Chiral Ligands from Abrine.4. Heterocycle-Containing 1,2,3,4-Tetrahydro-β-Carboline Methyl Ester Used for Catalysis of Enantioselective Addition of Diethylzinc to Benzaldehyde

Four 1, 2,3,4-tetrahydro - β - c arboline amino acid esters with a heterocycle at the C- 1position were used as chiral ligands in the enantioselective addition reactions. The differentpositions of the heteroatoms gave different effects, and medium but opposite enantioselectivitywas recorded.

Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo[4,3-c]-quinoline-2-carboxamide Derivatives

A series of 6-fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo[4,3-c]quinoline-2-carboxamide derivatives was designed based on the bioisosterism and combination principle in drug design. The target compounds were synthesized from substituted aniline through Michael addition, cyclization, Mannich reaction and condensation with 4-substituted semicarbazides, and the structures were confirmed by mass spectrometry（MS） and 1H NMR. The antifungal assay was carried out in vitro by two-fold dilution. The result shows that all the compounds are of antifungal activities against the tested fungi at different levels.

Efficient Synthesis of 3,5,6,8-Tetrahydro-4H-thiopyrano[4′,3′:4,5]· thieno[2,3-d]pyrimidin-4-ones via an Iminophosphorane

3,5,6,8-Tetrahydro-4H-thiopyrano[4＇,3＇：4,5]thieno[2,3-d]pyrimidin-4-ones（7） were synthesized via the base catalytic reactions of amines or phenols with carbodiimides（5）, which were obtained from the aza-Wittig reac tions of iminophosphoranes（4） with aromatic isocyanates.

6-硝亚氨基-4,8-二硝基-5,6,7,8-四氢化-4H-咪唑烷并[4,5-e]呋咱并[3,4-b]哌嗪的合成(英文)

1 Introduction In the last decades,the furazan fused ring compounds have been paid much more attention owing to their characteristics,such as high density,high specific volume and high nitrogen content.A novel energetic compound based on furazan fused ring,6-nitroimino-4,8-dinitro-5,6,7,8-tetrahydro-4H-imidazo furazano pyrazine(NIFDNP),was firstly designed and its properties of physico-chemical and detonation were calculated by Gaussian 09 program[4] and VLW method[5].Using glyoxal

Studies on the Chemical Constituents of Evodia rutaecarpa [Juss] Benth

从中药吴茱萸（Ｅｖｏｄｉａｒｕｔａｅｃａｒｐａ［ｊｕｓ］Ｂｅｎｔｈ）中分离出９个吲哚类生物碱和１个芳香胺。经光谱分析鉴定其结构为：ｅｖｏｄｉａｍｉｎｅ（１），ｒｕｔａｅｃａｒｐｉｎｅ（２），ｆｏｒｍｙｌｄｉｈｙｄｒｏｒｕｔａｅｃａｒｐｉｎｅ（３），ｇｏｓｈｕｙｕａｍｉｄｅＩ（４），ｅｖｏｄｉａｍｉｄｅ（５），ｈｙｄｒｏｘｙｅｖｏｄｉａｍｉｎｅ（６），βｃａｒｂｏｌｉｎｅ（７），１，２，３，４ｔｅｔｒａｈｙｄｒｏ１ｏｘｏβｃａｒｂｏｌｉｎｅ（８），ｄｅｈｙｄｒｏｅｖｏｄｉａｍｉｎｅ（９）和Ｎｍｅｔｈｙｌａｎｔｈｒａｎｙｌａｍｉｄｅ（１０）。其中８是新的天然产物，７是首次从该属植物中分离得到。

A New Benzylisoquinoline Alkaloid from Sabia parviflora

A new benzylisoquinoline alkaloid, 1, 2, 3, 4-tetrahydro-5-hydroxyl-8-methoxyl-2- methyl-4'-methoxyl-benzylisoquinoline, was isolated from the arial parts of Sabia parviflora. Its structure was established on the basis of spectral analysis.

Reaction of 2,3-Dihydro-1,5-benzothiazepines and Phenylacetyl Chloride in the Presence of Triethylamine:A New Aspect on the Formation Mechanism of Dihydro-1,3-oxazin-4-one Derivatives

2a,4-Disubstituted 2,2a,3,4-tetrahydro-2-phenyl-1H-azeto[2,1-d][1,5]benzothiazepin-1-ones, as well as 2-substi- tuted 2,3-dihydro-3-phenylacetyl-2-styryl-benzothiazoles and 4a,6-disubstituted 3-benzyl-4a,5-dihydro-2-phenyl- 1H,6H-[1,3]oxazino[2,3-d][1,5]benzothiazepin-1-ones, were obtained from the reaction of 2,4-disubstituted 2,3-dihydro-1,5-benzothiazepines with phenylacetyl chloride in the presence of triethylamine. The mechanism for the formation of 4a,5-dihydro-1H,6H-[1,3]oxazino[2,3-d][1,5]benzothiazepin-1-ones, 2,3-dihydro-1,3-oxazin-4-one derivatives, was suggested.