Poly (3, 4-ethylenedioxythiophene) (PEDOT), together with its dopes, such as poly (styrene sulfonate) (PSS), has been acknowledged to have a wide range of biomedical applications as an important conducting pol...Poly (3, 4-ethylenedioxythiophene) (PEDOT), together with its dopes, such as poly (styrene sulfonate) (PSS), has been acknowledged to have a wide range of biomedical applications as an important conducting polymer. In this study, gelatin can be polymerized into PEDOT/PSS polymers on indium tin oxide (ITO)-coated glass. PEDOT/PSS/gelatin layer on ITO-coated glass significantly decreases electrochemical impedance spectroscopy (EIS) and increases charge delivery capacity relative to the gelatin layer and bare ITO- coated glass, comparable to the PEDOT/PSS layer on ITO-coated glass. PEDOT/PSS/gelatin layer on ITO- coated glass enhances pheochromocytoma (PC 12) cell affinity, possesses a high biocompatibility and promotes PC 12 cell growth by delivery of electrical stimulation. These results suggest that gelatin can be incorporated into the PEDOT/PSS polymers through electrochemical polymerization and the PEDOT/PSS/gelatin layer on ITO-coated glass possesses high electrochemical and biological activities.展开更多
基金Funded by National Natural Science Foundation of China(Nos.11179015,51173108)Innovation Program of Shanghai Municipal Education Commission(No.12ZZ143)
文摘Poly (3, 4-ethylenedioxythiophene) (PEDOT), together with its dopes, such as poly (styrene sulfonate) (PSS), has been acknowledged to have a wide range of biomedical applications as an important conducting polymer. In this study, gelatin can be polymerized into PEDOT/PSS polymers on indium tin oxide (ITO)-coated glass. PEDOT/PSS/gelatin layer on ITO-coated glass significantly decreases electrochemical impedance spectroscopy (EIS) and increases charge delivery capacity relative to the gelatin layer and bare ITO- coated glass, comparable to the PEDOT/PSS layer on ITO-coated glass. PEDOT/PSS/gelatin layer on ITO- coated glass enhances pheochromocytoma (PC 12) cell affinity, possesses a high biocompatibility and promotes PC 12 cell growth by delivery of electrical stimulation. These results suggest that gelatin can be incorporated into the PEDOT/PSS polymers through electrochemical polymerization and the PEDOT/PSS/gelatin layer on ITO-coated glass possesses high electrochemical and biological activities.