In this paper,obtainment of 3 by simultaneous inversion of configurations of C_(22),C_(23) in 2 via its ditosylate or dimesylate was unsuccessful,leading to elimination products instead.However, monotosylate of 2 can ...In this paper,obtainment of 3 by simultaneous inversion of configurations of C_(22),C_(23) in 2 via its ditosylate or dimesylate was unsuccessful,leading to elimination products instead.However, monotosylate of 2 can be readily obtained with exclusive regioselectivity,which in turn gave a single epoxide 7b Hydrolysis of 7b gave 3 and 2 is a ratio of 2:1,with a combined yield of 80%.The recovered 2 can of course be recycled again.展开更多
Lithium metal has gained extensive attention as the most ideal candidate for next-generation battery anode owing to the ultrahigh specific capacity and the lowest electrochemical potential.However,uncontrollable dendr...Lithium metal has gained extensive attention as the most ideal candidate for next-generation battery anode owing to the ultrahigh specific capacity and the lowest electrochemical potential.However,uncontrollable dendrite growth and huge volume variation extremely restrict the future deployment of lithium metal batteries.Herein,we report metal chalcogenide SnSSe with unique nanoplate stacking structure as a robust substrate for stable Li metal anode.During the initial Li plating process,lithiophilic Li_(22)Sn_(5) alloy and Li_(2)S/Li_(2)Se sites are obtained via in-situ electrochemical reaction of Li metal and SnSSe.Density functional theory(DFT)calculation demonstrates that the formed Li_(2)S/Li_(2)Se achieves low Li diffusion energy barrier,ensuring rapid Li~+migration.Li_(22)Sn_(5) alloy provides strong nucleation sites,promoting uniform Li nucleation.Furthermore,in-situ optical microscopy analysis suggests that the synthesized effect fundamentally inhibits lithium dendrite growth.Consequently,SnSSe modified Cu foil delivered an ultralow nucleation overpotential,superior cycling stability with 450 cycles(Coulombic efficiency,>98%),and excellent plating/stripping behavior over 2200 h at 0.5 mA cm^(-2).Moreover,the brilliant reversible cycles and rate capability were also realized in Li@SnSSe//LiFePO_(4)(LFP)full cell,shedding light on the feasibility of SnSSe for stable and dendrite-free lithium metal anode.展开更多
The pathogenesis of inflammatory bowel disease （IBD） is only partially understood. Various environmental and host （e.g. genetic-, epithelial-, immune and nonimmune） factors are involved. It is a multifactorial pol...The pathogenesis of inflammatory bowel disease （IBD） is only partially understood. Various environmental and host （e.g. genetic-, epithelial-, immune and nonimmune） factors are involved. It is a multifactorial polygenic disease with probable genetic heterogeneity. Some genes are associated with IBD itself, while others increase the risk of ulcerative colitis （UC） or Crohn＇ s disease （CD） or are associated with disease location and/or behaviour. This review addresses recent advances in the genetics of IBD. The article discusses the current information on the crosstalk between microbial and genetic factors （e.g. NOD2/CARD15, SLC22A46A5 and DLG5）. The genetic data acquired in recent years help in understanding the pathogenesis of IBD and can identify a number of potential targets for therapeutic intervention. In the future, genetics may help more accurately diagnose and predict disease course in IBD.展开更多
At 02:04 on May 22,2021,an M_(S)7.4 earthquake occurred in Madoi County in Qinghai Province,China.This earthquake is the largest seismic event in China since the 2008M_(S) 8.0 Wenchuan earthquake.Thus,it is critical t...At 02:04 on May 22,2021,an M_(S)7.4 earthquake occurred in Madoi County in Qinghai Province,China.This earthquake is the largest seismic event in China since the 2008M_(S) 8.0 Wenchuan earthquake.Thus,it is critical to investigate surface deformation and damage in time to accurately understand the seismogenic structure of the Madoi earthquake and the seismogenic capacity of the blocks in this region.This study focuses on the Xuema Village,located at the eastern end of the coseismic surface ruptures produced by the event,and assesses the deformation and seismic damage in this area based on field surveys,UAV photogrammetry,and ground penetrating radar(GPR).The results indicate that the rupture scale is substantially smaller at the eastern end of the rupture zone compared to other segments.En echelon type shear tensile fractures are concentrated in a width range of 50–100 m,and the width of single fractures ranges from 20 to 30 cm.In contrast,the degree of seismic damage significantly increases at this site.All of the brick and timber houses are damaged or collapsed,while the steel frame structures and the color steel houses are slightly damaged.More than 80%of the bridge decks on the Changma River Bridge collapse,similar to the terraces along the Youerqu and Changma Rivers and the cut slopes of Provincial Highway S205.We infer that the seismogenic fault of the Madoi earthquake exerts a tail effect in this segment.The tension zone has led to a reduction at the eastern end of the rupture zone,causing shaking damage.Local topography and buildings without earthquake-resistant construction along the strike of the rupture zone have undergone different levels of seismic damage.展开更多
文摘In this paper,obtainment of 3 by simultaneous inversion of configurations of C_(22),C_(23) in 2 via its ditosylate or dimesylate was unsuccessful,leading to elimination products instead.However, monotosylate of 2 can be readily obtained with exclusive regioselectivity,which in turn gave a single epoxide 7b Hydrolysis of 7b gave 3 and 2 is a ratio of 2:1,with a combined yield of 80%.The recovered 2 can of course be recycled again.
基金financially supported by the National Natural Science Foundation of China(52074113,22005091,and 22005092)the Hunan University Outstanding Youth Science Foundation(531118040319)+5 种基金the Science and Technology Innovation Program of Hunan Province(2021RC3055)the Changsha Municipal Natural Science Foundation(kq2014037)the CITIC Metals Ningbo Energy Co.Ltd.(H202191380246)the Chongqing Talents:Exceptional Young Talents Project(CQYC202105015)the Shenzhen Virtual University Park Basic Research Project of Free exploration(2021Szvup036)financially supported by the Graduate Research and Innovation Projects of Hunan Province(QL20210088)。
文摘Lithium metal has gained extensive attention as the most ideal candidate for next-generation battery anode owing to the ultrahigh specific capacity and the lowest electrochemical potential.However,uncontrollable dendrite growth and huge volume variation extremely restrict the future deployment of lithium metal batteries.Herein,we report metal chalcogenide SnSSe with unique nanoplate stacking structure as a robust substrate for stable Li metal anode.During the initial Li plating process,lithiophilic Li_(22)Sn_(5) alloy and Li_(2)S/Li_(2)Se sites are obtained via in-situ electrochemical reaction of Li metal and SnSSe.Density functional theory(DFT)calculation demonstrates that the formed Li_(2)S/Li_(2)Se achieves low Li diffusion energy barrier,ensuring rapid Li~+migration.Li_(22)Sn_(5) alloy provides strong nucleation sites,promoting uniform Li nucleation.Furthermore,in-situ optical microscopy analysis suggests that the synthesized effect fundamentally inhibits lithium dendrite growth.Consequently,SnSSe modified Cu foil delivered an ultralow nucleation overpotential,superior cycling stability with 450 cycles(Coulombic efficiency,>98%),and excellent plating/stripping behavior over 2200 h at 0.5 mA cm^(-2).Moreover,the brilliant reversible cycles and rate capability were also realized in Li@SnSSe//LiFePO_(4)(LFP)full cell,shedding light on the feasibility of SnSSe for stable and dendrite-free lithium metal anode.
文摘The pathogenesis of inflammatory bowel disease （IBD） is only partially understood. Various environmental and host （e.g. genetic-, epithelial-, immune and nonimmune） factors are involved. It is a multifactorial polygenic disease with probable genetic heterogeneity. Some genes are associated with IBD itself, while others increase the risk of ulcerative colitis （UC） or Crohn＇ s disease （CD） or are associated with disease location and/or behaviour. This review addresses recent advances in the genetics of IBD. The article discusses the current information on the crosstalk between microbial and genetic factors （e.g. NOD2/CARD15, SLC22A46A5 and DLG5）. The genetic data acquired in recent years help in understanding the pathogenesis of IBD and can identify a number of potential targets for therapeutic intervention. In the future, genetics may help more accurately diagnose and predict disease course in IBD.
基金This research was supported by the National Natural Science Foundation of China(42072248,42041006)the National Key Research and Development Program(2021YFC3000601-3,2019YFE0108900)Scientific Research Project of China Datang Corporation Ltd.(DTXZ-02-2021).
文摘At 02:04 on May 22,2021,an M_(S)7.4 earthquake occurred in Madoi County in Qinghai Province,China.This earthquake is the largest seismic event in China since the 2008M_(S) 8.0 Wenchuan earthquake.Thus,it is critical to investigate surface deformation and damage in time to accurately understand the seismogenic structure of the Madoi earthquake and the seismogenic capacity of the blocks in this region.This study focuses on the Xuema Village,located at the eastern end of the coseismic surface ruptures produced by the event,and assesses the deformation and seismic damage in this area based on field surveys,UAV photogrammetry,and ground penetrating radar(GPR).The results indicate that the rupture scale is substantially smaller at the eastern end of the rupture zone compared to other segments.En echelon type shear tensile fractures are concentrated in a width range of 50–100 m,and the width of single fractures ranges from 20 to 30 cm.In contrast,the degree of seismic damage significantly increases at this site.All of the brick and timber houses are damaged or collapsed,while the steel frame structures and the color steel houses are slightly damaged.More than 80%of the bridge decks on the Changma River Bridge collapse,similar to the terraces along the Youerqu and Changma Rivers and the cut slopes of Provincial Highway S205.We infer that the seismogenic fault of the Madoi earthquake exerts a tail effect in this segment.The tension zone has led to a reduction at the eastern end of the rupture zone,causing shaking damage.Local topography and buildings without earthquake-resistant construction along the strike of the rupture zone have undergone different levels of seismic damage.
