We describe in this paper the fabrication of two- and one-dimensional nanostructures with organic molecular beam epitaxy （OMBE） principle based on controlled selfassembly by using adsorbate-substrate and intennolecu...We describe in this paper the fabrication of two- and one-dimensional nanostructures with organic molecular beam epitaxy （OMBE） principle based on controlled selfassembly by using adsorbate-substrate and intennolecular interactions that are important in molecular fabrication. Cu（100） single crystal was used as substrate in fabricating molecular nanostructures. Scanning tunneling microscopy （STM） experiments confirmed that Zn-tetra- [3,5-di-t-butylphenyl]porphyrin-molecules can be used to fabricate both monolayer and molecular wire on Cu（100） surface simultaneously, and the latter is arranged on the terrace edges. We herein briefly discuss the selectivity in terms of a mechanism in which the highest occupied and lowest unoccupied molecular orbitals （HOMO and LUMO） of the molecules interact with the surface.展开更多
The mean activity coefficient of 5, 10,15 , 20-tetrakis (P-methoxyl-O-sulfophenyl)porphyrin sodium in dilute aqueous solution has been determined in the modality range 0. 00547-0. 08871 mol · kg-1at 273. 2 K by t...The mean activity coefficient of 5, 10,15 , 20-tetrakis (P-methoxyl-O-sulfophenyl)porphyrin sodium in dilute aqueous solution has been determined in the modality range 0. 00547-0. 08871 mol · kg-1at 273. 2 K by the freezing-point depression method . The results of γ± are 0. 9945-0. 7695, it is in close agreement with that by isopiestic method.展开更多
Protoporphyrin IX (PPIX) fluorescence-guided brain tumor resection, using 5-aminolevulinic acid (5-ALA), is among the most valuable tools for determining tumor removal area. However, PPIX fluorescence is not necessari...Protoporphyrin IX (PPIX) fluorescence-guided brain tumor resection, using 5-aminolevulinic acid (5-ALA), is among the most valuable tools for determining tumor removal area. However, PPIX fluorescence is not necessarily achieved during an operation visually even when 5-ALA is used, and we do not know until tumor exposure to the excitation light of the ultraviolet region whether PPIX fluorescence has been achieved. When a particular biopsy and frozen section diagnosis is made, the reason for lack of PPIX fluorescence in the tissue cannot be judged. We do not know whether the tumor fails to fluoresce or no fluorescence is seen because it is not the main body of the tumor. We investigated whether the presence or absence of tumor fluorescence could be predicted by examining urinary porphyrin before surgery, at the time of intraoperative fluorescence diagnosis using 5-ALA. The urine of brain tumor patients 2 hours after 5-ALA administration was irradiated with a 405 ± 1 nm laser light. The patients were divided into a fluorescent urine group and negative fluorescent urine group. Red fluorescence was observed in response to the 405 ± 1 nm laser beam for all tumors in the fluorescent urine group. Clear red fluorescence was not observed even with 405 ± 1 nm laser beam irradiation in any tumors in the negative fluorescent urine group. Preoperative prediction of the intraoperative fluorescence of PPIX can be achieved by observation of urine 2 hours after 5-ALA administration with exposure to a 405 ± 1 nm laser light.展开更多
1,3-bis[5-(4-ethyoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(A),1-[5-(4-ethoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(B) are synthesized.Their structures are ...1,3-bis[5-(4-ethyoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(A),1-[5-(4-ethoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(B) are synthesized.Their structures are characterized by UV-Vis,IR,1HNMR and MS.The synthesis and separation conditions of the target compounds are studied.The results show that the yield is higher when DMF is used as the solvent at 115 ℃ for 11 h.The products are separated via column chroma to graphy with silica gel(200-300) separation is more satisfactory as the eluent when the column is 3 cm in diameter and 12 cm in height.展开更多
以丙酸和硝基苯为混合溶剂,苯甲醛、对羟基苯甲醛和吡咯为原料合成了5-对羟基苯基-10,15,20-三苯基卟啉(HPTPP).然后以HPTPP和环氧氯丙烷为原料,在NaOH催化条件下合成了5-[4-(2,3-环氧丙氧基)苯基]-10,15,20-三苯基卟啉(EPPTPP).利用傅...以丙酸和硝基苯为混合溶剂,苯甲醛、对羟基苯甲醛和吡咯为原料合成了5-对羟基苯基-10,15,20-三苯基卟啉(HPTPP).然后以HPTPP和环氧氯丙烷为原料,在NaOH催化条件下合成了5-[4-(2,3-环氧丙氧基)苯基]-10,15,20-三苯基卟啉(EPPTPP).利用傅里叶变换红外光谱仪(FTIR)、核磁共振波谱仪(NMR)、紫外可见分光光度计(UV-Vis)和荧光分光光度计分别对HPTPP和EPPTPP的化学结构和光学性质进行了表征与测试.结果表明:FTIR谱图中,1 347cm-1和917cm-1处为EPPTPP卟啉环中C N键伸缩振动吸收峰和环氧化物环的(C—OC键)不对称伸缩振动吸收峰.EPPTPP的1 H NMR谱图中,在δ2.94～4.56内5个位移峰峰面积比为1∶1∶1∶1∶1,与EPPTPP中环氧基团的不同氢原子数比完全一致.UV-Vis谱图中,具有与卟啉结构相符合的吸收峰,表明成功合成了EPPTPP.通过荧光光谱分析了HPTPP和EPPTPP的荧光性质,并计算得到了二者的荧光量子产率分别为0.140和0.143.展开更多
基金This work was supported by the Excellent Scientist Program of South China University of Technology (324-D60090), the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (B09-B7060040) and the National Natural Science Foundation of China (20643001)
文摘We describe in this paper the fabrication of two- and one-dimensional nanostructures with organic molecular beam epitaxy （OMBE） principle based on controlled selfassembly by using adsorbate-substrate and intennolecular interactions that are important in molecular fabrication. Cu（100） single crystal was used as substrate in fabricating molecular nanostructures. Scanning tunneling microscopy （STM） experiments confirmed that Zn-tetra- [3,5-di-t-butylphenyl]porphyrin-molecules can be used to fabricate both monolayer and molecular wire on Cu（100） surface simultaneously, and the latter is arranged on the terrace edges. We herein briefly discuss the selectivity in terms of a mechanism in which the highest occupied and lowest unoccupied molecular orbitals （HOMO and LUMO） of the molecules interact with the surface.
文摘The mean activity coefficient of 5, 10,15 , 20-tetrakis (P-methoxyl-O-sulfophenyl)porphyrin sodium in dilute aqueous solution has been determined in the modality range 0. 00547-0. 08871 mol · kg-1at 273. 2 K by the freezing-point depression method . The results of γ± are 0. 9945-0. 7695, it is in close agreement with that by isopiestic method.
文摘Protoporphyrin IX (PPIX) fluorescence-guided brain tumor resection, using 5-aminolevulinic acid (5-ALA), is among the most valuable tools for determining tumor removal area. However, PPIX fluorescence is not necessarily achieved during an operation visually even when 5-ALA is used, and we do not know until tumor exposure to the excitation light of the ultraviolet region whether PPIX fluorescence has been achieved. When a particular biopsy and frozen section diagnosis is made, the reason for lack of PPIX fluorescence in the tissue cannot be judged. We do not know whether the tumor fails to fluoresce or no fluorescence is seen because it is not the main body of the tumor. We investigated whether the presence or absence of tumor fluorescence could be predicted by examining urinary porphyrin before surgery, at the time of intraoperative fluorescence diagnosis using 5-ALA. The urine of brain tumor patients 2 hours after 5-ALA administration was irradiated with a 405 ± 1 nm laser light. The patients were divided into a fluorescent urine group and negative fluorescent urine group. Red fluorescence was observed in response to the 405 ± 1 nm laser beam for all tumors in the fluorescent urine group. Clear red fluorescence was not observed even with 405 ± 1 nm laser beam irradiation in any tumors in the negative fluorescent urine group. Preoperative prediction of the intraoperative fluorescence of PPIX can be achieved by observation of urine 2 hours after 5-ALA administration with exposure to a 405 ± 1 nm laser light.
文摘1,3-bis[5-(4-ethyoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(A),1-[5-(4-ethoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(B) are synthesized.Their structures are characterized by UV-Vis,IR,1HNMR and MS.The synthesis and separation conditions of the target compounds are studied.The results show that the yield is higher when DMF is used as the solvent at 115 ℃ for 11 h.The products are separated via column chroma to graphy with silica gel(200-300) separation is more satisfactory as the eluent when the column is 3 cm in diameter and 12 cm in height.
文摘以丙酸和硝基苯为混合溶剂,苯甲醛、对羟基苯甲醛和吡咯为原料合成了5-对羟基苯基-10,15,20-三苯基卟啉(HPTPP).然后以HPTPP和环氧氯丙烷为原料,在NaOH催化条件下合成了5-[4-(2,3-环氧丙氧基)苯基]-10,15,20-三苯基卟啉(EPPTPP).利用傅里叶变换红外光谱仪(FTIR)、核磁共振波谱仪(NMR)、紫外可见分光光度计(UV-Vis)和荧光分光光度计分别对HPTPP和EPPTPP的化学结构和光学性质进行了表征与测试.结果表明:FTIR谱图中,1 347cm-1和917cm-1处为EPPTPP卟啉环中C N键伸缩振动吸收峰和环氧化物环的(C—OC键)不对称伸缩振动吸收峰.EPPTPP的1 H NMR谱图中,在δ2.94～4.56内5个位移峰峰面积比为1∶1∶1∶1∶1,与EPPTPP中环氧基团的不同氢原子数比完全一致.UV-Vis谱图中,具有与卟啉结构相符合的吸收峰,表明成功合成了EPPTPP.通过荧光光谱分析了HPTPP和EPPTPP的荧光性质,并计算得到了二者的荧光量子产率分别为0.140和0.143.
