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SARS-CoV核蛋白和宿主细胞相互作用的初步研究 被引量:1
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作者 王芹 郝永华 +10 位作者 关武祥 于建石 张全福 李川 刘琴芝 曹守春 修梅红 刘峰 代晓霞 梁米芳 李德新 《病毒学报》 CAS CSCD 北大核心 2006年第3期186-192,共7页
寻找与SARS-CoV核蛋白相互作用的宿主细胞蛋白,从而探索SARS-CoV的致病机理。可溶性表达SARS-CoV核蛋白,利用His标签和离子交换层析对表达的蛋白进行了纯化,获得较纯的可溶性核蛋白。再将SPR/BIA技术与MALDI-TOF MS技术结合起来,使用SP... 寻找与SARS-CoV核蛋白相互作用的宿主细胞蛋白,从而探索SARS-CoV的致病机理。可溶性表达SARS-CoV核蛋白,利用His标签和离子交换层析对表达的蛋白进行了纯化,获得较纯的可溶性核蛋白。再将SPR/BIA技术与MALDI-TOF MS技术结合起来,使用SPR生物传感芯片作为亲和吸附的表面,分别捕获2BS细胞和A549细胞裂解液中与SARS-CoV核蛋白相互作用的细胞蛋白,收集足够量的相互作用蛋白,再利用MALDI-TOF-MS分析获得蛋白的性质。结果鉴定出与SARS-CoV核蛋白相互作用的蛋白:26S蛋白酶调节亚单位S10B(蛋白酶体亚单位p42)(蛋白酶体26S亚单位ATPase 6)(P62333),属于泛素/蛋白酶体系统;目前国内外尚未见类似报道。此研究初步发现了一种与SARS-CoV核蛋白在细胞外相互作用的蛋白,但这种相互作用在SARS-CoV感染及SARS的发生发展中发挥的作用还有待于深入研究和探索。 展开更多
关键词 SARS-COV 核蛋白 SPR/BIA MALDI-TOF-MS 26S蛋白酶调节亚单位S10B(p42)
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Certain oscillatory integrals on unit square and their applications 被引量:6
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作者 FAN DaShan WU HuoXiong 《Science China Mathematics》 SCIE 2008年第10期1895-1903,共9页
Let Q 2 = [0, 1]2 be the unit square in two dimension Euclidean space ?2. We study the L p boundedness properties of the oscillatory integral operators T α,β defined on the set S(?3) of Schwartz test functions f by ... Let Q 2 = [0, 1]2 be the unit square in two dimension Euclidean space ?2. We study the L p boundedness properties of the oscillatory integral operators T α,β defined on the set S(?3) of Schwartz test functions f by $$ \mathcal{T}_{\alpha ,\beta } f(x,y,z) = \int_{Q^2 } {f(x - t,y - s,z - t^k s^j )e^{ - it^{ - \beta _1 } s^{ - \beta 2} } t^{ - 1 - \alpha _1 } s^{ - 1 - \alpha _2 } dtds} , $$ where β1 > α1 ? 0, β2 > α2 ? 0 and (k, j) ∈ ?2. As applications, we obtain some L p boundedness results of rough singular integral operators on the product spaces. 展开更多
关键词 oscillatory integral singular integral rough kernel unit square product space 42b10 42B15 42B20
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Uniform dimension results for Gaussian random fields 被引量:6
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作者 WU DongSheng XIAO YiMin 《Science China Mathematics》 SCIE 2009年第7期1478-1496,共19页
Let X = {X(t), t ∈ ? N } be a Gaussian random field with values in ? d defined by (1) $$ X(t) = (X_1 (t),...,X_d (t)),\forall t \in \mathbb{R}^N . $$ . The properties of space and time anisotropy of X and their conne... Let X = {X(t), t ∈ ? N } be a Gaussian random field with values in ? d defined by (1) $$ X(t) = (X_1 (t),...,X_d (t)),\forall t \in \mathbb{R}^N . $$ . The properties of space and time anisotropy of X and their connections to uniform Hausdorff dimension results are discussed. It is shown that in general the uniform Hausdorff dimension result does not hold for the image sets of a space-anisotropic Gaussian random field X.When X is an (N, d)-Gaussian random field as in (1), where X 1,...,X d are independent copies of a real valued, centered Gaussian random field X 0 which is anisotropic in the time variable. We establish uniform Hausdorff dimension results for the image sets of X. These results extend the corresponding results on one-dimensional Brownian motion, fractional Brownian motion and the Brownian sheet. 展开更多
关键词 anisotropic Gaussian random fields sectorial local nondeterminism IMAGE Hausdorff dimension 60G15 60G17 60G60 42b10 43A46 28A80
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Oscillatory integrals for phase functions having certain degenerate critical points
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作者 Jinmyong KIM 《Science China Mathematics》 SCIE 2008年第3期474-480,共7页
The paper is concerned with oscillatory integrals for phase functions having certain de- generate critical points. Under a finite type condition of phase functions we show the estimate of oscillatory integrals of the ... The paper is concerned with oscillatory integrals for phase functions having certain de- generate critical points. Under a finite type condition of phase functions we show the estimate of oscillatory integrals of the first kind. The decay of the oscillatory integral depends on indices of the finite type, the spatial dimension and the symbol. 展开更多
关键词 oscillatory integral phase function finite type 42b10
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