小剂量5-氟脲嘧啶与顺铂持续输注治疗中晚期食管癌近期疗效观察

目的 :观察小剂量 5 氟脲嘧啶与顺铂持续输注化疗治疗中晚期食管癌的治疗效果。方法 :对 2 1例中晚期食管鳞癌患者均行右锁骨下静脉穿刺置管 ,应用英国佳士比公司生产的M 2 6、M 16微量注射泵作持续输注器 ,每日5 FU2 5 0mg/m2 及DDP6mg/m2 ,均经深静脉持续输注 ,连续 2 1d ,间隔 10d后重复第二疗程。结果 :治疗后取得6 6 .7%的有效率 ,疗效与传统FP方案相仿 ,但副作用减少。结论 :应用小剂量 5 FU与DDP持续输注化疗治疗中晚期食管癌疗效较好 ,副作用减少 。

Synthesis of Aminoglucose Conjugates of 5-Fluorouracil-1-acetic Acid and 5-Fluorouracil-1-propanoic Acid and Their Antitumor Activities

Six aminoglucose conjugates were synthesized by the reaction of aminoglucose with 5-fluorou-racil-1-acetic acid or 5-fluorouracil-1-propanoic acid and confirmed by IR, 1H NMR and elemental analyses. Their antitumor activities against A2780 cells and PC-14 cells were also evaluated.