In the present study, the performance of a 4-stroke diesel engine was experimentally evaluated upon adding Al2O3 or SiO2 nanoparticles to the engine oil （SAEISW40）. The viscosity and density of the resulting nanolub...In the present study, the performance of a 4-stroke diesel engine was experimentally evaluated upon adding Al2O3 or SiO2 nanoparticles to the engine oil （SAEISW40）. The viscosity and density of the resulting nanolubricants were determined while varying both the nanoparticle volume fraction and the temperature. Field emission scanning electron microscopy （FE-SEM） showed that the nanoparticles had a spherical morphology and dynamic light scattering analysis determined some aggregation of the nanoparticles in the engine oil. A pin-on-disc test apparatus was used for friction and wear analysis in the presence of the nanolubricants. Examination of wear scars by FE-SEM and energy dispersive spectroscopy found evidence of ball bearing and surface polishing effects, which were responsible for improvements in the tribological properties of the oil. The performance of these nanolubricants in a 4- stroke diesel engine test rig was assessed, and the greatest improvements in the tribological behavior and engine performance were observed when employing 0.3 vol% Al2O3.展开更多
目的探究急性缺血性脑卒中(AIS)患者血清间α胰蛋白酶抑制因子重链4(ITIH4)、髓样细胞白血病因子-1(MCL-1)表达与病情程度及预后的关系。方法纳入2019年7月—2022年7月河南科技大学附属黄河医院神经内科诊治AIS患者128例为AIS组。根据...目的探究急性缺血性脑卒中(AIS)患者血清间α胰蛋白酶抑制因子重链4(ITIH4)、髓样细胞白血病因子-1(MCL-1)表达与病情程度及预后的关系。方法纳入2019年7月—2022年7月河南科技大学附属黄河医院神经内科诊治AIS患者128例为AIS组。根据入院时美国国立卫生研究院卒中量表(NIHSS)评分,分为轻度亚组(NIHSS<6分,n=42)、中度亚组(NIHSS 6~<14分,n=52)和重度亚组(NIHSS≥14分,n=34)。根据出院3个月时AIS患者改良Rankins评分,分为预后不良亚组(mRS评分>2分,30例)和预后良好亚组(mRS评分≤2分,98例)。另选取同期医院体检的健康人70例为健康对照组。酶联免疫吸附试验检测血清ITIH4、MCL-1水平。Pearson相关分析血清ITIH4、MCL-1水平与病情程度及预后的相关性;多因素Logistic回归分析影响AIS患者预后的因素;受试者工作特征曲线分析血清ITIH4、MCL-1对AIS患者预后的预测价值。结果AIS组患者血清ITIH4、MCL-1水平显著低于健康对照组(t/P=43.211/<0.001,43.191/<0.001);病情程度越重,AIS患者血清ITIH4/MCL-1水平越低(F/P=107.796/<0.001,297.976/<0.001);预后不良亚组梗死面积、入院24 h NIHSS评分高于预后良好亚组(t/P=9.637/<0.001,9.752/<0.001),血清ITIH4、MCL-1水平及出院3个月简易智能状态量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分低于预后良好亚组(t/P=26.723/<0.001,11.709/<0.001,13.674/<0.001,10.782/<0.001);AIS患者血清ITIH4、MCL-1与梗死面积、入院24 h NIHSS评分呈负相关(r/P=-0.705/<0.001,-0.685/<0.001;-0.761/<0.001,-0.619/<0.001),与出院3个月MMSE评分、MoCA评分呈正相关(r/P=0.656/<0.001,0.632/<0.001;0.751/<0.001,0.789/<0.001);出院3个月MMSE评分高、出院3个月MoCA评分高是影响AIS患者预后不良的独立保护因素[0.622(0.446~0.868),0.606(0.427~0.861)],血清ITIH4低、MCL-1低、梗死面积大、入院24 h NIHSS评分高是危险因素[OR(95%CI)=1.467(1.150~1.870),1.415(1.094~1.829),1.605(1.168~2.205),1.765(1.233~2.526)];血清ITIH4、MCL-1及两项联合预测AIS预后不良的AUC分别为0.811、0.835、0.923,两项联合预测AIS预后不良的AUC大于单一指标,差异具有统计学意义(Z=4.258、4.119,P均<0.001)。结论AIS患者血清ITIH4、MCL-1表达下调,两者表达水平与病情严重程度有关,两者联合对AIS患者预后具有较高的预测价值。展开更多
目的探讨急性缺血性脑卒中(acute ischemic stroke,AIS)患者视黄醇结合蛋白4(retinolbinding protein 4,RBP4)水平与脑梗死体积的关系以及对病情严重程度的预测价值。方法前瞻性纳入2016年8月至2018年8月收治的130例首发AIS患者和同期10...目的探讨急性缺血性脑卒中(acute ischemic stroke,AIS)患者视黄醇结合蛋白4(retinolbinding protein 4,RBP4)水平与脑梗死体积的关系以及对病情严重程度的预测价值。方法前瞻性纳入2016年8月至2018年8月收治的130例首发AIS患者和同期100例健康人群作为研究对象。采用Pearson相关分析法分析血清RBP4水平与脑梗死体积的相关性。采用多元线性回归分析影响AIS患者出院6个月后病情严重程度的因素。结果对照组、不明原因脑卒中、大动脉粥样硬化型脑卒中、心源型脑卒中、小动脉闭塞型脑卒中患者RBP4水平分别为[(22.05±6.41)mg/L,n=100]、[(25.56±6.05)mg/L,n=52]、[(27.85±6.38)mg/L,n=30]、[(30.05±6.81)mg/L,n=20]和[(34.44±6.82)mg/L,n=28],RBP4水平逐渐升高,差异有统计学意义(F=18.02,P=0.01)。对照组、轻度脑卒中、中度脑卒中、重度脑卒中患者RBP4水平分别为[(22.05±6.41)mg/L,n=100]、[(26.05±6.15)mg/L,n=40]、[(29.58±6.48)mg/L,n=55]和[(33.19±6.42)mg/L,n=35],RBP4水平逐渐升高,差异有统计学意义(F=15.44,P=0.02)。AIS患者RBP4水平与脑梗死体积呈正相关(r=0.22,P=0.03)。年龄、收缩压、hs-CRP、RBP4为NIHSS评分的独立影响因素(t=2.03、2.85、8.48、4.41,P=0.04、P=0.01、<0.001、<0.001)。结论入院时血清RBP4水平与AIS患者脑梗死体积呈正相关,并能有效预测AIS患者短期病情严重程度。展开更多
文摘In the present study, the performance of a 4-stroke diesel engine was experimentally evaluated upon adding Al2O3 or SiO2 nanoparticles to the engine oil （SAEISW40）. The viscosity and density of the resulting nanolubricants were determined while varying both the nanoparticle volume fraction and the temperature. Field emission scanning electron microscopy （FE-SEM） showed that the nanoparticles had a spherical morphology and dynamic light scattering analysis determined some aggregation of the nanoparticles in the engine oil. A pin-on-disc test apparatus was used for friction and wear analysis in the presence of the nanolubricants. Examination of wear scars by FE-SEM and energy dispersive spectroscopy found evidence of ball bearing and surface polishing effects, which were responsible for improvements in the tribological properties of the oil. The performance of these nanolubricants in a 4- stroke diesel engine test rig was assessed, and the greatest improvements in the tribological behavior and engine performance were observed when employing 0.3 vol% Al2O3.
文摘目的探究急性缺血性脑卒中(AIS)患者血清间α胰蛋白酶抑制因子重链4(ITIH4)、髓样细胞白血病因子-1(MCL-1)表达与病情程度及预后的关系。方法纳入2019年7月—2022年7月河南科技大学附属黄河医院神经内科诊治AIS患者128例为AIS组。根据入院时美国国立卫生研究院卒中量表(NIHSS)评分,分为轻度亚组(NIHSS<6分,n=42)、中度亚组(NIHSS 6~<14分,n=52)和重度亚组(NIHSS≥14分,n=34)。根据出院3个月时AIS患者改良Rankins评分,分为预后不良亚组(mRS评分>2分,30例)和预后良好亚组(mRS评分≤2分,98例)。另选取同期医院体检的健康人70例为健康对照组。酶联免疫吸附试验检测血清ITIH4、MCL-1水平。Pearson相关分析血清ITIH4、MCL-1水平与病情程度及预后的相关性;多因素Logistic回归分析影响AIS患者预后的因素;受试者工作特征曲线分析血清ITIH4、MCL-1对AIS患者预后的预测价值。结果AIS组患者血清ITIH4、MCL-1水平显著低于健康对照组(t/P=43.211/<0.001,43.191/<0.001);病情程度越重,AIS患者血清ITIH4/MCL-1水平越低(F/P=107.796/<0.001,297.976/<0.001);预后不良亚组梗死面积、入院24 h NIHSS评分高于预后良好亚组(t/P=9.637/<0.001,9.752/<0.001),血清ITIH4、MCL-1水平及出院3个月简易智能状态量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分低于预后良好亚组(t/P=26.723/<0.001,11.709/<0.001,13.674/<0.001,10.782/<0.001);AIS患者血清ITIH4、MCL-1与梗死面积、入院24 h NIHSS评分呈负相关(r/P=-0.705/<0.001,-0.685/<0.001;-0.761/<0.001,-0.619/<0.001),与出院3个月MMSE评分、MoCA评分呈正相关(r/P=0.656/<0.001,0.632/<0.001;0.751/<0.001,0.789/<0.001);出院3个月MMSE评分高、出院3个月MoCA评分高是影响AIS患者预后不良的独立保护因素[0.622(0.446~0.868),0.606(0.427~0.861)],血清ITIH4低、MCL-1低、梗死面积大、入院24 h NIHSS评分高是危险因素[OR(95%CI)=1.467(1.150~1.870),1.415(1.094~1.829),1.605(1.168~2.205),1.765(1.233~2.526)];血清ITIH4、MCL-1及两项联合预测AIS预后不良的AUC分别为0.811、0.835、0.923,两项联合预测AIS预后不良的AUC大于单一指标,差异具有统计学意义(Z=4.258、4.119,P均<0.001)。结论AIS患者血清ITIH4、MCL-1表达下调,两者表达水平与病情严重程度有关,两者联合对AIS患者预后具有较高的预测价值。
文摘目的探讨急性缺血性脑卒中(acute ischemic stroke,AIS)患者视黄醇结合蛋白4(retinolbinding protein 4,RBP4)水平与脑梗死体积的关系以及对病情严重程度的预测价值。方法前瞻性纳入2016年8月至2018年8月收治的130例首发AIS患者和同期100例健康人群作为研究对象。采用Pearson相关分析法分析血清RBP4水平与脑梗死体积的相关性。采用多元线性回归分析影响AIS患者出院6个月后病情严重程度的因素。结果对照组、不明原因脑卒中、大动脉粥样硬化型脑卒中、心源型脑卒中、小动脉闭塞型脑卒中患者RBP4水平分别为[(22.05±6.41)mg/L,n=100]、[(25.56±6.05)mg/L,n=52]、[(27.85±6.38)mg/L,n=30]、[(30.05±6.81)mg/L,n=20]和[(34.44±6.82)mg/L,n=28],RBP4水平逐渐升高,差异有统计学意义(F=18.02,P=0.01)。对照组、轻度脑卒中、中度脑卒中、重度脑卒中患者RBP4水平分别为[(22.05±6.41)mg/L,n=100]、[(26.05±6.15)mg/L,n=40]、[(29.58±6.48)mg/L,n=55]和[(33.19±6.42)mg/L,n=35],RBP4水平逐渐升高,差异有统计学意义(F=15.44,P=0.02)。AIS患者RBP4水平与脑梗死体积呈正相关(r=0.22,P=0.03)。年龄、收缩压、hs-CRP、RBP4为NIHSS评分的独立影响因素(t=2.03、2.85、8.48、4.41,P=0.04、P=0.01、<0.001、<0.001)。结论入院时血清RBP4水平与AIS患者脑梗死体积呈正相关,并能有效预测AIS患者短期病情严重程度。
