) and (2E)-4-hydrox... It is demonstrated that (3Z)-nonenal (NON) and (3Z)-hexenal (HEX) are oxidized in a cascade by lipoxygenase (LOX) and hydroperoxide peroxygenase (HP peroxygenase) into (2E)-4-hydroxy-2- nonenal (HNE) and (2E)-4-hydroxy-2-hexenal (HHE), respectively. In turn, HNE inactivates LOX terminating the cascade. The hydroxy-alkenals produced serve to inhibit plant pathogens, which initiated the cascade. In addition to LOX, other unknown oxygenases may be involved in the cascade. 展开更多
关键词 (3Z)-Nonenal (3Z)-Hexenal (2E)-4-hydroxy-2-nonenal (2E)-4-hydroxy-2-hexenal (2E)-4-Hydroperoxy-2-hexenal LIPOXYGENASE Hydroperoxide Peroxygenase Hydroperoxide Lyase (2E)-4-Hydroperoxy-2-Nonenal 3 4-Epoxynonanal (2E)-4-Oxo-2-nonenal Glycine max Vica faba Plant Pathogen
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