目的:观察柴胡加龙骨牡蛎汤加减联合帕罗西汀对产后抑郁患者的疗效及5-HT的影响。方法:将我院2018年1月至2019年9月产后抑郁患者68例,随机分为两组,各34例,对照组采用帕罗西汀治疗;观察组采用帕罗西汀联合柴胡加龙骨牡蛎汤加减治疗。治...目的:观察柴胡加龙骨牡蛎汤加减联合帕罗西汀对产后抑郁患者的疗效及5-HT的影响。方法:将我院2018年1月至2019年9月产后抑郁患者68例,随机分为两组,各34例,对照组采用帕罗西汀治疗;观察组采用帕罗西汀联合柴胡加龙骨牡蛎汤加减治疗。治疗前、治疗2周和治疗4周时记录患者去甲肾上腺素(Norepinephrine, NE)、5-羟色胺(5-hydroxytryptamine, 5-HT)、多巴胺(dopamine, DA)及Hamilton汉密尔顿抑郁量表(Hamilton Depression Scale, HAMD)、匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index, PSQI)、健康调查简表(the MOS item short from health survey, SF-36),比较临床疗效及不良反应。结果:对照组有效率76.47%低于观察组94.12%,差异有统计学意义(P<0.05)。与治疗前比,两组治疗2周、治疗4周时血NE、5-HT、DA水平升高;与对照组比,观察组治疗2周、治疗4周时血NE、5-HT、DA水平较高,差异有统计学意义(P<0.05)。与治疗前比,两组治疗2周、治疗4周时HAMD量表、PSQI量表降低,SF-36评分升高;与对照组比,观察组治疗2周、治疗4周时HAMD量表、PSQI量表较低,SF-36评分较高,差异有统计学意义(P<0.05)。治疗期间两组患者无不良反应出现。结论:柴胡加龙骨牡蛎汤加减联合帕罗西汀对产后抑郁患者的疗效确切,可以改善抑郁症状,提高睡眠和生活质量,与提高神经递质有关,值得推广。展开更多
Inflammation may play a role in postoperative cognitive dysfunction. 5＇ Adenosine monophos- phate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-a are involved in inflamm...Inflammation may play a role in postoperative cognitive dysfunction. 5＇ Adenosine monophos- phate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-a are involved in inflammation. Therefore, these inflammatory mediators may be involved in postoperative cognitive dysfunction. Western immunoblot analysis revealed 5＇ adenosine mo- nophosphate-activated protein kinase and nuclear factor-kappa B in the hippocampus of aged rats were increased 1-7 days after splenectomy. Moreover, interleukin-1β and tumor necrosis fac- tor-α were upregulated and gradually decreased. Therefore, these inflammatory mediators may participate in the splenectomy model of postoperative cognitive dysfunction in aged rats.展开更多
目的:利用表面增强拉曼光谱(SERS)技术快速非靶向筛查保健酒中非法添加那非类药物。方法:制备合适的那非类药物胶体金SERS基底,基底与78种那非类药物混合后进行SERS分析,建立谱图筛查数据库,以匹配度是否高于70%作为评判是否疑似添加那...目的:利用表面增强拉曼光谱(SERS)技术快速非靶向筛查保健酒中非法添加那非类药物。方法:制备合适的那非类药物胶体金SERS基底,基底与78种那非类药物混合后进行SERS分析,建立谱图筛查数据库,以匹配度是否高于70%作为评判是否疑似添加那非类药物的依据。最后考察方法的灵敏度和特异性。结果:那非类药物胶体金SERS基底最佳制备方式为98.3 mL超纯水中加入1.0 mL 1%氯金酸和0.7 mL 1%柠檬酸三钠;最低检出质量浓度分别为西地那非0.05 mg/L、他达那非0.5 mg/L、硫代西地那非0.05 mg/L、乙酰伐地那非0.1 mg/L;对模拟样品进行检测,其定性结果与高效液相色谱—质谱法测量结果一致。结论:理论上,该方法可非靶向筛查出保健酒中非法添加的那非类药物。展开更多
We analyse the Casimir effect for parallel plates at finite temperature in the presence of compactified universal extra dimensions and analytically show the thermal corrections to the effect in detail. The Casimir eff...We analyse the Casimir effect for parallel plates at finite temperature in the presence of compactified universal extra dimensions and analytically show the thermal corrections to the effect in detail. The Casimir effect for different sizes of universal extra dimensions is investigated to test the five-dimensional Kaluza-Klein theory.展开更多
文摘目的:观察柴胡加龙骨牡蛎汤加减联合帕罗西汀对产后抑郁患者的疗效及5-HT的影响。方法:将我院2018年1月至2019年9月产后抑郁患者68例,随机分为两组,各34例,对照组采用帕罗西汀治疗;观察组采用帕罗西汀联合柴胡加龙骨牡蛎汤加减治疗。治疗前、治疗2周和治疗4周时记录患者去甲肾上腺素(Norepinephrine, NE)、5-羟色胺(5-hydroxytryptamine, 5-HT)、多巴胺(dopamine, DA)及Hamilton汉密尔顿抑郁量表(Hamilton Depression Scale, HAMD)、匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index, PSQI)、健康调查简表(the MOS item short from health survey, SF-36),比较临床疗效及不良反应。结果:对照组有效率76.47%低于观察组94.12%,差异有统计学意义(P<0.05)。与治疗前比,两组治疗2周、治疗4周时血NE、5-HT、DA水平升高;与对照组比,观察组治疗2周、治疗4周时血NE、5-HT、DA水平较高,差异有统计学意义(P<0.05)。与治疗前比,两组治疗2周、治疗4周时HAMD量表、PSQI量表降低,SF-36评分升高;与对照组比,观察组治疗2周、治疗4周时HAMD量表、PSQI量表较低,SF-36评分较高,差异有统计学意义(P<0.05)。治疗期间两组患者无不良反应出现。结论:柴胡加龙骨牡蛎汤加减联合帕罗西汀对产后抑郁患者的疗效确切,可以改善抑郁症状,提高睡眠和生活质量,与提高神经递质有关,值得推广。
文摘Inflammation may play a role in postoperative cognitive dysfunction. 5＇ Adenosine monophos- phate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-a are involved in inflammation. Therefore, these inflammatory mediators may be involved in postoperative cognitive dysfunction. Western immunoblot analysis revealed 5＇ adenosine mo- nophosphate-activated protein kinase and nuclear factor-kappa B in the hippocampus of aged rats were increased 1-7 days after splenectomy. Moreover, interleukin-1β and tumor necrosis fac- tor-α were upregulated and gradually decreased. Therefore, these inflammatory mediators may participate in the splenectomy model of postoperative cognitive dysfunction in aged rats.
文摘目的:利用表面增强拉曼光谱(SERS)技术快速非靶向筛查保健酒中非法添加那非类药物。方法:制备合适的那非类药物胶体金SERS基底,基底与78种那非类药物混合后进行SERS分析,建立谱图筛查数据库,以匹配度是否高于70%作为评判是否疑似添加那非类药物的依据。最后考察方法的灵敏度和特异性。结果:那非类药物胶体金SERS基底最佳制备方式为98.3 mL超纯水中加入1.0 mL 1%氯金酸和0.7 mL 1%柠檬酸三钠;最低检出质量浓度分别为西地那非0.05 mg/L、他达那非0.5 mg/L、硫代西地那非0.05 mg/L、乙酰伐地那非0.1 mg/L;对模拟样品进行检测,其定性结果与高效液相色谱—质谱法测量结果一致。结论:理论上,该方法可非靶向筛查出保健酒中非法添加的那非类药物。
文摘We analyse the Casimir effect for parallel plates at finite temperature in the presence of compactified universal extra dimensions and analytically show the thermal corrections to the effect in detail. The Casimir effect for different sizes of universal extra dimensions is investigated to test the five-dimensional Kaluza-Klein theory.
