We present photometric observations in Sloan filters g′, i′of the eclipsing W UMa stars USNOA2.0 1350-17365531, V471 Cas, V479 Lac and V560 Lac. The sinusoidal-like O-C diagram of V471 Cas indicates the presence of ...We present photometric observations in Sloan filters g′, i′of the eclipsing W UMa stars USNOA2.0 1350-17365531, V471 Cas, V479 Lac and V560 Lac. The sinusoidal-like O-C diagram of V471 Cas indicates the presence of a third body with mass 0.12 M_⊙(a red dwarf) at distance 897 R_⊙. The O-C diagram of V479 Lac reveals a period decrease of d P/dt =-1.69 × 10-6d yr-1. The results of the light curve solutions are:(i) the targets are overcontact binaries with small fill-out factors;(ii) their components are F–K stars, comparable in size, whose temperature differences are below 80 K;(iii) all targets undergo partial eclipses and to limit the possible mass ratios we carried out two-step q-search analysis. The target global parameters(luminosities, radii, masses) were obtained on the basis of their Gaia distances and the results of our light curve solutions. The obtained total mass of V560 Lac turns out to be smaller than the lower mass limit for presently known W UMa binaries of 1.0-1.2 M_⊙, i.e. this target is a peculiar overcontact system.展开更多
:Colorectal cancer(CRC)is a heterogeneous cancer,and many risk factors for colorectal cancer have been established.For CRC metastasis,tumor cell migration,adhesion as well as invasion are important processes.Wiskott-A...:Colorectal cancer(CRC)is a heterogeneous cancer,and many risk factors for colorectal cancer have been established.For CRC metastasis,tumor cell migration,adhesion as well as invasion are important processes.Wiskott-Aldrich syndrome protein family member 3(WASF3)is necessary for metastasis of various types of cancers.However,its role in CRC progression has not been fully elucidated.This study examined the in vitro functional roles of WASF3 in the CRC and explored the underlying molecular mechanisms.We used siRNA-WASF3 to gene silence WASF3 in colon cancer cell(HCT116)in vitro.The effects of WASF3 silencing on HCT116 cell apoptosis,proliferation,migration,as well as invasion were assessed by flow cytometry,CCK-8,and transwell assays.ZNF471 protein expressions were detected by immunofluorescence staining and RT-PCR.Moreover,the effects of ZNF471 were studied on a series of in vitro antitumor-promoting assays using HCT116.WASF3 knockdown expression using small interfering RNA(siRNA)ameliorated CRC cell proliferation,anchorage-independent growth,invasion,and metastasis.Furthermore,we observed that WASF3 contributed to upregulating the metastasis signaling pathway through inhibiting the expression of ZNF471.Our study suggests that targeting WASF3 signaling might be a novel therapeutic strategy for treating CRC.展开更多
The facile chemical synthesis of silver sulphide nanocrystals from metal-loaded organic media, containing a silver-selective organophosphorous ligand as extractant, is reported. The method involves the phase-transfer ...The facile chemical synthesis of silver sulphide nanocrystals from metal-loaded organic media, containing a silver-selective organophosphorous ligand as extractant, is reported. The method involves the phase-transfer of silver species from aqueous nitrate media to organic solution using the commercial extractant Cyanex? 471x (tri-isobutylphosphine sulphide, Cytec Co.) as extractant, followed by precipitation stripping using ammonium sulphide as strip reagent. The nanoparticles were structurally characterized, and some aspects of the synthetical process, are briefly discussed. Under the conditions studied, the extractant Cyanex? 471x was able to act as stabilizer adsorbing on the particles surface, maintaining the size of the particles nanometrical.展开更多
基金supported partly by project DN08/20 of the Scientific Foundation of the Bulgarian Ministry of Education and Scienceby project RD 08-142 of Shumen University+1 种基金the support of the private IRIDA Observatory operated remotely(www.iridaobservatory.org)Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement
文摘We present photometric observations in Sloan filters g′, i′of the eclipsing W UMa stars USNOA2.0 1350-17365531, V471 Cas, V479 Lac and V560 Lac. The sinusoidal-like O-C diagram of V471 Cas indicates the presence of a third body with mass 0.12 M_⊙(a red dwarf) at distance 897 R_⊙. The O-C diagram of V479 Lac reveals a period decrease of d P/dt =-1.69 × 10-6d yr-1. The results of the light curve solutions are:(i) the targets are overcontact binaries with small fill-out factors;(ii) their components are F–K stars, comparable in size, whose temperature differences are below 80 K;(iii) all targets undergo partial eclipses and to limit the possible mass ratios we carried out two-step q-search analysis. The target global parameters(luminosities, radii, masses) were obtained on the basis of their Gaia distances and the results of our light curve solutions. The obtained total mass of V560 Lac turns out to be smaller than the lower mass limit for presently known W UMa binaries of 1.0-1.2 M_⊙, i.e. this target is a peculiar overcontact system.
基金Key Research and Development Program of Shaanxi(Program No.2019SF-023)Basic Research Program of Natural Science in Shaanxi Province(Program No.2020JM-381)for their financial support.
文摘:Colorectal cancer(CRC)is a heterogeneous cancer,and many risk factors for colorectal cancer have been established.For CRC metastasis,tumor cell migration,adhesion as well as invasion are important processes.Wiskott-Aldrich syndrome protein family member 3(WASF3)is necessary for metastasis of various types of cancers.However,its role in CRC progression has not been fully elucidated.This study examined the in vitro functional roles of WASF3 in the CRC and explored the underlying molecular mechanisms.We used siRNA-WASF3 to gene silence WASF3 in colon cancer cell(HCT116)in vitro.The effects of WASF3 silencing on HCT116 cell apoptosis,proliferation,migration,as well as invasion were assessed by flow cytometry,CCK-8,and transwell assays.ZNF471 protein expressions were detected by immunofluorescence staining and RT-PCR.Moreover,the effects of ZNF471 were studied on a series of in vitro antitumor-promoting assays using HCT116.WASF3 knockdown expression using small interfering RNA(siRNA)ameliorated CRC cell proliferation,anchorage-independent growth,invasion,and metastasis.Furthermore,we observed that WASF3 contributed to upregulating the metastasis signaling pathway through inhibiting the expression of ZNF471.Our study suggests that targeting WASF3 signaling might be a novel therapeutic strategy for treating CRC.
基金This work was supported by grants from the Fondo de Apoyo a la Investigación(UASLP)and Fondos Mixtos Consejo Nacional de Ciencia y Tecnología-Gobierno de San Luis Potosí(Project FMSLP 2002-5630).
文摘The facile chemical synthesis of silver sulphide nanocrystals from metal-loaded organic media, containing a silver-selective organophosphorous ligand as extractant, is reported. The method involves the phase-transfer of silver species from aqueous nitrate media to organic solution using the commercial extractant Cyanex? 471x (tri-isobutylphosphine sulphide, Cytec Co.) as extractant, followed by precipitation stripping using ammonium sulphide as strip reagent. The nanoparticles were structurally characterized, and some aspects of the synthetical process, are briefly discussed. Under the conditions studied, the extractant Cyanex? 471x was able to act as stabilizer adsorbing on the particles surface, maintaining the size of the particles nanometrical.
