Aim: This study aimed to investigate the protective effects of flavonoids from the stem and leaves of Scutellaria baicalensis Georgi (SSFs) against Aβ<sub>1-42</sub>-induced oligodendrocytes (OL) damage. ...Aim: This study aimed to investigate the protective effects of flavonoids from the stem and leaves of Scutellaria baicalensis Georgi (SSFs) against Aβ<sub>1-42</sub>-induced oligodendrocytes (OL) damage. Methods: Immunofluorescence was used for the detection of myelin-associated glycoprotein (MAG), a characteristic protein of rat oligodendrocytes (OLN-93 cells). To evaluate the potential protective effects of SSFs on OLN-93 cells injured by Aβ<sub>1-42</sub>, an injury model was established by subjecting OLN-93 cells to Aβ<sub>1-42</sub> exposed. Cell morphology was examined using an inverted microscope, while cell viability was assessed using the colorimetric method of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Additionally, lactate dehydrogenase (LDH) was measured using the pyruvic acid reduction assay. The Ginkgo biloba leaf extract (GBE) injection was used as a positive control. Results: A total of >95% of the MAG immunofluorescence-positive cells were identified as oligodendrocytes. Gradually increasing concentrations of SSFs impaired the cells, and the maximum nondetrimental dose for OLN-93 cells was 75 mg/L. This study assessed the effects of SSFs on OLN-93 cells damaged by Aβ<sub>1-42</sub>. The results indicated that SSFs significantly improved OLN-93 cell morphological abnormal changes, increased the OLN-93 cell survival rate, and reduced LDH release. Conclusion: SSFs can alleviate Aβ<sub>1-42</sub>-induced damage of OL.展开更多
Bearing ring is the crucial component of bearing. With regard to such problems as material waste, low efficiency and high energy consumption in current process of producing large bearing ring, a new process named ＂ca...Bearing ring is the crucial component of bearing. With regard to such problems as material waste, low efficiency and high energy consumption in current process of producing large bearing ring, a new process named ＂casting-rolling compound forming technology＂ is researched by taking the typical 42CrMo slew bearing as object. Through theoretical analysis, the design criteria of the main casting-rolling forming parameters are put forward at first. Then the constitutive relationship model of as-cast 42CrMo steel and its mathematical model of dynamic recrystallization are obtained according to the results of the hot compression experiment. By a coupled thermal-mechanical finite element model for radial-axial rolling of bearing ring, the fraction of dynamic recrystallization is calculated and recrystallized grains size are predicated. Meanwhile, the effects of the initial rolling temperature and feed rate of idle roll on material microstructure evolution are analyzed. Finally, the industrial rolling experiment is designed and performed, based on the simulation results. In addition, mechanical and metallographic tests are conducted on rolled bearing ring to get the mechanical parameters and metallographic structure. The experimental data and results show that the mechanical properties of bearing ring produced by casting-rolling compound forming technology are up to industrial standard, and a qualified bearing ring can be successfully formed by employing this new technology. Through the study, a process of forming large bearing ring directly by using casting ring blank is obtained, which could provide an effective theoretical guidance for manufacturing large ring parts. It also has an edge in saving material, lowering energy and improving efficiency.展开更多
The cast preformed forming process(CPFP) is increasingly considered and applied in the metal forming industries due to its short process, low cost, and environmental friendliness, especially in the aerospace field. Ho...The cast preformed forming process(CPFP) is increasingly considered and applied in the metal forming industries due to its short process, low cost, and environmental friendliness, especially in the aerospace field. However, how to establish a unified model of a non-uniform as-cast billet depicting the flow stress and microstructure evolution behaviors during hot working is the key to microstructure prediction and parameter optimization of the CPFP. In this work, hot compression tests are performed using a non-uniform as-cast 42 CrMo billet at 1123–1423 K and 0.01–1sà1. The effect laws of the non-uniform state of the as-cast billet with different initial grain sizes on the flow stress and microstructure are revealed deeply. Based on experimental results, a unified model of flow stress and grain size evolutions is developed by the internal variable modeling method. Verified results show that the model can well describe the responses of the flow stress and microstructure to deformation conditions and initial grain sizes. To further evaluate its reliability, the unified model is applied to FE simulation of the cast preformed ring rolling process.The predictions of the rolling force and grain size indicate that it could well describe the flow stress and microstructure evolutions during the process.展开更多
采用芬兰Polar心率设备,以武术专业学生组(20.8±1.2岁)和大众健身组(47.5±10.30岁)为研究对象,对陈式太极拳竞赛套路的运动强度与能量消耗进行测量。结果表明:56式太极拳属于中等偏大强度的有氧运动项目;演练整套56式能量消...采用芬兰Polar心率设备,以武术专业学生组(20.8±1.2岁)和大众健身组(47.5±10.30岁)为研究对象,对陈式太极拳竞赛套路的运动强度与能量消耗进行测量。结果表明:56式太极拳属于中等偏大强度的有氧运动项目;演练整套56式能量消耗约为52.1±12.9 K cal。结论:在全民太极拳健身运动项目中,56式太极拳适合身体健康、追求强度的健康与亚健康群体,能够提高习练者的机体的运动质量与运动效率。展开更多
Polyhalite （K2SO4·MgSO4·2CaSO4·2H2O） is one of the widely distributed potash minerals. It is found in nearly all potash deposits of the sulphate type in Sichuan, Hubei and Shandong provinces. The stud...Polyhalite （K2SO4·MgSO4·2CaSO4·2H2O） is one of the widely distributed potash minerals. It is found in nearly all potash deposits of the sulphate type in Sichuan, Hubei and Shandong provinces. The study on the formative conditions of polyhalite and the interrelation between polyhalite and soluble potash minerals becomes important for the present mineral exploration.展开更多
文摘Aim: This study aimed to investigate the protective effects of flavonoids from the stem and leaves of Scutellaria baicalensis Georgi (SSFs) against Aβ<sub>1-42</sub>-induced oligodendrocytes (OL) damage. Methods: Immunofluorescence was used for the detection of myelin-associated glycoprotein (MAG), a characteristic protein of rat oligodendrocytes (OLN-93 cells). To evaluate the potential protective effects of SSFs on OLN-93 cells injured by Aβ<sub>1-42</sub>, an injury model was established by subjecting OLN-93 cells to Aβ<sub>1-42</sub> exposed. Cell morphology was examined using an inverted microscope, while cell viability was assessed using the colorimetric method of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Additionally, lactate dehydrogenase (LDH) was measured using the pyruvic acid reduction assay. The Ginkgo biloba leaf extract (GBE) injection was used as a positive control. Results: A total of >95% of the MAG immunofluorescence-positive cells were identified as oligodendrocytes. Gradually increasing concentrations of SSFs impaired the cells, and the maximum nondetrimental dose for OLN-93 cells was 75 mg/L. This study assessed the effects of SSFs on OLN-93 cells damaged by Aβ<sub>1-42</sub>. The results indicated that SSFs significantly improved OLN-93 cell morphological abnormal changes, increased the OLN-93 cell survival rate, and reduced LDH release. Conclusion: SSFs can alleviate Aβ<sub>1-42</sub>-induced damage of OL.
基金supported by Key Program of National Natural Science Foundation of China(Grant No.51135007)National Natural Science Foundation of China(Grant No.51075290)
文摘Bearing ring is the crucial component of bearing. With regard to such problems as material waste, low efficiency and high energy consumption in current process of producing large bearing ring, a new process named ＂casting-rolling compound forming technology＂ is researched by taking the typical 42CrMo slew bearing as object. Through theoretical analysis, the design criteria of the main casting-rolling forming parameters are put forward at first. Then the constitutive relationship model of as-cast 42CrMo steel and its mathematical model of dynamic recrystallization are obtained according to the results of the hot compression experiment. By a coupled thermal-mechanical finite element model for radial-axial rolling of bearing ring, the fraction of dynamic recrystallization is calculated and recrystallized grains size are predicated. Meanwhile, the effects of the initial rolling temperature and feed rate of idle roll on material microstructure evolution are analyzed. Finally, the industrial rolling experiment is designed and performed, based on the simulation results. In addition, mechanical and metallographic tests are conducted on rolled bearing ring to get the mechanical parameters and metallographic structure. The experimental data and results show that the mechanical properties of bearing ring produced by casting-rolling compound forming technology are up to industrial standard, and a qualified bearing ring can be successfully formed by employing this new technology. Through the study, a process of forming large bearing ring directly by using casting ring blank is obtained, which could provide an effective theoretical guidance for manufacturing large ring parts. It also has an edge in saving material, lowering energy and improving efficiency.
基金supported by the National Natural Science Foundation of China (No’s. 51575448 and 51135007)
文摘The cast preformed forming process(CPFP) is increasingly considered and applied in the metal forming industries due to its short process, low cost, and environmental friendliness, especially in the aerospace field. However, how to establish a unified model of a non-uniform as-cast billet depicting the flow stress and microstructure evolution behaviors during hot working is the key to microstructure prediction and parameter optimization of the CPFP. In this work, hot compression tests are performed using a non-uniform as-cast 42 CrMo billet at 1123–1423 K and 0.01–1sà1. The effect laws of the non-uniform state of the as-cast billet with different initial grain sizes on the flow stress and microstructure are revealed deeply. Based on experimental results, a unified model of flow stress and grain size evolutions is developed by the internal variable modeling method. Verified results show that the model can well describe the responses of the flow stress and microstructure to deformation conditions and initial grain sizes. To further evaluate its reliability, the unified model is applied to FE simulation of the cast preformed ring rolling process.The predictions of the rolling force and grain size indicate that it could well describe the flow stress and microstructure evolutions during the process.
文摘采用芬兰Polar心率设备,以武术专业学生组(20.8±1.2岁)和大众健身组(47.5±10.30岁)为研究对象,对陈式太极拳竞赛套路的运动强度与能量消耗进行测量。结果表明:56式太极拳属于中等偏大强度的有氧运动项目;演练整套56式能量消耗约为52.1±12.9 K cal。结论:在全民太极拳健身运动项目中,56式太极拳适合身体健康、追求强度的健康与亚健康群体,能够提高习练者的机体的运动质量与运动效率。
文摘Polyhalite （K2SO4·MgSO4·2CaSO4·2H2O） is one of the widely distributed potash minerals. It is found in nearly all potash deposits of the sulphate type in Sichuan, Hubei and Shandong provinces. The study on the formative conditions of polyhalite and the interrelation between polyhalite and soluble potash minerals becomes important for the present mineral exploration.
