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Synthesis, Structure Analysis, and Antitumor Activity of (R)-2,4-Dioxo-5-fluoro-l-[1-(methoxycarbonyl) Ethylaminocarbonylmethyl]-1,2,3,4-tetrahydropyrimidine 被引量:5
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作者 袁继新 蔡晓庆 +1 位作者 陈迪妹 胡茂林 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2007年第3期417-421,共5页
A new dipeptide compound, (R)-2,4-dioxo-5-fluoro-1-[1-(methoxycarbonyl) ethylaminocarbonylmethyl]-1,2,3, 4-tetrahydropyrimidine (5-FUAPM), has been synthesized and identified by means of elemental analysis, IR, ... A new dipeptide compound, (R)-2,4-dioxo-5-fluoro-1-[1-(methoxycarbonyl) ethylaminocarbonylmethyl]-1,2,3, 4-tetrahydropyrimidine (5-FUAPM), has been synthesized and identified by means of elemental analysis, IR, ^1H NMR and ^13C NMR spectra. The single crystal of compound 5-FUAPMoDMF was also obtained and characterized by DSC-TGA techniques. The crystal belongs to orthorhombic space group P212121 with the cell parameters: a= 0.4740(7) nm, b= 1.923(3) nm, c= 1.9229 nm, a=β=y=90°, V= 1.753 nm^3, Z=4, Dc= 1.312 g/cm^3, Mr=346.32, F(000)=728 and u=0.111 mm^-1. The final R and wR are 0.1378 and 0.2862, respectively. The result of the biological test showed that the compound 5-FUAPM has certain antitumor activities. 展开更多
关键词 5-fuapm SYNTHESIS STRUCTURE thermal analysis antitumor activity
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