Microwave irradiation of aromatic aldehyde and 2,4-thiazolidinedione provides a fast and high-yield access to 5-benzylidene-2,4-thiazolidinedione. Seven 3-alkyl-5-benzylidene-2,4-thiazolidinedione compounds were produ...Microwave irradiation of aromatic aldehyde and 2,4-thiazolidinedione provides a fast and high-yield access to 5-benzylidene-2,4-thiazolidinedione. Seven 3-alkyl-5-benzylidene-2,4-thiazolidinedione compounds were produced with high yield by reacting 5-benzylidene-2,4-thiazolidinedione with different alkylating agents under microwave irradiation.展开更多
The crystal of the title compound, 3-(4′-Methoxyl)-phenyl-5-cyano-6-methylthio pyrimidine-2, 4-diones, ([C13H11N3O3S]2, Mr=578.62)，has been prepared and determined by X-ray diffraction. The crystal belongs to the mo...The crystal of the title compound, 3-(4′-Methoxyl)-phenyl-5-cyano-6-methylthio pyrimidine-2, 4-diones, ([C13H11N3O3S]2, Mr=578.62)，has been prepared and determined by X-ray diffraction. The crystal belongs to the monoclinic system, space group P21/n with parameters: a = 11.602(2), b = 15.921(3), c = 13.918(3)?, ( = 94.38(3)(, V = 2563(1) ?3, Z = 4, Dc = 1.499g/cm3, μ(MoK()= 2.64cm-1, F(000)=1200. R and Rw are 0.054 and 0.059, respectively, for 1692 observed unique reflections. The pyrimidione ring is six-membered plane, and the dihedral angle between the pyrimidione ring and benzene ring is 121.05(. From the above result, it could be predicted that the negative atoms among the title compound might interact with target D1 protein, and thus express its inhibitory activity.展开更多
The chemoselective C-and O-prenylation of cyclic 1,3-diketones was achieved by tuning the prenyl source and catalyst.In the presence of the solid acid Nafion,the coupling of 1,3-cyclohexanediones with isoprene gave C-...The chemoselective C-and O-prenylation of cyclic 1,3-diketones was achieved by tuning the prenyl source and catalyst.In the presence of the solid acid Nafion,the coupling of 1,3-cyclohexanediones with isoprene gave C-prenylated 5-chromenones.Alternatively,using prenol as the substrate with the Lewis acid Al Cl3 as the catalyst resulted in the exclusive O-prenylation of 1,3-cyclohexanediones.Notably,the resulting products could easily undergo aromatization to deliver prenylated resorcinols that are otherwise difficult to prepare.Our methodology is highly selective,atom-economical,operationally simple,easily scalable,and has potential applications throughout organic synthesis.展开更多
文摘Microwave irradiation of aromatic aldehyde and 2,4-thiazolidinedione provides a fast and high-yield access to 5-benzylidene-2,4-thiazolidinedione. Seven 3-alkyl-5-benzylidene-2,4-thiazolidinedione compounds were produced with high yield by reacting 5-benzylidene-2,4-thiazolidinedione with different alkylating agents under microwave irradiation.
基金the National Natural Science Foundation of China (No. 29702006, 29832050), the Research Fund for the Doctoral Program of Higher
文摘The crystal of the title compound, 3-(4′-Methoxyl)-phenyl-5-cyano-6-methylthio pyrimidine-2, 4-diones, ([C13H11N3O3S]2, Mr=578.62)，has been prepared and determined by X-ray diffraction. The crystal belongs to the monoclinic system, space group P21/n with parameters: a = 11.602(2), b = 15.921(3), c = 13.918(3)?, ( = 94.38(3)(, V = 2563(1) ?3, Z = 4, Dc = 1.499g/cm3, μ(MoK()= 2.64cm-1, F(000)=1200. R and Rw are 0.054 and 0.059, respectively, for 1692 observed unique reflections. The pyrimidione ring is six-membered plane, and the dihedral angle between the pyrimidione ring and benzene ring is 121.05(. From the above result, it could be predicted that the negative atoms among the title compound might interact with target D1 protein, and thus express its inhibitory activity.
文摘The chemoselective C-and O-prenylation of cyclic 1,3-diketones was achieved by tuning the prenyl source and catalyst.In the presence of the solid acid Nafion,the coupling of 1,3-cyclohexanediones with isoprene gave C-prenylated 5-chromenones.Alternatively,using prenol as the substrate with the Lewis acid Al Cl3 as the catalyst resulted in the exclusive O-prenylation of 1,3-cyclohexanediones.Notably,the resulting products could easily undergo aromatization to deliver prenylated resorcinols that are otherwise difficult to prepare.Our methodology is highly selective,atom-economical,operationally simple,easily scalable,and has potential applications throughout organic synthesis.
