An efficient and concise synthesis of 5,6-dimethylxanthenone-4-acetic acid（DMXAA） was developed. The overall yield of this 3-step procedure was 82%. The key reaction is the one-step construction of xanthone scaffold...An efficient and concise synthesis of 5,6-dimethylxanthenone-4-acetic acid（DMXAA） was developed. The overall yield of this 3-step procedure was 82%. The key reaction is the one-step construction of xanthone scaffold between 2,5-dibromo-3,4-dimethylbenzoic acid and 2-hydroxyphenyl-acetic acid assisted by microwave irradiation.展开更多
基金Supported by the National Natural Science Foundation of China（No.81172982） and the Natural Science Fotmdation of Guangdong Province, China（No.2015A030311012）.
文摘An efficient and concise synthesis of 5,6-dimethylxanthenone-4-acetic acid（DMXAA） was developed. The overall yield of this 3-step procedure was 82%. The key reaction is the one-step construction of xanthone scaffold between 2,5-dibromo-3,4-dimethylbenzoic acid and 2-hydroxyphenyl-acetic acid assisted by microwave irradiation.
