Four new Schiff bases with promising anticancer activity have been synthesized from 4-amino-3,5-dimethyl-1,2,4-triazole and di-pyridyl-aldehydes. Structures have been established by various spectroscopic methods. The ...Four new Schiff bases with promising anticancer activity have been synthesized from 4-amino-3,5-dimethyl-1,2,4-triazole and di-pyridyl-aldehydes. Structures have been established by various spectroscopic methods. The compounds were tested in vitro to study their cytotoxicity and anti-oxidative activity in human lung carcinoma (A549), breast carcinoma (BT549), prostate adenocarcinoma (PC3) and mouse preadipocytes (3T3-L1) cells. Compound 1 was found to increase Glutathione (GSH) level slightly in all four cell lines. Compound 4 showed better selectivity and cytotoxicity against both BT549 and A549 cells compared to the anticancer drug tamoxifen. With the exception of compound 4 which reduced GSH levels in A549 and BT549, all other compounds maintained GSH levels in comparison to their respective controls.展开更多
Dispersion of KF on AlPO4-5 molecular sieve created basic sites and caused 1654 cm- band of bidentate carbonate in CO2 adsorption.After pre-treated above 823K. 5%KF/AlPO4-5exhibited basic catalytic activity in the iso...Dispersion of KF on AlPO4-5 molecular sieve created basic sites and caused 1654 cm- band of bidentate carbonate in CO2 adsorption.After pre-treated above 823K. 5%KF/AlPO4-5exhibited basic catalytic activity in the isomerization of butenes at 273K. and the activity increasedwith the pre-treatment temperature up to 923K.展开更多
Kinetic and conductivity of new Schiff bases compounds such （（12Z）N-（5Z）-1-bromo-5-（phenylimino）-1H- pyrrol-2（5 H）-ylidene）benzenamine {ArN（CNBrCCHCH）NAr} （Ar = C6H5） incorporating the chelating diamino ...Kinetic and conductivity of new Schiff bases compounds such （（12Z）N-（5Z）-1-bromo-5-（phenylimino）-1H- pyrrol-2（5 H）-ylidene）benzenamine {ArN（CNBrCCHCH）NAr} （Ar = C6H5） incorporating the chelating diamino has been studied in this paper and was found a second order of this reaction. Electronic Properties using hyperchem program study has been improved for this compound such angel and bond distance, and then this compound was defining as electric conductivity and did prove to be useful for conduclively compound.展开更多
Here we have synthesized cancer targeting drug delivery system that contains β-cyclodextrin as a drug carrier and folic acid as a targeting ligand. Folic acid was selected as a cancer targeting ligand because folic a...Here we have synthesized cancer targeting drug delivery system that contains β-cyclodextrin as a drug carrier and folic acid as a targeting ligand. Folic acid was selected as a cancer targeting ligand because folic acid receptors are highly expressed in a variety of tumor types. β-cyclodextrin and folic acid were connected through a linker [1,10-phenanthroline or 5-(hydroxymethyl) furfural]. β-cyclodextrin and folic acid were attached to the linker by formation of Schiffbase and ester, respectively. Our targeted synthetic products were confirmed by NMR, Mass and IR spectroscopy. We anticipate that our synthetic products can confer cancer cell-specific drug delivery as well as desired properties such as nanoparticle formation.展开更多
New series of pyrazolo[1,5-α]pyrimidine derivatives 7a-i,11a-c and Schiff bases 13a-c were synthesized and screened for their in vitro antitumor activity against three human carcinoma cell lines,namely colorectal car...New series of pyrazolo[1,5-α]pyrimidine derivatives 7a-i,11a-c and Schiff bases 13a-c were synthesized and screened for their in vitro antitumor activity against three human carcinoma cell lines,namely colorectal carcinoma（HCT116）,prostate adenocarcinoma（PC-3） and liver carcinoma（HepG-2） using MTT cytotoxicity assay at 100 μg/mL.Some of the tested compounds displayed good anticancer activities against HCT-116 and PC-3 cells.Whereas,compounds 7d and 11 a showed better antitumor activity than the rest of the compounds against both cell lines.A structure-activity relationship（SAR） has been discussed and structures of the newly synthesized compounds were confirmed by different spectral data（MS,IR,^1H NMR and ^13C NMR） and elemental analysis.展开更多
1诱导化疗在头颈癌治疗中的作用及未来的发展趋势
Current status and future directions in induction chemotherapy for head and neck cancer.Argiris A.Crit Rev Oncol Hematol,2013,88（1）：57-74.作为局部晚期头颈癌综合治疗的...1诱导化疗在头颈癌治疗中的作用及未来的发展趋势
Current status and future directions in induction chemotherapy for head and neck cancer.Argiris A.Crit Rev Oncol Hematol,2013,88（1）：57-74.作为局部晚期头颈癌综合治疗的组成部分,诱导化疗具有缩小瘤体、靶向治疗远处转移的作用。顺铂联合5-氟尿嘧啶辅以紫杉醇（TPF）较单独采用的PF方案效果更好。但是,最近的临床Ⅲ期试验显示,展开更多
文摘Four new Schiff bases with promising anticancer activity have been synthesized from 4-amino-3,5-dimethyl-1,2,4-triazole and di-pyridyl-aldehydes. Structures have been established by various spectroscopic methods. The compounds were tested in vitro to study their cytotoxicity and anti-oxidative activity in human lung carcinoma (A549), breast carcinoma (BT549), prostate adenocarcinoma (PC3) and mouse preadipocytes (3T3-L1) cells. Compound 1 was found to increase Glutathione (GSH) level slightly in all four cell lines. Compound 4 showed better selectivity and cytotoxicity against both BT549 and A549 cells compared to the anticancer drug tamoxifen. With the exception of compound 4 which reduced GSH levels in A549 and BT549, all other compounds maintained GSH levels in comparison to their respective controls.
文摘Dispersion of KF on AlPO4-5 molecular sieve created basic sites and caused 1654 cm- band of bidentate carbonate in CO2 adsorption.After pre-treated above 823K. 5%KF/AlPO4-5exhibited basic catalytic activity in the isomerization of butenes at 273K. and the activity increasedwith the pre-treatment temperature up to 923K.
文摘Kinetic and conductivity of new Schiff bases compounds such （（12Z）N-（5Z）-1-bromo-5-（phenylimino）-1H- pyrrol-2（5 H）-ylidene）benzenamine {ArN（CNBrCCHCH）NAr} （Ar = C6H5） incorporating the chelating diamino has been studied in this paper and was found a second order of this reaction. Electronic Properties using hyperchem program study has been improved for this compound such angel and bond distance, and then this compound was defining as electric conductivity and did prove to be useful for conduclively compound.
文摘Here we have synthesized cancer targeting drug delivery system that contains β-cyclodextrin as a drug carrier and folic acid as a targeting ligand. Folic acid was selected as a cancer targeting ligand because folic acid receptors are highly expressed in a variety of tumor types. β-cyclodextrin and folic acid were connected through a linker [1,10-phenanthroline or 5-(hydroxymethyl) furfural]. β-cyclodextrin and folic acid were attached to the linker by formation of Schiffbase and ester, respectively. Our targeted synthetic products were confirmed by NMR, Mass and IR spectroscopy. We anticipate that our synthetic products can confer cancer cell-specific drug delivery as well as desired properties such as nanoparticle formation.
文摘New series of pyrazolo[1,5-α]pyrimidine derivatives 7a-i,11a-c and Schiff bases 13a-c were synthesized and screened for their in vitro antitumor activity against three human carcinoma cell lines,namely colorectal carcinoma（HCT116）,prostate adenocarcinoma（PC-3） and liver carcinoma（HepG-2） using MTT cytotoxicity assay at 100 μg/mL.Some of the tested compounds displayed good anticancer activities against HCT-116 and PC-3 cells.Whereas,compounds 7d and 11 a showed better antitumor activity than the rest of the compounds against both cell lines.A structure-activity relationship（SAR） has been discussed and structures of the newly synthesized compounds were confirmed by different spectral data（MS,IR,^1H NMR and ^13C NMR） and elemental analysis.
文摘1诱导化疗在头颈癌治疗中的作用及未来的发展趋势
Current status and future directions in induction chemotherapy for head and neck cancer.Argiris A.Crit Rev Oncol Hematol,2013,88（1）：57-74.作为局部晚期头颈癌综合治疗的组成部分,诱导化疗具有缩小瘤体、靶向治疗远处转移的作用。顺铂联合5-氟尿嘧啶辅以紫杉醇（TPF）较单独采用的PF方案效果更好。但是,最近的临床Ⅲ期试验显示,
