4-Hydroxybenzoate （4HBA） is a naturally occurring aromatic compound, as a key intermediate metabolite not only for natural products but also for arti- ficial products. There are four metabolic pathways for 4HBA： pr...4-Hydroxybenzoate （4HBA） is a naturally occurring aromatic compound, as a key intermediate metabolite not only for natural products but also for arti- ficial products. There are four metabolic pathways for 4HBA： protocatechuate cleavage pathway; catechol cleavage pathway; anaerobic degradation pathway in anaerobes ; and gentisate cleavage pathway. The last pathway including a NIH shift reaction remains to be elucidated. In this review we emphasized on the NIH shift reaction involved in the 4HBA degrdation. The key enzymes of each 4HBA metabolic pathway also were introduced. Finnaly, we described the thermophilic Bacillus sp. B1 strain which was capable of degrading varous aromatic compounds including gHBA, and presented a direction for the research of NIH shift reaction.展开更多
基金Supported by the National Natural Science Foundation of China(31400099)Jiangsu Science and Technology Agency Project(BK20141148 and BK20140235)Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
文摘4-Hydroxybenzoate （4HBA） is a naturally occurring aromatic compound, as a key intermediate metabolite not only for natural products but also for arti- ficial products. There are four metabolic pathways for 4HBA： protocatechuate cleavage pathway; catechol cleavage pathway; anaerobic degradation pathway in anaerobes ; and gentisate cleavage pathway. The last pathway including a NIH shift reaction remains to be elucidated. In this review we emphasized on the NIH shift reaction involved in the 4HBA degrdation. The key enzymes of each 4HBA metabolic pathway also were introduced. Finnaly, we described the thermophilic Bacillus sp. B1 strain which was capable of degrading varous aromatic compounds including gHBA, and presented a direction for the research of NIH shift reaction.
