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抗帕金森病药物诱发5⁃羟色胺综合征1例 被引量:1
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作者 武冬冬 李淑华 +3 位作者 苏闻 刘银红 陈海波 陈頔 《诊断学理论与实践》 2023年第3期303-305,共3页
5⁃羟色胺综合征是一种用药产生的药物不良反应,其主要特征是神经肌肉的过度兴奋,大多数情况下该病症状轻微,但在某些情况下可能会严重危及生命。本文报道1例87岁帕金森病(Parkinson’s disease,PD)患者起初因肺部感染、发热入院,经相应... 5⁃羟色胺综合征是一种用药产生的药物不良反应,其主要特征是神经肌肉的过度兴奋,大多数情况下该病症状轻微,但在某些情况下可能会严重危及生命。本文报道1例87岁帕金森病(Parkinson’s disease,PD)患者起初因肺部感染、发热入院,经相应治疗后临床症状改善,但随后病情又波动,出现高热、大汗、意识障碍、肌张力高、肌酸激酶升高。医生结合上述临床表现,逐条分析抗PD药物种类剂量以及合并抗感染用药史后,发现患者超剂量服用司来吉兰,并与加用的抗感染药物利奈唑胺发生药物不良反应,及时诊断5⁃羟色胺综合征,并进行积极妥善处理,停用相关药物,结合物理降温、大量补液等对症支持治疗,使患者病情在24 h内得到有效控制,发病3 d后患者症状基本好转,发病5 d后其症状完全缓解。5⁃羟色胺综合征重在预防,临床医生应加强对此病的认识。 展开更多
关键词 5⁃羟色胺综合征 帕金森病 氧化酶抑制剂 利奈唑
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Effect of heat-sensitive moxibustion plus psychological intervention on SP, 5-HT and quality of life in patients with irritable bowel syndrome 被引量:14
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作者 Long Hai-yan 《Journal of Acupuncture and Tuina Science》 CSCD 2017年第6期420-425,共6页
Objective: To observe the effect of heat-sensitive moxibustion plus psychological intervention on serum contents of substance P(SP) and 5-hydroxytryptamine(5-HT), as well as the quality of life(QOL) in patients... Objective: To observe the effect of heat-sensitive moxibustion plus psychological intervention on serum contents of substance P(SP) and 5-hydroxytryptamine(5-HT), as well as the quality of life(QOL) in patients with irritable bowel syndrome(IBS). Methods: A total of 120 IBS patients were divided into three groups by random sampling method, 40 cases in each group. The heat-sensitive moxibustion group received heat-sensitive moxibustion, the psychological intervention group received psychological intervention, while the observation group received both methods. The therapeutic efficacy was evaluated after 3 courses of treatment. Results: After treatment, the therapeutic efficacy of the observation group was better than that of the heat-sensitive moxibustion group and the psychological intervention group(P〈0.01), and the heat-sensitive moxibsution group was better than the psychological intervention group(P〈0.05). In comparing the bowel symptom scale(BSS), the observation group was better than the other two groups(P〈0.05), and there was a significant difference between the heat-sensitive moxibustion group and the psychological intervention group(P〈0.05). In the comparison of QOL, the observation group was significantly superior to the other two groups(P〈0.05), and there was a significant difference between the heat-sensitive moxibustion group and psychological intervention group(P〈0.05). In comparing serum SP and 5-HT, the observation group was markedly better than the other two groups(P〈0.05), and there were significant differences between the heat-sensitive moxibustion group and psychological intervention group(P〈0.05). The self-rating anxiety scale(SAS) and self-rating depression scale(SDS) were used to estimate the mental state of the three groups, revealing that the observation group was better than the heat-sensitive moxibustion group and the psychological intervention group(P〈0.05), and there were significant differences between the latter two groups(P〈0.05). Conclusion: Heat-sensitive moxibustion plus psychological intervention can regulate the levels of SP and 5-HT, improve BSS, SDS, SAS and QOL in treating IBS. 展开更多
关键词 Moxibustion Therapy Moxa Stick Moxibustion Heat-sensitive Moxibustion PSYCHOTHERAPY Irritable BowelSyndrome Substance P 5-HYDROXYTRYPTAMINE Quality of Life
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