期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Synthesis of Oligomer with N-(O,O-diisopropyl)-phosphoryl Arginine and Its Effect on 5-Hydroxytryptamine Receptor
1
作者 李兆陇 付华 《Tsinghua Science and Technology》 SCIE EI CAS 1998年第2期89-93,共5页
Oligomer (OMPA) with N(O,Odiisopropyl) phosphoryl arginine (DIPPArg) has been synthesized and its structure has been identified by IR, 1H NMR,31P NMR, and elemental analysis. The functional conversion ratio of this re... Oligomer (OMPA) with N(O,Odiisopropyl) phosphoryl arginine (DIPPArg) has been synthesized and its structure has been identified by IR, 1H NMR,31P NMR, and elemental analysis. The functional conversion ratio of this reaction was found to be about 30%. The effect of OMPA on the 5hydroxytryptamine (5HT) receptor was studied by a functional test of constriction in rat blood vessels. The results showed that OMPA inhibited 5HT receptorinduced blood vessels constrictions with pD2 values of 565±021 (OMPA) and 745± 030 (DIPPArg) and exhibited significant pharmacological action of antagonism effect on the 5HT receptor. 展开更多
关键词 OLIGOMER Nphosphorylated arginine 5hydroxytryptamine receptor modulation
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部