The precipitation behavior of carbide in K416 B superalloy was investigated by means of creep measurement and microstructure observation. The results show that nanometer M6 C particles discontinuously precipitate in t...The precipitation behavior of carbide in K416 B superalloy was investigated by means of creep measurement and microstructure observation. The results show that nanometer M6 C particles discontinuously precipitate in the γ matrix or along the γ/γ′ interface of the alloy during high temperature tensile creep. Thereinto, the amount of fine M6 C carbide increases as creep goes on, and the coherent interfaces of M6 C phase precipitating from the γ matrix are {100} and {111} planes. The thermodynamics analysis indicates that the solubility of element carbon in the matrix decreases when the alloy is deformed by the axial tensile stress during creep, so as to cause the carbon segregating in the regions of stress concentration and combining with carbide-forming elements M（W, Co）, which promotes the fine M6 C carbide to precipitate from the γ matrix.展开更多
背景与目的:肝细胞癌(hepatocellular carcinoma,HCC)是最常见的恶性肿瘤之一,肝内复发转移是影响其中期生存率的主要因素,因此,转移标志物的寻找至关重要。该研究探讨HCC中肉瘤酪氨酸激酶磷酸化Tyr416(tyrosine kinase phosphorylation...背景与目的:肝细胞癌(hepatocellular carcinoma,HCC)是最常见的恶性肿瘤之一,肝内复发转移是影响其中期生存率的主要因素,因此,转移标志物的寻找至关重要。该研究探讨HCC中肉瘤酪氨酸激酶磷酸化Tyr416(tyrosine kinase phosphorylation Tyr416 of sarcoma,SRC p Y416)的表达与临床相关参数及肝内复发转移的关系。方法:采用免疫组织化学法和蛋白[质]印迹法(Western blot)检测112例HCC组织、40例相应癌旁正常肝脏组织中SRC p Y416的表达,化学发光法检测患者乙型肝炎病毒DNA(hepatitis B virusDNA,HBV-NDA)和甲胎蛋白(alpha fetoprotein,AFP),随访12个月,分析SRC p Y416与HCC患者临床相关参数及预后的关系。结果:SRC p Y416在HCC组织中的表达(65.40±15.69)均高于癌旁正常肝脏组织(11.25±2.73,P<0.001)。SRC p Y416的表达与患者年龄、肝硬化、包膜完整、分化程度、HBV-NDA及AFP均存在相关性(P<0.01)。单因素分析显示,HCC患者术后12个月肝内复发转移与患者年龄、AFP表达、分化程度、是否携带HBV及SRC p Y416蛋白表达有关(P<0.01),多因素分析显示,SRC p Y416蛋白表达是HCC患者12个月肝内复发转移的独立危险因素。结论:SRC p Y416可能在HCC转移中起重要作用,有望成为HCC肝内转移的分子标志物。展开更多
基金Projects(2010CB631200,2010CB631206)supported by the National Basic Research Program of ChinaProject(50931004)supported by the National Natural Science Foundation of China
文摘The precipitation behavior of carbide in K416 B superalloy was investigated by means of creep measurement and microstructure observation. The results show that nanometer M6 C particles discontinuously precipitate in the γ matrix or along the γ/γ′ interface of the alloy during high temperature tensile creep. Thereinto, the amount of fine M6 C carbide increases as creep goes on, and the coherent interfaces of M6 C phase precipitating from the γ matrix are {100} and {111} planes. The thermodynamics analysis indicates that the solubility of element carbon in the matrix decreases when the alloy is deformed by the axial tensile stress during creep, so as to cause the carbon segregating in the regions of stress concentration and combining with carbide-forming elements M（W, Co）, which promotes the fine M6 C carbide to precipitate from the γ matrix.
文摘背景与目的:肝细胞癌(hepatocellular carcinoma,HCC)是最常见的恶性肿瘤之一,肝内复发转移是影响其中期生存率的主要因素,因此,转移标志物的寻找至关重要。该研究探讨HCC中肉瘤酪氨酸激酶磷酸化Tyr416(tyrosine kinase phosphorylation Tyr416 of sarcoma,SRC p Y416)的表达与临床相关参数及肝内复发转移的关系。方法:采用免疫组织化学法和蛋白[质]印迹法(Western blot)检测112例HCC组织、40例相应癌旁正常肝脏组织中SRC p Y416的表达,化学发光法检测患者乙型肝炎病毒DNA(hepatitis B virusDNA,HBV-NDA)和甲胎蛋白(alpha fetoprotein,AFP),随访12个月,分析SRC p Y416与HCC患者临床相关参数及预后的关系。结果:SRC p Y416在HCC组织中的表达(65.40±15.69)均高于癌旁正常肝脏组织(11.25±2.73,P<0.001)。SRC p Y416的表达与患者年龄、肝硬化、包膜完整、分化程度、HBV-NDA及AFP均存在相关性(P<0.01)。单因素分析显示,HCC患者术后12个月肝内复发转移与患者年龄、AFP表达、分化程度、是否携带HBV及SRC p Y416蛋白表达有关(P<0.01),多因素分析显示,SRC p Y416蛋白表达是HCC患者12个月肝内复发转移的独立危险因素。结论:SRC p Y416可能在HCC转移中起重要作用,有望成为HCC肝内转移的分子标志物。
