PhCH2)3Sn·(O2CC5H4N)·(H2O)]n was synthesized by the reaction of 4-pyridine car-boxylic acid with the tribenzyltin o xide and was characterized by IR,1 H NMR and MS.Its crystal structure was determined by X-r...PhCH2)3Sn·(O2CC5H4N)·(H2O)]n was synthesized by the reaction of 4-pyridine car-boxylic acid with the tribenzyltin o xide and was characterized by IR,1 H NMR and MS.Its crystal structure was determined by X-ray single crystal diffraction.The crystal belongs to monoclinic.The space group P21 /c with unit cell parameters a=1.2241(8)nm,b=0.9660(6)nm,c=2.3708(15)nm,β=102.722(12)°,V=2.734(3)nm3,Z =4,Dc=1.298g·cm-3 .In crystal,the tin atom rendered five-coordinate in a trigo nal bipyramidal structure which is b ridged by 4-pyridine carboxy-late into one-dimensional chain polymers.展开更多
5-羟色胺系统与抑郁症关系密切,阐明5-羟色胺相关受体在抑郁症中的作用,有助于抗抑郁药物的开发与应用,提高抑郁症的治疗效果。在5-羟色胺的受体中,5-羟色胺2C受体(5-hydroxytryptamine type 2C receptor,5-HT2CR)在抑郁症的发病及治疗...5-羟色胺系统与抑郁症关系密切,阐明5-羟色胺相关受体在抑郁症中的作用,有助于抗抑郁药物的开发与应用,提高抑郁症的治疗效果。在5-羟色胺的受体中,5-羟色胺2C受体(5-hydroxytryptamine type 2C receptor,5-HT2CR)在抑郁症的发病及治疗机制中发挥重要的作用。虽然已有关于5-羟色胺2C受体与抑郁症具有相关性的报道,但近年来,5-羟色胺2C受体参与抑郁症的相关分子机制有了新的进展,本文将抑郁症分子机制中5-羟色胺2C受体的作用加以综述,以期为相关工作提供依据。展开更多
文摘PhCH2)3Sn·(O2CC5H4N)·(H2O)]n was synthesized by the reaction of 4-pyridine car-boxylic acid with the tribenzyltin o xide and was characterized by IR,1 H NMR and MS.Its crystal structure was determined by X-ray single crystal diffraction.The crystal belongs to monoclinic.The space group P21 /c with unit cell parameters a=1.2241(8)nm,b=0.9660(6)nm,c=2.3708(15)nm,β=102.722(12)°,V=2.734(3)nm3,Z =4,Dc=1.298g·cm-3 .In crystal,the tin atom rendered five-coordinate in a trigo nal bipyramidal structure which is b ridged by 4-pyridine carboxy-late into one-dimensional chain polymers.
文摘5-羟色胺系统与抑郁症关系密切,阐明5-羟色胺相关受体在抑郁症中的作用,有助于抗抑郁药物的开发与应用,提高抑郁症的治疗效果。在5-羟色胺的受体中,5-羟色胺2C受体(5-hydroxytryptamine type 2C receptor,5-HT2CR)在抑郁症的发病及治疗机制中发挥重要的作用。虽然已有关于5-羟色胺2C受体与抑郁症具有相关性的报道,但近年来,5-羟色胺2C受体参与抑郁症的相关分子机制有了新的进展,本文将抑郁症分子机制中5-羟色胺2C受体的作用加以综述,以期为相关工作提供依据。
