Objective To investigate the clinical features and Tlymphocytes subsets in patients with acquired immunedeficiency syndrome ( AIDS ) and cytomegalovirus(CMV) infection. Methods A total of 48 hospitalizedpatients with ...Objective To investigate the clinical features and Tlymphocytes subsets in patients with acquired immunedeficiency syndrome ( AIDS ) and cytomegalovirus(CMV) infection. Methods A total of 48 hospitalizedpatients with human immunodeficiency virus (HIV)-1 /AIDS and CMV infections were recruited at Peking UnionMedical College Hospital from Jan 2010 to Aug 2017.Their clinical features and immune function were retrospectivelyanalyzed. Patients with only HIV/AIDS inprevious study were recruited as controls. Results All 48patients were at C3 stage, including 36 men and12 women. Five of them were younger than 30 years old,33 cases within 31 - 50 years old,and 10 cases olderthan 50 years old.展开更多
Introduction:Incomplete pubertal development is a common phenomenon found in patients with Klinefelter syndrome (KFS).KFS combined with central precocious puberty (CPP) rarely occurs.We herein report a rare case of KF...Introduction:Incomplete pubertal development is a common phenomenon found in patients with Klinefelter syndrome (KFS).KFS combined with central precocious puberty (CPP) rarely occurs.We herein report a rare case of KFS with CPP and review several studies to determine the possible mechanism underlying this condition.Case presentation:An 8-year,5-month-old male patient was admitted to our hospital because of enlargement of the penis and small testes.Laboratory evaluation revealed high luteinizing hormone and follicle-stimulating hormone levels,a high testosterone level,and the 48,XXYY karyotype.He was treated with triptorelin.One year later,the patient's testosterone level decreased and pubertal arrest occurred.Conclusion:The literature review in this study showed that the occurrence of hypogonadism combined with CPP is not unique to patients with KFS;it has also been reported in individuals with Turner syndrome,adrenal hypoplasia congenita,and other diseases.Such individuals share common features including partial hypogonadism and a normal hypothalamic-pituitary-gonadal axis.CPP is considered a prelude to hypogonadism,and treatment with a gonadotropin-releasing hormone agonist may prevent gonadal failure.展开更多
文摘Objective To investigate the clinical features and Tlymphocytes subsets in patients with acquired immunedeficiency syndrome ( AIDS ) and cytomegalovirus(CMV) infection. Methods A total of 48 hospitalizedpatients with human immunodeficiency virus (HIV)-1 /AIDS and CMV infections were recruited at Peking UnionMedical College Hospital from Jan 2010 to Aug 2017.Their clinical features and immune function were retrospectivelyanalyzed. Patients with only HIV/AIDS inprevious study were recruited as controls. Results All 48patients were at C3 stage, including 36 men and12 women. Five of them were younger than 30 years old,33 cases within 31 - 50 years old,and 10 cases olderthan 50 years old.
文摘Introduction:Incomplete pubertal development is a common phenomenon found in patients with Klinefelter syndrome (KFS).KFS combined with central precocious puberty (CPP) rarely occurs.We herein report a rare case of KFS with CPP and review several studies to determine the possible mechanism underlying this condition.Case presentation:An 8-year,5-month-old male patient was admitted to our hospital because of enlargement of the penis and small testes.Laboratory evaluation revealed high luteinizing hormone and follicle-stimulating hormone levels,a high testosterone level,and the 48,XXYY karyotype.He was treated with triptorelin.One year later,the patient's testosterone level decreased and pubertal arrest occurred.Conclusion:The literature review in this study showed that the occurrence of hypogonadism combined with CPP is not unique to patients with KFS;it has also been reported in individuals with Turner syndrome,adrenal hypoplasia congenita,and other diseases.Such individuals share common features including partial hypogonadism and a normal hypothalamic-pituitary-gonadal axis.CPP is considered a prelude to hypogonadism,and treatment with a gonadotropin-releasing hormone agonist may prevent gonadal failure.
