目的研究非肌层浸润膀胱癌(non-muscle invasive bladder cancer,NMIBC)癌组织中结构域蛋白去泛素化酶5(domain protein ubiquitin 5,OTUD5)、环指蛋白186(ring finger protein 186,RNF186)表达与临床病理特征的关系及预后价值研究。方...目的研究非肌层浸润膀胱癌(non-muscle invasive bladder cancer,NMIBC)癌组织中结构域蛋白去泛素化酶5(domain protein ubiquitin 5,OTUD5)、环指蛋白186(ring finger protein 186,RNF186)表达与临床病理特征的关系及预后价值研究。方法收集2019年1月~2020年1月唐山市中医院收治的106例NMIBC患者。免疫组织化学检测NMIBC癌组织及癌旁组织OTUD5,RNF186表达。比较不同临床病理特征NMIBC癌组织OTUD5,RNF186表达差异。Kaplan-Meier曲线分析(Log-Rank检验)OTUD5,RNF186表达对NMIBC无进展生存预后的影响。COX回归模型分析影响NMIBC患者无进展生存预后的因素。结果NMIBC癌组织中OTUD5(62.26%),RNF186(66.04%)的阳性率高于癌旁组织(11.32%,8.49%),差异具有统计学意义(χ^(2)=59.146,75.079,均P<0.05)。NMIBC癌组织中OTUD5与RNF186表达呈显著正相关(r=0.659,P<0.05)。T 1期、高级别尿路上皮癌NMIBC癌组织中OTUD5(72.97%,84.21%),RNF186(77.03,86.84%)阳性率高于Ta/Tis期(37.50%,50.00%)、低级别尿路上皮癌(40.63%,54.41%),差异具有统计学意义(χ^(2)=11.964,13.199;12.143,11.431,均P<0.05)。OTUD5阳性组(40.91%)、RNF186阳性组(45.71%)三年累积无进展生存率低于OTUD5阴性组(90.00%)、RNF186阴性组(86.11%)患者(Log-Ranktestχ^(2)=24.710,14.586,均P<0.05)。OTUD5阳性(OR=1.446,95%CI:1.086~1.925)、RNF186阳性(OR=1.579,95%CI:1.132~2.024)、肿瘤TNM分期T1期(OR=1.582,95%CI:1.219~2.054)、病理分级高级别(OR=1.570,95%CI:1.188~2.074)是影响NMIBC患者无进展生存的独立危险因素(均P<0.001)。结论NMIBC患者癌组织OTUD5,RNF186表达升高,与肿瘤TNM分期、病理分级有关,是影响NMIBC患者预后的独立危险因素。展开更多
新一代5G无线通信网络(the fifth generation,5G)是利用软件定义网络(software defined network,SDN)、网络功能虚拟化(network funcion virtualization,NFV)等技术构建而成的虚拟切片网络。但在虚拟网络切片划分的过程中,由于用户接入...新一代5G无线通信网络(the fifth generation,5G)是利用软件定义网络(software defined network,SDN)、网络功能虚拟化(network funcion virtualization,NFV)等技术构建而成的虚拟切片网络。但在虚拟网络切片划分的过程中,由于用户接入网络具有跨区移动性特征,使得数据传输的切片接入服务存在着切片应用的分配和调度问题。为解决5G切片化网络的用户跨区移动带来的切片重新接入、切片流量分配问题,提出了基于切换管理算法的用户切换机制。根据用户业务类型、服务质量等级(quality of service,QoS),利用切换管理算法选择接入站点的网络切片,提供网络切片代理的接入服务,保证跨区移动用户的网络吞吐量、数据传输速率。仿真实验结果得出,在跨区用户数量、网络切片类型不断增多的情况下,基于切换管理算法的站点筛选、网络切片接入服务能够有效保证数据通信传输的高吞吐量,切片快速切换成功率在80%以上,有着更加优良的切换控制水平。展开更多
With the continuous improvement of solar energy production capacity,how to effectively use the electricity generated by renewable solar energy for electrochemical conversion of biomass is a hot topic.Electrochemical c...With the continuous improvement of solar energy production capacity,how to effectively use the electricity generated by renewable solar energy for electrochemical conversion of biomass is a hot topic.Electrochemical conversion of 5-hydroxymethylfurfural(HMF)to biofuels and value-added oxygenated commodity chemicals provides a promising and alternative pathway to convert re-newable electricity into chemicals.Although nickel-based eletrocatalysts are well-known for HMF oxidation,their relatively low intrinsic activity,poor conductivity and stability still limit the poten-tial applications.Here,we report the fabrication of a freestanding nickel-based electrode,in which Ni(OH)_(2) species were in-situ constructed on Ni foam(NF)support using a facile ac-id-corrosion-induced strategy.The Ni(OH)2/NF electrocatalyst exhibits stable and efficient electro-chemical HMF oxidation into 2,5-furandicarboxylic acid(FDCA)with HMF conversion close to 100% with high Faraday efficiency.In-situ formation strategy results in a compact interface between Ni(OH)_(2) and NF,which contributes to good conductivity and stability during electrochemical reac-tions.The superior performance benefits from dynamic cyclic evolution of Ni(OH)_(2) to NiOOH,which acts as the reactive species for HMF oxidation to FDCA.A scaled-up device based on a continu-ous-flow electrolytic cell was also established,giving stable operation with a high FDCA production rate of 27 mg h^(-1)cm^(−2).This job offers a straightforward,economical,and scalable design strategy to design efficient and durable catalysts for electrochemical conversion of valuable chemicals.展开更多
目的:探讨lgr5甲基化与人类卵巢癌临床病理之间的联系,以及其作为判定总的生存率的价值。方法:采用甲基化特异性聚合酶链式反应(methylation specific polymerase chain reaction,MSP)方法分析卵巢癌患者石蜡组织中lgr5启动子DNA甲基化...目的:探讨lgr5甲基化与人类卵巢癌临床病理之间的联系,以及其作为判定总的生存率的价值。方法:采用甲基化特异性聚合酶链式反应(methylation specific polymerase chain reaction,MSP)方法分析卵巢癌患者石蜡组织中lgr5启动子DNA甲基化情况。结果:lgr5在正常卵巢组织中几乎无甲基化改变,而在良性卵巢肿瘤中频率升高,上皮性卵巢癌组织中甲基化频率明显升高(P<0.01);lgr5甲基化与低分化上皮性卵巢癌(P<0.01)、肿瘤分期Ⅲ～Ⅳ(P<0.05)以及淋巴结转移(P<0.01)相关,但与组织类型关系不明显(P>0.05)。在70例上皮性卵巢癌患者组织中,lgr5甲基化频率为62.9%(44/70),并且5年总的生存率明显低于未甲基化的患者(P<0.05)。结论:lgr5甲基化与上皮性卵巢癌分化程度、肿瘤分期Ⅲ～Ⅳ以及淋巴结转移密切相关,同时也可以作为上皮性卵巢癌患者总的生存率的判定指标之一。展开更多
文摘新一代5G无线通信网络(the fifth generation,5G)是利用软件定义网络(software defined network,SDN)、网络功能虚拟化(network funcion virtualization,NFV)等技术构建而成的虚拟切片网络。但在虚拟网络切片划分的过程中,由于用户接入网络具有跨区移动性特征,使得数据传输的切片接入服务存在着切片应用的分配和调度问题。为解决5G切片化网络的用户跨区移动带来的切片重新接入、切片流量分配问题,提出了基于切换管理算法的用户切换机制。根据用户业务类型、服务质量等级(quality of service,QoS),利用切换管理算法选择接入站点的网络切片,提供网络切片代理的接入服务,保证跨区移动用户的网络吞吐量、数据传输速率。仿真实验结果得出,在跨区用户数量、网络切片类型不断增多的情况下,基于切换管理算法的站点筛选、网络切片接入服务能够有效保证数据通信传输的高吞吐量,切片快速切换成功率在80%以上,有着更加优良的切换控制水平。
文摘With the continuous improvement of solar energy production capacity,how to effectively use the electricity generated by renewable solar energy for electrochemical conversion of biomass is a hot topic.Electrochemical conversion of 5-hydroxymethylfurfural(HMF)to biofuels and value-added oxygenated commodity chemicals provides a promising and alternative pathway to convert re-newable electricity into chemicals.Although nickel-based eletrocatalysts are well-known for HMF oxidation,their relatively low intrinsic activity,poor conductivity and stability still limit the poten-tial applications.Here,we report the fabrication of a freestanding nickel-based electrode,in which Ni(OH)_(2) species were in-situ constructed on Ni foam(NF)support using a facile ac-id-corrosion-induced strategy.The Ni(OH)2/NF electrocatalyst exhibits stable and efficient electro-chemical HMF oxidation into 2,5-furandicarboxylic acid(FDCA)with HMF conversion close to 100% with high Faraday efficiency.In-situ formation strategy results in a compact interface between Ni(OH)_(2) and NF,which contributes to good conductivity and stability during electrochemical reac-tions.The superior performance benefits from dynamic cyclic evolution of Ni(OH)_(2) to NiOOH,which acts as the reactive species for HMF oxidation to FDCA.A scaled-up device based on a continu-ous-flow electrolytic cell was also established,giving stable operation with a high FDCA production rate of 27 mg h^(-1)cm^(−2).This job offers a straightforward,economical,and scalable design strategy to design efficient and durable catalysts for electrochemical conversion of valuable chemicals.
文摘目的:探讨lgr5甲基化与人类卵巢癌临床病理之间的联系,以及其作为判定总的生存率的价值。方法:采用甲基化特异性聚合酶链式反应(methylation specific polymerase chain reaction,MSP)方法分析卵巢癌患者石蜡组织中lgr5启动子DNA甲基化情况。结果:lgr5在正常卵巢组织中几乎无甲基化改变,而在良性卵巢肿瘤中频率升高,上皮性卵巢癌组织中甲基化频率明显升高(P<0.01);lgr5甲基化与低分化上皮性卵巢癌(P<0.01)、肿瘤分期Ⅲ～Ⅳ(P<0.05)以及淋巴结转移(P<0.01)相关,但与组织类型关系不明显(P>0.05)。在70例上皮性卵巢癌患者组织中,lgr5甲基化频率为62.9%(44/70),并且5年总的生存率明显低于未甲基化的患者(P<0.05)。结论:lgr5甲基化与上皮性卵巢癌分化程度、肿瘤分期Ⅲ～Ⅳ以及淋巴结转移密切相关,同时也可以作为上皮性卵巢癌患者总的生存率的判定指标之一。
