Bowel preparation protocol for hospitalized patients ages 50 years or older:A randomized controlled trial

BACKGROUND The incidence and mortality rate of colorectal cancer progressively increase with age and become particularly prominent after the age of 50 years.Therefore,the population that is≥50 years in age requires long-term and regular colonoscopies.Uncomfortable bowel preparation is the main reason preventing patients from undergoing regular colonoscopies.The standard bowel preparation regimen of 4-L polyethylene glycol(PEG)is effective but poorly tolerated.AIM To investigate an effective and comfortable bowel preparation regimen for hospitalized patients≥50 years in age.METHODS Patients were randomly assigned to group 1(2-L PEG+30-mL lactulose+a lowresidue diet)or group 2(4-L PEG).Adequate bowel preparation was defined as a Boston bowel preparation scale(BBPS)score of≥6,with a score of≥2 for each segment.Non-inferiority was prespecified with a margin of 10%.Additionally,the degree of comfort was assessed based on the comfort questionnaire.RESULTS The proportion of patients with a BBPS score of≥6 in group 1 was not significantly different from that in group 2,as demonstrated by intention-to-treat(91.2%vs 91.0%,P=0.953)and per-protocol(91.8%vs 91.0%,P=0.802)analyses.Furthermore,in patients≥75 years in age,the proportion of BBPS scores of≥6 in group 1 was not significantly different from that in group 2(90.9%vs 97.0%,P=0.716).Group 1 had higher comfort scores(8.85±1.162 vs 7.59±1.735,P<0.001),longer sleep duration(6.86±1.204 h vs 5.80±1.730 h,P<0.001),and fewer awakenings(1.42±1.183 vs 2.04±1.835,P=0.026)than group 2.CONCLUSION For hospitalized patients≥50 years in age,the bowel preparation regimen comprising 2-L PEG+30-mL lactulose+a low-residue diet produced a cleanse that was as effective as the 4-L PEG regimen and even provided better comfort.

Morphological changes of silver and bighead carp in the Yangtze River over the past 50 years

Multivariate analysis was adopted to analyze 30 morphometrical characteristics of 121 one-year-old juvenile silver carp （Hypophthalmichthys molitrix） and bighead carp （Aristichthys nobilis） bred during the 1950s （＂the former population＂） and 2008 （＂the current population＂） and collected from the middle reach of the Yangtze River. The average discriminant accuracies of the former and current silver and bighead carp population were 94.2% and 98.0%, respectively. Discriminant analysis also revealed that significant differences in morphology occurred between the former and current populations of both carp in overall characteristics. One-way analysis of variance indicated that between former and current populations, silver carp showed highly significant differences （P0.01） in twelve of their characteristics and significant differences （P0.05） in eight of their characteristics, while bighead carp showed highly significant differences （P0.01） in eight of their characteristics and significant differences （P0.05） in eight of their characteristics. Six head morphology variables of the current silver and bighead carp were significantly or highly significantly larger than the former populations; fourteen characteristics of silver carp and ten characteristics of bighead carp of the current populations, mainly reflecting truck and tail morphology, were significantly or very significantly smaller than the former populations. Our results indicate that silver and bighead carp have developed a larger head and smaller truck and tail during the last 50 years. Due to such morphological changes, it seems apparent that the heads of these fish species need to be considered in regards to human diets, particularly in relation to economic and nutritious value.

Characteristics of the HIV/AIDS Epidemic among People Aged≥50 Years in China during 2018–2021

Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2018 to 2021.It also aimed to recommend targeted interventions for the prevention and treatment of HIV/AIDS in elderly patients.Methods Data on newly reported cases of PLWHA,aged≥50 years in China from 2018 to 2021,were collected using the CRIMS.Trend tests and spatial analyses were also conducted.Results Between 2018 and 2021,237,724 HIV/AIDS cases were reported among patients aged≥50 years in China.The main transmission route was heterosexual transmission(91.24%).Commercial heterosexual transmission(CHC)was the primary mode of transmission among males,while non-marital non-CHC([NMNCHC];60.59%)was the prevalent route in women.The proportion of patients with CHC decreased over time(Z=67.716,P<0.01),while that of patients with NMNCHC increased(Z=153.05,P<0.01).The sex ratio varied among the different modes of infection,and it peaked at 17.65 for CHC.The spatial analysis indicated spatial clustering,and the high-high clustering areas were mainly distributed in the southwestern and central-southern provinces.Conclusion In China,PLWHA,aged≥50 years,were predominantly infected through heterosexual transmission.The primary modes of infection were CHC and NMNCHC.There were variations in the sex ratio among different age groups,infected through various sexual behaviors.HIV/AIDS cases exhibited spatial clustering.Based on these results,the expansion of HIV testing,treatment,and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.

Three Development Stages for the Tibetan Family and Tibet's Modernization——A Survey of Social Changes in Tibet in Last 50 Years

I Since 1990, as a person in charge of key research projects of the China Tibetology Research Center, I have had opportunities almost every year to conduct field surveys on anthropology in Tibet together with my colleagues. Our investigations focus on the family. The purpose of our surveys is to see social changes in Tibet during the 50 years after the Democratic Reform through the study of the family as a social cell.

Distribution and characteristics of initial PSA and PSA velocity in men younger than 50 years without prostate cancer

Objective To explore the distribution and characteristics of initial PSA and PSA velocity in men younger than years without prostate cancer. Methods PSA in men younger than 50 years without prostate cancer from January 2001 to November 2009 were retrieved retrospec-

Benefits for Future Sino-US Relations from Lessons of Past 50 Years

The roller coaster Sino-US relations over the past 50 years have dipped to a newlow once again this year, with clamor for strategic competition drowning outadvocacy of strategic cooperation on the other shore of the Pacific Ocean. Why bi-lateral ties have thus far failed to shatter this erratic puzzling bind ? A review of thepast 50 years will perhaps offer us much food for thought.

LESSONS FROM THE 50 POSTWAR YEARS

Fifty years is but a twinkle of the eye in the long stream ofhuman history,but each 50 year period is one of the links in thechain that connects the past to the present,and each link has itown significance.At the turn of the century it is fit for us to re-view cool-headly the changes in world politics in the last 50 yearsso as to be able to explore on the world of the 21st century.

Ailogeneic hematopoietic cell transplantation for malignant hematological diseases in patients older than 50 years of age

Objective To investigate the efficiency and safety of allogeneic hematopoietic cell transplantation for malignant hematological diseases in patients older than 50 years of age. Methods From May 2002 to January 2010,35 patients P 】 50 years with malignant hematological diseases received allogeneic hematopoietic

CAS RESEARCH CONTINGENT CONSTRUCTION IN THE PAST 50 YEARS

The achievement of high-level R&D results and the nurture of high-level research professionals are the two principal missions committed to the CAS by our nation. So, the development of a competent research contingent is ever regarded as a top priority in the work agenda of CAS leaders, and this is a topic of vital importance to the Party, the central government and the people.

A Healthy Relationship China-Africa medical cooperation still going strong after 50 years

The [medical] areas of cooperation [between China and Africa] have amso been expanded from sending medical teams to training local medical personnel; from building hospitals and providing free medication to conducting joint medical research.

Exhibition on 50 Years of Democratic Reform in Tibet

On the cold morning of February 24, 2009, a few hundred people were gathered outside Beijing Cultural Palace of the Nationalities. Among them were ethnic Tibetan students of the Central University for Nationalities, retired Tibetan cadres and people from all walks of life. They were waiting for the opening of the exhibition 50 Years of Democratic Reform in Tibet.

Development of a Meteorological and Hydrological Coupling Index for Droughts and Floods along the Yangtze River Valley of China

To comprehensively investigate characteristics of summer droughts and floods in the Yangtze River valley, a meteorological and hydrological coupling index （MHCI） was developed using meteorological and hydro- logical data. The results indicate that： （1） in representing drought/flood information for the Yangtze River valley, the MHCI can reflect composite features of precipitation and hydrological observations; （2） compre- hensive analysis of the interannual phase difference of the precipitation and hydrological indices is important to recognize and predict annual drought/flood events along the valley; the hydrological index contributes more strongly to nonlinear and continuity features that indicate transition from long-term drought to flood conditions; （3） time series of the MHCI from 1960-2009 are very effective and sensitive in reflecting annual drought/flood characteristics, i.e. there is more rainfall or typical flooding in the valley when the MHCI is positive, and vice versa; and （4） verification of the MHCI indicates that there is significant correlation between precipitation and hydrologic responses in the valley during summer; the correlation coefficient was found to reach 0.82, exceeding the 0.001 significance level.

Chinese Women 50 Years On (Part Ⅱ)

IN accordance with thegovernment’s shift in focustoward the realization of thenation’s modernization in 1978,the year when China adopted itspolicy of reform, the All-ChinaWomen’s Federation mobilizedwomen to take an active part inthe new economic construction. Itplaced this work as its own focusfor the new era.

Still in Love After 50 Years

QUIET in the deep night. The golden anniversary celebration has ended and the relatives and friends have gone. In our room only a pair of red candles burn silently. In the flickering candlelight, two pairs of hands are tightly clasped. The backs of the hands are covered with blue veins and age spots. Bai and I sit face to face, smiling and recalling the past, our frustrating and beautiful lifetime.

Memory of Japan Visit 50 Years Ago

My career as a'people-to-people diplomat' began 51 years ago when I graduated from Peking University and landed a job with the Chinese People’s Committee for Safeguarding World Peace,or Heda,as it was commonly known at the time.Since then,I lived,worked and grew up—literally and politically—on the organization’s garden-like campus in Beijing,devoting my prime years to